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Articleid 50029359

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283749
PNG
((S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=O)[C@@H](N)CS)Cc1cccs1)C(O)=O
Show InChI InChI=1S/C18H29N3O4S3/c1-27-9-6-15(18(24)25)21-16(22)12(10-13-5-3-8-28-13)4-2-7-20-17(23)14(19)11-26/h3,5,8,12,14-15,26H,2,4,6-7,9-11,19H2,1H3,(H,20,23)(H,21,22)(H,24,25)/t12-,14+,15+/m1/s1
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Article
n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283752
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1cccs1)C(O)=O
Show InChI InChI=1S/C18H29N3O4S3/c1-27-9-6-15(18(24)25)21-16(22)12(10-13-5-3-8-28-13)4-2-7-20-17(23)14(19)11-26/h3,5,8,12,14-15,26H,2,4,6-7,9-11,19H2,1H3,(H,20,23)(H,21,22)(H,24,25)/t12-,14-,15-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283736
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2...)
Show SMILES CSCC[C@H](NC(=O)C(CCCNC(=O)[C@@H](N)CS)Cc1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C20H30FN3O4S2/c1-30-10-8-17(20(27)28)24-18(25)14(11-13-4-6-15(21)7-5-13)3-2-9-23-19(26)16(22)12-29/h4-7,14,16-17,29H,2-3,8-12,22H2,1H3,(H,23,26)(H,24,25)(H,27,28)/t14?,16-,17-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283737
PNG
((S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=O)[C@@H](N)CS)Cc1cc(F)cc(F)c1)C(O)=O
Show InChI InChI=1S/C20H29F2N3O4S2/c1-31-6-4-17(20(28)29)25-18(26)13(3-2-5-24-19(27)16(23)11-30)7-12-8-14(21)10-15(22)9-12/h8-10,13,16-17,30H,2-7,11,23H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t13-,16+,17+/m1/s1
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n/an/a 16n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283742
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31N3O4S2/c1-29-11-9-17(20(26)27)23-18(24)15(12-14-6-3-2-4-7-14)8-5-10-22-19(25)16(21)13-28/h2-4,6-7,15-17,28H,5,8-13,21H2,1H3,(H,22,25)(H,23,24)(H,26,27)/t15-,16-,17-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283751
PNG
((S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=O)[C@@H](N)CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31N3O4S2/c1-29-11-9-17(20(26)27)23-18(24)15(12-14-6-3-2-4-7-14)8-5-10-22-19(25)16(21)13-28/h2-4,6-7,15-17,28H,5,8-13,21H2,1H3,(H,22,25)(H,23,24)(H,26,27)/t15-,16+,17+/m1/s1
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283742
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31N3O4S2/c1-29-11-9-17(20(26)27)23-18(24)15(12-14-6-3-2-4-7-14)8-5-10-22-19(25)16(21)13-28/h2-4,6-7,15-17,28H,5,8-13,21H2,1H3,(H,22,25)(H,23,24)(H,26,27)/t15-,16-,17-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283746
PNG
((S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionyl...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CC[C@@H](NC(=O)[C@@H](N)CS)C(C)C)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C23H37N3O4S2/c1-15(2)19(25-22(28)18(24)14-31)10-9-17(13-16-7-5-4-6-8-16)21(27)26-20(23(29)30)11-12-32-3/h4-8,15,17-20,31H,9-14,24H2,1-3H3,(H,25,28)(H,26,27)(H,29,30)/t17-,18-,19+,20-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283738
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1cc(F)cc(F)c1)C(O)=O
Show InChI InChI=1S/C20H29F2N3O4S2/c1-31-6-4-17(20(28)29)25-18(26)13(3-2-5-24-19(27)16(23)11-30)7-12-8-14(21)10-15(22)9-12/h8-10,13,16-17,30H,2-7,11,23H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t13-,16-,17-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283756
PNG
((S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propylami...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CC[C@@H](NC[C@@H](N)CS)C(C)C)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C23H39N3O3S2/c1-16(2)20(25-14-19(24)15-30)10-9-18(13-17-7-5-4-6-8-17)22(27)26-21(23(28)29)11-12-31-3/h4-8,16,18-21,25,30H,9-15,24H2,1-3H3,(H,26,27)(H,28,29)/t18-,19+,20+,21-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283740
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propylamino)-2-be...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC[C@@H](N)CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H33N3O3S2/c1-28-11-9-18(20(25)26)23-19(24)16(12-15-6-3-2-4-7-15)8-5-10-22-13-17(21)14-27/h2-4,6-7,16-18,22,27H,5,8-14,21H2,1H3,(H,23,24)(H,25,26)/t16-,17+,18-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283736
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2...)
Show SMILES CSCC[C@H](NC(=O)C(CCCNC(=O)[C@@H](N)CS)Cc1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C20H30FN3O4S2/c1-30-10-8-17(20(27)28)24-18(25)14(11-13-4-6-15(21)7-5-13)3-2-9-23-19(26)16(22)12-29/h4-7,14,16-17,29H,2-3,8-12,22H2,1H3,(H,23,26)(H,24,25)(H,27,28)/t14?,16-,17-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283748
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C21H33N3O4S2/c1-14-5-7-15(8-6-14)12-16(4-3-10-23-20(26)17(22)13-29)19(25)24-18(21(27)28)9-11-30-2/h5-8,16-18,29H,3-4,9-13,22H2,1-2H3,(H,23,26)(H,24,25)(H,27,28)/t16-,17-,18-/m0/s1
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n/an/a 105n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283745
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2...)
Show SMILES COc1ccc(CC(CCCNC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCSC)C(O)=O)cc1
Show InChI InChI=1S/C21H33N3O5S2/c1-29-16-7-5-14(6-8-16)12-15(4-3-10-23-20(26)17(22)13-30)19(25)24-18(21(27)28)9-11-31-2/h5-8,15,17-18,30H,3-4,9-13,22H2,1-2H3,(H,23,26)(H,24,25)(H,27,28)/t15?,17-,18-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283739
PNG
((S)-2-[(E)-(R)-5-((R)-2-Amino-3-mercapto-propionyl...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)\C=C\CNC(=O)[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C20H29N3O4S2/c1-29-11-9-17(20(26)27)23-18(24)15(12-14-6-3-2-4-7-14)8-5-10-22-19(25)16(21)13-28/h2-8,15-17,28H,9-13,21H2,1H3,(H,22,25)(H,23,24)(H,26,27)/b8-5+/t15-,16-,17-/m0/s1
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n/an/a 230n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283757
PNG
((S)-2-{2-[3-((R)-2-Amino-3-mercapto-propylamino)-p...)
Show SMILES CSCC[C@H](NC(=O)Cc1cccc(NC[C@@H](N)CS)c1)C(O)=O
Show InChI InChI=1S/C16H25N3O3S2/c1-24-6-5-14(16(21)22)19-15(20)8-11-3-2-4-13(7-11)18-9-12(17)10-23/h2-4,7,12,14,18,23H,5-6,8-10,17H2,1H3,(H,19,20)(H,21,22)/t12-,14+/m1/s1
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n/an/a 240n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283734
PNG
((S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=O)[C@@H](N)CS)Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C21H33N3O4S2/c1-14-5-7-15(8-6-14)12-16(4-3-10-23-20(26)17(22)13-29)19(25)24-18(21(27)28)9-11-30-2/h5-8,16-18,29H,3-4,9-13,22H2,1-2H3,(H,23,26)(H,24,25)(H,27,28)/t16-,17+,18+/m1/s1
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n/an/a 315n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283751
PNG
((S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=O)[C@@H](N)CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31N3O4S2/c1-29-11-9-17(20(26)27)23-18(24)15(12-14-6-3-2-4-7-14)8-5-10-22-19(25)16(21)13-28/h2-4,6-7,15-17,28H,5,8-13,21H2,1H3,(H,22,25)(H,23,24)(H,26,27)/t15-,16+,17+/m1/s1
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n/an/a 330n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283540
PNG
((S)-2-{3-[((R)-2-Amino-3-mercapto-propionylamino)-...)
Show SMILES CSCC[C@H](NC(=O)c1cccc(CNC(=O)[C@@H]([NH3+])CS)c1)C([O-])=O
Show InChI InChI=1S/C16H23N3O4S2/c1-25-6-5-13(16(22)23)19-14(20)11-4-2-3-10(7-11)8-18-15(21)12(17)9-24/h2-4,7,12-13,24H,5-6,8-9,17H2,1H3,(H,18,21)(H,19,20)(H,22,23)/t12-,13-/m0/s1
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n/an/a 350n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283734
PNG
((S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=O)[C@@H](N)CS)Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C21H33N3O4S2/c1-14-5-7-15(8-6-14)12-16(4-3-10-23-20(26)17(22)13-29)19(25)24-18(21(27)28)9-11-30-2/h5-8,16-18,29H,3-4,9-13,22H2,1-2H3,(H,23,26)(H,24,25)(H,27,28)/t16-,17+,18+/m1/s1
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n/an/a 510n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283749
PNG
((S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=O)[C@@H](N)CS)Cc1cccs1)C(O)=O
Show InChI InChI=1S/C18H29N3O4S3/c1-27-9-6-15(18(24)25)21-16(22)12(10-13-5-3-8-28-13)4-2-7-20-17(23)14(19)11-26/h3,5,8,12,14-15,26H,2,4,6-7,9-11,19H2,1H3,(H,20,23)(H,21,22)(H,24,25)/t12-,14+,15+/m1/s1
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n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283743
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propionylamino)-...)
Show SMILES CSCC[C@H](NC(=O)c1cccc2C(CCCc12)NC(=O)[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C19H27N3O4S2/c1-28-9-8-16(19(25)26)22-17(23)13-6-2-5-12-11(13)4-3-7-15(12)21-18(24)14(20)10-27/h2,5-6,14-16,27H,3-4,7-10,20H2,1H3,(H,21,24)(H,22,23)(H,25,26)/t14-,15?,16-/m0/s1
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n/an/a 940n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283737
PNG
((S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=O)[C@@H](N)CS)Cc1cc(F)cc(F)c1)C(O)=O
Show InChI InChI=1S/C20H29F2N3O4S2/c1-31-6-4-17(20(28)29)25-18(26)13(3-2-5-24-19(27)16(23)11-30)7-12-8-14(21)10-15(22)9-12/h8-10,13,16-17,30H,2-7,11,23H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t13-,16+,17+/m1/s1
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n/an/a 990n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283755
PNG
((S)-2-[7-((R)-2-Amino-3-mercapto-propionylamino)-h...)
Show SMILES CSCC[C@H](NC(=O)CCCCCCNC(=O)[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C15H29N3O4S2/c1-24-9-7-12(15(21)22)18-13(19)6-4-2-3-5-8-17-14(20)11(16)10-23/h11-12,23H,2-10,16H2,1H3,(H,17,20)(H,18,19)(H,21,22)/t11-,12-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283742
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31N3O4S2/c1-29-11-9-17(20(26)27)23-18(24)15(12-14-6-3-2-4-7-14)8-5-10-22-19(25)16(21)13-28/h2-4,6-7,15-17,28H,5,8-13,21H2,1H3,(H,22,25)(H,23,24)(H,26,27)/t15-,16-,17-/m0/s1
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n/an/a 1.01E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283745
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2...)
Show SMILES COc1ccc(CC(CCCNC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCSC)C(O)=O)cc1
Show InChI InChI=1S/C21H33N3O5S2/c1-29-16-7-5-14(6-8-16)12-15(4-3-10-23-20(26)17(22)13-30)19(25)24-18(21(27)28)9-11-31-2/h5-8,15,17-18,30H,3-4,9-13,22H2,1-2H3,(H,23,26)(H,24,25)(H,27,28)/t15?,17-,18-/m0/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283741
PNG
((S)-2-{3-[((R)-2-Amino-3-mercapto-propylamino)-met...)
Show SMILES CSCC[C@H](NC(=O)c1cccc(CNC[C@@H](N)CS)c1)C(O)=O
Show InChI InChI=1S/C16H25N3O3S2/c1-24-6-5-14(16(21)22)19-15(20)12-4-2-3-11(7-12)8-18-9-13(17)10-23/h2-4,7,13-14,18,23H,5-6,8-10,17H2,1H3,(H,19,20)(H,21,22)/t13-,14+/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283747
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2...)
Show SMILES CSCC[C@H](NC(=O)C(CCCNC(=O)[C@@H](N)CS)CC(c1ccccc1)c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H37N3O4S2/c1-36-16-14-24(27(33)34)30-25(31)21(13-8-15-29-26(32)23(28)18-35)17-22(19-9-4-2-5-10-19)20-11-6-3-7-12-20/h2-7,9-12,21-24,35H,8,13-18,28H2,1H3,(H,29,32)(H,30,31)(H,33,34)/t21?,23-,24-/m0/s1
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n/an/a 1.86E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283753
PNG
((S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionyl...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CC[C@@H](NC(=O)[C@@H](N)CS)C(C)C)CC1CCCCC1)C(O)=O
Show InChI InChI=1S/C23H43N3O4S2/c1-15(2)19(25-22(28)18(24)14-31)10-9-17(13-16-7-5-4-6-8-16)21(27)26-20(23(29)30)11-12-32-3/h15-20,31H,4-14,24H2,1-3H3,(H,25,28)(H,26,27)(H,29,30)/t17-,18-,19+,20-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283739
PNG
((S)-2-[(E)-(R)-5-((R)-2-Amino-3-mercapto-propionyl...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)\C=C\CNC(=O)[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C20H29N3O4S2/c1-29-11-9-17(20(26)27)23-18(24)15(12-14-6-3-2-4-7-14)8-5-10-22-19(25)16(21)13-28/h2-8,15-17,28H,9-13,21H2,1H3,(H,22,25)(H,23,24)(H,26,27)/b8-5+/t15-,16-,17-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283747
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2...)
Show SMILES CSCC[C@H](NC(=O)C(CCCNC(=O)[C@@H](N)CS)CC(c1ccccc1)c1ccccc1)C(O)=O
Show InChI InChI=1S/C27H37N3O4S2/c1-36-16-14-24(27(33)34)30-25(31)21(13-8-15-29-26(32)23(28)18-35)17-22(19-9-4-2-5-10-19)20-11-6-3-7-12-20/h2-7,9-12,21-24,35H,8,13-18,28H2,1H3,(H,29,32)(H,30,31)(H,33,34)/t21?,23-,24-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283738
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1cc(F)cc(F)c1)C(O)=O
Show InChI InChI=1S/C20H29F2N3O4S2/c1-31-6-4-17(20(28)29)25-18(26)13(3-2-5-24-19(27)16(23)11-30)7-12-8-14(21)10-15(22)9-12/h8-10,13,16-17,30H,2-7,11,23H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t13-,16-,17-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283750
PNG
((S)-2-{2-[3-((R)-2-Amino-3-mercapto-propionylamino...)
Show SMILES CSCC[C@H](NC(=O)Cc1cccc(NC(=O)[C@@H](N)CS)c1)C(O)=O
Show InChI InChI=1S/C16H23N3O4S2/c1-25-6-5-13(16(22)23)19-14(20)8-10-3-2-4-11(7-10)18-15(21)12(17)9-24/h2-4,7,12-13,24H,5-6,8-9,17H2,1H3,(H,18,21)(H,19,20)(H,22,23)/t12-,13-/m0/s1
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n/an/a 3.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283756
PNG
((S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propylami...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CC[C@@H](NC[C@@H](N)CS)C(C)C)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C23H39N3O3S2/c1-16(2)20(25-14-19(24)15-30)10-9-18(13-17-7-5-4-6-8-17)22(27)26-21(23(28)29)11-12-31-3/h4-8,16,18-21,25,30H,9-15,24H2,1-3H3,(H,26,27)(H,28,29)/t18-,19+,20+,21-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283742
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31N3O4S2/c1-29-11-9-17(20(26)27)23-18(24)15(12-14-6-3-2-4-7-14)8-5-10-22-19(25)16(21)13-28/h2-4,6-7,15-17,28H,5,8-13,21H2,1H3,(H,22,25)(H,23,24)(H,26,27)/t15-,16-,17-/m0/s1
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n/an/a 4.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283752
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1cccs1)C(O)=O
Show InChI InChI=1S/C18H29N3O4S3/c1-27-9-6-15(18(24)25)21-16(22)12(10-13-5-3-8-28-13)4-2-7-20-17(23)14(19)11-26/h3,5,8,12,14-15,26H,2,4,6-7,9-11,19H2,1H3,(H,20,23)(H,21,22)(H,24,25)/t12-,14-,15-/m0/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283740
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propylamino)-2-be...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC[C@@H](N)CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H33N3O3S2/c1-28-11-9-18(20(25)26)23-19(24)16(12-15-6-3-2-4-7-15)8-5-10-22-13-17(21)14-27/h2-4,6-7,16-18,22,27H,5,8-14,21H2,1H3,(H,23,24)(H,25,26)/t16-,17+,18-/m0/s1
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n/an/a 5.95E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283754
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-p...)
Show SMILES CSCC[C@H](NC(=O)CCCCNC(=O)[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C13H25N3O4S2/c1-22-7-5-10(13(19)20)16-11(17)4-2-3-6-15-12(18)9(14)8-21/h9-10,21H,2-8,14H2,1H3,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1
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n/an/a 6.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283746
PNG
((S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionyl...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CC[C@@H](NC(=O)[C@@H](N)CS)C(C)C)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C23H37N3O4S2/c1-15(2)19(25-22(28)18(24)14-31)10-9-17(13-16-7-5-4-6-8-16)21(27)26-20(23(29)30)11-12-32-3/h4-8,15,17-20,31H,9-14,24H2,1-3H3,(H,25,28)(H,26,27)(H,29,30)/t17-,18-,19+,20-/m0/s1
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n/an/a 8.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283735
PNG
((S)-2-{(R)-2-[3-((R)-2-Amino-3-mercapto-propionyla...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)c1cccc(NC(=O)[C@@H](N)CS)c1)C(O)=O
Show InChI InChI=1S/C23H29N3O4S2/c1-32-11-10-20(23(29)30)26-21(27)18(12-15-6-3-2-4-7-15)16-8-5-9-17(13-16)25-22(28)19(24)14-31/h2-9,13,18-20,31H,10-12,14,24H2,1H3,(H,25,28)(H,26,27)(H,29,30)/t18-,19+,20+/m1/s1
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n/an/a 9.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283757
PNG
((S)-2-{2-[3-((R)-2-Amino-3-mercapto-propylamino)-p...)
Show SMILES CSCC[C@H](NC(=O)Cc1cccc(NC[C@@H](N)CS)c1)C(O)=O
Show InChI InChI=1S/C16H25N3O3S2/c1-24-6-5-14(16(21)22)19-15(20)8-11-3-2-4-13(7-11)18-9-12(17)10-23/h2-4,7,12,14,18,23H,5-6,8-10,17H2,1H3,(H,19,20)(H,21,22)/t12-,14+/m1/s1
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n/an/a 9.74E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283735
PNG
((S)-2-{(R)-2-[3-((R)-2-Amino-3-mercapto-propionyla...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)c1cccc(NC(=O)[C@@H](N)CS)c1)C(O)=O
Show InChI InChI=1S/C23H29N3O4S2/c1-32-11-10-20(23(29)30)26-21(27)18(12-15-6-3-2-4-7-15)16-8-5-9-17(13-16)25-22(28)19(24)14-31/h2-9,13,18-20,31H,10-12,14,24H2,1H3,(H,25,28)(H,26,27)(H,29,30)/t18-,19+,20+/m1/s1
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n/an/a 1.17E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283540
PNG
((S)-2-{3-[((R)-2-Amino-3-mercapto-propionylamino)-...)
Show SMILES CSCC[C@H](NC(=O)c1cccc(CNC(=O)[C@@H]([NH3+])CS)c1)C([O-])=O
Show InChI InChI=1S/C16H23N3O4S2/c1-25-6-5-13(16(22)23)19-14(20)11-4-2-3-10(7-11)8-18-15(21)12(17)9-24/h2-4,7,12-13,24H,5-6,8-9,17H2,1H3,(H,18,21)(H,19,20)(H,22,23)/t12-,13-/m0/s1
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n/an/a 1.84E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283753
PNG
((S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionyl...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CC[C@@H](NC(=O)[C@@H](N)CS)C(C)C)CC1CCCCC1)C(O)=O
Show InChI InChI=1S/C23H43N3O4S2/c1-15(2)19(25-22(28)18(24)14-31)10-9-17(13-16-7-5-4-6-8-16)21(27)26-20(23(29)30)11-12-32-3/h15-20,31H,4-14,24H2,1-3H3,(H,25,28)(H,26,27)(H,29,30)/t17-,18-,19+,20-/m0/s1
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n/an/a 1.84E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283743
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propionylamino)-...)
Show SMILES CSCC[C@H](NC(=O)c1cccc2C(CCCc12)NC(=O)[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C19H27N3O4S2/c1-28-9-8-16(19(25)26)22-17(23)13-6-2-5-12-11(13)4-3-7-15(12)21-18(24)14(20)10-27/h2,5-6,14-16,27H,3-4,7-10,20H2,1H3,(H,21,24)(H,22,23)(H,25,26)/t14-,15?,16-/m0/s1
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n/an/a 1.86E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283744
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propylamino)-pent...)
Show SMILES CSCC[C@H](NC(=O)CCCCNC[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C13H27N3O3S2/c1-21-7-5-11(13(18)19)16-12(17)4-2-3-6-15-8-10(14)9-20/h10-11,15,20H,2-9,14H2,1H3,(H,16,17)(H,18,19)/t10-,11+/m1/s1
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n/an/a 2.04E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283741
PNG
((S)-2-{3-[((R)-2-Amino-3-mercapto-propylamino)-met...)
Show SMILES CSCC[C@H](NC(=O)c1cccc(CNC[C@@H](N)CS)c1)C(O)=O
Show InChI InChI=1S/C16H25N3O3S2/c1-24-6-5-14(16(21)22)19-15(20)12-4-2-3-11(7-12)8-18-9-13(17)10-23/h2-4,7,13-14,18,23H,5-6,8-10,17H2,1H3,(H,19,20)(H,21,22)/t13-,14+/m1/s1
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n/an/a 2.12E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283748
PNG
((S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](CCCNC(=O)[C@@H](N)CS)Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C21H33N3O4S2/c1-14-5-7-15(8-6-14)12-16(4-3-10-23-20(26)17(22)13-29)19(25)24-18(21(27)28)9-11-30-2/h5-8,16-18,29H,3-4,9-13,22H2,1-2H3,(H,23,26)(H,24,25)(H,27,28)/t16-,17-,18-/m0/s1
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n/an/a 2.65E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283750
PNG
((S)-2-{2-[3-((R)-2-Amino-3-mercapto-propionylamino...)
Show SMILES CSCC[C@H](NC(=O)Cc1cccc(NC(=O)[C@@H](N)CS)c1)C(O)=O
Show InChI InChI=1S/C16H23N3O4S2/c1-25-6-5-13(16(22)23)19-14(20)8-10-3-2-4-11(7-10)18-15(21)12(17)9-24/h2-4,7,12-13,24H,5-6,8-9,17H2,1H3,(H,18,21)(H,19,20)(H,22,23)/t12-,13-/m0/s1
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n/an/a 3.86E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283754
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-p...)
Show SMILES CSCC[C@H](NC(=O)CCCCNC(=O)[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C13H25N3O4S2/c1-22-7-5-10(13(19)20)16-11(17)4-2-3-6-15-12(18)9(14)8-21/h9-10,21H,2-8,14H2,1H3,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1
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n/an/a 6.55E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50283744
PNG
((S)-2-[5-((R)-2-Amino-3-mercapto-propylamino)-pent...)
Show SMILES CSCC[C@H](NC(=O)CCCCNC[C@@H](N)CS)C(O)=O
Show InChI InChI=1S/C13H27N3O3S2/c1-21-7-5-11(13(18)19)16-12(17)4-2-3-6-15-8-10(14)9-20/h10-11,15,20H,2-9,14H2,1H3,(H,16,17)(H,18,19)/t10-,11+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against geranylgeranyl transferase


Bioorg Med Chem Lett 4: 2775-2780 (1994)


Article DOI: 10.1016/S0960-894X(01)80593-X
BindingDB Entry DOI: 10.7270/Q21J99Q0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%