BindingDB logo
myBDB logout

Articleid 50029106

Compile data set for download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281520
PNG
(CHEMBL123348 | [3-Ethyl-3-methyl-5-oxo-1-[2'-(1H-t...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC1(C)CC
Show InChI InChI=1S/C25H27N5O3/c1-4-25(3)15-22(31)30(21(25)14-23(32)33-5-2)16-17-10-12-18(13-11-17)19-8-6-7-9-20(19)24-26-28-29-27-24/h6-14H,4-5,15-16H2,1-3H3,(H,26,27,28,29)/b21-14-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281522
PNG
(CHEMBL121871 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC11CCCCCC1
Show InChI InChI=1S/C28H31N5O3/c1-2-36-26(35)17-24-28(15-7-3-4-8-16-28)18-25(34)33(24)19-20-11-13-21(14-12-20)22-9-5-6-10-23(22)27-29-31-32-30-27/h5-6,9-14,17H,2-4,7-8,15-16,18-19H2,1H3,(H,29,30,31,32)/b24-17-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281524
PNG
(CHEMBL123713 | [3,3-Diethyl-5-oxo-1-[2'-(1H-tetraz...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC1(CC)CC
Show InChI InChI=1S/C26H29N5O3/c1-4-26(5-2)16-23(32)31(22(26)15-24(33)34-6-3)17-18-11-13-19(14-12-18)20-9-7-8-10-21(20)25-27-29-30-28-25/h7-15H,4-6,16-17H2,1-3H3,(H,27,28,29,30)/b22-15-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281519
PNG
(CHEMBL124449 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC11CCCCC1
Show InChI InChI=1S/C27H29N5O3/c1-2-35-25(34)16-23-27(14-6-3-7-15-27)17-24(33)32(23)18-19-10-12-20(13-11-19)21-8-4-5-9-22(21)26-28-30-31-29-26/h4-5,8-13,16H,2-3,6-7,14-15,17-18H2,1H3,(H,28,29,30,31)/b23-16-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 140n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281523
PNG
(CHEMBL421094 | [3-Oxo-2-[2'-(1H-tetrazol-5-yl)-bip...)
Show SMILES CCOC(=O)\C=C1/N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC11CCCC1
Show InChI InChI=1S/C26H27N5O3/c1-2-34-24(33)15-22-26(13-5-6-14-26)16-23(32)31(22)17-18-9-11-19(12-10-18)20-7-3-4-8-21(20)25-27-29-30-28-25/h3-4,7-12,15H,2,5-6,13-14,16-17H2,1H3,(H,27,28,29,30)/b22-15-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 250n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 425n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50281521
PNG
(CHEMBL330866 | [3-Methyl-5-oxo-1-[2'-(1H-tetrazol-...)
Show SMILES CCOC(=O)\C=C1\C(C)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H23N5O3/c1-3-31-22(30)13-20-15(2)12-21(29)28(20)14-16-8-10-17(11-9-16)18-6-4-5-7-19(18)23-24-26-27-25-23/h4-11,13,15H,3,12,14H2,1-2H3,(H,24,25,26,27)/b20-13-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 3.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...


Bioorg Med Chem Lett 3: 369-374 (1993)


Article DOI: 10.1016/S0960-894X(01)80914-8
BindingDB Entry DOI: 10.7270/Q20G3K2H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%