Compile Data Set for Download or QSAR
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Found 27 Enz. Inhib. hit(s) with all data for entry = 50007615
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50244142(CHEMBL4086356 | US10533010, Example I-240 | US1120...)
Affinity DataKi: <1nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50510966(CHEMBL4457559)
Affinity DataKi:  2.40nMAssay Description:Inhibition of MCL1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50244142(CHEMBL4086356 | US10533010, Example I-240 | US1120...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50038704(CHEMBL3354882)
Affinity DataKi:  5.30nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50244111(CHEMBL4082389 | US10533010, Example I-39 | US11208...)
Affinity DataKi:  23nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50244111(CHEMBL4082389 | US10533010, Example I-39 | US11208...)
Affinity DataKi:  108nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50424732(CHEMBL2314209)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs in presence of 1% FBS by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50220817(CHEMBL57792)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of HDAC in human K562 cell extracts using (QSY-7)-RGGRGLGK(Ac)-GGARRHRK(TAMRA)NH2 as substrate preincubated for 30 mins followed by additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50510962(CHEMBL4454646)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC in human HeLa cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  20nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  36nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  47nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50242817(CHEMBL4087968)
Affinity DataIC50:  67nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50242817(CHEMBL4087968)
Affinity DataIC50:  78nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50458323(CHEMBL4207448)
Affinity DataIC50:  78nMAssay Description:Inhibition of HDAC1 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50242817(CHEMBL4087968)
Affinity DataIC50:  95nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  143nMAssay Description:Inhibition of HDAC in human K562 cell extracts using (QSY-7)-RGGRGLGK(Ac)-GGARRHRK(TAMRA)NH2 as substrate preincubated for 30 mins followed by additi...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50242817(CHEMBL4087968)
Affinity DataIC50:  160nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50510963(D-24851 | Indibulin | ZIO-301)
Affinity DataIC50:  250nMAssay Description:Inhibition of bovine brain tubulin polymerization incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50458323(CHEMBL4207448)
Affinity DataIC50:  290nMAssay Description:Inhibition of HDAC6 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50458323(CHEMBL4207448)
Affinity DataIC50:  380nMAssay Description:Inhibition of HDAC8 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50510964(CHEMBL4465340)
Affinity DataIC50:  2.12E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization by spectrometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50510965(CHEMBL4564431)
Affinity DataIC50:  8.72E+3nMAssay Description:Inhibition of recombinant human CYP19 using MFC as substrate incubated for 30 mins in presence of NADPH by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed