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Articleid 50029602

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286027
PNG
(6-(4-Fluoro-phenyl)-3-[[(Z)-hydroxyimino]-((R)-3-p...)
Show SMILES CN(C)C(=O)n1cc(C(N=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H24FN5O2S/c1-33(2)29(36)35-16-24(22-10-7-19(14-25(22)35)18-5-8-21(30)9-6-18)27(32-37)23-11-13-34-26(23)17-38-28(34)20-4-3-12-31-15-20/h3-16,27-28H,17H2,1-2H3/t27?,28-/m1/s1
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Article
0.370n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286012
PNG
(3-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+]([O-])c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H23FN4O3S/c1-31(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-38-28(33)20-4-3-12-32(37)15-20/h3-16,28H,17H2,1-2H3/t28-/m1/s1
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Article
2.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286032
PNG
(2-[6-(4-Fluoro-phenyl)-3-((R)-3-pyridin-3-yl-1H-py...)
Show SMILES NS(=O)(=O)CCn1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN4O3S2/c29-21-6-3-18(4-7-21)19-5-8-22-24(16-32(25(22)14-19)12-13-38(30,35)36)27(34)23-9-11-33-26(23)17-37-28(33)20-2-1-10-31-15-20/h1-11,14-16,28H,12-13,17H2,(H2,30,35,36)/t28-/m1/s1
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Article
3.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50035397
PNG
(6-(4-Fluoro-phenyl)-3-((R)-3-pyridin-3-yl-1H-pyrro...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H23FN4O2S/c1-32(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-37-28(33)20-4-3-12-31-15-20/h3-16,28H,17H2,1-2H3/t28-/m1/s1
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Article
3.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286033
PNG
(CHEMBL99481 | indole analogue)
Show SMILES CN(C)C(=O)O\N=C(/c1ccn2[C@H](SCc12)c1cccnc1)c1cn(C(=O)N(C)C)c2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H29FN6O3S/c1-36(2)31(40)39-18-26(24-12-9-21(16-27(24)39)20-7-10-23(33)11-8-20)29(35-42-32(41)37(3)4)25-13-15-38-28(25)19-43-30(38)22-6-5-14-34-17-22/h5-18,30H,19H2,1-4H3/b35-29+/t30-/m1/s1
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6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286035
PNG
(6-Pyridin-3-yl-3-((R)-3-pyridin-3-yl-1H-pyrrolo[1,...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H23N5O2S/c1-31(2)28(35)33-16-23(21-8-7-18(13-24(21)33)19-5-3-10-29-14-19)26(34)22-9-12-32-25(22)17-36-27(32)20-6-4-11-30-15-20/h3-16,27H,17H2,1-2H3/t27-/m1/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286043
PNG
(CHEMBL100257 | N-{2-[6-(4-Fluoro-phenyl)-3-((R)-3-...)
Show SMILES CS(=O)(=O)NCCn1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN4O3S2/c1-39(36,37)32-12-14-33-17-25(23-9-6-20(15-26(23)33)19-4-7-22(30)8-5-19)28(35)24-10-13-34-27(24)18-38-29(34)21-3-2-11-31-16-21/h2-11,13,15-17,29,32H,12,14,18H2,1H3/t29-/m1/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286029
PNG
(CHEMBL317335 | indole analogue)
Show SMILES CN(C)C(=O)n1cc(\C(=N\OC(=O)c2ccccc2S(O)(=O)=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C36H28FN5O6S2/c1-40(2)36(44)42-20-29(26-14-11-23(18-30(26)42)22-9-12-25(37)13-10-22)33(39-48-35(43)28-7-3-4-8-32(28)50(45,46)47)27-15-17-41-31(27)21-49-34(41)24-6-5-16-38-19-24/h3-20,34H,21H2,1-2H3,(H,45,46,47)/b39-33+/t34-/m1/s1
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11n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286018
PNG
(6-(4-Hydroxymethyl-phenyl)-3-((R)-3-pyridin-3-yl-1...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(CO)cc1
Show InChI InChI=1S/C30H26N4O3S/c1-32(2)30(37)34-16-25(23-10-9-21(14-26(23)34)20-7-5-19(17-35)6-8-20)28(36)24-11-13-33-27(24)18-38-29(33)22-4-3-12-31-15-22/h3-16,29,35H,17-18H2,1-2H3/t29-/m1/s1
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16n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286021
PNG
(CHEMBL98359 | [6-(4-Fluoro-phenyl)-3-((R)-3-pyridi...)
Show SMILES OC(=O)Cn1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H20FN3O3S/c29-20-6-3-17(4-7-20)18-5-8-21-23(14-31(15-26(33)34)24(21)12-18)27(35)22-9-11-32-25(22)16-36-28(32)19-2-1-10-30-13-19/h1-14,28H,15-16H2,(H,33,34)/t28-/m1/s1
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18n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286030
PNG
(CHEMBL319609 | [6-(4-Fluoro-phenyl)-1-tetrazol-2-y...)
Show SMILES Fc1ccc(cc1)-c1ccc2c(cn(Cn3ncnn3)c2c1)C(=O)c1ccn2[C@H](SCc12)c1cccnc1
Show InChI InChI=1S/C28H20FN7OS/c29-21-6-3-18(4-7-21)19-5-8-22-24(14-34(25(22)12-19)17-36-32-16-31-33-36)27(37)23-9-11-35-26(23)15-38-28(35)20-2-1-10-30-13-20/h1-14,16,28H,15,17H2/t28-/m1/s1
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19n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286044
PNG
(CHEMBL320371 | [6-(4-Fluoro-phenyl)-3-((R)-3-pyrid...)
Show SMILES CN1CCN(CC1)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H28FN5O2S/c1-35-13-15-36(16-14-35)32(40)38-19-27(25-9-6-22(17-28(25)38)21-4-7-24(33)8-5-21)30(39)26-10-12-37-29(26)20-41-31(37)23-3-2-11-34-18-23/h2-12,17-19,31H,13-16,20H2,1H3/t31-/m1/s1
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28n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286016
PNG
(CHEMBL328632 | [1-(2-Amino-ethyl)-6-(4-fluoro-phen...)
Show SMILES NCCn1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN4OS/c29-21-6-3-18(4-7-21)19-5-8-22-24(16-32(13-10-30)25(22)14-19)27(34)23-9-12-33-26(23)17-35-28(33)20-2-1-11-31-15-20/h1-9,11-12,14-16,28H,10,13,17,30H2/t28-/m1/s1
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38n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286028
PNG
(6-Furan-2-yl-3-((R)-3-pyridin-3-yl-1H-pyrrolo[1,2-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccco1
Show InChI InChI=1S/C27H22N4O3S/c1-29(2)27(33)31-15-21(19-8-7-17(13-22(19)31)24-6-4-12-34-24)25(32)20-9-11-30-23(20)16-35-26(30)18-5-3-10-28-14-18/h3-15,26H,16H2,1-2H3/t26-/m1/s1
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39n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286024
PNG
(3-((R)-3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C29H25N5O4S2/c1-32(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(9-6-18)40(30,37)38)27(35)23-11-13-33-26(23)17-39-28(33)20-4-3-12-31-15-20/h3-16,28H,17H2,1-2H3,(H2,30,37,38)/t28-/m1/s1
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45n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286031
PNG
(CHEMBL318009 | indole analogue)
Show SMILES CN(C)C(=O)n1cc(\C(=N\OC(=O)c2ccc(cc2)S([O-])(=O)=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C36H28FN5O6S2/c1-40(2)36(44)42-20-30(28-14-9-24(18-31(28)42)22-5-10-26(37)11-6-22)33(39-48-35(43)23-7-12-27(13-8-23)50(45,46)47)29-15-17-41-32(29)21-49-34(41)25-4-3-16-38-19-25/h3-20,34H,21H2,1-2H3,(H,45,46,47)/p-1/b39-33+/t34-/m1/s1
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Article
53n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286038
PNG
((S)-2-Amino-3-{4-[1-dimethylcarbamoyl-3-((R)-3-pyr...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(C[C@H](N)C(O)=O)cc1
Show InChI InChI=1S/C32H29N5O4S/c1-35(2)32(41)37-17-25(29(38)24-11-13-36-28(24)18-42-30(36)22-4-3-12-34-16-22)23-10-9-21(15-27(23)37)20-7-5-19(6-8-20)14-26(33)31(39)40/h3-13,15-17,26,30H,14,18,33H2,1-2H3,(H,39,40)/t26-,30+/m0/s1
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54n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286015
PNG
(3-((R)-3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1nccs1
Show InChI InChI=1S/C26H21N5O2S2/c1-29(2)26(33)31-14-20(18-6-5-16(12-21(18)31)24-28-9-11-34-24)23(32)19-7-10-30-22(19)15-35-25(30)17-4-3-8-27-13-17/h3-14,25H,15H2,1-2H3/t25-/m1/s1
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71n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286023
PNG
(CHEMBL99773 | [1-[1-Dimethylcarbamoyl-6-(4-fluoro-...)
Show SMILES CN(C)C(=O)n1cc(\C(=N\OCC(O)=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C31H26FN5O4S/c1-35(2)31(40)37-16-25(23-10-7-20(14-26(23)37)19-5-8-22(32)9-6-19)29(34-41-17-28(38)39)24-11-13-36-27(24)18-42-30(36)21-4-3-12-33-15-21/h3-16,30H,17-18H2,1-2H3,(H,38,39)/b34-29+/t30-/m1/s1
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74n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286026
PNG
(1-Carbamoylimino-5-{(R)-7-[1-dimethylcarbamoyl-6-(...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+](NC(N)=O)c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C30H25FN6O3S/c1-34(2)30(40)37-16-24(22-10-7-19(14-25(22)37)18-5-8-21(31)9-6-18)27(38)23-11-13-36-26(23)17-41-28(36)20-4-3-12-35(15-20)33-29(32)39/h3-16,28H,17H2,1-2H3,(H2-,32,33,39)/p+1/t28-/m1/s1
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100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for Platelet Activating Factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286039
PNG
(CHEMBL98818 | Potassium; 3-[6-(4-fluoro-phenyl)-3-...)
Show SMILES [O-]S(=O)(=O)CCCn1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H24FN3O4S2/c30-22-7-4-19(5-8-22)20-6-9-23-25(17-32(26(23)15-20)12-2-14-39(35,36)37)28(34)24-10-13-33-27(24)18-38-29(33)21-3-1-11-31-16-21/h1,3-11,13,15-17,29H,2,12,14,18H2,(H,35,36,37)/p-1/t29-/m1/s1
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100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286025
PNG
(6-(3-Amino-phenyl)-3-((R)-3-pyridin-3-yl-1H-pyrrol...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1cccc(N)c1
Show InChI InChI=1S/C29H25N5O2S/c1-32(2)29(36)34-16-24(22-9-8-19(14-25(22)34)18-5-3-7-21(30)13-18)27(35)23-10-12-33-26(23)17-37-28(33)20-6-4-11-31-15-20/h3-16,28H,17,30H2,1-2H3/t28-/m1/s1
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110n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286022
PNG
(5-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+](NC(=O)c3cccnc3)c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C35H27FN6O3S/c1-39(2)35(45)42-20-29(27-12-9-23(17-30(27)42)22-7-10-26(36)11-8-22)32(43)28-13-16-41-31(28)21-46-34(41)25-6-4-15-40(19-25)38-33(44)24-5-3-14-37-18-24/h3-20,34H,21H2,1-2H3/p+1/t34-/m1/s1
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286017
PNG
(CHEMBL319603 | {[6-(4-Fluoro-phenyl)-3-((R)-3-pyri...)
Show SMILES OC(=O)CNC(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H21FN4O4S/c30-20-6-3-17(4-7-20)18-5-8-21-23(15-34(24(21)12-18)29(38)32-14-26(35)36)27(37)22-9-11-33-25(22)16-39-28(33)19-2-1-10-31-13-19/h1-13,15,28H,14,16H2,(H,32,38)(H,35,36)/t28-/m1/s1
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130n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286042
PNG
(3-[6-(4-Fluoro-phenyl)-3-((R)-3-pyridin-3-yl-1H-py...)
Show SMILES OC(=O)CCn1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H22FN3O3S/c30-21-6-3-18(4-7-21)19-5-8-22-24(16-32(25(22)14-19)12-10-27(34)35)28(36)23-9-13-33-26(23)17-37-29(33)20-2-1-11-31-15-20/h1-9,11,13-16,29H,10,12,17H2,(H,34,35)/t29-/m1/s1
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160n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286020
PNG
(3-[[(Z)-3-Dimethylamino-propoxyimino]-((R)-3-pyrid...)
Show SMILES CN(C)CCCO\N=C(/c1ccn2[C@H](SCc12)c1cccnc1)c1cn(C(=O)N(C)C)c2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C34H35FN6O2S/c1-38(2)16-6-18-43-37-32(28-14-17-40-31(28)22-44-33(40)25-7-5-15-36-20-25)29-21-41(34(42)39(3)4)30-19-24(10-13-27(29)30)23-8-11-26(35)12-9-23/h5,7-15,17,19-21,33H,6,16,18,22H2,1-4H3/b37-32+/t33-/m1/s1
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160n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286036
PNG
(3-[[(Z)-2-Dimethylamino-ethoxyimino]-((R)-3-pyridi...)
Show SMILES CN(C)CCO\N=C(/c1ccn2[C@H](SCc12)c1cccnc1)c1cn(C(=O)N(C)C)c2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C33H33FN6O2S/c1-37(2)16-17-42-36-31(27-13-15-39-30(27)21-43-32(39)24-6-5-14-35-19-24)28-20-40(33(41)38(3)4)29-18-23(9-12-26(28)29)22-7-10-25(34)11-8-22/h5-15,18-20,32H,16-17,21H2,1-4H3/b36-31+/t32-/m1/s1
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200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286019
PNG
(6-(2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1c[nH]c(=O)[nH]c1=O
Show InChI InChI=1S/C27H22N6O4S/c1-31(2)27(37)33-13-20(17-6-5-15(10-21(17)33)19-12-29-26(36)30-24(19)35)23(34)18-7-9-32-22(18)14-38-25(32)16-4-3-8-28-11-16/h3-13,25H,14H2,1-2H3,(H2,29,30,35,36)/t25-/m1/s1
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240n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286034
PNG
(CHEMBL431037 | Phosphoric acid mono-{4-[1-dimethyl...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(OP(O)(O)=O)cc1
Show InChI InChI=1S/C29H25N4O6PS/c1-31(2)29(35)33-16-24(27(34)23-11-13-32-26(23)17-41-28(32)20-4-3-12-30-15-20)22-10-7-19(14-25(22)33)18-5-8-21(9-6-18)39-40(36,37)38/h3-16,28H,17H2,1-2H3,(H2,36,37,38)/t28-/m1/s1
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250n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286045
PNG
(CHEMBL100201 | Potassium; 2-[6-(4-fluoro-phenyl)-3...)
Show SMILES [O-]S(=O)(=O)c1ccccc1C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C33H22FN3O5S2/c34-23-10-7-20(8-11-23)21-9-12-24-27(18-37(28(24)16-21)32(39)26-5-1-2-6-30(26)44(40,41)42)31(38)25-13-15-36-29(25)19-43-33(36)22-4-3-14-35-17-22/h1-18,33H,19H2,(H,40,41,42)/p-1/t33-/m1/s1
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300n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286037
PNG
(6-(4-Fluoro-phenyl)-3-{((R)-3-pyridin-3-yl-1H-pyrr...)
Show SMILES CN(C)C(=O)n1cc(\C(=N\OCCCN2CCCC2)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C36H37FN6O2S/c1-40(2)36(44)43-23-31(29-13-10-26(21-32(29)43)25-8-11-28(37)12-9-25)34(39-45-20-6-18-41-16-3-4-17-41)30-14-19-42-33(30)24-46-35(42)27-7-5-15-38-22-27/h5,7-15,19,21-23,35H,3-4,6,16-18,20,24H2,1-2H3/b39-34+/t35-/m1/s1
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450n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286040
PNG
(2-{[6-(4-Fluoro-phenyl)-3-((R)-3-pyridin-3-yl-1H-p...)
Show SMILES OS(=O)(=O)CCNC(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H23FN4O5S2/c30-21-6-3-18(4-7-21)19-5-8-22-24(16-34(25(22)14-19)29(36)32-11-13-41(37,38)39)27(35)23-9-12-33-26(23)17-40-28(33)20-2-1-10-31-15-20/h1-10,12,14-16,28H,11,13,17H2,(H,32,36)(H,37,38,39)/t28-/m1/s1
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680n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286014
PNG
(5-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+](N)c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN5O2S/c1-32(2)29(37)35-16-24(22-10-7-19(14-25(22)35)18-5-8-21(30)9-6-18)27(36)23-11-13-34-26(23)17-38-28(34)20-4-3-12-33(31)15-20/h3-16,28H,17,31H2,1-2H3/q+1/t28-/m1/s1
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2.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50286041
PNG
(5-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)C2=C[NH+](C)CC=C2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C30H27FN4O2S/c1-32(2)30(37)35-17-25(23-11-8-20(15-26(23)35)19-6-9-22(31)10-7-19)28(36)24-12-14-34-27(24)18-38-29(34)21-5-4-13-33(3)16-21/h4-12,14-17,29H,13,18H2,1-3H3/p+1/t29-/m1/s1
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4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for platelet activating factor receptor using [3H]-PAF in rabbit platelet membranes


Bioorg Med Chem Lett 5: 2913-2918 (1995)


Article DOI: 10.1016/0960-894X(95)00511-Q
BindingDB Entry DOI: 10.7270/Q2NC6157
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%