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Articleid 50028925

Compile data set for download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
12-Lipoxygenase (12-LOX)


(Homo sapiens (Human))
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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Article
n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human platelet 12-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 420n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against soyabean 15-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 520n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50009941
PNG
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Show SMILES O=C1CCCN(N1)c1ccccc1
Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)
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n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Cyclooxygenase


(RAT)
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a 800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against intact rat PMNL, PGE-2 cyclooxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50009941
PNG
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Show SMILES O=C1CCCN(N1)c1ccccc1
Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50009941
PNG
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Show SMILES O=C1CCCN(N1)c1ccccc1
Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 1.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 1.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50009941
PNG
(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Show SMILES O=C1CCCN(N1)c1ccccc1
Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)
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n/an/a 4.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a 4.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a 5.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a 7.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 1.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against human whole blood, TXB2 cyclooxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a 1.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Cyclooxygenase


(RAT)
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 1.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
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n/an/a 9.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a 9.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Association rate constant of the compound was determined against 3-dehydroquinate synthase


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
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n/an/a 2.13E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against soyabean 15-lipoxygenase was evaluated


Bioorg Med Chem Lett 2: 1353-1356 (1992)


Article DOI: 10.1016/S0960-894X(00)80511-9
BindingDB Entry DOI: 10.7270/Q2H41RC2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%