BindingDB PrimarySearch_ki

Found 84 Enz. Inhib. hit(s) with all data for entry = 50009675

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)

IC50: 1nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)

IC50: 1nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)

IC50: 1nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)

IC50: 1nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 2nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 2nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531066(CHEMBL4588786)

IC50: 10nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531066(CHEMBL4588786)

IC50: 10nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531065(CHEMBL4452906)

IC50: 20nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531065(CHEMBL4452906)

IC50: 20nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531069(CHEMBL4437863)

IC50: 30nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531069(CHEMBL4437863)

IC50: 30nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531061(CHEMBL4537422)

IC50: 40nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531061(CHEMBL4537422)

IC50: 40nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531066(CHEMBL4588786)

IC50: 60nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531066(CHEMBL4588786)

IC50: 60nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 90nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 90nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531065(CHEMBL4452906)

IC50: 100nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531065(CHEMBL4452906)

IC50: 100nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531069(CHEMBL4437863)

IC50: 110nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Details Article PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531069(CHEMBL4437863)

IC50: 110nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)

IC50: 130nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)

IC50: 130nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531061(CHEMBL4537422)

IC50: 190nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531061(CHEMBL4537422)

IC50: 190nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)

IC50: 390nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)

IC50: 390nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 1.23E+3nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 1.23E+3nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)

IC50: 3.17E+3nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)

IC50: 3.17E+3nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)

IC50: 4.99E+3nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)

IC50: 4.99E+3nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531061(CHEMBL4537422)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50442880(4-Epi-Hederagenin | Hederagenin | US11660306, Exam...)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531062(CHEMBL4454172)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531063(CHEMBL4470692)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531061(CHEMBL4537422)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50442880(4-Epi-Hederagenin | Hederagenin | US11660306, Exam...)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531064(CHEMBL4460981)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50442880(4-Epi-Hederagenin | Hederagenin | US11660306, Exam...)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531067(CHEMBL4456487)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531063(CHEMBL4470692)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531064(CHEMBL4460981)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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MCE
KEGG PC cid PC sid Patents Similars

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Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50442880(4-Epi-Hederagenin | Hederagenin | US11660306, Exam...)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid Similars

Details Article PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531066(CHEMBL4588786)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
Soochow University

Curated by ChEMBL

PNG

BDBM50531068(CHEMBL4554092)

IC50: >2.00E+4nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

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