BindingDB logo
myBDB logout

PubMed code 2898533

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367721
PNG
(CHEMBL1202512)
Show SMILES O=C1C2C(C3CCC2C2CCC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H33N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3,8-9,16-21H,1-2,4-7,10-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367719
PNG
(CHEMBL1202513)
Show SMILES O=C1C2C(C3C=CC2C2CCC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H31N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3,6-9,16-21H,1-2,4-5,10-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367726
PNG
(CHEMBL1202507)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C26H33N3O3/c1-32-22-7-3-2-6-21(22)28-14-12-27(13-15-28)10-4-5-11-29-25(30)23-17-8-9-18(20-16-19(17)20)24(23)26(29)31/h2-3,6-9,17-20,23-24H,4-5,10-16H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367735
PNG
(CHEMBL1204093)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3C=CC43)C2=O)CC1
Show InChI InChI=1S/C27H33N3O3/c1-33-23-7-3-2-6-22(23)29-16-14-28(15-17-29)12-4-5-13-30-26(31)24-20-10-11-21(25(24)27(30)32)19-9-8-18(19)20/h2-3,6-11,18-21,24-25H,4-5,12-17H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367733
PNG
(CHEMBL1202527)
Show SMILES O=C1C2C(C3CCC2CCC3)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C23H33N5O2/c29-21-19-17-5-3-6-18(8-7-17)20(19)22(30)28(21)12-2-1-11-26-13-15-27(16-14-26)23-24-9-4-10-25-23/h4,9-10,17-20H,1-3,5-8,11-16H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367736
PNG
(CHEMBL1202530)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)C23C4CCC(C4)C12C1CCC3C1
Show InChI InChI=1S/C26H35N5O2/c32-22-25-18-4-5-19(16-18)26(25,21-7-6-20(25)17-21)23(33)31(22)11-2-1-10-29-12-14-30(15-13-29)24-27-8-3-9-28-24/h3,8-9,18-21H,1-2,4-7,10-17H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020115
PNG
(4-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-4-az...)
Show SMILES O=C1C2C3CCC(C3)C2C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
9n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50005127
PNG
(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367731
PNG
(CHEMBL1202506)
Show SMILES O=C1C2C(C3CCCC2C=C3)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C23H31N5O2/c29-21-19-17-5-3-6-18(8-7-17)20(19)22(30)28(21)12-2-1-11-26-13-15-27(16-14-26)23-24-9-4-10-25-23/h4,7-10,17-20H,1-3,5-6,11-16H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367723
PNG
(CHEMBL1202494)
Show SMILES O=C1C2C(C3CCC2C2CC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C23H31N5O2/c29-21-19-15-4-5-16(18-14-17(15)18)20(19)22(30)28(21)9-2-1-8-26-10-12-27(13-11-26)23-24-6-3-7-25-23/h3,6-7,15-20H,1-2,4-5,8-14H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020142
PNG
(4-{4-[4-(3-chlorophenyl)hexahydro-1-pyrazinyl]buty...)
Show SMILES Clc1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C25H30ClN3O2/c26-16-4-3-5-17(14-16)28-12-10-27(11-13-28)8-1-2-9-29-24(30)22-18-6-7-19(21-15-20(18)21)23(22)25(29)31/h3-7,14,18-23H,1-2,8-13,15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367725
PNG
(CHEMBL1202520)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)C23C4CC(C=C4)C12C1CC3C=C1
Show InChI InChI=1S/C26H31N5O2/c32-22-25-18-4-5-19(16-18)26(25,21-7-6-20(25)17-21)23(33)31(22)11-2-1-10-29-12-14-30(15-13-29)24-27-8-3-9-28-24/h3-9,18-21H,1-2,10-17H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50367726
PNG
(CHEMBL1202507)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C26H33N3O3/c1-32-22-7-3-2-6-21(22)28-14-12-27(13-15-28)10-4-5-11-29-25(30)23-17-8-9-18(20-16-19(17)20)24(23)26(29)31/h2-3,6-9,17-20,23-24H,4-5,10-16H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
16n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367734
PNG
(CHEMBL1202523)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4CCC3CCC4)C2=O)CC1
Show InChI InChI=1S/C26H34F3N3O2/c27-26(28,29)20-7-4-8-21(17-20)31-15-13-30(14-16-31)11-1-2-12-32-24(33)22-18-5-3-6-19(10-9-18)23(22)25(32)34/h4,7-8,17-19,22-23H,1-3,5-6,9-16H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
17n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367729
PNG
(CHEMBL1204094)
Show SMILES O=C1C2C(C3C=CC2C2C=CC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H29N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3-9,16-21H,1-2,10-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
17n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020126
PNG
(4-{4-[4-(3-chlorophenyl)hexahydro-1-pyrazinyl]buty...)
Show SMILES Clc1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CCC43)C2=O)CC1
Show InChI InChI=1S/C26H32ClN3O2/c27-17-4-3-5-18(16-17)29-14-12-28(13-15-29)10-1-2-11-30-25(31)23-21-8-9-22(24(23)26(30)32)20-7-6-19(20)21/h3-5,8-9,16,19-24H,1-2,6-7,10-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
19n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367732
PNG
(CHEMBL1202493)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4CCC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C26H32F3N3O2/c27-26(28,29)16-4-3-5-17(14-16)31-12-10-30(11-13-31)8-1-2-9-32-24(33)22-18-6-7-19(21-15-20(18)21)23(22)25(32)34/h3-5,14,18-23H,1-2,6-13,15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367728
PNG
(CHEMBL1202515)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3C=CC43)C2=O)CC1
Show InChI InChI=1S/C27H30F3N3O2/c28-27(29,30)17-4-3-5-18(16-17)32-14-12-31(13-15-32)10-1-2-11-33-25(34)23-21-8-9-22(24(23)26(33)35)20-7-6-19(20)21/h3-9,16,19-24H,1-2,10-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
25n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367730
PNG
(CHEMBL1202508)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C26H30F3N3O2/c27-26(28,29)16-4-3-5-17(14-16)31-12-10-30(11-13-31)8-1-2-9-32-24(33)22-18-6-7-19(21-15-20(18)21)23(22)25(32)34/h3-7,14,18-23H,1-2,8-13,15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
26n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020145
PNG
(4-{4-[4-(3-chloro-2-pyrazinyl)hexahydro-1-pyraziny...)
Show SMILES Clc1nccnc1N1CCN(CCCCN2C(=O)C3C(C4CCC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C23H30ClN5O2/c24-20-21(26-6-5-25-20)28-11-9-27(10-12-28)7-1-2-8-29-22(30)18-14-3-4-15(17-13-16(14)17)19(18)23(29)31/h5-6,14-19H,1-4,7-13H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
26n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020121
PNG
(4-[4-(3'-Chloro-2,3,5,6-tetrahydro-[1,2']bipyrazin...)
Show SMILES Clc1nccnc1N1CCN(CCCCN2C(=O)C3C4CC(C=C4)C3C2=O)CC1
Show InChI InChI=1S/C21H26ClN5O2/c22-18-19(24-6-5-23-18)26-11-9-25(10-12-26)7-1-2-8-27-20(28)16-14-3-4-15(13-14)17(16)21(27)29/h3-6,14-17H,1-2,7-13H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
37n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367720
PNG
(CHEMBL1202504)
Show SMILES O=C1C2C(C3C=CC2C2CC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C23H29N5O2/c29-21-19-15-4-5-16(18-14-17(15)18)20(19)22(30)28(21)9-2-1-8-26-10-12-27(13-11-26)23-24-6-3-7-25-23/h3-7,15-20H,1-2,8-14H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
38n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020131
PNG
(4-{4-[4-(3-chlorophenyl)hexahydro-1-pyrazinyl]buty...)
Show SMILES Clc1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3C=CC43)C2=O)CC1
Show InChI InChI=1S/C26H30ClN3O2/c27-17-4-3-5-18(16-17)29-14-12-28(13-15-29)10-1-2-11-30-25(31)23-21-8-9-22(24(23)26(30)32)20-7-6-19(20)21/h3-9,16,19-24H,1-2,10-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
41n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367722
PNG
(CHEMBL1202511)
Show SMILES O=C1C2C(C3C=CC2C2CCC32)C(=O)N1CCCCN1CCN(CC1)c1cnccn1
Show InChI InChI=1S/C24H31N5O2/c30-23-21-18-5-6-19(17-4-3-16(17)18)22(21)24(31)29(23)10-2-1-9-27-11-13-28(14-12-27)20-15-25-7-8-26-20/h5-8,15-19,21-22H,1-4,9-14H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
41n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020123
PNG
(4-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-4-az...)
Show SMILES O=C1C2C3CC(C=C3)C2C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H27N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3-7,15-18H,1-2,8-14H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
42n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020122
PNG
(4-{4-[4-(6-chloro-2-pyrazinyl)hexahydro-1-pyraziny...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4CCC3C3CCC43)C2=O)CC1
Show InChI InChI=1S/C24H32ClN5O2/c25-19-13-26-14-20(27-19)29-11-9-28(10-12-29)7-1-2-8-30-23(31)21-17-5-6-18(22(21)24(30)32)16-4-3-15(16)17/h13-18,21-22H,1-12H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
51n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50367721
PNG
(CHEMBL1202512)
Show SMILES O=C1C2C(C3CCC2C2CCC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H33N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3,8-9,16-21H,1-2,4-7,10-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
53n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367724
PNG
(CHEMBL1202516)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CCC43)C2=O)CC1
Show InChI InChI=1S/C27H32F3N3O2/c28-27(29,30)17-4-3-5-18(16-17)32-14-12-31(13-15-32)10-1-2-11-33-25(34)23-21-8-9-22(24(23)26(33)35)20-7-6-19(20)21/h3-5,8-9,16,19-24H,1-2,6-7,10-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
57n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020122
PNG
(4-{4-[4-(6-chloro-2-pyrazinyl)hexahydro-1-pyraziny...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4CCC3C3CCC43)C2=O)CC1
Show InChI InChI=1S/C24H32ClN5O2/c25-19-13-26-14-20(27-19)29-11-9-28(10-12-29)7-1-2-8-30-23(31)21-17-5-6-18(22(21)24(30)32)16-4-3-15(16)17/h13-18,21-22H,1-12H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
65n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020137
PNG
(4-{4-[4-(3-chloro-2-pyrazinyl)hexahydro-1-pyraziny...)
Show SMILES Clc1nccnc1N1CCN(CCCCN2C(=O)C3C(C4CCC3C3CCC43)C2=O)CC1
Show InChI InChI=1S/C24H32ClN5O2/c25-21-22(27-8-7-26-21)29-13-11-28(12-14-29)9-1-2-10-30-23(31)19-17-5-6-18(20(19)24(30)32)16-4-3-15(16)17/h7-8,15-20H,1-6,9-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
74n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50367719
PNG
(CHEMBL1202513)
Show SMILES O=C1C2C(C3C=CC2C2CCC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H31N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3,6-9,16-21H,1-2,4-5,10-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
85n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020130
PNG
(4-[4-(6'-Chloro-2,3,5,6-tetrahydro-[1,2']bipyrazin...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4CCCC3C=C4)C2=O)CC1
Show InChI InChI=1S/C23H30ClN5O2/c24-18-14-25-15-19(26-18)28-12-10-27(11-13-28)8-1-2-9-29-22(30)20-16-4-3-5-17(7-6-16)21(20)23(29)31/h6-7,14-17,20-21H,1-5,8-13H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
107n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
119n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020116
PNG
(4-[4-(6'-Chloro-2,3,5,6-tetrahydro-[1,2']bipyrazin...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4CCCCC3C=C4)C2=O)CC1
Show InChI InChI=1S/C24H32ClN5O2/c25-19-15-26-16-20(27-19)29-13-11-28(12-14-29)9-3-4-10-30-23(31)21-17-5-1-2-6-18(8-7-17)22(21)24(30)32/h7-8,15-18,21-22H,1-6,9-14H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
122n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50367727
PNG
(CHEMBL1202502)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2cnccn2)C(=O)C23C4CC(C=C4)C12C1CC3C=C1
Show InChI InChI=1S/C26H31N5O2/c32-23-25-18-3-4-19(15-18)26(25,21-6-5-20(25)16-21)24(33)31(23)10-2-1-9-29-11-13-30(14-12-29)22-17-27-7-8-28-22/h3-8,17-21H,1-2,9-16H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
129n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50367723
PNG
(CHEMBL1202494)
Show SMILES O=C1C2C(C3CCC2C2CC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C23H31N5O2/c29-21-19-15-4-5-16(18-14-17(15)18)20(19)22(30)28(21)9-2-1-8-26-10-12-27(13-11-26)23-24-6-3-7-25-23/h3,6-7,15-20H,1-2,4-5,8-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
140n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020124
PNG
(4-{4-[4-(6-chloro-2-pyrazinyl)hexahydro-1-pyraziny...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C23H28ClN5O2/c24-18-12-25-13-19(26-18)28-9-7-27(8-10-28)5-1-2-6-29-22(30)20-14-3-4-15(17-11-16(14)17)21(20)23(29)31/h3-4,12-17,20-21H,1-2,5-11H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
162n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020138
PNG
(4-[4-(6'-Chloro-2,3,5,6-tetrahydro-[1,2']bipyrazin...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4CCC3CCC4)C2=O)CC1
Show InChI InChI=1S/C23H32ClN5O2/c24-18-14-25-15-19(26-18)28-12-10-27(11-13-28)8-1-2-9-29-22(30)20-16-4-3-5-17(7-6-16)21(20)23(29)31/h14-17,20-21H,1-13H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
162n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50020113
PNG
(4-{4-[4-(6-chloro-2-pyrazinyl)hexahydro-1-pyraziny...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CCC43)C2=O)CC1
Show InChI InChI=1S/C24H30ClN5O2/c25-19-13-26-14-20(27-19)29-11-9-28(10-12-29)7-1-2-8-30-23(31)21-17-5-6-18(22(21)24(30)32)16-4-3-15(16)17/h5-6,13-18,21-22H,1-4,7-12H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
190n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue.


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020123
PNG
(4-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-4-az...)
Show SMILES O=C1C2C3CC(C=C3)C2C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H27N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3-7,15-18H,1-2,8-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
248n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50367729
PNG
(CHEMBL1204094)
Show SMILES O=C1C2C(C3C=CC2C2C=CC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C24H29N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3-9,16-21H,1-2,10-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
345n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020116
PNG
(4-[4-(6'-Chloro-2,3,5,6-tetrahydro-[1,2']bipyrazin...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4CCCCC3C=C4)C2=O)CC1
Show InChI InChI=1S/C24H32ClN5O2/c25-19-15-26-16-20(27-19)29-13-11-28(12-14-29)9-3-4-10-30-23(31)21-17-5-1-2-6-18(8-7-17)22(21)24(30)32/h7-8,15-18,21-22H,1-6,9-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
345n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020144
PNG
(2-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-hexa...)
Show SMILES O=C1C2CCCCC2C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C20H29N5O2/c26-18-16-6-1-2-7-17(16)19(27)25(18)11-4-3-10-23-12-14-24(15-13-23)20-21-8-5-9-22-20/h5,8-9,16-17H,1-4,6-7,10-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
374n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020113
PNG
(4-{4-[4-(6-chloro-2-pyrazinyl)hexahydro-1-pyraziny...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CCC43)C2=O)CC1
Show InChI InChI=1S/C24H30ClN5O2/c25-19-13-26-14-20(27-19)29-11-9-28(10-12-29)7-1-2-8-30-23(31)21-17-5-6-18(22(21)24(30)32)16-4-3-15(16)17/h5-6,13-18,21-22H,1-4,7-12H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
413n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50367720
PNG
(CHEMBL1202504)
Show SMILES O=C1C2C(C3C=CC2C2CC32)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C23H29N5O2/c29-21-19-15-4-5-16(18-14-17(15)18)20(19)22(30)28(21)9-2-1-8-26-10-12-27(13-11-26)23-24-6-3-7-25-23/h3-7,15-20H,1-2,8-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
488n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020124
PNG
(4-{4-[4-(6-chloro-2-pyrazinyl)hexahydro-1-pyraziny...)
Show SMILES Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C23H28ClN5O2/c24-18-12-25-13-19(26-18)28-9-7-27(8-10-28)5-1-2-6-29-22(30)20-14-3-4-15(17-11-16(14)17)21(20)23(29)31/h3-4,12-17,20-21H,1-2,5-11H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
690n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020136
PNG
(4-[4-(6'-Chloro-2,3,5,6-tetrahydro-[1,2']bipyrazin...)
Show SMILES CC(C)=C1C2C=CC1C1C2C(=O)N(CCCCN2CCN(CC2)c2cncc(Cl)n2)C1=O
Show InChI InChI=1S/C24H30ClN5O2/c1-15(2)20-16-5-6-17(20)22-21(16)23(31)30(24(22)32)8-4-3-7-28-9-11-29(12-10-28)19-14-26-13-18(25)27-19/h5-6,13-14,16-17,21-22H,3-4,7-12H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
968n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020141
PNG
(4-{4-[4-(6-chloro-3-pyridazinyl)hexahydro-1-pyrazi...)
Show SMILES Clc1ccc(nn1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CCC43)C2=O)CC1
Show InChI InChI=1S/C24H30ClN5O2/c25-19-7-8-20(27-26-19)29-13-11-28(12-14-29)9-1-2-10-30-23(31)21-17-5-6-18(22(21)24(30)32)16-4-3-15(16)17/h5-8,15-18,21-22H,1-4,9-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.93E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020125
PNG
(4-{4-[4-(6-chloro-3-pyridazinyl)hexahydro-1-pyrazi...)
Show SMILES Clc1ccc(nn1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1
Show InChI InChI=1S/C23H28ClN5O2/c24-18-5-6-19(26-25-18)28-11-9-27(10-12-28)7-1-2-8-29-22(30)20-14-3-4-15(17-13-16(14)17)21(20)23(29)31/h3-6,14-17,20-21H,1-2,7-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.33E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue


J Med Chem 31: 1382-92 (1988)


Article DOI: 10.1021/jm00402a023
BindingDB Entry DOI: 10.7270/Q2PC32Z4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%