BindingDB logo
myBDB logout

PubMed code 3397992

Compile data set for download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50241107
PNG
(1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazo...)
Show SMILES Clc1ccc2n(C3CCN(CCCn4c5ccccc5[nH]c4=O)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.20n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023801
PNG
(3-Amino-2-chloro-11-ethyl-6,7,8,9,10,11,12,13,14,1...)
Show SMILES CCN1CCCCCOc2cc(N)c(Cl)cc2C(=O)NCCC1
Show InChI InChI=1S/C17H26ClN3O2/c1-2-21-8-4-3-5-10-23-16-12-15(19)14(18)11-13(16)17(22)20-7-6-9-21/h11-12H,2-10,19H2,1H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.70n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023804
PNG
(6-Methoxy-1H-benzotriazole-5-carboxylic acid (1-al...)
Show SMILES COc1cc2nn[nH]c2cc1C(=O)NCC1CCCN1CC=C
Show InChI InChI=1S/C16H21N5O2/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM48320
PNG
(4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 565n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023799
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(=O)c1cccs1
Show InChI InChI=1S/C19H24ClN3O3S/c1-3-23(4-2)8-7-22-19(25)13-10-14(20)15(21)11-17(13)26-12-16(24)18-6-5-9-27-18/h5-6,9-11H,3-4,7-8,12,21H2,1-2H3,(H,22,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023813
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(C)O
Show InChI InChI=1S/C16H26ClN3O3/c1-4-20(5-2)7-6-19-16(22)12-8-13(17)14(18)9-15(12)23-10-11(3)21/h8-9,11,21H,4-7,10,18H2,1-3H3,(H,19,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023843
PNG
(8-Amino-7-chloro-4-(2-diethylamino-ethyl)-3,4-dihy...)
Show SMILES CCN(CC)CCN1CCOc2cc(N)c(Cl)cc2C1=O
Show InChI InChI=1S/C15H22ClN3O2/c1-3-18(4-2)5-6-19-7-8-21-14-10-13(17)12(16)9-11(14)15(19)20/h9-10H,3-8,17H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023850
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2,3-d...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(O)CO
Show InChI InChI=1S/C16H26ClN3O4/c1-3-20(4-2)6-5-19-16(23)12-7-13(17)14(18)8-15(12)24-10-11(22)9-21/h7-8,11,21-22H,3-6,9-10,18H2,1-2H3,(H,19,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50023802
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC(C)C(C)O
Show InChI InChI=1S/C17H28ClN3O3/c1-5-21(6-2)8-7-20-17(23)13-9-14(18)15(19)10-16(13)24-12(4)11(3)22/h9-12,22H,5-8,19H2,1-4H3,(H,20,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452525
PNG
(CHEMBL2114431)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC[C@@H](C)O
Show InChI InChI=1S/C16H26ClN3O3/c1-4-20(5-2)7-6-19-16(22)12-8-13(17)14(18)9-15(12)23-10-11(3)21/h8-9,11,21H,4-7,10,18H2,1-3H3,(H,19,22)/t11-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023811
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-hydrox...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1O
Show InChI InChI=1S/C13H20ClN3O2/c1-3-17(4-2)6-5-16-13(19)9-7-10(14)11(15)8-12(9)18/h7-8,18H,3-6,15H2,1-2H3,(H,16,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023814
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCCO
Show InChI InChI=1S/C15H24ClN3O3/c1-3-19(4-2)6-5-18-15(21)11-9-12(16)13(17)10-14(11)22-8-7-20/h9-10,20H,3-8,17H2,1-2H3,(H,18,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023815
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC1CCCC1=O
Show InChI InChI=1S/C18H26ClN3O3/c1-3-22(4-2)9-8-21-18(24)12-10-13(19)14(20)11-17(12)25-16-7-5-6-15(16)23/h10-11,16H,3-9,20H2,1-2H3,(H,21,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023816
PNG
(2-(1-Acetyl-but-3-enyloxy)-4-amino-5-chloro-N-(2-d...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC(CC=C)C(C)=O
Show InChI InChI=1S/C19H28ClN3O3/c1-5-8-17(13(4)24)26-18-12-16(21)15(20)11-14(18)19(25)22-9-10-23(6-2)7-3/h5,11-12,17H,1,6-10,21H2,2-4H3,(H,22,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023827
PNG
(4-Amino-2-but-2-enyloxy-5-chloro-N-(2-diethylamino...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC\C=C\C
Show InChI InChI=1S/C17H26ClN3O2/c1-4-7-10-23-16-12-15(19)14(18)11-13(16)17(22)20-8-9-21(5-2)6-3/h4,7,11-12H,5-6,8-10,19H2,1-3H3,(H,20,22)/b7-4+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023833
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC(C)C(C)N=O
Show InChI InChI=1S/C17H27ClN4O3/c1-5-22(6-2)8-7-20-17(23)13-9-14(18)15(19)10-16(13)25-12(4)11(3)21-24/h9-12H,5-8,19H2,1-4H3,(H,20,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023841
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC1CCCC[C@@H]1O
Show InChI InChI=1S/C19H30ClN3O3/c1-3-23(4-2)10-9-22-19(25)13-11-14(20)15(21)12-18(13)26-17-8-6-5-7-16(17)24/h11-12,16-17,24H,3-10,21H2,1-2H3,(H,22,25)/t16-,17?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023838
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo...)
Show SMILES CCCC(=O)COc1cc(N)c(Cl)cc1C(=O)NCCN(CC)CC
Show InChI InChI=1S/C18H28ClN3O3/c1-4-7-13(23)12-25-17-11-16(20)15(19)10-14(17)18(24)21-8-9-22(5-2)6-3/h10-11H,4-9,12,20H2,1-3H3,(H,21,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023849
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(C)OC
Show InChI InChI=1S/C17H28ClN3O3/c1-5-21(6-2)8-7-20-17(22)13-9-14(18)15(19)10-16(13)24-11-12(3)23-4/h9-10,12H,5-8,11,19H2,1-4H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023859
PNG
(CHEMBL289070 | N-[7-Chloro-4-(2-diethylamino-ethyl...)
Show SMILES CCN(CC)CCN1C(C)=C(C)Oc2cc(NC=O)c(Cl)cc2C1=O
Show InChI InChI=1S/C18H24ClN3O3/c1-5-21(6-2)7-8-22-12(3)13(4)25-17-10-16(20-11-23)15(19)9-14(17)18(22)24/h9-11H,5-8H2,1-4H3,(H,20,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023851
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2,2-d...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(OC)OC
Show InChI InChI=1S/C17H28ClN3O4/c1-5-21(6-2)8-7-20-17(22)12-9-13(18)14(19)10-15(12)25-11-16(23-3)24-4/h9-10,16H,5-8,11,19H2,1-4H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023863
PNG
(8-Amino-7-chloro-4-(2-diethylamino-ethyl)-2,3-dime...)
Show SMILES CCN(CC)CCN1C(C)=C(C)Oc2cc(N)c(Cl)cc2C1=O
Show InChI InChI=1S/C17H24ClN3O2/c1-5-20(6-2)7-8-21-11(3)12(4)23-16-10-15(19)14(18)9-13(16)17(21)22/h9-10H,5-8,19H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023857
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(3-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCc1cc(C)no1
Show InChI InChI=1S/C18H25ClN4O3/c1-4-23(5-2)7-6-21-18(24)14-9-15(19)16(20)10-17(14)25-11-13-8-12(3)22-26-13/h8-10H,4-7,11,20H2,1-3H3,(H,21,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023800
PNG
(4-Amino-5-chloro-2-cyanomethoxy-N-(2-diethylamino-...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC#N
Show InChI InChI=1S/C15H21ClN4O2/c1-3-20(4-2)7-6-19-15(21)11-9-12(16)13(18)10-14(11)22-8-5-17/h9-10H,3-4,6-8,18H2,1-2H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023802
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC(C)C(C)O
Show InChI InChI=1S/C17H28ClN3O3/c1-5-21(6-2)8-7-20-17(23)13-9-14(18)15(19)10-16(13)24-12(4)11(3)22/h9-12,22H,5-8,19H2,1-4H3,(H,20,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023812
PNG
(2-Chloro-4-(3-diethylamino-propane-1-sulfinyl)-5-m...)
Show SMILES CCN(CC)CCCS(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C14H23ClN2O2S/c1-4-17(5-2)7-6-8-20(18)14-9-11(15)12(16)10-13(14)19-3/h9-10H,4-8,16H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023809
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC1CCCC[C@H]1OC
Show InChI InChI=1S/C20H32ClN3O3/c1-4-24(5-2)11-10-23-20(25)14-12-15(21)16(22)13-19(14)27-18-9-7-6-8-17(18)26-3/h12-13,17-18H,4-11,22H2,1-3H3,(H,23,25)/t17-,18?/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023810
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(C)(C)O
Show InChI InChI=1S/C17H28ClN3O3/c1-5-21(6-2)8-7-20-16(22)12-9-13(18)14(19)10-15(12)24-11-17(3,4)23/h9-10,23H,5-8,11,19H2,1-4H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023820
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(3-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCCC(C)O
Show InChI InChI=1S/C17H28ClN3O3/c1-4-21(5-2)8-7-20-17(23)13-10-14(18)15(19)11-16(13)24-9-6-12(3)22/h10-12,22H,4-9,19H2,1-3H3,(H,20,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023821
PNG
(4-Amino-5-chloro-2,3-dimethyl-benzofuran-7-carboxy...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)c2c(C)c(C)oc12
Show InChI InChI=1S/C17H24ClN3O2/c1-5-21(6-2)8-7-20-17(22)12-9-13(18)15(19)14-10(3)11(4)23-16(12)14/h9H,5-8,19H2,1-4H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023823
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCOCCOC
Show InChI InChI=1S/C17H28ClN3O4/c1-4-21(5-2)7-6-20-17(22)13-10-14(18)15(19)11-16(13)25-12-24-9-8-23-3/h10-11H,4-9,12,19H2,1-3H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023825
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-oxiran...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC1CO1
Show InChI InChI=1S/C16H24ClN3O3/c1-3-20(4-2)6-5-19-16(21)12-7-13(17)14(18)8-15(12)23-10-11-9-22-11/h7-8,11H,3-6,9-10,18H2,1-2H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023836
PNG
(6-Hydroxy-1H-benzotriazole-5-carboxylic acid (1-al...)
Show SMILES Oc1cc2nn[nH]c2cc1C(=O)NCC1CCCN1CC=C
Show InChI InChI=1S/C15H19N5O2/c1-2-5-20-6-3-4-10(20)9-16-15(22)11-7-12-13(8-14(11)21)18-19-17-12/h2,7-8,10,21H,1,3-6,9H2,(H,16,22)(H,17,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023848
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-hydrox...)
Show SMILES CCN(CC)CCN(C)C(=O)c1cc(Cl)c(N)cc1O
Show InChI InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17(3)14(20)10-8-11(15)12(16)9-13(10)19/h8-9,19H,4-7,16H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50452526
PNG
(CHEMBL2114428)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(=O)Cc1ccccc1
Show InChI InChI=1S/C22H28ClN3O3/c1-3-26(4-2)11-10-25-22(28)18-13-19(23)20(24)14-21(18)29-15-17(27)12-16-8-6-5-7-9-16/h5-9,13-14H,3-4,10-12,15,24H2,1-2H3,(H,25,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023826
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(C)N=O
Show InChI InChI=1S/C16H25ClN4O3/c1-4-21(5-2)7-6-19-16(22)12-8-13(17)14(18)9-15(12)24-10-11(3)20-23/h8-9,11H,4-7,10,18H2,1-3H3,(H,19,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023830
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(tetra...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC1CCCO1
Show InChI InChI=1S/C18H28ClN3O3/c1-3-22(4-2)8-7-21-18(23)14-10-15(19)16(20)11-17(14)25-12-13-6-5-9-24-13/h10-11,13H,3-9,12,20H2,1-2H3,(H,21,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023831
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(1-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC(C)C(C)=O
Show InChI InChI=1S/C17H26ClN3O3/c1-5-21(6-2)8-7-20-17(23)13-9-14(18)15(19)10-16(13)24-12(4)11(3)22/h9-10,12H,5-8,19H2,1-4H3,(H,20,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023839
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(O)Cc1ccccc1
Show InChI InChI=1S/C22H30ClN3O3/c1-3-26(4-2)11-10-25-22(28)18-13-19(23)20(24)14-21(18)29-15-17(27)12-16-8-6-5-7-9-16/h5-9,13-14,17,27H,3-4,10-12,15,24H2,1-2H3,(H,25,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023854
PNG
(6-(1-Methyl-2-oxo-propoxy)-1H-benzotriazole-5-carb...)
Show SMILES CC(Oc1cc2nn[nH]c2cc1C(=O)NCC1CCCN1CC=C)C(C)=O
Show InChI InChI=1S/C19H25N5O3/c1-4-7-24-8-5-6-14(24)11-20-19(26)15-9-16-17(22-23-21-16)10-18(15)27-13(3)12(2)25/h4,9-10,13-14H,1,5-8,11H2,2-3H3,(H,20,26)(H,21,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023858
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(=O)CC
Show InChI InChI=1S/C17H26ClN3O3/c1-4-12(22)11-24-16-10-15(19)14(18)9-13(16)17(23)20-7-8-21(5-2)6-3/h9-10H,4-8,11,19H2,1-3H3,(H,20,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50452525
PNG
(CHEMBL2114431)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC[C@@H](C)O
Show InChI InChI=1S/C16H26ClN3O3/c1-4-20(5-2)7-6-19-16(22)12-8-13(17)14(18)9-15(12)23-10-11(3)21/h8-9,11,21H,4-7,10,18H2,1-3H3,(H,19,22)/t11-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023808
PNG
(4-Amino-2-but-3-enyloxy-5-chloro-N-(2-diethylamino...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCCC=C
Show InChI InChI=1S/C17H26ClN3O2/c1-4-7-10-23-16-12-15(19)14(18)11-13(16)17(22)20-8-9-21(5-2)6-3/h4,11-12H,1,5-10,19H2,2-3H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023818
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(4,5-d...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC1=NCCN1
Show InChI InChI=1S/C17H26ClN5O2/c1-3-23(4-2)8-7-22-17(24)12-9-13(18)14(19)10-15(12)25-11-16-20-5-6-21-16/h9-10H,3-8,11,19H2,1-2H3,(H,20,21)(H,22,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023842
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(O)COC
Show InChI InChI=1S/C17H28ClN3O4/c1-4-21(5-2)7-6-20-17(23)13-8-14(18)15(19)9-16(13)25-11-12(22)10-24-3/h8-9,12,22H,4-7,10-11,19H2,1-3H3,(H,20,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023846
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(1-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC(C)C(=O)CC
Show InChI InChI=1S/C18H28ClN3O3/c1-5-16(23)12(4)25-17-11-15(20)14(19)10-13(17)18(24)21-8-9-22(6-2)7-3/h10-12H,5-9,20H2,1-4H3,(H,21,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023844
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC1(C)CO1
Show InChI InChI=1S/C17H26ClN3O3/c1-4-21(5-2)7-6-20-16(22)12-8-13(18)14(19)9-15(12)23-10-17(3)11-24-17/h8-9H,4-7,10-11,19H2,1-3H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023855
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(1,1-d...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC(C)(C)C(C)=O
Show InChI InChI=1S/C18H28ClN3O3/c1-6-22(7-2)9-8-21-17(24)13-10-14(19)15(20)11-16(13)25-18(4,5)12(3)23/h10-11H,6-9,20H2,1-5H3,(H,21,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023864
PNG
(2-Allyloxy-4-amino-5-chloro-N-(2-diethylamino-ethy...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC=C
Show InChI InChI=1S/C16H24ClN3O2/c1-4-9-22-15-11-14(18)13(17)10-12(15)16(21)19-7-8-20(5-2)6-3/h4,10-11H,1,5-9,18H2,2-3H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023803
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methox...)
Show SMILES CCN(CC)CCN(C)C(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C15H24ClN3O2/c1-5-19(6-2)8-7-18(3)15(20)11-9-12(16)13(17)10-14(11)21-4/h9-10H,5-8,17H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023806
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hyd...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC1CCCC[C@H]1O
Show InChI InChI=1S/C19H30ClN3O3/c1-3-23(4-2)10-9-22-19(25)13-11-14(20)15(21)12-18(13)26-17-8-6-5-7-16(17)24/h11-12,16-17,24H,3-10,21H2,1-2H3,(H,22,25)/t16-,17?/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023832
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(pyrid...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCc1ccccn1
Show InChI InChI=1S/C19H25ClN4O2/c1-3-24(4-2)10-9-23-19(25)15-11-16(20)17(21)12-18(15)26-13-14-7-5-6-8-22-14/h5-8,11-12H,3-4,9-10,13,21H2,1-2H3,(H,23,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023835
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-([1,3]...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC1OCCO1
Show InChI InChI=1S/C17H26ClN3O4/c1-3-21(4-2)6-5-20-17(22)12-9-13(18)14(19)10-15(12)25-11-16-23-7-8-24-16/h9-10,16H,3-8,11,19H2,1-2H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023834
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2,2-d...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC1COC(C)(C)O1
Show InChI InChI=1S/C19H30ClN3O4/c1-5-23(6-2)8-7-22-18(24)14-9-15(20)16(21)10-17(14)25-11-13-12-26-19(3,4)27-13/h9-10,13H,5-8,11-12,21H2,1-4H3,(H,22,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023847
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(1-eth...)
Show SMILES CCC(Oc1cc(N)c(Cl)cc1C(=O)NCCN(CC)CC)C(C)=O
Show InChI InChI=1S/C18H28ClN3O3/c1-5-16(12(4)23)25-17-11-15(20)14(19)10-13(17)18(24)21-8-9-22(6-2)7-3/h10-11,16H,5-9,20H2,1-4H3,(H,21,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023845
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCCOC
Show InChI InChI=1S/C16H26ClN3O3/c1-4-20(5-2)7-6-19-16(21)12-10-13(17)14(18)11-15(12)23-9-8-22-3/h10-11H,4-9,18H2,1-3H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023852
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC1CCCC[C@@H]1OC
Show InChI InChI=1S/C20H32ClN3O3/c1-4-24(5-2)11-10-23-20(25)14-12-15(21)16(22)13-19(14)27-18-9-7-6-8-17(18)26-3/h12-13,17-18H,4-11,22H2,1-3H3,(H,23,25)/t17-,18?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023862
PNG
(CHEMBL416980 | [5-Amino-4-chloro-2-(2-diethylamino...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(=O)OC
Show InChI InChI=1S/C16H24ClN3O4/c1-4-20(5-2)7-6-19-16(22)11-8-12(17)13(18)9-14(11)24-10-15(21)23-3/h8-9H,4-7,10,18H2,1-3H3,(H,19,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023861
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-[2-(2-...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCCOCCOC
Show InChI InChI=1S/C18H30ClN3O4/c1-4-22(5-2)7-6-21-18(23)14-12-15(19)16(20)13-17(14)26-11-10-25-9-8-24-3/h12-13H,4-11,20H2,1-3H3,(H,21,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023860
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(C)=O
Show InChI InChI=1S/C16H24ClN3O3/c1-4-20(5-2)7-6-19-16(22)12-8-13(17)14(18)9-15(12)23-10-11(3)21/h8-9H,4-7,10,18H2,1-3H3,(H,19,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023822
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC\C(C)=N\OC
Show InChI InChI=1S/C17H27ClN4O3/c1-5-22(6-2)8-7-20-17(23)13-9-14(18)15(19)10-16(13)25-11-12(3)21-24-4/h9-10H,5-8,11,19H2,1-4H3,(H,20,23)/b21-12+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023819
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(=O)c1ccccc1
Show InChI InChI=1S/C21H26ClN3O3/c1-3-25(4-2)11-10-24-21(27)16-12-17(22)18(23)13-20(16)28-14-19(26)15-8-6-5-7-9-15/h5-9,12-13H,3-4,10-11,14,23H2,1-2H3,(H,24,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023853
PNG
(4-Amino-5-chloro-2-(cyano-methyl-methoxy)-N-(2-die...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC(C)C#N
Show InChI InChI=1S/C16H23ClN4O2/c1-4-21(5-2)7-6-20-16(22)12-8-13(17)14(19)9-15(12)23-11(3)10-18/h8-9,11H,4-7,19H2,1-3H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023856
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(3-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCCC(C)OC
Show InChI InChI=1S/C18H30ClN3O3/c1-5-22(6-2)9-8-21-18(23)14-11-15(19)16(20)12-17(14)25-10-7-13(3)24-4/h11-13H,5-10,20H2,1-4H3,(H,21,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023798
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2,N'-dim...)
Show SMILES CCN(CC)CCNC(=NOC)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C15H25ClN4O2/c1-5-20(6-2)8-7-18-15(19-22-4)11-9-12(16)13(17)10-14(11)21-3/h9-10H,5-8,17H2,1-4H3,(H,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023807
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-[2-(2-...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCCC1(C)OCCO1
Show InChI InChI=1S/C19H30ClN3O4/c1-4-23(5-2)8-7-22-18(24)14-12-15(20)16(21)13-17(14)25-9-6-19(3)26-10-11-27-19/h12-13H,4-11,21H2,1-3H3,(H,22,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023805
PNG
(4-Amino-2-benzyloxy-5-chloro-N-(2-diethylamino-eth...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCc1ccccc1
Show InChI InChI=1S/C20H26ClN3O2/c1-3-24(4-2)11-10-23-20(25)16-12-17(21)18(22)13-19(16)26-14-15-8-6-5-7-9-15/h5-9,12-13H,3-4,10-11,14,22H2,1-2H3,(H,23,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023817
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(3-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(=O)C(C)C
Show InChI InChI=1S/C18H28ClN3O3/c1-5-22(6-2)8-7-21-18(24)13-9-14(19)15(20)10-17(13)25-11-16(23)12(3)4/h9-10,12H,5-8,11,20H2,1-4H3,(H,21,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023828
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC1CCCCC1=O
Show InChI InChI=1S/C19H28ClN3O3/c1-3-23(4-2)10-9-22-19(25)13-11-14(20)15(21)12-18(13)26-17-8-6-5-7-16(17)24/h11-12,17H,3-10,21H2,1-2H3,(H,22,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023829
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-propox...)
Show SMILES CCCOc1cc(N)c(Cl)cc1C(=O)NCCN(CC)CC
Show InChI InChI=1S/C16H26ClN3O2/c1-4-9-22-15-11-14(18)13(17)10-12(15)16(21)19-7-8-20(5-2)6-3/h10-11H,4-9,18H2,1-3H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023837
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-met...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC(C)=C
Show InChI InChI=1S/C17H26ClN3O2/c1-5-21(6-2)8-7-20-17(22)13-9-14(18)15(19)10-16(13)23-11-12(3)4/h9-10H,3,5-8,11,19H2,1-2,4H3,(H,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023840
PNG
(3-Amino-2-chloro-11-ethyl-6,7,10,11,12,13,14,15-oc...)
Show SMILES CCN1CCCNC(=O)c2cc(Cl)c(N)cc2OCCOCC1
Show InChI InChI=1S/C16H24ClN3O3/c1-2-20-5-3-4-19-16(21)12-10-13(17)14(18)11-15(12)23-9-8-22-7-6-20/h10-11H,2-9,18H2,1H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50023865
PNG
(4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-prop-2...)
Show SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OCC#C
Show InChI InChI=1S/C16H22ClN3O2/c1-4-9-22-15-11-14(18)13(17)10-12(15)16(21)19-7-8-20(5-2)6-3/h1,10-11H,5-9,18H2,2-3H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Company

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding


J Med Chem 31: 1548-58 (1988)


Article DOI: 10.1021/jm00403a011
BindingDB Entry DOI: 10.7270/Q25B032R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%