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PubMed code 2884314

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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34n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019738
PNG
(2-(4-Quinolin-2-yl-butyl)-2,3,4,9-tetrahydro-1H-be...)
Show SMILES C(CCc1ccc2ccccc2n1)CN1CCc2c(C1)[nH]c1ccccc21
Show InChI InChI=1S/C24H25N3/c1-3-10-22-18(7-1)12-13-19(25-22)8-5-6-15-27-16-14-21-20-9-2-4-11-23(20)26-24(21)17-27/h1-4,7,9-13,26H,5-6,8,14-17H2
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83n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019748
PNG
(4-(4-Chloro-phenyl)-1-{3-[2-(2-pyridin-2-yl-ethyl)...)
Show SMILES OC1(CCN(CCCn2c3CN(CCc4ccccn4)CCc3c3ccccc23)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H37ClN4O/c33-26-11-9-25(10-12-26)32(38)15-22-35(23-16-32)18-5-19-37-30-8-2-1-7-28(30)29-14-21-36(24-31(29)37)20-13-27-6-3-4-17-34-27/h1-4,6-12,17,38H,5,13-16,18-24H2
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91n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019750
PNG
(2-(2-Quinolin-2-yl-ethyl)-2,3,4,9-tetrahydro-1H-be...)
Show SMILES C(Cc1ccc2ccccc2n1)N1CCc2c(C1)[nH]c1ccccc21
Show InChI InChI=1S/C22H21N3/c1-3-7-20-16(5-1)9-10-17(23-20)11-13-25-14-12-19-18-6-2-4-8-21(18)24-22(19)15-25/h1-10,24H,11-15H2
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116n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019740
PNG
(1-(4-Fluoro-phenyl)-4-[2-(2-pyridin-2-yl-ethyl)-1,...)
Show SMILES Fc1ccc(cc1)C(=O)CCCn1c2CN(CCc3ccccn3)CCc2c2ccccc12
Show InChI InChI=1S/C28H28FN3O/c29-22-12-10-21(11-13-22)28(33)9-5-17-32-26-8-2-1-7-24(26)25-15-19-31(20-27(25)32)18-14-23-6-3-4-16-30-23/h1-4,6-8,10-13,16H,5,9,14-15,17-20H2
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118n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50019738
PNG
(2-(4-Quinolin-2-yl-butyl)-2,3,4,9-tetrahydro-1H-be...)
Show SMILES C(CCc1ccc2ccccc2n1)CN1CCc2c(C1)[nH]c1ccccc21
Show InChI InChI=1S/C24H25N3/c1-3-10-22-18(7-1)12-13-19(25-22)8-5-6-15-27-16-14-21-20-9-2-4-11-23(20)26-24(21)17-27/h1-4,7,9-13,26H,5-6,8,14-17H2
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139n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine receptor D2 of rat striatum labeled with [3H]-spiperone was determined


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019747
PNG
(2-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1...)
Show SMILES Fc1ccc(cc1)C(N1CCN(CCCN2CCc3c(C2)[nH]c2ccccc32)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C31H34F2N4/c32-25-10-6-23(7-11-25)31(24-8-12-26(33)13-9-24)37-20-18-35(19-21-37)15-3-16-36-17-14-28-27-4-1-2-5-29(27)34-30(28)22-36/h1-2,4-13,31,34H,3,14-22H2
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143n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019734
PNG
(2-[4,4-Bis-(4-fluoro-phenyl)-butyl]-2,3,4,9-tetrah...)
Show SMILES Fc1ccc(cc1)C(CCCN1CCc2c(C1)[nH]c1ccccc21)c1ccc(F)cc1
Show InChI InChI=1S/C27H26F2N2/c28-21-11-7-19(8-12-21)23(20-9-13-22(29)14-10-20)5-3-16-31-17-15-25-24-4-1-2-6-26(24)30-27(25)18-31/h1-2,4,6-14,23,30H,3,5,15-18H2
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145n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019741
PNG
(2-(4-Quinolin-4-yl-butyl)-2,3,4,9-tetrahydro-1H-be...)
Show SMILES C(CCc1ccnc2ccccc12)CN1CCc2c(C1)[nH]c1ccccc21
Show InChI InChI=1S/C24H25N3/c1-3-10-22-19(8-1)18(12-14-25-22)7-5-6-15-27-16-13-21-20-9-2-4-11-23(20)26-24(21)17-27/h1-4,8-12,14,26H,5-7,13,15-17H2
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172n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019743
PNG
(9-Benzyl-2-(2-pyridin-2-yl-ethyl)-2,3,4,9-tetrahyd...)
Show SMILES C(Cc1ccccn1)N1CCc2c(C1)n(Cc1ccccc1)c1ccccc21
Show InChI InChI=1S/C25H25N3/c1-2-8-20(9-3-1)18-28-24-12-5-4-11-22(24)23-14-17-27(19-25(23)28)16-13-21-10-6-7-15-26-21/h1-12,15H,13-14,16-19H2
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185n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019733
PNG
(6-Fluoro-2-(4-quinolin-4-yl-butyl)-2,3,4,9-tetrahy...)
Show SMILES Fc1ccc2[nH]c3CN(CCCCc4ccnc5ccccc45)CCc3c2c1
Show InChI InChI=1S/C24H24FN3/c25-18-8-9-23-21(15-18)20-11-14-28(16-24(20)27-23)13-4-3-5-17-10-12-26-22-7-2-1-6-19(17)22/h1-2,6-10,12,15,27H,3-5,11,13-14,16H2
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194n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50019750
PNG
(2-(2-Quinolin-2-yl-ethyl)-2,3,4,9-tetrahydro-1H-be...)
Show SMILES C(Cc1ccc2ccccc2n1)N1CCc2c(C1)[nH]c1ccccc21
Show InChI InChI=1S/C22H21N3/c1-3-7-20-16(5-1)9-10-17(23-20)11-13-25-14-12-19-18-6-2-4-8-21(18)24-22(19)15-25/h1-10,24H,11-15H2
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211n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019737
PNG
(9-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Clc1cccc(c1)N1CCN(CCCn2c3CN(CCc4ccccn4)CCc3c3ccccc23)CC1
Show InChI InChI=1S/C31H36ClN5/c32-25-7-5-9-27(23-25)36-21-19-34(20-22-36)15-6-16-37-30-11-2-1-10-28(30)29-13-18-35(24-31(29)37)17-12-26-8-3-4-14-33-26/h1-5,7-11,14,23H,6,12-13,15-22,24H2
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213n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019732
PNG
(6-Fluoro-2-(2-quinolin-2-yl-ethyl)-2,3,4,9-tetrahy...)
Show SMILES Fc1ccc2[nH]c3CN(CCc4ccc5ccccc5n4)CCc3c2c1
Show InChI InChI=1S/C22H20FN3/c23-16-6-8-21-19(13-16)18-10-12-26(14-22(18)25-21)11-9-17-7-5-15-3-1-2-4-20(15)24-17/h1-8,13,25H,9-12,14H2
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216n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019744
PNG
(2-(7-Pyridin-4-yl-heptyl)-2,3,4,9-tetrahydro-1H-be...)
Show SMILES C(CCCN1CCc2c(C1)[nH]c1ccccc21)CCCc1ccncc1
Show InChI InChI=1S/C23H29N3/c1(2-4-8-19-11-14-24-15-12-19)3-7-16-26-17-13-21-20-9-5-6-10-22(20)25-23(21)18-26/h5-6,9-12,14-15,25H,1-4,7-8,13,16-18H2
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252n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019746
PNG
(9-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Show SMILES Clc1cccc(c1)N1CCN(CCCn2c3CN(CCCc4cccnc4)CCc3c3ccccc23)CC1
Show InChI InChI=1S/C32H38ClN5/c33-27-9-3-10-28(23-27)37-21-19-35(20-22-37)16-6-17-38-31-12-2-1-11-29(31)30-13-18-36(25-32(30)38)15-5-8-26-7-4-14-34-24-26/h1-4,7,9-12,14,23-24H,5-6,8,13,15-22,25H2
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306n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019735
PNG
(2-{3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCN2CCc3c(C2)[nH]c2ccccc32)CC1
Show InChI InChI=1S/C25H29F3N4/c26-25(27,28)19-5-3-6-20(17-19)32-15-13-30(14-16-32)10-4-11-31-12-9-22-21-7-1-2-8-23(21)29-24(22)18-31/h1-3,5-8,17,29H,4,9-16,18H2
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407n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019749
PNG
(2-(4-Pyridin-4-yl-butyl)-2,3,4,9-tetrahydro-1H-bet...)
Show SMILES C(CCc1ccncc1)CN1CCc2c(C1)[nH]c1ccccc21
Show InChI InChI=1S/C20H23N3/c1-2-7-19-17(6-1)18-10-14-23(15-20(18)22-19)13-4-3-5-16-8-11-21-12-9-16/h1-2,6-9,11-12,22H,3-5,10,13-15H2
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525n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine receptor D2 of rat striatum labeled with [3H]-spiperone was determined


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019745
PNG
(2-[3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propyl]-2,3...)
Show SMILES C(CN1CCN(CC1)c1ncccn1)CN1CCc2c(C1)[nH]c1ccccc21
Show InChI InChI=1S/C22H28N6/c1-2-6-20-18(5-1)19-7-12-27(17-21(19)25-20)11-4-10-26-13-15-28(16-14-26)22-23-8-3-9-24-22/h1-3,5-6,8-9,25H,4,7,10-17H2
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574n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50019749
PNG
(2-(4-Pyridin-4-yl-butyl)-2,3,4,9-tetrahydro-1H-bet...)
Show SMILES C(CCc1ccncc1)CN1CCc2c(C1)[nH]c1ccccc21
Show InChI InChI=1S/C20H23N3/c1-2-7-19-17(6-1)18-10-14-23(15-20(18)22-19)13-4-3-5-16-8-11-21-12-9-16/h1-2,6-9,11-12,22H,3-5,10,13-15H2
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680n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine receptor D2 of rat striatum labeled with [3H]-spiperone was determined


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019739
PNG
(6-Fluoro-2-(4-pyridin-4-yl-butyl)-2,3,4,9-tetrahyd...)
Show SMILES Fc1ccc2[nH]c3CN(CCCCc4ccncc4)CCc3c2c1
Show InChI InChI=1S/C20H22FN3/c21-16-4-5-19-18(13-16)17-8-12-24(14-20(17)23-19)11-2-1-3-15-6-9-22-10-7-15/h4-7,9-10,13,23H,1-3,8,11-12,14H2
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720n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone was determined at 10 uM concentration.


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019736
PNG
(6-Chloro-2-(2-pyridin-4-yl-ethyl)-2,3,4,9-tetrahyd...)
Show SMILES Clc1ccc2[nH]c3CN(CCc4ccncc4)CCc3c2c1
Show InChI InChI=1S/C18H18ClN3/c19-14-1-2-17-16(11-14)15-6-10-22(12-18(15)21-17)9-5-13-3-7-20-8-4-13/h1-4,7-8,11,21H,5-6,9-10,12H2
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768n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019753
PNG
(2-(3-Pyridin-4-yl-propyl)-2,3,4,9-tetrahydro-1H-be...)
Show SMILES C(CN1CCc2c(C1)[nH]c1ccccc21)Cc1ccncc1
Show InChI InChI=1S/C19H21N3/c1-2-6-18-16(5-1)17-9-13-22(14-19(17)21-18)12-3-4-15-7-10-20-11-8-15/h1-2,5-8,10-11,21H,3-4,9,12-14H2
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1.12E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019752
PNG
(2-{3-[4-(4-Trifluoromethyl-benzyl)-piperazin-1-yl]...)
Show SMILES FC(F)(F)c1ccc(CN2CCN(CCCN3CCc4c(C3)[nH]c3ccccc43)CC2)cc1
Show InChI InChI=1S/C26H31F3N4/c27-26(28,29)21-8-6-20(7-9-21)18-33-16-14-31(15-17-33)11-3-12-32-13-10-23-22-4-1-2-5-24(22)30-25(23)19-32/h1-2,4-9,30H,3,10-19H2
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1.20E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019751
PNG
(2-(3-Pyridin-3-yl-propyl)-2,3,4,9-tetrahydro-1H-be...)
Show SMILES C(CN1CCc2c(C1)[nH]c1ccccc21)Cc1cccnc1
Show InChI InChI=1S/C19H21N3/c1-2-8-18-16(7-1)17-9-12-22(14-19(17)21-18)11-4-6-15-5-3-10-20-13-15/h1-3,5,7-8,10,13,21H,4,6,9,11-12,14H2
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2.70E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50019742
PNG
(9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...)
Show SMILES C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1
Show InChI InChI=1S/C21H27N3/c1-16-14-23(15-17(2)22-16)12-7-13-24-20-10-5-3-8-18(20)19-9-4-6-11-21(19)24/h3-6,8-11,16-17,22H,7,12-15H2,1-2H3/t16-,17+
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>1.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]-spiperone


J Med Chem 30: 1100-5 (1987)


Article DOI: 10.1021/jm00389a022
BindingDB Entry DOI: 10.7270/Q2K35SNV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%