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PubMed code 28105274

Compile data set for download or QSAR
Found 108 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208064
PNG
(CHEMBL3933619)
Show SMILES OC(=O)C1CCN(CC1)c1ccc(cc1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-17-6-5-15(27-19(21,22)23)11-16(17)12-1-3-14(4-2-12)24-9-7-13(8-10-24)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208108
PNG
(CHEMBL3954140 | US9708270, 33)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c19-18(20,21)14-3-8-22-15(12-14)23-9-6-17(7-10-23)4-1-13(2-5-17)11-16(24)25/h3,8,12-13H,1-2,4-7,9-11H2,(H,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208151
PNG
(CHEMBL3986483 | US9708270, 97)
Show SMILES OC(=O)CC1CCC2(CCN(CC2)c2cc(OC(F)(F)F)ccc2Cl)OC1
Show InChI InChI=1S/C18H21ClF3NO4/c19-14-2-1-13(27-18(20,21)22)10-15(14)23-7-5-17(6-8-23)4-3-12(11-26-17)9-16(24)25/h1-2,10,12H,3-9,11H2,(H,24,25)
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n/an/an/an/a 2.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208084
PNG
(CHEMBL3977361 | US9708270, 8)
Show SMILES COc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO3/c1-24-15-2-3-16(20)17(13-15)21-10-8-19(9-11-21)6-4-14(5-7-19)12-18(22)23/h2-3,13-14H,4-12H2,1H3,(H,22,23)
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n/an/an/an/a 5.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208157
PNG
(CHEMBL3893026 | US9708270, 30)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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n/an/an/an/a 51n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208154
PNG
(CHEMBL3973034 | US9708270, 35)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1C#N
Show InChI InChI=1S/C20H23F3N2O3/c21-20(22,23)28-16-2-1-15(13-24)17(12-16)25-9-7-19(8-10-25)5-3-14(4-6-19)11-18(26)27/h1-2,12,14H,3-11H2,(H,26,27)
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n/an/an/an/a 200n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208146
PNG
(CHEMBL3901994 | US9708270, 38)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(Cl)c1F
Show InChI InChI=1S/C18H22ClF2NO2/c19-14-10-13(20)11-15(17(14)21)22-7-5-18(6-8-22)3-1-12(2-4-18)9-16(23)24/h10-12H,1-9H2,(H,23,24)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208157
PNG
(CHEMBL3893026 | US9708270, 30)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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n/an/an/an/a 220n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208146
PNG
(CHEMBL3901994 | US9708270, 38)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(Cl)c1F
Show InChI InChI=1S/C18H22ClF2NO2/c19-14-10-13(20)11-15(17(14)21)22-7-5-18(6-8-22)3-1-12(2-4-18)9-16(23)24/h10-12H,1-9H2,(H,23,24)
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n/an/an/an/a 190n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208154
PNG
(CHEMBL3973034 | US9708270, 35)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1C#N
Show InChI InChI=1S/C20H23F3N2O3/c21-20(22,23)28-16-2-1-15(13-24)17(12-16)25-9-7-19(8-10-25)5-3-14(4-6-19)11-18(26)27/h1-2,12,14H,3-11H2,(H,26,27)
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n/an/an/an/a 200n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208093
PNG
(CHEMBL3953289 | US9708270, 25)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(SC(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C20H23F3N2O2S/c21-20(22,23)28-17-10-15(13-24)9-16(12-17)25-7-5-19(6-8-25)3-1-14(2-4-19)11-18(26)27/h9-10,12,14H,1-8,11H2,(H,26,27)
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n/an/an/an/a 360n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208108
PNG
(CHEMBL3954140 | US9708270, 33)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c19-18(20,21)14-3-8-22-15(12-14)23-9-6-17(7-10-23)4-1-13(2-5-17)11-16(24)25/h3,8,12-13H,1-2,4-7,9-11H2,(H,24,25)
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n/an/an/an/a 1.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208149
PNG
(CHEMBL3937916 | US9708270, 11)
Show SMILES CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(O)=O)CC4)CC3)c2O1
Show InChI InChI=1S/C22H30ClNO3/c1-21(2)14-16-12-17(23)13-18(20(16)27-21)24-9-7-22(8-10-24)5-3-15(4-6-22)11-19(25)26/h12-13,15H,3-11,14H2,1-2H3,(H,25,26)
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n/an/an/an/a 3.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208149
PNG
(CHEMBL3937916 | US9708270, 11)
Show SMILES CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(O)=O)CC4)CC3)c2O1
Show InChI InChI=1S/C22H30ClNO3/c1-21(2)14-16-12-17(23)13-18(20(16)27-21)24-9-7-22(8-10-24)5-3-15(4-6-22)11-19(25)26/h12-13,15H,3-11,14H2,1-2H3,(H,25,26)
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n/an/an/an/a 4.00E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208158
PNG
(CHEMBL3920891)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1ccccc1Cl
Show InChI InChI=1S/C18H24ClNO2/c19-15-3-1-2-4-16(15)20-11-9-18(10-12-20)7-5-14(6-8-18)13-17(21)22/h1-4,14H,5-13H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208153
PNG
(CHEMBL3969920)
Show SMILES CC1CC2(CCC1CC(O)=O)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H25ClF3NO3/c1-13-12-19(5-4-14(13)10-18(26)27)6-8-25(9-7-19)17-11-15(2-3-16(17)21)28-20(22,23)24/h2-3,11,13-14H,4-10,12H2,1H3,(H,26,27)
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n/an/an/an/a 4.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208150
PNG
(CHEMBL3947837 | US9708270, 16)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C19H23F4NO2/c20-15-2-1-14(19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208071
PNG
(CHEMBL3964985)
Show SMILES OC(=O)c1ccc(cc1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208157
PNG
(CHEMBL3893026 | US9708270, 30)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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n/an/an/an/a 6.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208150
PNG
(CHEMBL3947837 | US9708270, 16)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C19H23F4NO2/c20-15-2-1-14(19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208084
PNG
(CHEMBL3977361 | US9708270, 8)
Show SMILES COc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO3/c1-24-15-2-3-16(20)17(13-15)21-10-8-19(9-11-21)6-4-14(5-7-19)12-18(22)23/h2-3,13-14H,4-12H2,1H3,(H,22,23)
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n/an/an/an/a 2.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208108
PNG
(CHEMBL3954140 | US9708270, 33)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c19-18(20,21)14-3-8-22-15(12-14)23-9-6-17(7-10-23)4-1-13(2-5-17)11-16(24)25/h3,8,12-13H,1-2,4-7,9-11H2,(H,24,25)
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n/an/an/an/a 1.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208146
PNG
(CHEMBL3901994 | US9708270, 38)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(Cl)c1F
Show InChI InChI=1S/C18H22ClF2NO2/c19-14-10-13(20)11-15(17(14)21)22-7-5-18(6-8-22)3-1-12(2-4-18)9-16(23)24/h10-12H,1-9H2,(H,23,24)
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n/an/an/an/a 420n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208071
PNG
(CHEMBL3964985)
Show SMILES OC(=O)c1ccc(cc1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208153
PNG
(CHEMBL3969920)
Show SMILES CC1CC2(CCC1CC(O)=O)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H25ClF3NO3/c1-13-12-19(5-4-14(13)10-18(26)27)6-8-25(9-7-19)17-11-15(2-3-16(17)21)28-20(22,23)24/h2-3,11,13-14H,4-10,12H2,1H3,(H,26,27)
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n/an/an/an/a 2.70E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208154
PNG
(CHEMBL3973034 | US9708270, 35)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1C#N
Show InChI InChI=1S/C20H23F3N2O3/c21-20(22,23)28-16-2-1-15(13-24)17(12-16)25-9-7-19(8-10-25)5-3-14(4-6-19)11-18(26)27/h1-2,12,14H,3-11H2,(H,26,27)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208064
PNG
(CHEMBL3933619)
Show SMILES OC(=O)C1CCN(CC1)c1ccc(cc1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-17-6-5-15(27-19(21,22)23)11-16(17)12-1-3-14(4-2-12)24-9-7-13(8-10-24)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208158
PNG
(CHEMBL3920891)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1ccccc1Cl
Show InChI InChI=1S/C18H24ClNO2/c19-15-3-1-2-4-16(15)20-11-9-18(10-12-20)7-5-14(6-8-18)13-17(21)22/h1-4,14H,5-13H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208093
PNG
(CHEMBL3953289 | US9708270, 25)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(SC(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C20H23F3N2O2S/c21-20(22,23)28-17-10-15(13-24)9-16(12-17)25-7-5-19(6-8-25)3-1-14(2-4-19)11-18(26)27/h9-10,12,14H,1-8,11H2,(H,26,27)
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n/an/an/an/a 44n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208157
PNG
(CHEMBL3893026 | US9708270, 30)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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n/an/an/an/a 220n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208148
PNG
(CHEMBL3891920 | US9708270, 7)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 470n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208156
PNG
(CHEMBL3906716)
Show SMILES OC(=O)C1CCC(CC1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h5-6,11-14H,1-4,7-10H2,(H,25,26)
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n/an/an/an/a 990n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208094
PNG
(CHEMBL3897637 | US9708270, 85)
Show SMILES OC(=O)CCC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H25ClF3NO3/c21-16-3-2-15(28-20(22,23)24)13-17(16)25-11-9-19(10-12-25)7-5-14(6-8-19)1-4-18(26)27/h2-3,13-14H,1,4-12H2,(H,26,27)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50203653
PNG
(CHEMBL3896657)
Show SMILES OC(=O)CCc1cc2cc(ccc2o1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
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n/an/an/an/a 16n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208071
PNG
(CHEMBL3964985)
Show SMILES OC(=O)c1ccc(cc1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208093
PNG
(CHEMBL3953289 | US9708270, 25)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(SC(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C20H23F3N2O2S/c21-20(22,23)28-17-10-15(13-24)9-16(12-17)25-7-5-19(6-8-25)3-1-14(2-4-19)11-18(26)27/h9-10,12,14H,1-8,11H2,(H,26,27)
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n/an/an/an/a 360n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208160
PNG
(CHEMBL3940359)
Show SMILES CC1CC(CC(O)=O)CCC11CCN(CC1)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H25ClF3NO3/c1-13-10-14(11-18(26)27)4-5-19(13)6-8-25(9-7-19)17-12-15(2-3-16(17)21)28-20(22,23)24/h2-3,12-14H,4-11H2,1H3,(H,26,27)
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n/an/an/an/a 580n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208155
PNG
(CHEMBL3957767)
Show SMILES OC(=O)CN1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H22F4N2O3/c19-14-2-1-13(27-18(20,21)22)11-15(14)24-9-5-17(6-10-24)3-7-23(8-4-17)12-16(25)26/h1-2,11H,3-10,12H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208093
PNG
(CHEMBL3953289 | US9708270, 25)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(SC(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C20H23F3N2O2S/c21-20(22,23)28-17-10-15(13-24)9-16(12-17)25-7-5-19(6-8-25)3-1-14(2-4-19)11-18(26)27/h9-10,12,14H,1-8,11H2,(H,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208156
PNG
(CHEMBL3906716)
Show SMILES OC(=O)C1CCC(CC1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h5-6,11-14H,1-4,7-10H2,(H,25,26)
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n/an/an/an/a 1.49E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208156
PNG
(CHEMBL3906716)
Show SMILES OC(=O)C1CCC(CC1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h5-6,11-14H,1-4,7-10H2,(H,25,26)
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n/an/an/an/a 700n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50203652
PNG
(CHEMBL3909872)
Show SMILES Cc1cc(cc(C)c1OCCCC(O)=O)-c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H18ClF3O4/c1-11-8-13(9-12(2)18(11)26-7-3-4-17(24)25)15-10-14(5-6-16(15)20)27-19(21,22)23/h5-6,8-10H,3-4,7H2,1-2H3,(H,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208156
PNG
(CHEMBL3906716)
Show SMILES OC(=O)C1CCC(CC1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h5-6,11-14H,1-4,7-10H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208108
PNG
(CHEMBL3954140 | US9708270, 33)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c19-18(20,21)14-3-8-22-15(12-14)23-9-6-17(7-10-23)4-1-13(2-5-17)11-16(24)25/h3,8,12-13H,1-2,4-7,9-11H2,(H,24,25)
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n/an/an/an/a 9.20E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208158
PNG
(CHEMBL3920891)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1ccccc1Cl
Show InChI InChI=1S/C18H24ClNO2/c19-15-3-1-2-4-16(15)20-11-9-18(10-12-20)7-5-14(6-8-18)13-17(21)22/h1-4,14H,5-13H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208152
PNG
(CHEMBL3967504 | US9708270, 50)
Show SMILES OCCC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H25ClF3NO2/c20-16-2-1-15(26-19(21,22)23)13-17(16)24-10-8-18(9-11-24)6-3-14(4-7-18)5-12-25/h1-2,13-14,25H,3-12H2
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n/an/an/an/a 4.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50203652
PNG
(CHEMBL3909872)
Show SMILES Cc1cc(cc(C)c1OCCCC(O)=O)-c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H18ClF3O4/c1-11-8-13(9-12(2)18(11)26-7-3-4-17(24)25)15-10-14(5-6-16(15)20)27-19(21,22)23/h5-6,8-10H,3-4,7H2,1-2H3,(H,24,25)
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n/an/an/an/a 94n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208071
PNG
(CHEMBL3964985)
Show SMILES OC(=O)c1ccc(cc1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208156
PNG
(CHEMBL3906716)
Show SMILES OC(=O)C1CCC(CC1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h5-6,11-14H,1-4,7-10H2,(H,25,26)
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n/an/an/an/a 1.49E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208095
PNG
(CHEMBL3919973)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 66n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208149
PNG
(CHEMBL3937916 | US9708270, 11)
Show SMILES CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(O)=O)CC4)CC3)c2O1
Show InChI InChI=1S/C22H30ClNO3/c1-21(2)14-16-12-17(23)13-18(20(16)27-21)24-9-7-22(8-10-24)5-3-15(4-6-22)11-19(25)26/h12-13,15H,3-11,14H2,1-2H3,(H,25,26)
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n/an/an/an/a 670n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208148
PNG
(CHEMBL3891920 | US9708270, 7)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 470n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208150
PNG
(CHEMBL3947837 | US9708270, 16)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C19H23F4NO2/c20-15-2-1-14(19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208084
PNG
(CHEMBL3977361 | US9708270, 8)
Show SMILES COc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO3/c1-24-15-2-3-16(20)17(13-15)21-10-8-19(9-11-21)6-4-14(5-7-19)12-18(22)23/h2-3,13-14H,4-12H2,1H3,(H,22,23)
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n/an/an/an/a 5.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208152
PNG
(CHEMBL3967504 | US9708270, 50)
Show SMILES OCCC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H25ClF3NO2/c20-16-2-1-15(26-19(21,22)23)13-17(16)24-10-8-18(9-11-24)6-3-14(4-7-18)5-12-25/h1-2,13-14,25H,3-12H2
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n/an/an/an/a 4.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208095
PNG
(CHEMBL3919973)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 98n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208149
PNG
(CHEMBL3937916 | US9708270, 11)
Show SMILES CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(O)=O)CC4)CC3)c2O1
Show InChI InChI=1S/C22H30ClNO3/c1-21(2)14-16-12-17(23)13-18(20(16)27-21)24-9-7-22(8-10-24)5-3-15(4-6-22)11-19(25)26/h12-13,15H,3-11,14H2,1-2H3,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50203653
PNG
(CHEMBL3896657)
Show SMILES OC(=O)CCc1cc2cc(ccc2o1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
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n/an/an/an/a 43n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208154
PNG
(CHEMBL3973034 | US9708270, 35)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1C#N
Show InChI InChI=1S/C20H23F3N2O3/c21-20(22,23)28-16-2-1-15(13-24)17(12-16)25-9-7-19(8-10-25)5-3-14(4-6-19)11-18(26)27/h1-2,12,14H,3-11H2,(H,26,27)
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n/an/an/an/a 290n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208150
PNG
(CHEMBL3947837 | US9708270, 16)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C19H23F4NO2/c20-15-2-1-14(19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 1.20E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208160
PNG
(CHEMBL3940359)
Show SMILES CC1CC(CC(O)=O)CCC11CCN(CC1)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H25ClF3NO3/c1-13-10-14(11-18(26)27)4-5-19(13)6-8-25(9-7-19)17-12-15(2-3-16(17)21)28-20(22,23)24/h2-3,12-14H,4-11H2,1H3,(H,26,27)
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n/an/an/an/a 440n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208146
PNG
(CHEMBL3901994 | US9708270, 38)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(Cl)c1F
Show InChI InChI=1S/C18H22ClF2NO2/c19-14-10-13(20)11-15(17(14)21)22-7-5-18(6-8-22)3-1-12(2-4-18)9-16(23)24/h10-12H,1-9H2,(H,23,24)
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n/an/an/an/a 190n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208157
PNG
(CHEMBL3893026 | US9708270, 30)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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n/an/an/an/a 6.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208084
PNG
(CHEMBL3977361 | US9708270, 8)
Show SMILES COc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO3/c1-24-15-2-3-16(20)17(13-15)21-10-8-19(9-11-21)6-4-14(5-7-19)12-18(22)23/h2-3,13-14H,4-12H2,1H3,(H,22,23)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208095
PNG
(CHEMBL3919973)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 66n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208147
PNG
(CHEMBL3949142)
Show SMILES OC(=O)C1CC11CCC2(CCN(CC2)c2cc(OC(F)(F)F)ccc2Cl)CC1
Show InChI InChI=1S/C20H23ClF3NO3/c21-15-2-1-13(28-20(22,23)24)11-16(15)25-9-7-18(8-10-25)3-5-19(6-4-18)12-14(19)17(26)27/h1-2,11,14H,3-10,12H2,(H,26,27)
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n/an/an/an/a 2.20E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208149
PNG
(CHEMBL3937916 | US9708270, 11)
Show SMILES CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(O)=O)CC4)CC3)c2O1
Show InChI InChI=1S/C22H30ClNO3/c1-21(2)14-16-12-17(23)13-18(20(16)27-21)24-9-7-22(8-10-24)5-3-15(4-6-22)11-19(25)26/h12-13,15H,3-11,14H2,1-2H3,(H,25,26)
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n/an/an/an/a 4.00E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208151
PNG
(CHEMBL3986483 | US9708270, 97)
Show SMILES OC(=O)CC1CCC2(CCN(CC2)c2cc(OC(F)(F)F)ccc2Cl)OC1
Show InChI InChI=1S/C18H21ClF3NO4/c19-14-2-1-13(27-18(20,21)22)10-15(14)23-7-5-17(6-8-23)4-3-12(11-26-17)9-16(24)25/h1-2,10,12H,3-9,11H2,(H,24,25)
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n/an/an/an/a 2.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208108
PNG
(CHEMBL3954140 | US9708270, 33)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c19-18(20,21)14-3-8-22-15(12-14)23-9-6-17(7-10-23)4-1-13(2-5-17)11-16(24)25/h3,8,12-13H,1-2,4-7,9-11H2,(H,24,25)
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n/an/an/an/a 9.20E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208154
PNG
(CHEMBL3973034 | US9708270, 35)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1C#N
Show InChI InChI=1S/C20H23F3N2O3/c21-20(22,23)28-16-2-1-15(13-24)17(12-16)25-9-7-19(8-10-25)5-3-14(4-6-19)11-18(26)27/h1-2,12,14H,3-11H2,(H,26,27)
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n/an/an/an/a 290n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208071
PNG
(CHEMBL3964985)
Show SMILES OC(=O)c1ccc(cc1)C1CCN(CC1)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-16-6-5-15(27-19(21,22)23)11-17(16)24-9-7-13(8-10-24)12-1-3-14(4-2-12)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208064
PNG
(CHEMBL3933619)
Show SMILES OC(=O)C1CCN(CC1)c1ccc(cc1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-17-6-5-15(27-19(21,22)23)11-16(17)12-1-3-14(4-2-12)24-9-7-13(8-10-24)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a 320n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208095
PNG
(CHEMBL3919973)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 33n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208095
PNG
(CHEMBL3919973)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208158
PNG
(CHEMBL3920891)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1ccccc1Cl
Show InChI InChI=1S/C18H24ClNO2/c19-15-3-1-2-4-16(15)20-11-9-18(10-12-20)7-5-14(6-8-18)13-17(21)22/h1-4,14H,5-13H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208151
PNG
(CHEMBL3986483 | US9708270, 97)
Show SMILES OC(=O)CC1CCC2(CCN(CC2)c2cc(OC(F)(F)F)ccc2Cl)OC1
Show InChI InChI=1S/C18H21ClF3NO4/c19-14-2-1-13(27-18(20,21)22)10-15(14)23-7-5-17(6-8-23)4-3-12(11-26-17)9-16(24)25/h1-2,10,12H,3-9,11H2,(H,24,25)
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n/an/an/an/a 5.70E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50203652
PNG
(CHEMBL3909872)
Show SMILES Cc1cc(cc(C)c1OCCCC(O)=O)-c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H18ClF3O4/c1-11-8-13(9-12(2)18(11)26-7-3-4-17(24)25)15-10-14(5-6-16(15)20)27-19(21,22)23/h5-6,8-10H,3-4,7H2,1-2H3,(H,24,25)
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n/an/an/an/a 94n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208093
PNG
(CHEMBL3953289 | US9708270, 25)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(SC(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C20H23F3N2O2S/c21-20(22,23)28-17-10-15(13-24)9-16(12-17)25-7-5-19(6-8-25)3-1-14(2-4-19)11-18(26)27/h9-10,12,14H,1-8,11H2,(H,26,27)
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n/an/an/an/a 44n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208159
PNG
(CHEMBL3928591)
Show SMILES CC(C1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl)C(O)=O
Show InChI InChI=1S/C20H25ClF3NO3/c1-13(18(26)27)14-4-6-19(7-5-14)8-10-25(11-9-19)17-12-15(2-3-16(17)21)28-20(22,23)24/h2-3,12-14H,4-11H2,1H3,(H,26,27)
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n/an/an/an/a 4.40E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208148
PNG
(CHEMBL3891920 | US9708270, 7)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 700n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208148
PNG
(CHEMBL3891920 | US9708270, 7)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208155
PNG
(CHEMBL3957767)
Show SMILES OC(=O)CN1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H22F4N2O3/c19-14-2-1-13(27-18(20,21)22)11-15(14)24-9-5-17(6-10-24)3-7-23(8-4-17)12-16(25)26/h1-2,11H,3-10,12H2,(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50203652
PNG
(CHEMBL3909872)
Show SMILES Cc1cc(cc(C)c1OCCCC(O)=O)-c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H18ClF3O4/c1-11-8-13(9-12(2)18(11)26-7-3-4-17(24)25)15-10-14(5-6-16(15)20)27-19(21,22)23/h5-6,8-10H,3-4,7H2,1-2H3,(H,24,25)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208148
PNG
(CHEMBL3891920 | US9708270, 7)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H23F4NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 700n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208150
PNG
(CHEMBL3947837 | US9708270, 16)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C19H23F4NO2/c20-15-2-1-14(19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208157
PNG
(CHEMBL3893026 | US9708270, 30)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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n/an/an/an/a 120n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208084
PNG
(CHEMBL3977361 | US9708270, 8)
Show SMILES COc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO3/c1-24-15-2-3-16(20)17(13-15)21-10-8-19(9-11-21)6-4-14(5-7-19)12-18(22)23/h2-3,13-14H,4-12H2,1H3,(H,22,23)
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n/an/an/an/a 2.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50203653
PNG
(CHEMBL3896657)
Show SMILES OC(=O)CCc1cc2cc(ccc2o1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
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n/an/an/an/a 16n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50203653
PNG
(CHEMBL3896657)
Show SMILES OC(=O)CCc1cc2cc(ccc2o1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
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n/an/an/an/a 63n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208160
PNG
(CHEMBL3940359)
Show SMILES CC1CC(CC(O)=O)CCC11CCN(CC1)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H25ClF3NO3/c1-13-10-14(11-18(26)27)4-5-19(13)6-8-25(9-7-19)17-12-15(2-3-16(17)21)28-20(22,23)24/h2-3,12-14H,4-11H2,1H3,(H,26,27)
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n/an/an/an/a 580n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208147
PNG
(CHEMBL3949142)
Show SMILES OC(=O)C1CC11CCC2(CCN(CC2)c2cc(OC(F)(F)F)ccc2Cl)CC1
Show InChI InChI=1S/C20H23ClF3NO3/c21-15-2-1-13(28-20(22,23)24)11-16(15)25-9-7-18(8-10-25)3-5-19(6-4-18)12-14(19)17(26)27/h1-2,11,14H,3-10,12H2,(H,26,27)
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n/an/an/an/a 3.90E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208158
PNG
(CHEMBL3920891)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1ccccc1Cl
Show InChI InChI=1S/C18H24ClNO2/c19-15-3-1-2-4-16(15)20-11-9-18(10-12-20)7-5-14(6-8-18)13-17(21)22/h1-4,14H,5-13H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50203652
PNG
(CHEMBL3909872)
Show SMILES Cc1cc(cc(C)c1OCCCC(O)=O)-c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H18ClF3O4/c1-11-8-13(9-12(2)18(11)26-7-3-4-17(24)25)15-10-14(5-6-16(15)20)27-19(21,22)23/h5-6,8-10H,3-4,7H2,1-2H3,(H,24,25)
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n/an/an/an/a 16n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208095
PNG
(CHEMBL3919973)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 54n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50208093
PNG
(CHEMBL3953289 | US9708270, 25)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(SC(F)(F)F)cc(c1)C#N
Show InChI InChI=1S/C20H23F3N2O2S/c21-20(22,23)28-17-10-15(13-24)9-16(12-17)25-7-5-19(6-8-25)3-1-14(2-4-19)11-18(26)27/h9-10,12,14H,1-8,11H2,(H,26,27)
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n/an/an/an/a 140n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208094
PNG
(CHEMBL3897637 | US9708270, 85)
Show SMILES OC(=O)CCC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C20H25ClF3NO3/c21-16-3-2-15(28-20(22,23)24)13-17(16)25-11-9-19(10-12-25)7-5-14(6-8-19)1-4-18(26)27/h2-3,13-14H,1,4-12H2,(H,26,27)
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n/an/an/an/a 2.70E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208150
PNG
(CHEMBL3947837 | US9708270, 16)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C19H23F4NO2/c20-15-2-1-14(19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26)
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n/an/an/an/a 2.20E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208064
PNG
(CHEMBL3933619)
Show SMILES OC(=O)C1CCN(CC1)c1ccc(cc1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H17F4NO3/c20-17-6-5-15(27-19(21,22)23)11-16(17)12-1-3-14(4-2-12)24-9-7-13(8-10-24)18(25)26/h1-6,11,13H,7-10H2,(H,25,26)
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n/an/an/an/a 1.60E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50203653
PNG
(CHEMBL3896657)
Show SMILES OC(=O)CCc1cc2cc(ccc2o1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
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n/an/an/an/a 1.83E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208149
PNG
(CHEMBL3937916 | US9708270, 11)
Show SMILES CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(O)=O)CC4)CC3)c2O1
Show InChI InChI=1S/C22H30ClNO3/c1-21(2)14-16-12-17(23)13-18(20(16)27-21)24-9-7-22(8-10-24)5-3-15(4-6-22)11-19(25)26/h12-13,15H,3-11,14H2,1-2H3,(H,25,26)
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n/an/an/an/a 3.30E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208159
PNG
(CHEMBL3928591)
Show SMILES CC(C1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl)C(O)=O
Show InChI InChI=1S/C20H25ClF3NO3/c1-13(18(26)27)14-4-6-19(7-5-14)8-10-25(11-9-19)17-12-15(2-3-16(17)21)28-20(22,23)24/h2-3,12-14H,4-11H2,1H3,(H,26,27)
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n/an/an/an/a 3.50E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208146
PNG
(CHEMBL3901994 | US9708270, 38)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(F)cc(Cl)c1F
Show InChI InChI=1S/C18H22ClF2NO2/c19-14-10-13(20)11-15(17(14)21)22-7-5-18(6-8-22)3-1-12(2-4-18)9-16(23)24/h10-12H,1-9H2,(H,23,24)
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n/an/an/an/a 8.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50208108
PNG
(CHEMBL3954140 | US9708270, 33)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N2O2/c19-18(20,21)14-3-8-22-15(12-14)23-9-6-17(7-10-23)4-1-13(2-5-17)11-16(24)25/h3,8,12-13H,1-2,4-7,9-11H2,(H,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208158
PNG
(CHEMBL3920891)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1ccccc1Cl
Show InChI InChI=1S/C18H24ClNO2/c19-15-3-1-2-4-16(15)20-11-9-18(10-12-20)7-5-14(6-8-18)13-17(21)22/h1-4,14H,5-13H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50203653
PNG
(CHEMBL3896657)
Show SMILES OC(=O)CCc1cc2cc(ccc2o1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
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n/an/an/an/a 63n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 assessed as induction of IP1 accumulation


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50208157
PNG
(CHEMBL3893026 | US9708270, 30)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H23Cl2NO2/c19-14-10-15(20)12-16(11-14)21-7-5-18(6-8-21)3-1-13(2-4-18)9-17(22)23/h10-13H,1-9H2,(H,22,23)
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n/an/an/an/a 190n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 9...


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208158
PNG
(CHEMBL3920891)
Show SMILES OC(=O)CC1CCC2(CC1)CCN(CC2)c1ccccc1Cl
Show InChI InChI=1S/C18H24ClNO2/c19-15-3-1-2-4-16(15)20-11-9-18(10-12-20)7-5-14(6-8-18)13-17(21)22/h1-4,14H,5-13H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
Omega-3 fatty acid receptor 1


(Mus musculus)
BDBM50208084
PNG
(CHEMBL3977361 | US9708270, 8)
Show SMILES COc1ccc(Cl)c(c1)N1CCC2(CCC(CC(O)=O)CC2)CC1
Show InChI InChI=1S/C19H26ClNO3/c1-24-15-2-3-16(20)17(13-15)21-10-8-19(9-11-21)6-4-14(5-7-19)12-18(22)23/h2-3,13-14H,4-12H2,1H3,(H,22,23)
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UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/an/an/a 570n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 49-54 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00360
BindingDB Entry DOI: 10.7270/Q26W9D2Q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%