Found 39 Enz. Inhib. hit(s) with all data for entry = 50002367 
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
University Of Colorado
Curated by ChEMBL
University Of Colorado
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of PKC in TLR null HEK-blue cells assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quan...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
University Of Colorado
Curated by ChEMBL
University Of Colorado
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of PKC in HEK-blue cells expressing human TLR7 assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 2...More data for this Ligand-Target Pair
Affinity DataIC50: 720nMAssay Description:Inhibition of IL1R in TLR null HEK-blue cells assessed as decrease in IL-1beta-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs ...More data for this Ligand-Target Pair
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
University Of Colorado
Curated by ChEMBL
University Of Colorado
Curated by ChEMBL
Affinity DataIC50: 770nMAssay Description:Inhibition of TNFR in TLR null HEK-blue cells assessed as decrease in TNFalpha-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 990nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.83E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 3.09E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.32E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.47E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 2.78E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 4.48E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
