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Articleid 50029714

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Homo sapiens (Human))
BDBM50071960
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C24H24BrCl2N3O2/c1-32-23-17-6-3-2-5-16(17)19(25)15-18(23)24(31)28-9-10-29-11-13-30(14-12-29)21-8-4-7-20(26)22(21)27/h2-8,15H,9-14H2,1H3,(H,28,31)
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Article
8n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287178
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C24H25BrN4O4/c1-33-23-18-7-3-2-6-17(18)20(25)16-19(23)24(30)26-10-11-27-12-14-28(15-13-27)21-8-4-5-9-22(21)29(31)32/h2-9,16H,10-15H2,1H3,(H,26,30)
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Article
24n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287161
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H26BrN3O2/c1-30-23-20-10-6-5-9-19(20)22(25)17-21(23)24(29)26-11-12-27-13-15-28(16-14-27)18-7-3-2-4-8-18/h2-10,17H,11-16H2,1H3,(H,26,29)
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24n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287176
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1S/C24H25BrClN3O2/c1-31-23-18-7-3-2-6-17(18)20(25)16-19(23)24(30)27-10-11-28-12-14-29(15-13-28)22-9-5-4-8-21(22)26/h2-9,16H,10-15H2,1H3,(H,27,30)
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39n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287175
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25BrClN3O2/c1-31-23-20-8-3-2-7-19(20)22(25)16-21(23)24(30)27-9-10-28-11-13-29(14-12-28)18-6-4-5-17(26)15-18/h2-8,15-16H,9-14H2,1H3,(H,27,30)
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40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287163
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(C)c1C
Show InChI InChI=1S/C26H30BrN3O2/c1-18-7-6-10-24(19(18)2)30-15-13-29(14-16-30)12-11-28-26(31)22-17-23(27)20-8-4-5-9-21(20)25(22)32-3/h4-10,17H,11-16H2,1-3H3,(H,28,31)
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50n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287173
PNG
(4-Chloro-1-methoxy-naphthalene-2-carboxylic acid [...)
Show SMILES COc1c(cc(Cl)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H26ClN3O2/c1-30-23-20-10-6-5-9-19(20)22(25)17-21(23)24(29)26-11-12-27-13-15-28(16-14-27)18-7-3-2-4-8-18/h2-10,17H,11-16H2,1H3,(H,26,29)
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55n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287165
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1C
Show InChI InChI=1S/C25H28BrN3O2/c1-18-7-3-6-10-23(18)29-15-13-28(14-16-29)12-11-27-25(30)21-17-22(26)19-8-4-5-9-20(19)24(21)31-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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66n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287179
PNG
(4-Cyano-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(C#N)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H26N4O2/c1-31-24-22-10-6-5-9-21(22)19(18-26)17-23(24)25(30)27-11-12-28-13-15-29(16-14-28)20-7-3-2-4-8-20/h2-10,17H,11-16H2,1H3,(H,27,30)
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71n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287168
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)c2cc(Br)c3ccccc3c2OC)CC1
Show InChI InChI=1S/C25H28BrN3O3/c1-31-23-10-6-5-9-22(23)29-15-13-28(14-16-29)12-11-27-25(30)20-17-21(26)18-7-3-4-8-19(18)24(20)32-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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76n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287179
PNG
(4-Cyano-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(C#N)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H26N4O2/c1-31-24-22-10-6-5-9-21(22)19(18-26)17-23(24)25(30)27-11-12-28-13-15-29(16-14-28)20-7-3-2-4-8-20/h2-10,17H,11-16H2,1H3,(H,27,30)
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131n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287180
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H25BrClN3O2/c1-31-23-20-5-3-2-4-19(20)22(25)16-21(23)24(30)27-10-11-28-12-14-29(15-13-28)18-8-6-17(26)7-9-18/h2-9,16H,10-15H2,1H3,(H,27,30)
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132n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287178
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C24H25BrN4O4/c1-33-23-18-7-3-2-6-17(18)20(25)16-19(23)24(30)26-10-11-27-12-14-28(15-13-27)21-8-4-5-9-22(21)29(31)32/h2-9,16H,10-15H2,1H3,(H,26,30)
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151n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287169
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccc(C)cc1
Show InChI InChI=1S/C25H28BrN3O2/c1-18-7-9-19(10-8-18)29-15-13-28(14-16-29)12-11-27-25(30)22-17-23(26)20-5-3-4-6-21(20)24(22)31-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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260n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287164
PNG
(4-Bromo-1-ethoxy-naphthalene-2-carboxylic acid [2-...)
Show SMILES CCOc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H28BrN3O2/c1-2-31-24-21-11-7-6-10-20(21)23(26)18-22(24)25(30)27-12-13-28-14-16-29(17-15-28)19-8-4-3-5-9-19/h3-11,18H,2,12-17H2,1H3,(H,27,30)
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267n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287170
PNG
(1-Methoxy-naphthalene-2-carboxylic acid [2-(4-phen...)
Show SMILES COc1c(ccc2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H27N3O2/c1-29-23-21-10-6-5-7-19(21)11-12-22(23)24(28)25-13-14-26-15-17-27(18-16-26)20-8-3-2-4-9-20/h2-12H,13-18H2,1H3,(H,25,28)
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270n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287168
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1ccccc1N1CCN(CCNC(=O)c2cc(Br)c3ccccc3c2OC)CC1
Show InChI InChI=1S/C25H28BrN3O3/c1-31-23-10-6-5-9-22(23)29-15-13-28(14-16-29)12-11-27-25(30)20-17-21(26)18-7-3-4-8-19(18)24(20)32-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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303n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287167
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(C)c1
Show InChI InChI=1S/C25H28BrN3O2/c1-18-6-5-7-19(16-18)29-14-12-28(13-15-29)11-10-27-25(30)22-17-23(26)20-8-3-4-9-21(20)24(22)31-2/h3-9,16-17H,10-15H2,1-2H3,(H,27,30)
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339n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287165
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1C
Show InChI InChI=1S/C25H28BrN3O2/c1-18-7-3-6-10-23(18)29-15-13-28(14-16-29)12-11-27-25(30)21-17-22(26)19-8-4-5-9-20(19)24(21)31-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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484n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287176
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1S/C24H25BrClN3O2/c1-31-23-18-7-3-2-6-17(18)20(25)16-19(23)24(30)27-10-11-28-12-14-29(15-13-28)22-9-5-4-8-21(22)26/h2-9,16H,10-15H2,1H3,(H,27,30)
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517n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287166
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1cccc(c1)N1CCN(CCNC(=O)c2cc(Br)c3ccccc3c2OC)CC1
Show InChI InChI=1S/C25H28BrN3O3/c1-31-19-7-5-6-18(16-19)29-14-12-28(13-15-29)11-10-27-25(30)22-17-23(26)20-8-3-4-9-21(20)24(22)32-2/h3-9,16-17H,10-15H2,1-2H3,(H,27,30)
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652n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287162
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C24H25BrN4O4/c1-33-23-20-8-3-2-7-19(20)22(25)16-21(23)24(30)26-9-10-27-11-13-28(14-12-27)17-5-4-6-18(15-17)29(31)32/h2-8,15-16H,9-14H2,1H3,(H,26,30)
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652n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287175
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25BrClN3O2/c1-31-23-20-8-3-2-7-19(20)22(25)16-21(23)24(30)27-9-10-28-11-13-29(14-12-28)18-6-4-5-17(26)15-18/h2-8,15-16H,9-14H2,1H3,(H,27,30)
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703n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287177
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1ccc(cc1)N1CCN(CCNC(=O)c2cc(Br)c3ccccc3c2OC)CC1
Show InChI InChI=1S/C25H28BrN3O3/c1-31-19-9-7-18(8-10-19)29-15-13-28(14-16-29)12-11-27-25(30)22-17-23(26)20-5-3-4-6-21(20)24(22)32-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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731n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287174
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C24H25BrN4O4/c1-33-23-20-5-3-2-4-19(20)22(25)16-21(23)24(30)26-10-11-27-12-14-28(15-13-27)17-6-8-18(9-7-17)29(31)32/h2-9,16H,10-15H2,1H3,(H,26,30)
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731n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287169
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccc(C)cc1
Show InChI InChI=1S/C25H28BrN3O2/c1-18-7-9-19(10-8-18)29-15-13-28(14-16-29)12-11-27-25(30)22-17-23(26)20-5-3-4-6-21(20)24(22)31-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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996n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287163
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(C)c1C
Show InChI InChI=1S/C26H30BrN3O2/c1-18-7-6-10-24(19(18)2)30-15-13-29(14-16-30)12-11-28-26(31)22-17-23(27)20-8-4-5-9-21(20)25(22)32-3/h4-10,17H,11-16H2,1-3H3,(H,28,31)
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1.17E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287167
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(C)c1
Show InChI InChI=1S/C25H28BrN3O2/c1-18-6-5-7-19(16-18)29-14-12-28(13-15-29)11-10-27-25(30)22-17-23(26)20-8-3-4-9-21(20)24(22)31-2/h3-9,16-17H,10-15H2,1-2H3,(H,27,30)
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1.21E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287166
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1cccc(c1)N1CCN(CCNC(=O)c2cc(Br)c3ccccc3c2OC)CC1
Show InChI InChI=1S/C25H28BrN3O3/c1-31-19-7-5-6-18(16-19)29-14-12-28(13-15-29)11-10-27-25(30)22-17-23(26)20-8-3-4-9-21(20)24(22)32-2/h3-9,16-17H,10-15H2,1-2H3,(H,27,30)
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1.29E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287162
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C24H25BrN4O4/c1-33-23-20-8-3-2-7-19(20)22(25)16-21(23)24(30)26-9-10-27-11-13-28(14-12-27)17-5-4-6-18(15-17)29(31)32/h2-8,15-16H,9-14H2,1H3,(H,26,30)
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1.29E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287161
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H26BrN3O2/c1-30-23-20-10-6-5-9-19(20)22(25)17-21(23)24(29)26-11-12-27-13-15-28(16-14-27)18-7-3-2-4-8-18/h2-10,17H,11-16H2,1H3,(H,26,29)
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1.89E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287173
PNG
(4-Chloro-1-methoxy-naphthalene-2-carboxylic acid [...)
Show SMILES COc1c(cc(Cl)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H26ClN3O2/c1-30-23-20-10-6-5-9-19(20)22(25)17-21(23)24(29)26-11-12-27-13-15-28(16-14-27)18-7-3-2-4-8-18/h2-10,17H,11-16H2,1H3,(H,26,29)
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2.53E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287174
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C24H25BrN4O4/c1-33-23-20-5-3-2-4-19(20)22(25)16-21(23)24(30)26-10-11-27-12-14-28(15-13-27)17-6-8-18(9-7-17)29(31)32/h2-9,16H,10-15H2,1H3,(H,26,30)
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5.69E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287177
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1ccc(cc1)N1CCN(CCNC(=O)c2cc(Br)c3ccccc3c2OC)CC1
Show InChI InChI=1S/C25H28BrN3O3/c1-31-19-9-7-18(8-10-19)29-15-13-28(14-16-29)12-11-27-25(30)22-17-23(26)20-5-3-4-6-21(20)24(22)32-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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5.69E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287170
PNG
(1-Methoxy-naphthalene-2-carboxylic acid [2-(4-phen...)
Show SMILES COc1c(ccc2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H27N3O2/c1-29-23-21-10-6-5-7-19(21)11-12-22(23)24(28)25-13-14-26-15-17-27(18-16-26)20-8-3-2-4-9-20/h2-12H,13-18H2,1H3,(H,25,28)
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7.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287172
PNG
(4-Bromo-1-hydroxy-naphthalene-2-carboxylic acid [2...)
Show SMILES Oc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H24BrN3O2/c24-21-16-20(22(28)19-9-5-4-8-18(19)21)23(29)25-10-11-26-12-14-27(15-13-26)17-6-2-1-3-7-17/h1-9,16,28H,10-15H2,(H,25,29)
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287164
PNG
(4-Bromo-1-ethoxy-naphthalene-2-carboxylic acid [2-...)
Show SMILES CCOc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H28BrN3O2/c1-2-31-24-21-11-7-6-10-20(21)23(26)18-22(24)25(30)27-12-13-28-14-16-29(17-15-28)19-8-4-3-5-9-19/h3-11,18H,2,12-17H2,1H3,(H,27,30)
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287171
PNG
(4-Bromo-naphthalene-2-carboxylic acid [2-(4-phenyl...)
Show SMILES Brc1cc(cc2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H24BrN3O/c24-22-17-19(16-18-6-4-5-9-21(18)22)23(28)25-10-11-26-12-14-27(15-13-26)20-7-2-1-3-8-20/h1-9,16-17H,10-15H2,(H,25,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287172
PNG
(4-Bromo-1-hydroxy-naphthalene-2-carboxylic acid [2...)
Show SMILES Oc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H24BrN3O2/c24-21-16-20(22(28)19-9-5-4-8-18(19)21)23(29)25-10-11-26-12-14-27(15-13-26)17-6-2-1-3-7-17/h1-9,16,28H,10-15H2,(H,25,29)
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50287171
PNG
(4-Bromo-naphthalene-2-carboxylic acid [2-(4-phenyl...)
Show SMILES Brc1cc(cc2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H24BrN3O/c24-22-17-19(16-18-6-4-5-9-21(18)22)23(28)25-10-11-26-12-14-27(15-13-26)20-7-2-1-3-8-20/h1-9,16-17H,10-15H2,(H,25,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D2 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287176
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1S/C24H25BrClN3O2/c1-31-23-18-7-3-2-6-17(18)20(25)16-19(23)24(30)27-10-11-28-12-14-29(15-13-28)22-9-5-4-8-21(22)26/h2-9,16H,10-15H2,1H3,(H,27,30)
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n/an/an/an/a 83n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at Dopamine D3 receptors in rat striatum by [3H]-spiperone displacement.


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287165
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1C
Show InChI InChI=1S/C25H28BrN3O2/c1-18-7-3-6-10-23(18)29-15-13-28(14-16-29)12-11-27-25(30)21-17-22(26)19-8-4-5-9-20(19)24(21)31-2/h3-10,17H,11-16H2,1-2H3,(H,27,30)
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n/an/an/an/a>1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287161
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid [2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H26BrN3O2/c1-30-23-20-10-6-5-9-19(20)22(25)17-21(23)24(29)26-11-12-27-13-15-28(16-14-27)18-7-3-2-4-8-18/h2-10,17H,11-16H2,1H3,(H,26,29)
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n/an/an/an/a 68n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50071960
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C24H24BrCl2N3O2/c1-32-23-17-6-3-2-5-16(17)19(25)15-18(23)24(31)28-9-10-29-11-13-30(14-12-29)21-8-4-7-20(26)22(21)27/h2-8,15H,9-14H2,1H3,(H,28,31)
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n/an/an/an/a 13n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287163
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(C)c1C
Show InChI InChI=1S/C26H30BrN3O2/c1-18-7-6-10-24(19(18)2)30-15-13-29(14-16-30)12-11-28-26(31)22-17-23(27)20-8-4-5-9-21(20)25(22)32-3/h4-10,17H,11-16H2,1-3H3,(H,28,31)
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n/an/an/an/a 68n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for effective concentration required for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50287175
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {2...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NCCN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25BrClN3O2/c1-31-23-20-8-3-2-7-19(20)22(25)16-21(23)24(30)27-9-10-28-11-13-29(14-12-28)18-6-4-5-17(26)15-18/h2-8,15-16H,9-14H2,1H3,(H,27,30)
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n/an/an/an/a 28n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells


Bioorg Med Chem Lett 6: 1361-1366 (1996)


Article DOI: 10.1016/0960-894X(96)00231-4
BindingDB Entry DOI: 10.7270/Q2PV6K9S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%