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Articleid 50029614

Compile data set for download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM13373
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50108076
PNG
((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CCSC)C(O)=O
Show InChI InChI=1S/C19H36N4O5S2/c1-6-11(4)15(18(26)21-13(19(27)28)7-8-30-5)23-17(25)14(10(2)3)22-16(24)12(20)9-29/h10-15,29H,6-9,20H2,1-5H3,(H,21,26)(H,22,24)(H,23,25)(H,27,28)/t11-,12-,13-,14-,15-/m0/s1
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n/an/a 250n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286187
PNG
((S)-2-{(S)-2-[(S)-2-(5-Bromo-2-hydroxy-benzylamino...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(Br)ccc1O)C(C)C)C(O)=O
Show InChI InChI=1S/C26H34BrN3O5S/c1-16(2)23(28-15-18-14-19(27)9-10-22(18)31)25(33)30-21(13-17-7-5-4-6-8-17)24(32)29-20(26(34)35)11-12-36-3/h4-10,14,16,20-21,23,28,31H,11-13,15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t20-,21-,23-/m0/s1
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n/an/a 450n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286193
PNG
((S)-2-{(S)-2-[(S)-2-(5-Chloro-2-hydroxy-benzylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(Cl)ccc1O)C(C)C)C(O)=O
Show InChI InChI=1S/C26H34ClN3O5S/c1-16(2)23(28-15-18-14-19(27)9-10-22(18)31)25(33)30-21(13-17-7-5-4-6-8-17)24(32)29-20(26(34)35)11-12-36-3/h4-10,14,16,20-21,23,28,31H,11-13,15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t20-,21-,23-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286191
PNG
((S)-2-((S)-2-{(S)-2-[5-Chloro-2-(2-methoxy-ethoxym...)
Show SMILES COCCOCOc1ccc(Cl)cc1CN[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O
Show InChI InChI=1S/C30H42ClN3O7S/c1-20(2)27(32-18-22-17-23(31)10-11-26(22)41-19-40-14-13-39-3)29(36)34-25(16-21-8-6-5-7-9-21)28(35)33-24(30(37)38)12-15-42-4/h5-11,17,20,24-25,27,32H,12-16,18-19H2,1-4H3,(H,33,35)(H,34,36)(H,37,38)/t24-,25-,27-/m0/s1
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n/an/a 760n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286197
PNG
((S)-2-{(S)-2-[(S)-2-(5-Fluoro-2-hydroxy-benzylamin...)
Show SMILES CC(C)[C@H](NCc1cc(F)ccc1O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)=O)C(O)=O
Show InChI InChI=1S/C26H34FN3O6S/c1-16(2)23(28-15-18-14-19(27)9-10-22(18)31)25(33)30-21(13-17-7-5-4-6-8-17)24(32)29-20(26(34)35)11-12-37(3)36/h4-10,14,16,20-21,23,28,31H,11-13,15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t20-,21-,23-,37?/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286186
PNG
((S)-2-{(S)-2-[(S)-2-(2-Hydroxy-5-trifluoromethyl-b...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(ccc1O)C(F)(F)F)C(C)C)C(O)=O
Show InChI InChI=1S/C27H34F3N3O5S/c1-16(2)23(31-15-18-14-19(27(28,29)30)9-10-22(18)34)25(36)33-21(13-17-7-5-4-6-8-17)24(35)32-20(26(37)38)11-12-39-3/h4-10,14,16,20-21,23,31,34H,11-13,15H2,1-3H3,(H,32,35)(H,33,36)(H,37,38)/t20-,21-,23-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286185
PNG
((S)-2-{(S)-2-[(S)-2-(5-Chloro-2-hydroxy-benzylamin...)
Show SMILES Cl.Cl.Cl.CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@@H](NCc1cc(Cl)ccc1O)C(C)C)C(O)=O
Show InChI InChI=1S/C26H36ClN3O4S/c1-17(2)23(28-15-19-14-20(27)9-10-24(19)31)16-29-22(13-18-7-5-4-6-8-18)25(32)30-21(26(33)34)11-12-35-3/h4-10,14,17,21-23,28-29,31H,11-13,15-16H2,1-3H3,(H,30,32)(H,33,34)/t21-,22-,23+/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286199
PNG
((S)-2-{(S)-2-[(S)-2-(2-Hydroxy-benzylamino)-3-meth...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ccccc1O)C(C)C)C(O)=O
Show InChI InChI=1S/C26H35N3O5S/c1-17(2)23(27-16-19-11-7-8-12-22(19)30)25(32)29-21(15-18-9-5-4-6-10-18)24(31)28-20(26(33)34)13-14-35-3/h4-12,17,20-21,23,27,30H,13-16H2,1-3H3,(H,28,31)(H,29,32)(H,33,34)/t20-,21-,23-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286195
PNG
((S)-2-{(S)-2-[(S)-2-(3-Fluoro-2-hydroxy-benzylamin...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cccc(F)c1O)C(C)C)C(O)=O
Show InChI InChI=1S/C26H34FN3O5S/c1-16(2)22(28-15-18-10-7-11-19(27)23(18)31)25(33)30-21(14-17-8-5-4-6-9-17)24(32)29-20(26(34)35)12-13-36-3/h4-11,16,20-22,28,31H,12-15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)/t20-,21-,22-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286184
PNG
((S)-2-{(S)-2-[(S)-2-(2-Hydroxy-5-methoxy-benzylami...)
Show SMILES COc1ccc(O)c(CN[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCSC)C(O)=O)c1
Show InChI InChI=1S/C27H37N3O6S/c1-17(2)24(28-16-19-15-20(36-3)10-11-23(19)31)26(33)30-22(14-18-8-6-5-7-9-18)25(32)29-21(27(34)35)12-13-37-4/h5-11,15,17,21-22,24,28,31H,12-14,16H2,1-4H3,(H,29,32)(H,30,33)(H,34,35)/t21-,22-,24-/m0/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286192
PNG
((S)-2-((S)-2-{(S)-2-[(2-Hydroxy-naphthalen-1-ylmet...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1c(O)ccc2ccccc12)C(C)C)C(O)=O
Show InChI InChI=1S/C30H37N3O5S/c1-19(2)27(31-18-23-22-12-8-7-11-21(22)13-14-26(23)34)29(36)33-25(17-20-9-5-4-6-10-20)28(35)32-24(30(37)38)15-16-39-3/h4-14,19,24-25,27,31,34H,15-18H2,1-3H3,(H,32,35)(H,33,36)(H,37,38)/t24-,25-,27-/m0/s1
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n/an/a 6.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286178
PNG
(3-({(S)-1-[(S)-1-((S)-1-Carboxy-3-methylsulfanyl-p...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(ccc1O)C(O)=O)C(C)C)C(O)=O
Show InChI InChI=1S/C27H35N3O7S/c1-16(2)23(28-15-19-14-18(26(34)35)9-10-22(19)31)25(33)30-21(13-17-7-5-4-6-8-17)24(32)29-20(27(36)37)11-12-38-3/h4-10,14,16,20-21,23,28,31H,11-13,15H2,1-3H3,(H,29,32)(H,30,33)(H,34,35)(H,36,37)/t20-,21-,23-/m0/s1
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n/an/a 8.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against Farnesyl transferase; 8.5-27.0


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286198
PNG
((S)-2-{(S)-2-[(S)-2-(3-Hydroxy-benzylamino)-3-meth...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cccc(O)c1)C(C)C)C(O)=O
Show InChI InChI=1S/C26H35N3O5S/c1-17(2)23(27-16-19-10-7-11-20(30)14-19)25(32)29-22(15-18-8-5-4-6-9-18)24(31)28-21(26(33)34)12-13-35-3/h4-11,14,17,21-23,27,30H,12-13,15-16H2,1-3H3,(H,28,31)(H,29,32)(H,33,34)/t21-,22-,23-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286180
PNG
((S)-2-((S)-2-{(S)-2-[2-(2-Methoxy-ethoxymethoxy)-5...)
Show SMILES COCCOCOc1ccc(cc1CN[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C31H42F3N3O7S/c1-20(2)27(35-18-22-17-23(31(32,33)34)10-11-26(22)44-19-43-14-13-42-3)29(39)37-25(16-21-8-6-5-7-9-21)28(38)36-24(30(40)41)12-15-45-4/h5-11,17,20,24-25,27,35H,12-16,18-19H2,1-4H3,(H,36,38)(H,37,39)(H,40,41)/t24-,25-,27-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286183
PNG
((S)-2-{(S)-2-[(S)-2-(4-Hydroxy-benzylamino)-3-meth...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ccc(O)cc1)C(C)C)C(O)=O
Show InChI InChI=1S/C26H35N3O5S/c1-17(2)23(27-16-19-9-11-20(30)12-10-19)25(32)29-22(15-18-7-5-4-6-8-18)24(31)28-21(26(33)34)13-14-35-3/h4-12,17,21-23,27,30H,13-16H2,1-3H3,(H,28,31)(H,29,32)(H,33,34)/t21-,22-,23-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286190
PNG
((S)-2-[(S)-2-((S)-2-Benzylamino-3-methyl-butyrylam...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ccccc1)C(C)C)C(O)=O
Show InChI InChI=1S/C26H35N3O4S/c1-18(2)23(27-17-20-12-8-5-9-13-20)25(31)29-22(16-19-10-6-4-7-11-19)24(30)28-21(26(32)33)14-15-34-3/h4-13,18,21-23,27H,14-17H2,1-3H3,(H,28,30)(H,29,31)(H,32,33)/t21-,22-,23-/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286182
PNG
((S)-2-{(S)-2-[(S)-2-(2-Mercapto-benzylamino)-3-met...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ccccc1S)C(C)C)C(O)=O
Show InChI InChI=1S/C26H35N3O4S2/c1-17(2)23(27-16-19-11-7-8-12-22(19)34)25(31)29-21(15-18-9-5-4-6-10-18)24(30)28-20(26(32)33)13-14-35-3/h4-12,17,20-21,23,27,34H,13-16H2,1-3H3,(H,28,30)(H,29,31)(H,32,33)/t20-,21-,23-/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286188
PNG
((S)-2-{(S)-2-[(S)-2-(2,5-Dihydroxy-benzylamino)-3-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cc(O)ccc1O)C(C)C)C(O)=O
Show InChI InChI=1S/C26H35N3O6S/c1-16(2)23(27-15-18-14-19(30)9-10-22(18)31)25(33)29-21(13-17-7-5-4-6-8-17)24(32)28-20(26(34)35)11-12-36-3/h4-10,14,16,20-21,23,27,30-31H,11-13,15H2,1-3H3,(H,28,32)(H,29,33)(H,34,35)/t20-,21-,23-/m0/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286194
PNG
((S)-2-((S)-2-{(S)-2-[(3-Hydroxy-pyridin-2-ylmethyl...)
Show SMILES Cl.Cl.CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1ncccc1O)C(C)C)C(O)=O
Show InChI InChI=1S/C25H34N4O5S/c1-16(2)22(27-15-20-21(30)10-7-12-26-20)24(32)29-19(14-17-8-5-4-6-9-17)23(31)28-18(25(33)34)11-13-35-3/h4-10,12,16,18-19,22,27,30H,11,13-15H2,1-3H3,(H,28,31)(H,29,32)(H,33,34)/t18-,19-,22-/m0/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286196
PNG
((S)-2-[(S)-2-((S)-2-{[Bis-(3-hydroxy-pyridin-2-yl)...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(c1ncccc1O)c1ncccc1O)C(C)C)C(O)=O
Show InChI InChI=1S/C30H37N5O6S/c1-18(2)24(35-27(25-22(36)11-7-14-31-25)26-23(37)12-8-15-32-26)29(39)34-21(17-19-9-5-4-6-10-19)28(38)33-20(30(40)41)13-16-42-3/h4-12,14-15,18,20-21,24,27,35-37H,13,16-17H2,1-3H3,(H,33,38)(H,34,39)(H,40,41)/t20-,21-,24-/m0/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286179
PNG
((S)-2-((S)-2-{(S)-2-[2-Hydroxy-3-((2E,6E)-3,7,11-t...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NCc1cccc(OC\C=C(/C)CC\C=C(/C)CCC=C(C)C)c1O)C(C)C)C(O)=O
Show InChI InChI=1S/C41H59N3O6S/c1-28(2)14-11-15-30(5)16-12-17-31(6)22-24-50-36-21-13-20-33(38(36)45)27-42-37(29(3)4)40(47)44-35(26-32-18-9-8-10-19-32)39(46)43-34(41(48)49)23-25-51-7/h8-10,13-14,16,18-22,29,34-35,37,42,45H,11-12,15,17,23-27H2,1-7H3,(H,43,46)(H,44,47)(H,48,49)/b30-16+,31-22+/t34-,35-,37-/m0/s1
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n/an/a 7.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50286181
PNG
((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-hydroxy-propion...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCSC)C(O)=O
Show InChI InChI=1S/C19H36N4O6S/c1-6-11(4)15(18(27)21-13(19(28)29)7-8-30-5)23-17(26)14(10(2)3)22-16(25)12(20)9-24/h10-15,24H,6-9,20H2,1-5H3,(H,21,27)(H,22,25)(H,23,26)(H,28,29)/t11-,12-,13-,14-,15-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of farnesyl transferase


Bioorg Med Chem Lett 5: 3073-3078 (1995)


Article DOI: 10.1016/0960-894X(95)00540-3
BindingDB Entry DOI: 10.7270/Q2765F95
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%