Affinity Data by PubMed id=32428392

PubMed code 32428392

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Replicase polyprotein 1ab (2019-nCoV)	BDBM31524 (5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia					Assay Description Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...				ACS Infect Dis 6: 2099-2109 (2020) BindingDB Entry DOI: 10.7270/Q2474D7W
University of Georgia					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM31523 (Compound 6 \| Naphthalene and Benzamide Derivative,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	Purchase PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia					Assay Description Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...				ACS Infect Dis 6: 2099-2109 (2020) BindingDB Entry DOI: 10.7270/Q2474D7W
University of Georgia					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM420300 (7724772 \| med.21724, Compound 157) Show SMILES CC(NC(=O)c1ccccc1C)c1ccc2ccccc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	UniChem	PubMed	n/a	n/a	2.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia					Assay Description Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...				ACS Infect Dis 6: 2099-2109 (2020) BindingDB Entry DOI: 10.7270/Q2474D7W
University of Georgia					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM420301 (6577871) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	UniChem	PubMed	n/a	n/a	1.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia					Assay Description Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...				ACS Infect Dis 6: 2099-2109 (2020) BindingDB Entry DOI: 10.7270/Q2474D7W
University of Georgia					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM420302 (9247873) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	UniChem	PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia					Assay Description Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...				ACS Infect Dis 6: 2099-2109 (2020) BindingDB Entry DOI: 10.7270/Q2474D7W
University of Georgia					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM31524 (5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.76E+4	n/a	n/a	n/a	n/a
University of Georgia					Assay Description Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...				ACS Infect Dis 6: 2099-2109 (2020) BindingDB Entry DOI: 10.7270/Q2474D7W
University of Georgia					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM31523 (Compound 6 \| Naphthalene and Benzamide Derivative,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	Purchase PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a
University of Georgia					Assay Description Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...				ACS Infect Dis 6: 2099-2109 (2020) BindingDB Entry DOI: 10.7270/Q2474D7W
University of Georgia					More data for this Ligand-Target Pair

* indicates data uncertainty>20%