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PubMed code 28206758

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236543
PNG
(CHEMBL4078550)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C21H17N3O2/c1-13(25)24-17-6-2-14(3-7-17)16-10-19-20(12-23-21(19)22-11-16)15-4-8-18(26)9-5-15/h2-12,26H,1H3,(H,22,23)(H,24,25)
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n/an/a 6.60n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50445231
PNG
(CHEMBL3102950)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H14N2O2/c22-15-5-1-12(2-6-15)14-9-17-18(11-21-19(17)20-10-14)13-3-7-16(23)8-4-13/h1-11,22-23H,(H,20,21)
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n/an/a 14n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50445231
PNG
(CHEMBL3102950)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H14N2O2/c22-15-5-1-12(2-6-15)14-9-17-18(11-21-19(17)20-10-14)13-3-7-16(23)8-4-13/h1-11,22-23H,(H,20,21)
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n/an/a 15n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Cyclin-dependent kinase 1-cyclin B


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236541
PNG
(CHEMBL4067661)
Show SMILES NC(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C20H16N4O2/c21-20(26)24-15-5-1-12(2-6-15)14-9-17-18(11-23-19(17)22-10-14)13-3-7-16(25)8-4-13/h1-11,25H,(H,22,23)(H3,21,24,26)
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n/an/a 17n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236541
PNG
(CHEMBL4067661)
Show SMILES NC(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C20H16N4O2/c21-20(26)24-15-5-1-12(2-6-15)14-9-17-18(11-23-19(17)22-10-14)13-3-7-16(25)8-4-13/h1-11,25H,(H,22,23)(H3,21,24,26)
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n/an/a 31n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Cyclin-dependent kinase 1-cyclin B


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236544
PNG
(CHEMBL4096575)
Show SMILES Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-12(2-6-15)14-9-17-18(11-22-19(17)21-10-14)13-3-7-16(23)8-4-13/h1-11,23H,20H2,(H,21,22)
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n/an/a 32n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM100152
PNG
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Show SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21
Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
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n/an/a 33n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236543
PNG
(CHEMBL4078550)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C21H17N3O2/c1-13(25)24-17-6-2-14(3-7-17)16-10-19-20(12-23-21(19)22-11-16)15-4-8-18(26)9-5-15/h2-12,26H,1H3,(H,22,23)(H,24,25)
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n/an/a 38n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236545
PNG
(CHEMBL4087125)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C20H12N6O/c27-16-7-5-13(6-8-16)18-11-22-20-17(18)9-15(10-21-20)12-1-3-14(4-2-12)19-23-25-26-24-19/h1-11,27H
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n/an/a 42n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236544
PNG
(CHEMBL4096575)
Show SMILES Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-12(2-6-15)14-9-17-18(11-22-19(17)21-10-14)13-3-7-16(23)8-4-13/h1-11,23H,20H2,(H,21,22)
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n/an/a 43n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236546
PNG
(CHEMBL4065701)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C21H13N3O/c25-17-4-1-13(2-5-17)19-12-24-21-18(19)10-16(11-23-21)14-3-6-20-15(9-14)7-8-22-20/h1-12,25H/b16-14+
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n/an/a 51n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50347750
PNG
(CHEMBL1802358)
Show SMILES O=C1NC(Nc2ccccc2)=NC1=Cc1ccc2OCOc2c1
Show InChI InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)
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n/an/a 55n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin)


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236542
PNG
(CHEMBL4088888)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C20H17N3O3S/c1-27(25,26)23-16-6-2-13(3-7-16)15-10-18-19(12-22-20(18)21-11-15)14-4-8-17(24)9-5-14/h2-12,23-24H,1H3,(H,21,22)
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n/an/a 56n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50347750
PNG
(CHEMBL1802358)
Show SMILES O=C1NC(Nc2ccccc2)=NC1=Cc1ccc2OCOc2c1
Show InChI InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)
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n/an/a 71n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin)


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236537
PNG
(CHEMBL4084605)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C21H13N3O/c25-17-4-1-13(2-5-17)16-10-18-19(12-24-21(18)23-11-16)14-3-6-20-15(9-14)7-8-22-20/h1-12,25H/b19-14-
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n/an/a 83n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236545
PNG
(CHEMBL4087125)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C20H12N6O/c27-16-7-5-13(6-8-16)18-11-22-20-17(18)9-15(10-21-20)12-1-3-14(4-2-12)19-23-25-26-24-19/h1-11,27H
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n/an/a 86n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236550
PNG
(CHEMBL4105239)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)C(=O)Nc1cccc(O)c1
Show InChI InChI=1S/C20H15N3O3/c24-15-6-4-12(5-7-15)18-11-22-19-17(18)8-13(10-21-19)20(26)23-14-2-1-3-16(25)9-14/h1-11,24-25H,(H,21,22)(H,23,26)
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n/an/a 127n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236540
PNG
(CHEMBL4080994)
Show SMILES Oc1ccc(NC(=O)c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1
Show InChI InChI=1S/C20H15N3O3/c24-15-5-1-12(2-6-15)18-11-22-19-17(18)9-13(10-21-19)20(26)23-14-3-7-16(25)8-4-14/h1-11,24-25H,(H,21,22)(H,23,26)
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n/an/a 128n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236542
PNG
(CHEMBL4088888)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C20H17N3O3S/c1-27(25,26)23-16-6-2-13(3-7-16)15-10-18-19(12-22-20(18)21-11-15)14-4-8-17(24)9-5-14/h2-12,23-24H,1H3,(H,21,22)
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n/an/a 130n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236550
PNG
(CHEMBL4105239)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)C(=O)Nc1cccc(O)c1
Show InChI InChI=1S/C20H15N3O3/c24-15-6-4-12(5-7-15)18-11-22-19-17(18)8-13(10-21-19)20(26)23-14-2-1-3-16(25)9-14/h1-11,24-25H,(H,21,22)(H,23,26)
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n/an/a 138n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM100152
PNG
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Show SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21
Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
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n/an/a 160n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged DYRK1B (unknown origin) expressed in Escherichia coli using DYRKtide as substrate after 5 mins in presence of [g...


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50445231
PNG
(CHEMBL3102950)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H14N2O2/c22-15-5-1-12(2-6-15)14-9-17-18(11-21-19(17)20-10-14)13-3-7-16(23)8-4-13/h1-11,22-23H,(H,20,21)
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n/an/a 166n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236537
PNG
(CHEMBL4084605)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C21H13N3O/c25-17-4-1-13(2-5-17)16-10-18-19(12-24-21(18)23-11-16)14-3-6-20-15(9-14)7-8-22-20/h1-12,25H/b19-14-
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n/an/a 169n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236536
PNG
(CHEMBL4102553)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(cc3)-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C20H12N6O/c27-16-7-5-12(6-8-16)15-9-17-18(11-22-20(17)21-10-15)13-1-3-14(4-2-13)19-23-25-26-24-19/h1-11,27H
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n/an/a 172n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236547
PNG
(CHEMBL4075959)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H13N3O3/c23-16-7-3-13(4-8-16)18-11-21-19-17(18)9-14(10-20-19)12-1-5-15(6-2-12)22(24)25/h1-11,23H,(H,20,21)
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n/an/a 198n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236546
PNG
(CHEMBL4065701)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C21H13N3O/c25-17-4-1-13(2-5-17)19-12-24-21-18(19)10-16(11-23-21)14-3-6-20-15(9-14)7-8-22-20/h1-12,25H/b16-14+
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236547
PNG
(CHEMBL4075959)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H13N3O3/c23-16-7-3-13(4-8-16)18-11-21-19-17(18)9-14(10-20-19)12-1-5-15(6-2-12)22(24)25/h1-11,23H,(H,20,21)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236536
PNG
(CHEMBL4102553)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(cc3)-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C20H12N6O/c27-16-7-5-12(6-8-16)15-9-17-18(11-22-20(17)21-10-15)13-1-3-14(4-2-13)19-23-25-26-24-19/h1-11,27H
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236540
PNG
(CHEMBL4080994)
Show SMILES Oc1ccc(NC(=O)c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1
Show InChI InChI=1S/C20H15N3O3/c24-15-5-1-12(2-6-15)18-11-22-19-17(18)9-13(10-21-19)20(26)23-14-3-7-16(25)8-4-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236545
PNG
(CHEMBL4087125)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C20H12N6O/c27-16-7-5-13(6-8-16)18-11-22-20-17(18)9-15(10-21-20)12-1-3-14(4-2-12)19-23-25-26-24-19/h1-11,27H
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 3


(Homo sapiens (Human))
BDBM100152
PNG
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Show SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21
Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant human GST-tagged DYRK3 expressed in Escherichia coli using woodtide as substrate after 30 mins in presence of [...


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236536
PNG
(CHEMBL4102553)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(cc3)-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C20H12N6O/c27-16-7-5-12(6-8-16)15-9-17-18(11-22-20(17)21-10-15)13-1-3-14(4-2-13)19-23-25-26-24-19/h1-11,27H
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Cyclin-dependent kinase 1-cyclin B


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236541
PNG
(CHEMBL4067661)
Show SMILES NC(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C20H16N4O2/c21-20(26)24-15-5-1-12(2-6-15)14-9-17-18(11-23-19(17)22-10-14)13-3-7-16(25)8-4-13/h1-11,25H,(H,22,23)(H3,21,24,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236543
PNG
(CHEMBL4078550)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C21H17N3O2/c1-13(25)24-17-6-2-14(3-7-17)16-10-19-20(12-23-21(19)22-11-16)15-4-8-18(26)9-5-15/h2-12,26H,1H3,(H,22,23)(H,24,25)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236544
PNG
(CHEMBL4096575)
Show SMILES Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-12(2-6-15)14-9-17-18(11-22-19(17)21-10-14)13-3-7-16(23)8-4-13/h1-11,23H,20H2,(H,21,22)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236537
PNG
(CHEMBL4084605)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C21H13N3O/c25-17-4-1-13(2-5-17)16-10-18-19(12-24-21(18)23-11-16)14-3-6-20-15(9-14)7-8-22-20/h1-12,25H/b19-14-
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Cyclin-dependent kinase 1-cyclin B


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236546
PNG
(CHEMBL4065701)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C21H13N3O/c25-17-4-1-13(2-5-17)19-12-24-21-18(19)10-16(11-23-21)14-3-6-20-15(9-14)7-8-22-20/h1-12,25H/b16-14+
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236544
PNG
(CHEMBL4096575)
Show SMILES Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-12(2-6-15)14-9-17-18(11-22-19(17)21-10-14)13-3-7-16(23)8-4-13/h1-11,23H,20H2,(H,21,22)
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n/an/a 711n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to the human androgen receptor (hAR), using [3H]DHT as radioligand in a competitive binding assay


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236542
PNG
(CHEMBL4088888)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C20H17N3O3S/c1-27(25,26)23-16-6-2-13(3-7-16)15-10-18-19(12-22-20(18)21-11-15)14-4-8-17(24)9-5-14/h2-12,23-24H,1H3,(H,21,22)
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n/an/a 724n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236550
PNG
(CHEMBL4105239)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)C(=O)Nc1cccc(O)c1
Show InChI InChI=1S/C20H15N3O3/c24-15-6-4-12(5-7-15)18-11-22-19-17(18)8-13(10-21-19)20(26)23-14-2-1-3-16(25)9-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236551
PNG
(CHEMBL4092345)
Show SMILES Nc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-13(2-6-15)18-11-22-19-17(18)9-14(10-21-19)12-3-7-16(23)8-4-12/h1-11,23H,20H2,(H,21,22)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236549
PNG
(CHEMBL4070354)
Show SMILES Oc1ccc(NC(=O)c2c[nH]c3ncc(cc23)-c2ccc(O)cc2)cc1
Show InChI InChI=1S/C20H15N3O3/c24-15-5-1-12(2-6-15)13-9-17-18(11-22-19(17)21-10-13)20(26)23-14-3-7-16(25)8-4-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236549
PNG
(CHEMBL4070354)
Show SMILES Oc1ccc(NC(=O)c2c[nH]c3ncc(cc23)-c2ccc(O)cc2)cc1
Show InChI InChI=1S/C20H15N3O3/c24-15-5-1-12(2-6-15)13-9-17-18(11-22-19(17)21-10-13)20(26)23-14-3-7-16(25)8-4-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236551
PNG
(CHEMBL4092345)
Show SMILES Nc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-13(2-6-15)18-11-22-19-17(18)9-14(10-21-19)12-3-7-16(23)8-4-12/h1-11,23H,20H2,(H,21,22)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236539
PNG
(CHEMBL4073972)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ccc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C20H15NO2/c22-16-6-1-13(2-7-16)15-5-10-20-18(11-15)19(12-21-20)14-3-8-17(23)9-4-14/h1-12,21-23H
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236549
PNG
(CHEMBL4070354)
Show SMILES Oc1ccc(NC(=O)c2c[nH]c3ncc(cc23)-c2ccc(O)cc2)cc1
Show InChI InChI=1S/C20H15N3O3/c24-15-5-1-12(2-6-15)13-9-17-18(11-22-19(17)21-10-13)20(26)23-14-3-7-16(25)8-4-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236548
PNG
(CHEMBL4097535)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(C(=O)Nc3cccc(O)c3)c2c1
Show InChI InChI=1S/C20H15N3O3/c24-15-6-4-12(5-7-15)13-8-17-18(11-22-19(17)21-10-13)20(26)23-14-2-1-3-16(25)9-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to the human androgen receptor (hAR), using [3H]DHT as radioligand in a competitive binding assay


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236540
PNG
(CHEMBL4080994)
Show SMILES Oc1ccc(NC(=O)c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1
Show InChI InChI=1S/C20H15N3O3/c24-15-5-1-12(2-6-15)18-11-22-19-17(18)9-13(10-21-19)20(26)23-14-3-7-16(25)8-4-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236547
PNG
(CHEMBL4075959)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H13N3O3/c23-16-7-3-13(4-8-16)18-11-21-19-17(18)9-14(10-20-19)12-1-5-15(6-2-12)22(24)25/h1-11,23H,(H,20,21)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity to the human androgen receptor (hAR) in CV-1 cells


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236538
PNG
(CHEMBL4083661)
Show SMILES Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H14N2O2/c22-15-6-1-12(2-7-15)14-5-10-18-17(11-14)19(21-20-18)13-3-8-16(23)9-4-13/h1-11,22-23H,(H,20,21)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1B (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236551
PNG
(CHEMBL4092345)
Show SMILES Nc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-13(2-6-15)18-11-22-19-17(18)9-14(10-21-19)12-3-7-16(23)8-4-12/h1-11,23H,20H2,(H,21,22)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to the human androgen receptor (hAR), using [3H]DHT as radioligand in a competitive binding assay


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B


(Homo sapiens (Human))
BDBM50236548
PNG
(CHEMBL4097535)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(C(=O)Nc3cccc(O)c3)c2c1
Show InChI InChI=1S/C20H15N3O3/c24-15-6-4-12(5-7-15)13-8-17-18(11-22-19(17)21-10-13)20(26)23-14-2-1-3-16(25)9-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity to the human androgen receptor (hAR) in CV-1 cells


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236538
PNG
(CHEMBL4083661)
Show SMILES Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H14N2O2/c22-15-6-1-12(2-7-15)14-5-10-18-17(11-14)19(21-20-18)13-3-8-16(23)9-4-13/h1-11,22-23H,(H,20,21)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236548
PNG
(CHEMBL4097535)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(C(=O)Nc3cccc(O)c3)c2c1
Show InChI InChI=1S/C20H15N3O3/c24-15-6-4-12(5-7-15)13-8-17-18(11-22-19(17)21-10-13)20(26)23-14-2-1-3-16(25)9-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236539
PNG
(CHEMBL4073972)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ccc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C20H15NO2/c22-16-6-1-13(2-7-16)15-5-10-20-18(11-15)19(12-21-20)14-3-8-17(23)9-4-14/h1-12,21-23H
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50236538
PNG
(CHEMBL4083661)
Show SMILES Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H14N2O2/c22-15-6-1-12(2-7-15)14-5-10-18-17(11-14)19(21-20-18)13-3-8-16(23)9-4-13/h1-11,22-23H,(H,20,21)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM50236539
PNG
(CHEMBL4073972)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ccc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C20H15NO2/c22-16-6-1-13(2-7-16)15-5-10-20-18(11-15)19(12-21-20)14-3-8-17(23)9-4-14/h1-12,21-23H
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2


(Homo sapiens (Human))
BDBM100152
PNG
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Show SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21
Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 4


(Homo sapiens (Human))
BDBM100152
PNG
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Show SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21
Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
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n/an/a 8.00E+4n/an/an/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of full-length recombinant human GST-tagged DYRK4 expressed in baculovirus infected insect cells using DYRKtide as substrate after 5 mins ...


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236547
PNG
(CHEMBL4075959)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H13N3O3/c23-16-7-3-13(4-8-16)18-11-21-19-17(18)9-14(10-20-19)12-1-5-15(6-2-12)22(24)25/h1-11,23H,(H,20,21)
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n/an/an/an/a 1.87E+5n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236542
PNG
(CHEMBL4088888)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C20H17N3O3S/c1-27(25,26)23-16-6-2-13(3-7-16)15-10-18-19(12-22-20(18)21-11-15)14-4-8-17(24)9-5-14/h2-12,23-24H,1H3,(H,21,22)
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n/an/an/an/a 4.40E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236551
PNG
(CHEMBL4092345)
Show SMILES Nc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-13(2-6-15)18-11-22-19-17(18)9-14(10-21-19)12-3-7-16(23)8-4-12/h1-11,23H,20H2,(H,21,22)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236537
PNG
(CHEMBL4084605)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2c1
Show InChI InChI=1S/C21H13N3O/c25-17-4-1-13(2-5-17)16-10-18-19(12-24-21(18)23-11-16)14-3-6-20-15(9-14)7-8-22-20/h1-12,25H/b19-14-
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n/an/an/an/a 1.17E+5n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236544
PNG
(CHEMBL4096575)
Show SMILES Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C19H15N3O/c20-15-5-1-12(2-6-15)14-9-17-18(11-22-19(17)21-10-14)13-3-7-16(23)8-4-13/h1-11,23H,20H2,(H,21,22)
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n/an/an/an/a 3.40E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236538
PNG
(CHEMBL4083661)
Show SMILES Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H14N2O2/c22-15-6-1-12(2-7-15)14-5-10-18-17(11-14)19(21-20-18)13-3-8-16(23)9-4-13/h1-11,22-23H,(H,20,21)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236548
PNG
(CHEMBL4097535)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(C(=O)Nc3cccc(O)c3)c2c1
Show InChI InChI=1S/C20H15N3O3/c24-15-6-4-12(5-7-15)13-8-17-18(11-22-19(17)21-10-13)20(26)23-14-2-1-3-16(25)9-14/h1-11,24-25H,(H,21,22)(H,23,26)
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QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to the human androgen receptor (hAR), using [3H]DHT as radioligand in a competitive binding assay


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236546
PNG
(CHEMBL4065701)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C21H13N3O/c25-17-4-1-13(2-5-17)19-12-24-21-18(19)10-16(11-23-21)14-3-6-20-15(9-14)7-8-22-20/h1-12,25H/b16-14+
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n/an/an/an/a 2.60E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236550
PNG
(CHEMBL4105239)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)C(=O)Nc1cccc(O)c1
Show InChI InChI=1S/C20H15N3O3/c24-15-6-4-12(5-7-15)18-11-22-19-17(18)8-13(10-21-19)20(26)23-14-2-1-3-16(25)9-14/h1-11,24-25H,(H,21,22)(H,23,26)
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n/an/an/an/a 3.40E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236545
PNG
(CHEMBL4087125)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C20H12N6O/c27-16-7-5-13(6-8-16)18-11-22-20-17(18)9-15(10-21-20)12-1-3-14(4-2-12)19-23-25-26-24-19/h1-11,27H
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n/an/an/an/a 7.00E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236536
PNG
(CHEMBL4102553)
Show SMILES Oc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(cc3)-c3nnn[nH]3)c2c1
Show InChI InChI=1S/C20H12N6O/c27-16-7-5-12(6-8-16)15-9-17-18(11-22-20(17)21-10-15)13-1-3-14(4-2-13)19-23-25-26-24-19/h1-11,27H
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n/an/an/an/a 8.50E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236549
PNG
(CHEMBL4070354)
Show SMILES Oc1ccc(NC(=O)c2c[nH]c3ncc(cc23)-c2ccc(O)cc2)cc1
Show InChI InChI=1S/C20H15N3O3/c24-15-5-1-12(2-6-15)13-9-17-18(11-22-19(17)21-10-13)20(26)23-14-3-7-16(25)8-4-14/h1-11,24-25H,(H,21,22)(H,23,26)
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n/an/an/an/a>1.00E+6n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236541
PNG
(CHEMBL4067661)
Show SMILES NC(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C20H16N4O2/c21-20(26)24-15-5-1-12(2-6-15)14-9-17-18(11-23-19(17)22-10-14)13-3-7-16(25)8-4-13/h1-11,25H,(H,22,23)(H3,21,24,26)
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n/an/an/an/a 9.60E+3n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236539
PNG
(CHEMBL4073972)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ccc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C20H15NO2/c22-16-6-1-13(2-7-16)15-5-10-20-18(11-15)19(12-21-20)14-3-8-17(23)9-4-14/h1-12,21-23H
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n/an/an/an/a>1.00E+6n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50445231
PNG
(CHEMBL3102950)
Show SMILES Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(O)cc1
Show InChI InChI=1S/C19H14N2O2/c22-15-5-1-12(2-6-15)14-9-17-18(11-21-19(17)20-10-14)13-3-7-16(23)8-4-13/h1-11,22-23H,(H,20,21)
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n/an/an/an/a 4.80E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236543
PNG
(CHEMBL4078550)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C21H17N3O2/c1-13(25)24-17-6-2-14(3-7-17)16-10-19-20(12-23-21(19)22-11-16)15-4-8-18(26)9-5-15/h2-12,26H,1H3,(H,22,23)(H,24,25)
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n/an/an/an/a 3.50E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50236540
PNG
(CHEMBL4080994)
Show SMILES Oc1ccc(NC(=O)c2cnc3[nH]cc(-c4ccc(O)cc4)c3c2)cc1
Show InChI InChI=1S/C20H15N3O3/c24-15-5-1-12(2-6-15)18-11-22-19-17(18)9-13(10-21-19)20(26)23-14-3-7-16(25)8-4-14/h1-11,24-25H,(H,21,22)(H,23,26)
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n/an/an/an/a 1.20E+4n/an/an/an/a



QIMR Berghofer Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CLK1 (unknown origin) using KKGRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting


J Med Chem 60: 2052-2070 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%