Compile Data Set for Download or QSAR
maximum 50k data
Found 46 Enz. Inhib. hit(s) with all data for entry = 50001503
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50241662(CHEMBL4104741)
Affinity DataIC50:  7nMAssay Description:Inhibition of GST-tagged EED (unknown origin) after 1 hr by OG(488) as probe-based TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 1(Homo sapiens)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282169(CHEBI:3507 | Cefsulodin)
Affinity DataIC50:  98nMAssay Description:Inhibition of L3MBTL1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 1(Homo sapiens)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM60983((E)-2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5...)
Affinity DataIC50:  282nMAssay Description:Inhibition of L3MBTL1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant SUMO-tagged MLL1 (unknown origin) by histone methyl transferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282161(CHEMBL4175336)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by 3-FAM labelled fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282163(CHEMBL4171889)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by 3-FAM labelled fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataIC50:  3.87E+3nMAssay Description:Inhibition of full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by 3-FAM labelled fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of Cbx7 (unknown origin) using FITC-labeled SETDB1-K1170me3 peptide as probe by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50058655(1,1',1'',1'''-[disulfanediylbis(carbonothioylnitri...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of JARID1A PHD finger domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50009454(CHEMBL3234136)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of N terminally fluorescein-tagged H3K27me3 binding to N terminallyHis6-tagged human Cbx7 expressed in Escherichia coli BL21 (DE3) by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTP53-binding protein 1(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM154563(N-(3-(Tert-butylamino)propyl)-3-iodobenzamide (19))
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of 53BP1 methyllysine binding domain (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTP53-binding protein 1(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM154564(N-(3-(Tert-butylamino)propyl)-3-isopropylbenzamide...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of 53BP1 methyllysine binding domain (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTP53-binding protein 1(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM154565(N-(3-(Tert-butylamino)propyl)-3-(trifluoromethyl)b...)
Affinity DataIC50:  2.20E+4nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heartMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM92787(WAG-003)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of recombinant HQ5-Halo-tagged JARID1A PHD3 finger domain (unknown origin) expressed in BL21(DE3)pLysS cells after 1 hr by chemiluminescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM92788(WAG-005)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of recombinant HQ5-Halo-tagged JARID1A PHD3 finger domain (unknown origin) expressed in BL21(DE3)pLysS cells after 1 hr by chemiluminescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTP53-binding protein 1(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM154545(3-Bromo-N-(3-(tert-butylamino)propyl)benzamide (UN...)
Affinity DataIC50:  3.00E+4nMAssay Description:Competitive displacement of p53K382me2 from His-tagged 53BP1 tandem Tudor domain (unknown origin)More data for this Ligand-Target Pair
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50189780(CHEMBL3827954)
Affinity DataIC50:  6.70E+4nMAssay Description:Inhibition of Cbx7 (unknown origin) using FITC-labeled SETDB1-K1170me3 peptide as probe by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282162(CHEMBL4173016)
Affinity DataKd:  800nMAssay Description:Inhibition of JARID1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromodomain Y-like protein 2(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282159(CHEMBL4168117)
Affinity DataKd:  640nMAssay Description:Binding affinity to C-terminal His-tagged CDYL2 (1 to 75 residues) (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282160(CHEMBL4176399)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to GLP (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282113(CHEMBL4168535)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to GLP (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282163(CHEMBL4171889)
Affinity DataKd:  680nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282164(CHEMBL4164708)
Affinity DataKd:  8.80E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282165(CHEMBL4168151)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataKd:  82nMAssay Description:Binding affinity to EED (unknown origin) by ITC methodMore data for this Ligand-Target Pair
TargetInhibitor of growth protein 2(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282166(CHEMBL4176148)
Affinity DataKd:  16nMAssay Description:Binding affinity to 15N-labeled GST-tagged ING2 PHD finger domain (212 to 264 residues) (unknown origin) expressed in Escherichia coli Rosetta2 BL21(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of growth protein 2(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282167(CHEMBL1092710 | P-Sulfonatocalix[4]Arene)
Affinity DataKd:  15nMAssay Description:Binding affinity to 15N-labeled GST-tagged ING2 PHD finger domain (212 to 264 residues) (unknown origin) expressed in Escherichia coli Rosetta2 BL21(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50189780(CHEMBL3827954)
Affinity DataKd:  2.90E+4nMAssay Description:Binding affinity to Cbx7 (unknown origin)More data for this Ligand-Target Pair
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282161(CHEMBL4175336)
Affinity DataKd:  1.09E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282160(CHEMBL4176399)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to G9a (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTP53-binding protein 1(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM154545(3-Bromo-N-(3-(tert-butylamino)propyl)benzamide (UN...)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to 53BP1 methyllysine binding domain (unknown origin) by ITC methodMore data for this Ligand-Target Pair
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50194259(CHEMBL3939958)
Affinity DataKd:  97nMAssay Description:Binding affinity to Cbx7 (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromodomain Y-like protein(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282159(CHEMBL4168117)
Affinity DataKd:  490nMAssay Description:Binding affinity to N-terminal GST-tagged CDYL (1 to 78 residues) (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of growth protein 2(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282158(CHEMBL4168964)
Affinity DataKd:  50nMAssay Description:Binding affinity to 15N-labeled GST-tagged ING2 PHD finger domain (212 to 264 residues) (unknown origin) expressed in Escherichia coli Rosetta2 BL21(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataKd:  1.14E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282115(CHEMBL4165111)
Affinity DataKd:  800nMAssay Description:Inhibition of JARID1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282115(CHEMBL4165111)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to 15N-labeled GST-tagged MLL1 PHD3 finger domain (1565 to 1627 residues) (unknown origin) expressed in Escherichia coli Rosetta2 BL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50194463(CHEMBL3974828)
Affinity DataKd:  6.70E+3nMAssay Description:Binding affinity to Cbx7 (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282114(CHEMBL4160235)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells by ITC methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282113(CHEMBL4168535)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to G9a (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 SUMO-protein ligase CBX4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50194259(CHEMBL3939958)
Affinity DataKd:  97nMAssay Description:Binding affinity to Cbx4 (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282170(CHEMBL4169589)
Affinity DataKd:  1.10E+5nMAssay Description:Binding affinity to Cbx7 (unknown origin) by ITC methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282168(CHEMBL4175216)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to Cbx7 (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromodomain Y-like protein 2(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50194259(CHEMBL3939958)
Affinity DataKd:  850nMAssay Description:Binding affinity to C-terminal His-tagged CDYL2 (1 to 75 residues) (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromodomain Y-like protein(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50194259(CHEMBL3939958)
Affinity DataKd:  910nMAssay Description:Binding affinity to CDYL1b (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTestis-specific chromodomain protein Y 1(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50194259(CHEMBL3939958)
Affinity DataKd:  6.30E+3nMAssay Description:Binding affinity to N-terminal GST-tagged CDY1 (1 to 101 residues) (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed