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Articleid 50029600

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285986
PNG
(2-[6-(4-Fluoro-phenyl)-3-(3-pyridin-3-yl-1H-pyrrol...)
Show SMILES CN(C)C(=O)Cn1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C30H25FN4O2S/c1-33(2)28(36)17-34-16-25(23-10-7-20(14-26(23)34)19-5-8-22(31)9-6-19)29(37)24-11-13-35-27(24)18-38-30(35)21-4-3-12-32-15-21/h3-16,30H,17-18H2,1-2H3
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Article
0.700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285993
PNG
(6-(4-Fluoro-phenoxy)-3-(3-pyridin-3-yl-1H-pyrrolo[...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(Oc3ccc(F)cc3)cc12
Show InChI InChI=1S/C29H23FN4O3S/c1-32(2)29(36)34-16-24(22-10-9-21(14-25(22)34)37-20-7-5-19(30)6-8-20)27(35)23-11-13-33-26(23)17-38-28(33)18-4-3-12-31-15-18/h3-16,28H,17H2,1-2H3
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Article
1.70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50035397
PNG
(6-(4-Fluoro-phenyl)-3-((R)-3-pyridin-3-yl-1H-pyrro...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H23FN4O2S/c1-32(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-37-28(33)20-4-3-12-31-15-20/h3-16,28H,17H2,1-2H3/t28-/m1/s1
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3.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285994
PNG
(CHEMBL98835 | [6-(4-Fluoro-phenyl)-1-(2-hydroxy-et...)
Show SMILES OCCn1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H22FN3O2S/c29-21-6-3-18(4-7-21)19-5-8-22-24(16-31(12-13-33)25(22)14-19)27(34)23-9-11-32-26(23)17-35-28(32)20-2-1-10-30-15-20/h1-11,14-16,28,33H,12-13,17H2
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Article
5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286011
PNG
(6-(4-Fluoro-phenyl)-3-(3-pyridin-3-yl-1H-pyrrolo[1...)
Show SMILES NC(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C27H19FN4O2S/c28-19-6-3-16(4-7-19)17-5-8-20-22(14-32(27(29)34)23(20)12-17)25(33)21-9-11-31-24(21)15-35-26(31)18-2-1-10-30-13-18/h1-14,26H,15H2,(H2,29,34)
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6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286000
PNG
(CHEMBL99583 | [6-(4-Fluoro-phenyl)-1-methyl-1H-ind...)
Show SMILES Cn1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN3OS/c1-30-15-23(21-9-6-18(13-24(21)30)17-4-7-20(28)8-5-17)26(32)22-10-12-31-25(22)16-33-27(31)19-3-2-11-29-14-19/h2-15,27H,16H2,1H3
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Article
7n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285996
PNG
(6-(4-Fluoro-phenyl)-3-(3-pyridin-3-yl-1H-pyrrolo[1...)
Show SMILES CNC(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H21FN4O2S/c1-30-28(35)33-15-23(21-9-6-18(13-24(21)33)17-4-7-20(29)8-5-17)26(34)22-10-12-32-25(22)16-36-27(32)19-3-2-11-31-14-19/h2-15,27H,16H2,1H3,(H,30,35)
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286008
PNG
(6-Pyridin-3-yl-3-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H23N5O2S/c1-31(2)28(35)33-16-23(21-8-7-18(13-24(21)33)19-5-3-10-29-14-19)26(34)22-9-12-32-25(22)17-36-27(32)20-6-4-11-30-15-20/h3-16,27H,17H2,1-2H3
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11n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286009
PNG
(6-Benzyl-3-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]thiazo...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C30H26N4O2S/c1-32(2)30(36)34-18-25(23-11-10-21(16-26(23)34)15-20-7-4-3-5-8-20)28(35)24-12-14-33-27(24)19-37-29(33)22-9-6-13-31-17-22/h3-14,16-18,29H,15,19H2,1-2H3
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Article
13n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286001
PNG
(6-Bromo-3-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]thiazol...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(Br)cc12
Show InChI InChI=1S/C23H19BrN4O2S/c1-26(2)23(30)28-12-18(16-6-5-15(24)10-19(16)28)21(29)17-7-9-27-20(17)13-31-22(27)14-4-3-8-25-11-14/h3-12,22H,13H2,1-2H3
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15n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285989
PNG
(6-Benzyloxy-3-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]thi...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(OCc3ccccc3)cc12
Show InChI InChI=1S/C30H26N4O3S/c1-32(2)30(36)34-17-25(23-11-10-22(15-26(23)34)37-18-20-7-4-3-5-8-20)28(35)24-12-14-33-27(24)19-38-29(33)21-9-6-13-31-16-21/h3-17,29H,18-19H2,1-2H3
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17n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285984
PNG
(6-(4-Fluoro-phenylsulfanyl)-3-(3-pyridin-3-yl-1H-p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(Sc3ccc(F)cc3)cc12
Show InChI InChI=1S/C29H23FN4O2S2/c1-32(2)29(36)34-16-24(22-10-9-21(14-25(22)34)38-20-7-5-19(30)6-8-20)27(35)23-11-13-33-26(23)17-37-28(33)18-4-3-12-31-15-18/h3-16,28H,17H2,1-2H3
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17n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285987
PNG
(6-(4-Fluoro-phenyl)-3-(3-pyridin-3-yl-1H-pyrrolo[1...)
Show SMILES CCNC(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H23FN4O2S/c1-2-32-29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-37-28(33)20-4-3-12-31-15-20/h3-16,28H,2,17H2,1H3,(H,32,36)
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Article
19n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286003
PNG
(6-Phenyl-3-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]thiazo...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C29H24N4O2S/c1-31(2)29(35)33-17-24(22-11-10-20(15-25(22)33)19-7-4-3-5-8-19)27(34)23-12-14-32-26(23)18-36-28(32)21-9-6-13-30-16-21/h3-17,28H,18H2,1-2H3
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Article
23n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285998
PNG
(6-(4-Fluoro-phenyl)-3-(3-pyridin-3-yl-1H-pyrrolo[1...)
Show SMILES NNC(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN5O2S/c28-19-6-3-16(4-7-19)17-5-8-20-22(14-33(23(20)12-17)27(35)31-29)25(34)21-9-11-32-24(21)15-36-26(32)18-2-1-10-30-13-18/h1-14,26H,15,29H2,(H,31,35)
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25n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286002
PNG
(CHEMBL319325 | [1-(2-Amino-ethyl)-6-(4-fluoro-phen...)
Show SMILES NCCn1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN4OS/c29-21-6-3-18(4-7-21)19-5-8-22-24(16-32(13-10-30)25(22)14-19)27(34)23-9-12-33-26(23)17-35-28(33)20-2-1-11-31-15-20/h1-9,11-12,14-16,28H,10,13,17,30H2
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Article
38n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286004
PNG
((1H-Indol-3-yl)-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]t...)
Show SMILES O=C(c1ccn2C(SCc12)c1cccnc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3OS/c24-19(16-11-22-17-6-2-1-5-14(16)17)15-7-9-23-18(15)12-25-20(23)13-4-3-8-21-10-13/h1-11,20,22H,12H2
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Article
53n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285995
PNG
((6-Benzyloxy-1H-indol-3-yl)-(3-pyridin-3-yl-1H-pyr...)
Show SMILES O=C(c1ccn2C(SCc12)c1cccnc1)c1c[nH]c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C27H21N3O2S/c31-26(22-10-12-30-25(22)17-33-27(30)19-7-4-11-28-14-19)23-15-29-24-13-20(8-9-21(23)24)32-16-18-5-2-1-3-6-18/h1-15,27,29H,16-17H2
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Article
64n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285988
PNG
(CHEMBL98831 | [6-(4-Fluoro-phenyl)-1H-indol-3-yl]-...)
Show SMILES Fc1ccc(cc1)-c1ccc2c(c[nH]c2c1)C(=O)c1ccn2C(SCc12)c1cccnc1
Show InChI InChI=1S/C26H18FN3OS/c27-19-6-3-16(4-7-19)17-5-8-20-22(14-29-23(20)12-17)25(31)21-9-11-30-24(21)15-32-26(30)18-2-1-10-28-13-18/h1-14,26,29H,15H2
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75n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285997
PNG
(6-Chloro-3-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]thiazo...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(Cl)cc12
Show InChI InChI=1S/C23H19ClN4O2S/c1-26(2)23(30)28-12-18(16-6-5-15(24)10-19(16)28)21(29)17-7-9-27-20(17)13-31-22(27)14-4-3-8-25-11-14/h3-12,22H,13H2,1-2H3
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89n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285991
PNG
((7-Benzyloxy-1H-indol-3-yl)-(3-pyridin-3-yl-1H-pyr...)
Show SMILES O=C(c1ccn2C(SCc12)c1cccnc1)c1c[nH]c2c(OCc3ccccc3)cccc12
Show InChI InChI=1S/C27H21N3O2S/c31-26(21-11-13-30-23(21)17-33-27(30)19-8-5-12-28-14-19)22-15-29-25-20(22)9-4-10-24(25)32-16-18-6-2-1-3-7-18/h1-15,27,29H,16-17H2
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90n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285985
PNG
(3-(3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carb...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccccc12
Show InChI InChI=1S/C23H20N4O2S/c1-25(2)23(29)27-13-18(16-7-3-4-8-19(16)27)21(28)17-9-11-26-20(17)14-30-22(26)15-6-5-10-24-12-15/h3-13,22H,14H2,1-2H3
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95n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286006
PNG
(3-(3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carb...)
Show SMILES CC(C)(C)OC(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccccc12
Show InChI InChI=1S/C25H23N3O3S/c1-25(2,3)31-24(30)28-14-19(17-8-4-5-9-20(17)28)22(29)18-10-12-27-21(18)15-32-23(27)16-7-6-11-26-13-16/h4-14,23H,15H2,1-3H3
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110n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285990
PNG
(5-Benzyloxy-3-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]thi...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C30H26N4O3S/c1-32(2)30(36)34-17-25(24-15-22(10-11-26(24)34)37-18-20-7-4-3-5-8-20)28(35)23-12-14-33-27(23)19-38-29(33)21-9-6-13-31-16-21/h3-17,29H,18-19H2,1-2H3
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285983
PNG
(3-[6-(4-Fluoro-phenyl)-3-(3-pyridin-3-yl-1H-pyrrol...)
Show SMILES OC(=O)CCn1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H22FN3O3S/c30-21-6-3-18(4-7-21)19-5-8-22-24(16-32(25(22)14-19)12-10-27(34)35)28(36)23-9-13-33-26(23)17-37-29(33)20-2-1-11-31-15-20/h1-9,11,13-16,29H,10,12,17H2,(H,34,35)
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160n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286010
PNG
(7-Benzyloxy-3-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]thi...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2cccc(OCc3ccccc3)c12
Show InChI InChI=1S/C30H26N4O3S/c1-32(2)30(36)34-17-24(22-11-6-12-26(27(22)34)37-18-20-8-4-3-5-9-20)28(35)23-13-15-33-25(23)19-38-29(33)21-10-7-14-31-16-21/h3-17,29H,18-19H2,1-2H3
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170n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286005
PNG
((5-Benzyloxy-1H-indol-3-yl)-(3-pyridin-3-yl-1H-pyr...)
Show SMILES O=C(c1ccn2C(SCc12)c1cccnc1)c1c[nH]c2ccc(OCc3ccccc3)cc12
Show InChI InChI=1S/C27H21N3O2S/c31-26(21-10-12-30-25(21)17-33-27(30)19-7-4-11-28-14-19)23-15-29-24-9-8-20(13-22(23)24)32-16-18-5-2-1-3-6-18/h1-15,27,29H,16-17H2
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180n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285999
PNG
(CHEMBL98853 | Morpholin-4-yl-[3-(3-pyridin-3-yl-1H...)
Show SMILES O=C(N1CCOCC1)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccccc12
Show InChI InChI=1S/C25H22N4O3S/c30-23(19-7-9-28-22(19)16-33-24(28)17-4-3-8-26-14-17)20-15-29(21-6-2-1-5-18(20)21)25(31)27-10-12-32-13-11-27/h1-9,14-15,24H,10-13,16H2
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225n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286007
PNG
((4-Hydroxy-1H-indol-3-yl)-(3-pyridin-3-yl-1H-pyrro...)
Show SMILES Oc1cccc2[nH]cc(C(=O)c3ccn4C(SCc34)c3cccnc3)c12
Show InChI InChI=1S/C20H15N3O2S/c24-17-5-1-4-15-18(17)14(10-22-15)19(25)13-6-8-23-16(13)11-26-20(23)12-3-2-7-21-9-12/h1-10,20,22,24H,11H2
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327n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50285992
PNG
(6-(4-Fluoro-phenyl)-3-(3-pyridin-3-yl-1H-pyrrolo[1...)
Show SMILES CN(C)S(=O)(=O)n1cc(C(=O)c2ccn3C(SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN4O3S2/c1-31(2)38(35,36)33-16-24(22-10-7-19(14-25(22)33)18-5-8-21(29)9-6-18)27(34)23-11-13-32-26(23)17-37-28(32)20-4-3-12-30-15-20/h3-16,28H,17H2,1-2H3
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940n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for antagonistic activity to displace [3H]-PAF from rabbit platelet membrane PAF receptors


Bioorg Med Chem Lett 5: 2903-2908 (1995)


Article DOI: 10.1016/0960-894X(95)00509-R
BindingDB Entry DOI: 10.7270/Q2WW7HN1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%