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PubMed code 28105282

Compile data set for download or QSAR
Found 95 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit Nav1.5


(Homo sapiens (Human))
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of Nav1.5 (unknown origin)


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Voltage-gated calcium channel


(HUMAN)
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of Cav1.2 (unknown origin)


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human CYP2D6


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human CYP2C9


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human CYP3A4


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207063
PNG
(CHEMBL3971857)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)ncc1F
Show InChI InChI=1S/C21H22FNO4/c22-18-12-23-20(27-15-2-1-3-15)11-17(18)13-5-8-19-14(10-13)4-6-16(26-19)7-9-21(24)25/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a 230n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207071
PNG
(CHEMBL3978465)
Show SMILES COc1cc(OC(F)(F)F)cc(c1F)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C20H18F4N4O3/c1-29-17-10-14(31-20(22,23)24)9-15(19(17)21)11-3-6-16-12(8-11)2-4-13(30-16)5-7-18-25-27-28-26-18/h3,6,8-10,13H,2,4-5,7H2,1H3,(H,25,26,27,28)/t13-/m1/s1
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n/an/an/an/a 150n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207053
PNG
(CHEMBL3950444)
Show SMILES OC(=O)[C@H]1C[C@@H]1[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C20H16F4O4/c21-16-4-3-12(28-20(22,23)24)8-13(16)10-1-5-17-11(7-10)2-6-18(27-17)14-9-15(14)19(25)26/h1,3-5,7-8,14-15,18H,2,6,9H2,(H,25,26)/t14-,15-,18+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207073
PNG
(CHEMBL3940429)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H25FO5/c1-27-21-13-18(28-16-3-2-4-16)12-19(23(21)24)14-6-9-20-15(11-14)5-7-17(29-20)8-10-22(25)26/h6,9,11-13,16-17H,2-5,7-8,10H2,1H3,(H,25,26)/t17-/m1/s1
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n/an/an/an/a 9n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207075
PNG
(CHEMBL3898962)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C23H24FNO5/c1-28-19-11-20(29-14-3-2-4-14)25-22(21(19)24)13-6-7-17-12(9-13)5-8-18(30-17)15-10-16(15)23(26)27/h6-7,9,11,14-16,18H,2-5,8,10H2,1H3,(H,26,27)/t15-,16-,18-/m1/s1
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n/an/an/an/a 18n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207055
PNG
(CHEMBL3960231)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H16F4O4/c20-16-6-4-14(27-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(26-17)5-8-18(24)25/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25)/t13-/m1/s1
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n/an/an/an/a 170n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207077
PNG
(CHEMBL3890035)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(c1)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C25H27FO6/c1-29-15-8-16(9-15)31-17-10-18(24(26)23(11-17)30-2)13-3-5-21-14(7-13)4-6-22(32-21)19-12-20(19)25(27)28/h3,5,7,10-11,15-16,19-20,22H,4,6,8-9,12H2,1-2H3,(H,27,28)/t15-,16-,19-,20-,22-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207077
PNG
(CHEMBL3890035)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(c1)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C25H27FO6/c1-29-15-8-16(9-15)31-17-10-18(24(26)23(11-17)30-2)13-3-5-21-14(7-13)4-6-22(32-21)19-12-20(19)25(27)28/h3,5,7,10-11,15-16,19-20,22H,4,6,8-9,12H2,1-2H3,(H,27,28)/t15-,16-,19-,20-,22-/m1/s1
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n/an/an/an/a 55n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207068
PNG
(CHEMBL3900705)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cnc1F
Show InChI InChI=1S/C21H22FNO4/c22-21-18(11-17(12-23-21)26-15-2-1-3-15)13-5-8-19-14(10-13)4-6-16(27-19)7-9-20(24)25/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a 79n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207057
PNG
(CHEMBL3960738)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H24FNO5/c1-27-18-12-19(29-15-3-2-4-15)24-22(21(18)23)14-6-9-17-13(11-14)5-7-16(28-17)8-10-20(25)26/h6,9,11-12,15-16H,2-5,7-8,10H2,1H3,(H,25,26)/t16-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207058
PNG
(CHEMBL3970166)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C24H25FO5/c1-28-22-11-16(29-15-3-2-4-15)10-17(23(22)25)13-5-7-20-14(9-13)6-8-21(30-20)18-12-19(18)24(26)27/h5,7,9-11,15,18-19,21H,2-4,6,8,12H2,1H3,(H,26,27)/t18-,19-,21-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207059
PNG
(CHEMBL3932664)
Show SMILES COc1cc(OC2CC2)cc(c1F)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C22H23FN4O3/c1-28-20-12-17(29-15-5-6-15)11-18(22(20)23)13-3-8-19-14(10-13)2-4-16(30-19)7-9-21-24-26-27-25-21/h3,8,10-12,15-16H,2,4-7,9H2,1H3,(H,24,25,26,27)/t16-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207062
PNG
(CHEMBL3959144)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)cc(Cl)c1F
Show InChI InChI=1S/C19H15ClF4O4/c20-15-9-13(28-19(22,23)24)8-14(18(15)21)10-2-5-16-11(7-10)1-3-12(27-16)4-6-17(25)26/h2,5,7-9,12H,1,3-4,6H2,(H,25,26)/t12-/m1/s1
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n/an/an/an/a 72n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207064
PNG
(CHEMBL3943315)
Show SMILES COc1cc(Oc2ncc(C)s2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H22FNO5S/c1-13-12-25-23(31-13)30-17-10-18(22(24)20(11-17)28-2)14-4-7-19-15(9-14)3-5-16(29-19)6-8-21(26)27/h4,7,9-12,16H,3,5-6,8H2,1-2H3,(H,26,27)/t16-/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207065
PNG
(CHEMBL3971308)
Show SMILES OC(=O)[C@@H]1C[C@H]1[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C20H16F4O4/c21-16-4-3-12(28-20(22,23)24)8-13(16)10-1-5-17-11(7-10)2-6-18(27-17)14-9-15(14)19(25)26/h1,3-5,7-8,14-15,18H,2,6,9H2,(H,25,26)/t14-,15-,18-/m1/s1
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n/an/an/an/a 69n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207066
PNG
(CHEMBL3890089)
Show SMILES COc1cc(OC(F)(F)F)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C20H18F4O5/c1-27-17-10-14(29-20(22,23)24)9-15(19(17)21)11-3-6-16-12(8-11)2-4-13(28-16)5-7-18(25)26/h3,6,8-10,13H,2,4-5,7H2,1H3,(H,25,26)/t13-/m1/s1
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n/an/an/an/a 4.40E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207055
PNG
(CHEMBL3960231)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H16F4O4/c20-16-6-4-14(27-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(26-17)5-8-18(24)25/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25)/t13-/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207064
PNG
(CHEMBL3943315)
Show SMILES COc1cc(Oc2ncc(C)s2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H22FNO5S/c1-13-12-25-23(31-13)30-17-10-18(22(24)20(11-17)28-2)14-4-7-19-15(9-14)3-5-16(29-19)6-8-21(26)27/h4,7,9-12,16H,3,5-6,8H2,1-2H3,(H,26,27)/t16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207060
PNG
(CHEMBL3952043)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H26FNO6/c1-28-16-10-17(11-16)31-20-12-19(29-2)22(24)23(25-20)14-4-7-18-13(9-14)3-5-15(30-18)6-8-21(26)27/h4,7,9,12,15-17H,3,5-6,8,10-11H2,1-2H3,(H,26,27)/t15-,16-,17-/m1/s1
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n/an/an/an/a 5n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207050
PNG
(CHEMBL3972870)
Show SMILES Cc1cnc(Oc2cc(Cl)c(F)c(c2)-c2ccc3O[C@@H](CCC(O)=O)CCc3c2)s1
Show InChI InChI=1S/C22H19ClFNO4S/c1-12-11-25-22(30-12)29-16-9-17(21(24)18(23)10-16)13-3-6-19-14(8-13)2-4-15(28-19)5-7-20(26)27/h3,6,8-11,15H,2,4-5,7H2,1H3,(H,26,27)/t15-/m1/s1
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n/an/an/an/a 14n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207051
PNG
(CHEMBL3947070)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(F)c1F
Show InChI InChI=1S/C22H22F2O4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/m1/s1
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n/an/an/an/a 21n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207067
PNG
(CHEMBL3941726)
Show SMILES OC(=O)CC[C@@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H16F4O4/c20-16-6-4-14(27-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(26-17)5-8-18(24)25/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25)/t13-/m0/s1
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n/an/an/an/a 180n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207075
PNG
(CHEMBL3898962)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C23H24FNO5/c1-28-19-11-20(29-14-3-2-4-14)25-22(21(19)24)13-6-7-17-12(9-13)5-8-18(30-17)15-10-16(15)23(26)27/h6-7,9,11,14-16,18H,2-5,8,10H2,1H3,(H,26,27)/t15-,16-,18-/m1/s1
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n/an/an/an/a 7.80n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207050
PNG
(CHEMBL3972870)
Show SMILES Cc1cnc(Oc2cc(Cl)c(F)c(c2)-c2ccc3O[C@@H](CCC(O)=O)CCc3c2)s1
Show InChI InChI=1S/C22H19ClFNO4S/c1-12-11-25-22(30-12)29-16-9-17(21(24)18(23)10-16)13-3-6-19-14(8-13)2-4-15(28-19)5-7-20(26)27/h3,6,8-11,15H,2,4-5,7H2,1H3,(H,26,27)/t15-/m1/s1
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n/an/an/an/a 5.60n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207064
PNG
(CHEMBL3943315)
Show SMILES COc1cc(Oc2ncc(C)s2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H22FNO5S/c1-13-12-25-23(31-13)30-17-10-18(22(24)20(11-17)28-2)14-4-7-19-15(9-14)3-5-16(29-19)6-8-21(26)27/h4,7,9-12,16H,3,5-6,8H2,1-2H3,(H,26,27)/t16-/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207071
PNG
(CHEMBL3978465)
Show SMILES COc1cc(OC(F)(F)F)cc(c1F)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C20H18F4N4O3/c1-29-17-10-14(31-20(22,23)24)9-15(19(17)21)11-3-6-16-12(8-11)2-4-13(30-16)5-7-18-25-27-28-26-18/h3,6,8-10,13H,2,4-5,7H2,1H3,(H,25,26,27,28)/t13-/m1/s1
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n/an/an/an/a 130n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207077
PNG
(CHEMBL3890035)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(c1)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C25H27FO6/c1-29-15-8-16(9-15)31-17-10-18(24(26)23(11-17)30-2)13-3-5-21-14(7-13)4-6-22(32-21)19-12-20(19)25(27)28/h3,5,7,10-11,15-16,19-20,22H,4,6,8-9,12H2,1-2H3,(H,27,28)/t15-,16-,19-,20-,22-/m1/s1
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n/an/an/an/a 78n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207052
PNG
(CHEMBL3909773)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(Cl)c1F
Show InChI InChI=1S/C22H22ClFO4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/m1/s1
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n/an/an/an/a 8.30n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207050
PNG
(CHEMBL3972870)
Show SMILES Cc1cnc(Oc2cc(Cl)c(F)c(c2)-c2ccc3O[C@@H](CCC(O)=O)CCc3c2)s1
Show InChI InChI=1S/C22H19ClFNO4S/c1-12-11-25-22(30-12)29-16-9-17(21(24)18(23)10-16)13-3-6-19-14(8-13)2-4-15(28-19)5-7-20(26)27/h3,6,8-11,15H,2,4-5,7H2,1H3,(H,26,27)/t15-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207057
PNG
(CHEMBL3960738)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H24FNO5/c1-27-18-12-19(29-15-3-2-4-15)24-22(21(18)23)14-6-9-17-13(11-14)5-7-16(28-17)8-10-20(25)26/h6,9,11-12,15-16H,2-5,7-8,10H2,1H3,(H,25,26)/t16-/m1/s1
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n/an/an/an/a 15n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50207060
PNG
(CHEMBL3952043)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H26FNO6/c1-28-16-10-17(11-16)31-20-12-19(29-2)22(24)23(25-20)14-4-7-18-13(9-14)3-5-15(30-18)6-8-21(26)27/h4,7,9,12,15-17H,3,5-6,8,10-11H2,1-2H3,(H,26,27)/t15-,16-,17-/m1/s1
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n/an/an/an/a 4.60n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/an/an/a 24n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207069
PNG
(CHEMBL3959068)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(c1)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C24H24F2O5/c1-29-14-7-15(8-14)30-16-9-17(23(26)20(25)10-16)12-2-4-21-13(6-12)3-5-22(31-21)18-11-19(18)24(27)28/h2,4,6,9-10,14-15,18-19,22H,3,5,7-8,11H2,1H3,(H,27,28)/t14-,15-,18-,19-,22-/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207072
PNG
(CHEMBL3946820)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1nc(OC2CCC2)ccc1F
Show InChI InChI=1S/C21H22FNO4/c22-17-8-10-19(27-15-2-1-3-15)23-21(17)14-5-9-18-13(12-14)4-6-16(26-18)7-11-20(24)25/h5,8-10,12,15-16H,1-4,6-7,11H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a 21n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207059
PNG
(CHEMBL3932664)
Show SMILES COc1cc(OC2CC2)cc(c1F)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C22H23FN4O3/c1-28-20-12-17(29-15-5-6-15)11-18(22(20)23)13-3-8-19-14(10-13)2-4-16(30-19)7-9-21-24-26-27-25-21/h3,8,10-12,15-16H,2,4-7,9H2,1H3,(H,24,25,26,27)/t16-/m1/s1
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n/an/an/an/a 32n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207071
PNG
(CHEMBL3978465)
Show SMILES COc1cc(OC(F)(F)F)cc(c1F)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C20H18F4N4O3/c1-29-17-10-14(31-20(22,23)24)9-15(19(17)21)11-3-6-16-12(8-11)2-4-13(30-16)5-7-18-25-27-28-26-18/h3,6,8-10,13H,2,4-5,7H2,1H3,(H,25,26,27,28)/t13-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207076
PNG
(CHEMBL3979448)
Show SMILES Fc1ccc(OC(F)(F)F)cc1-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C19H16F4N4O2/c20-16-6-4-14(29-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(28-17)5-8-18-24-26-27-25-18/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25,26,27)/t13-/m1/s1
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n/an/an/an/a 890n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207053
PNG
(CHEMBL3950444)
Show SMILES OC(=O)[C@H]1C[C@@H]1[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C20H16F4O4/c21-16-4-3-12(28-20(22,23)24)8-13(16)10-1-5-17-11(7-10)2-6-18(27-17)14-9-15(14)19(25)26/h1,3-5,7-8,14-15,18H,2,6,9H2,(H,25,26)/t14-,15-,18+/m0/s1
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n/an/an/an/a 130n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207059
PNG
(CHEMBL3932664)
Show SMILES COc1cc(OC2CC2)cc(c1F)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C22H23FN4O3/c1-28-20-12-17(29-15-5-6-15)11-18(22(20)23)13-3-8-19-14(10-13)2-4-16(30-19)7-9-21-24-26-27-25-21/h3,8,10-12,15-16H,2,4-7,9H2,1H3,(H,24,25,26,27)/t16-/m1/s1
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n/an/an/an/a 51n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207052
PNG
(CHEMBL3909773)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(Cl)c1F
Show InChI InChI=1S/C22H22ClFO4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/m1/s1
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n/an/an/an/a 40n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207055
PNG
(CHEMBL3960231)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H16F4O4/c20-16-6-4-14(27-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(26-17)5-8-18(24)25/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25)/t13-/m1/s1
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n/an/an/an/a 2.10E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207056
PNG
(CHEMBL3970238)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)ccc1F
Show InChI InChI=1S/C22H23FO4/c23-20-9-7-18(26-16-2-1-3-16)13-19(20)14-5-10-21-15(12-14)4-6-17(27-21)8-11-22(24)25/h5,7,9-10,12-13,16-17H,1-4,6,8,11H2,(H,24,25)/t17-/m1/s1
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n/an/an/an/a 3.60E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207058
PNG
(CHEMBL3970166)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C24H25FO5/c1-28-22-11-16(29-15-3-2-4-15)10-17(23(22)25)13-5-7-20-14(9-13)6-8-21(30-20)18-12-19(18)24(26)27/h5,7,9-11,15,18-19,21H,2-4,6,8,12H2,1H3,(H,26,27)/t18-,19-,21-/m1/s1
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n/an/an/an/a 25n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207062
PNG
(CHEMBL3959144)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)cc(Cl)c1F
Show InChI InChI=1S/C19H15ClF4O4/c20-15-9-13(28-19(22,23)24)8-14(18(15)21)10-2-5-16-11(7-10)1-3-12(27-16)4-6-17(25)26/h2,5,7-9,12H,1,3-4,6H2,(H,25,26)/t12-/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207065
PNG
(CHEMBL3971308)
Show SMILES OC(=O)[C@@H]1C[C@H]1[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C20H16F4O4/c21-16-4-3-12(28-20(22,23)24)8-13(16)10-1-5-17-11(7-10)2-6-18(27-17)14-9-15(14)19(25)26/h1,3-5,7-8,14-15,18H,2,6,9H2,(H,25,26)/t14-,15-,18-/m1/s1
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n/an/an/an/a 33n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207051
PNG
(CHEMBL3947070)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(F)c1F
Show InChI InChI=1S/C22H22F2O4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207052
PNG
(CHEMBL3909773)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(Cl)c1F
Show InChI InChI=1S/C22H22ClFO4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207060
PNG
(CHEMBL3952043)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H26FNO6/c1-28-16-10-17(11-16)31-20-12-19(29-2)22(24)23(25-20)14-4-7-18-13(9-14)3-5-15(30-18)6-8-21(26)27/h4,7,9,12,15-17H,3,5-6,8,10-11H2,1-2H3,(H,26,27)/t15-,16-,17-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207072
PNG
(CHEMBL3946820)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1nc(OC2CCC2)ccc1F
Show InChI InChI=1S/C21H22FNO4/c22-17-8-10-19(27-15-2-1-3-15)23-21(17)14-5-9-18-13(12-14)4-6-16(26-18)7-11-20(24)25/h5,8-10,12,15-16H,1-4,6-7,11H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207073
PNG
(CHEMBL3940429)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H25FO5/c1-27-21-13-18(28-16-3-2-4-16)12-19(23(21)24)14-6-9-20-15(11-14)5-7-17(29-20)8-10-22(25)26/h6,9,11-13,16-17H,2-5,7-8,10H2,1H3,(H,25,26)/t17-/m1/s1
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n/an/an/an/a 15n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207056
PNG
(CHEMBL3970238)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)ccc1F
Show InChI InChI=1S/C22H23FO4/c23-20-9-7-18(26-16-2-1-3-16)13-19(20)14-5-10-21-15(12-14)4-6-17(27-21)8-11-22(24)25/h5,7,9-10,12-13,16-17H,1-4,6,8,11H2,(H,24,25)/t17-/m1/s1
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n/an/an/an/a 10n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207051
PNG
(CHEMBL3947070)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cc(F)c1F
Show InChI InChI=1S/C22H22F2O4/c23-19-12-17(27-15-2-1-3-15)11-18(22(19)24)13-5-8-20-14(10-13)4-6-16(28-20)7-9-21(25)26/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,25,26)/t16-/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207054
PNG
(CHEMBL3907996)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(c1)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C24H27FN4O4/c1-30-17-10-18(11-17)32-19-12-20(24(25)22(13-19)31-2)14-4-7-21-15(9-14)3-5-16(33-21)6-8-23-26-28-29-27-23/h4,7,9,12-13,16-18H,3,5-6,8,10-11H2,1-2H3,(H,26,27,28,29)/t16-,17-,18-/m1/s1
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n/an/an/an/a 43n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207068
PNG
(CHEMBL3900705)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cnc1F
Show InChI InChI=1S/C21H22FNO4/c22-21-18(11-17(12-23-21)26-15-2-1-3-15)13-5-8-19-14(10-13)4-6-16(27-19)7-9-20(24)25/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50207060
PNG
(CHEMBL3952043)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H26FNO6/c1-28-16-10-17(11-16)31-20-12-19(29-2)22(24)23(25-20)14-4-7-18-13(9-14)3-5-15(30-18)6-8-21(26)27/h4,7,9,12,15-17H,3,5-6,8,10-11H2,1-2H3,(H,26,27)/t15-,16-,17-/m1/s1
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n/an/an/an/a 5.60n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207058
PNG
(CHEMBL3970166)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C24H25FO5/c1-28-22-11-16(29-15-3-2-4-15)10-17(23(22)25)13-5-7-20-14(9-13)6-8-21(30-20)18-12-19(18)24(26)27/h5,7,9-11,15,18-19,21H,2-4,6,8,12H2,1H3,(H,26,27)/t18-,19-,21-/m1/s1
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n/an/an/an/a 8n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207054
PNG
(CHEMBL3907996)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(c1)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C24H27FN4O4/c1-30-17-10-18(11-17)32-19-12-20(24(25)22(13-19)31-2)14-4-7-21-15(9-14)3-5-16(33-21)6-8-23-26-28-29-27-23/h4,7,9,12-13,16-18H,3,5-6,8,10-11H2,1-2H3,(H,26,27,28,29)/t16-,17-,18-/m1/s1
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n/an/an/an/a 53n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207074
PNG
(CHEMBL3916986)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(c1)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C23H24F2N4O3/c1-30-16-9-17(10-16)31-18-11-19(23(25)20(24)12-18)13-3-6-21-14(8-13)2-4-15(32-21)5-7-22-26-28-29-27-22/h3,6,8,11-12,15-17H,2,4-5,7,9-10H2,1H3,(H,26,27,28,29)/t15-,16-,17-/m1/s1
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n/an/an/an/a 240n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207069
PNG
(CHEMBL3959068)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(c1)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C24H24F2O5/c1-29-14-7-15(8-14)30-16-9-17(23(26)20(25)10-16)12-2-4-21-13(6-12)3-5-22(31-21)18-11-19(18)24(27)28/h2,4,6,9-10,14-15,18-19,22H,3,5,7-8,11H2,1H3,(H,27,28)/t14-,15-,18-,19-,22-/m1/s1
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n/an/an/an/a 45n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207066
PNG
(CHEMBL3890089)
Show SMILES COc1cc(OC(F)(F)F)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C20H18F4O5/c1-27-17-10-14(29-20(22,23)24)9-15(19(17)21)11-3-6-16-12(8-11)2-4-13(28-16)5-7-18(25)26/h3,6,8-10,13H,2,4-5,7H2,1H3,(H,25,26)/t13-/m1/s1
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n/an/an/an/a 11n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207063
PNG
(CHEMBL3971857)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)ncc1F
Show InChI InChI=1S/C21H22FNO4/c22-18-12-23-20(27-15-2-1-3-15)11-17(18)13-5-8-19-14(10-13)4-6-16(26-19)7-9-21(24)25/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a 250n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207065
PNG
(CHEMBL3971308)
Show SMILES OC(=O)[C@@H]1C[C@H]1[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C20H16F4O4/c21-16-4-3-12(28-20(22,23)24)8-13(16)10-1-5-17-11(7-10)2-6-18(27-17)14-9-15(14)19(25)26/h1,3-5,7-8,14-15,18H,2,6,9H2,(H,25,26)/t14-,15-,18-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207074
PNG
(CHEMBL3916986)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(c1)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C23H24F2N4O3/c1-30-16-9-17(10-16)31-18-11-19(23(25)20(24)12-18)13-3-6-21-14(8-13)2-4-15(32-21)5-7-22-26-28-29-27-22/h3,6,8,11-12,15-17H,2,4-5,7,9-10H2,1H3,(H,26,27,28,29)/t15-,16-,17-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/an/an/a 6.80n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207067
PNG
(CHEMBL3941726)
Show SMILES OC(=O)CC[C@@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H16F4O4/c20-16-6-4-14(27-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(26-17)5-8-18(24)25/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25)/t13-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207053
PNG
(CHEMBL3950444)
Show SMILES OC(=O)[C@H]1C[C@@H]1[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C20H16F4O4/c21-16-4-3-12(28-20(22,23)24)8-13(16)10-1-5-17-11(7-10)2-6-18(27-17)14-9-15(14)19(25)26/h1,3-5,7-8,14-15,18H,2,6,9H2,(H,25,26)/t14-,15-,18+/m0/s1
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n/an/an/an/a 320n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207067
PNG
(CHEMBL3941726)
Show SMILES OC(=O)CC[C@@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C19H16F4O4/c20-16-6-4-14(27-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(26-17)5-8-18(24)25/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25)/t13-/m0/s1
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n/an/an/an/a 42n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207069
PNG
(CHEMBL3959068)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(c1)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C24H24F2O5/c1-29-14-7-15(8-14)30-16-9-17(23(26)20(25)10-16)12-2-4-21-13(6-12)3-5-22(31-21)18-11-19(18)24(27)28/h2,4,6,9-10,14-15,18-19,22H,3,5,7-8,11H2,1H3,(H,27,28)/t14-,15-,18-,19-,22-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207060
PNG
(CHEMBL3952043)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H26FNO6/c1-28-16-10-17(11-16)31-20-12-19(29-2)22(24)23(25-20)14-4-7-18-13(9-14)3-5-15(30-18)6-8-21(26)27/h4,7,9,12,15-17H,3,5-6,8,10-11H2,1-2H3,(H,26,27)/t15-,16-,17-/m1/s1
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n/an/an/an/a 14n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207072
PNG
(CHEMBL3946820)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1nc(OC2CCC2)ccc1F
Show InChI InChI=1S/C21H22FNO4/c22-17-8-10-19(27-15-2-1-3-15)23-21(17)14-5-9-18-13(12-14)4-6-16(26-18)7-11-20(24)25/h5,8-10,12,15-16H,1-4,6-7,11H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207066
PNG
(CHEMBL3890089)
Show SMILES COc1cc(OC(F)(F)F)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C20H18F4O5/c1-27-17-10-14(29-20(22,23)24)9-15(19(17)21)11-3-6-16-12(8-11)2-4-13(28-16)5-7-18(25)26/h3,6,8-10,13H,2,4-5,7H2,1H3,(H,25,26)/t13-/m1/s1
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n/an/an/an/a 25n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207076
PNG
(CHEMBL3979448)
Show SMILES Fc1ccc(OC(F)(F)F)cc1-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C19H16F4N4O2/c20-16-6-4-14(29-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(28-17)5-8-18-24-26-27-25-18/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25,26,27)/t13-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207062
PNG
(CHEMBL3959144)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC(F)(F)F)cc(Cl)c1F
Show InChI InChI=1S/C19H15ClF4O4/c20-15-9-13(28-19(22,23)24)8-14(18(15)21)10-2-5-16-11(7-10)1-3-12(27-16)4-6-17(25)26/h2,5,7-9,12H,1,3-4,6H2,(H,25,26)/t12-/m1/s1
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n/an/an/an/a 2.20E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207070
PNG
(CHEMBL3986721)
Show SMILES Fc1ccc(OC2CCC2)cc1-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C22H23FN4O2/c23-20-9-7-18(28-16-2-1-3-16)13-19(20)14-5-10-21-15(12-14)4-6-17(29-21)8-11-22-24-26-27-25-22/h5,7,9-10,12-13,16-17H,1-4,6,8,11H2,(H,24,25,26,27)/t17-/m1/s1
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n/an/an/an/a 84n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207075
PNG
(CHEMBL3898962)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@H](CCc2c1)[C@@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C23H24FNO5/c1-28-19-11-20(29-14-3-2-4-14)25-22(21(19)24)13-6-7-17-12(9-13)5-8-18(30-17)15-10-16(15)23(26)27/h6-7,9,11,14-16,18H,2-5,8,10H2,1H3,(H,26,27)/t15-,16-,18-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207073
PNG
(CHEMBL3940429)
Show SMILES COc1cc(OC2CCC2)cc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H25FO5/c1-27-21-13-18(28-16-3-2-4-16)12-19(23(21)24)14-6-9-20-15(11-14)5-7-17(29-20)8-10-22(25)26/h6,9,11-13,16-17H,2-5,7-8,10H2,1H3,(H,25,26)/t17-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207074
PNG
(CHEMBL3916986)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(c1)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C23H24F2N4O3/c1-30-16-9-17(10-16)31-18-11-19(23(25)20(24)12-18)13-3-6-21-14(8-13)2-4-15(32-21)5-7-22-26-28-29-27-22/h3,6,8,11-12,15-17H,2,4-5,7,9-10H2,1H3,(H,26,27,28,29)/t15-,16-,17-/m1/s1
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n/an/an/an/a 170n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207057
PNG
(CHEMBL3960738)
Show SMILES COc1cc(OC2CCC2)nc(c1F)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H24FNO5/c1-27-18-12-19(29-15-3-2-4-15)24-22(21(18)23)14-6-9-17-13(11-14)5-7-16(28-17)8-10-20(25)26/h6,9,11-12,15-16H,2-5,7-8,10H2,1H3,(H,25,26)/t16-/m1/s1
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n/an/an/an/a 6.20n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207070
PNG
(CHEMBL3986721)
Show SMILES Fc1ccc(OC2CCC2)cc1-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C22H23FN4O2/c23-20-9-7-18(28-16-2-1-3-16)13-19(20)14-5-10-21-15(12-14)4-6-17(29-21)8-11-22-24-26-27-25-22/h5,7,9-10,12-13,16-17H,1-4,6,8,11H2,(H,24,25,26,27)/t17-/m1/s1
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n/an/an/an/a 220n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207076
PNG
(CHEMBL3979448)
Show SMILES Fc1ccc(OC(F)(F)F)cc1-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C19H16F4N4O2/c20-16-6-4-14(29-19(21,22)23)10-15(16)11-2-7-17-12(9-11)1-3-13(28-17)5-8-18-24-26-27-25-18/h2,4,6-7,9-10,13H,1,3,5,8H2,(H,24,25,26,27)/t13-/m1/s1
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n/an/an/an/a 330n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207063
PNG
(CHEMBL3971857)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)ncc1F
Show InChI InChI=1S/C21H22FNO4/c22-18-12-23-20(27-15-2-1-3-15)11-17(18)13-5-8-19-14(10-13)4-6-16(26-19)7-9-21(24)25/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Mus musculus)
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/an/an/a 6.40n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Mus musculus)
BDBM50207060
PNG
(CHEMBL3952043)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C23H26FNO6/c1-28-16-10-17(11-16)31-20-12-19(29-2)22(24)23(25-20)14-4-7-18-13(9-14)3-5-15(30-18)6-8-21(26)27/h4,7,9,12,15-17H,3,5-6,8,10-11H2,1-2H3,(H,26,27)/t15-,16-,17-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR40 assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207054
PNG
(CHEMBL3907996)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(OC)c(F)c(c1)-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C24H27FN4O4/c1-30-17-10-18(11-17)32-19-12-20(24(25)22(13-19)31-2)14-4-7-21-15(9-14)3-5-16(33-21)6-8-23-26-28-29-27-23/h4,7,9,12-13,16-18H,3,5-6,8,10-11H2,1-2H3,(H,26,27,28,29)/t16-,17-,18-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (human))
BDBM50207070
PNG
(CHEMBL3986721)
Show SMILES Fc1ccc(OC2CCC2)cc1-c1ccc2O[C@@H](CCc3nnn[nH]3)CCc2c1
Show InChI InChI=1S/C22H23FN4O2/c23-20-9-7-18(28-16-2-1-3-16)13-19(20)14-5-10-21-15(12-14)4-6-17(29-21)8-11-22-24-26-27-25-22/h5,7,9-10,12-13,16-17H,1-4,6,8,11H2,(H,24,25,26,27)/t17-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207056
PNG
(CHEMBL3970238)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)ccc1F
Show InChI InChI=1S/C22H23FO4/c23-20-9-7-18(26-16-2-1-3-16)13-19(20)14-5-10-21-15(12-14)4-6-17(27-21)8-11-22(24)25/h5,7,9-10,12-13,16-17H,1-4,6,8,11H2,(H,24,25)/t17-/m1/s1
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n/an/an/an/a 28n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Mus musculus)
BDBM50207061
PNG
(CHEMBL3980898)
Show SMILES CO[C@H]1C[C@@H](C1)Oc1cc(F)c(F)c(n1)-c1ccc2O[C@@H](CCC(O)=O)CCc2c1
Show InChI InChI=1S/C22H23F2NO5/c1-28-15-9-16(10-15)30-19-11-17(23)21(24)22(25-19)13-3-6-18-12(8-13)2-4-14(29-18)5-7-20(26)27/h3,6,8,11,14-16H,2,4-5,7,9-10H2,1H3,(H,26,27)/t14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR40 assessed as increase in IP1 accumulation after 60 mins by HTRF assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
Free fatty acid receptor 4


(Homo sapiens)
BDBM50207068
PNG
(CHEMBL3900705)
Show SMILES OC(=O)CC[C@H]1CCc2cc(ccc2O1)-c1cc(OC2CCC2)cnc1F
Show InChI InChI=1S/C21H22FNO4/c22-21-18(11-17(12-23-21)26-15-2-1-3-15)13-5-8-19-14(10-13)4-6-16(27-19)7-9-20(24)25/h5,8,10-12,15-16H,1-4,6-7,9H2,(H,24,25)/t16-/m1/s1
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n/an/an/an/a 140n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay


ACS Med Chem Lett 8: 96-101 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00394
BindingDB Entry DOI: 10.7270/Q2R213CP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%