BindingDB PrimarySearch_ki

Found 61 Enz. Inhib. hit(s) with all data for entry = 50008922

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM415557(US10428104, Example 88)

Ki: 0.0200nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50462572(CHEMBL4249337)

IC50: 0.130nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523629(CHEMBL4564327)

IC50: 0.160nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523646(CHEMBL4541714)

IC50: 0.160nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523642(CHEMBL4539612)

IC50: <0.200nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523646(CHEMBL4541714)

IC50: 0.25nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50462572(CHEMBL4249337)

IC50: 0.25nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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3D Structure (crystal)

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523655(CHEMBL4577464)

IC50: 0.320nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523643(CHEMBL4454890)

IC50: 0.400nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523641(CHEMBL4543007)

IC50: 0.400nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523663(CHEMBL4536042)

IC50: 0.600nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523641(CHEMBL4543007)

IC50: 0.790nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523656(CHEMBL4579773)

IC50: 0.800nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM415582(US10428104, Example 112)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523638(CHEMBL4470815 | US10709709, Example 200)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM415556(US10428104, Example 87)

IC50: 1nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523661(CHEMBL4547524 | US10709709, Example 154)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM415554((2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidi...)

IC50: 1nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523631(CHEMBL4585734)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523649(CHEMBL4448266 | US10709709, Example 198)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523652(CHEMBL4445368 | US10709709, Example 89)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523657(CHEMBL4563402)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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3D Structure (crystal)

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523654(CHEMBL4455651 | US10709709, Example 212)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523654(CHEMBL4455651 | US10709709, Example 212)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523650(CHEMBL4541232 | US10709709, Example 91)

IC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523656(CHEMBL4579773)

IC50: 1.30nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523636(CHEMBL4457371)

IC50: 2nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM415529((Scheme R) (2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-py...)

IC50: 2nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523658(CHEMBL4460647)

IC50: 2nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523651(CHEMBL4579108 | US10709709, Example 90)

IC50: 2nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523655(CHEMBL4577464)

IC50: 2nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523639(CHEMBL4460965)

IC50: 3nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523653(CHEMBL4582424)

IC50: 3nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523642(CHEMBL4539612)

IC50: 4nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM415556(US10428104, Example 87)

IC50: 4.30nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovir...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523644(CHEMBL4541070)

IC50: 5nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523630(CHEMBL4439077)

IC50: 6.30nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523629(CHEMBL4564327)

IC50: 6.30nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523644(CHEMBL4541070)

IC50: 6.30nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523630(CHEMBL4439077)

IC50: 7.90nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523634(CHEMBL4540972)

IC50: 7.90nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523632(CHEMBL4454122)

IC50: 8.70nMAssay Description:Inhibition of PRMT5 (unknown origin) assessed as reduction in SAH formation using histone H2A and SAM incubated for 60 mins by high throughput mass s...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523659(CHEMBL4557058)

IC50: 9nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50366992(CHEMBL4168754)

IC50: 9.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovir...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523635(CHEMBL4556400)

IC50: 16nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523662(CHEMBL4465375)

IC50: 17nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523645(CHEMBL4576734)

IC50: 20nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523647(CHEMBL4524391)

IC50: 22nMAssay Description:Inhibition of PRMT5 (unknown origin) assessed as reduction in SAH formation using histone H2A and SAM incubated for 60 mins by high throughput mass s...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Methylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523633(CHEMBL4554624)

IC50: 26nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL

PNG

BDBM50523634(CHEMBL4540972)

IC50: 51nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

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