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Articleid 50034787

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366358
PNG
(CHEMBL559010 | EMD-60400)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)Cc1ccccc1N
Show InChI InChI=1S/C21H27N3O2/c1-23(21(26)13-17-9-5-6-10-19(17)22)20(16-7-3-2-4-8-16)15-24-12-11-18(25)14-24/h2-10,18,20,25H,11-15,22H2,1H3/t18-,20+/m0/s1
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1n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50000780
PNG
(2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1...)
Show SMILES CN([C@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m0/s1
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1n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366356
PNG
(ASIMADOLINE HYDROCHLORIDE | EMD-61753)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H30N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,24-26,30H,17-20H2,1H3/t24-,25+/m0/s1
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2n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366350
PNG
(CHEMBL555800)
Show SMILES CC(C)C(C(=O)N(C)[C@H](CN1CC[C@H](O)C1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-18(2)23(20-12-8-5-9-13-20)24(28)25(3)22(19-10-6-4-7-11-19)17-26-15-14-21(27)16-26/h4-13,18,21-23,27H,14-17H2,1-3H3/t21-,22+,23?/m0/s1
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3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366349
PNG
(CHEMBL543707)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1cccs1)c1cccs1
Show InChI InChI=1S/C23H26N2O2S2/c1-24(23(27)22(20-9-5-13-28-20)21-10-6-14-29-21)19(17-7-3-2-4-8-17)16-25-12-11-18(26)15-25/h2-10,13-14,18-19,22,26H,11-12,15-16H2,1H3/t18-,19+/m0/s1
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366363
PNG
(CHEMBL543236)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C28H30N2O2/c1-29(26(20-9-3-2-4-10-20)19-30-16-15-23(31)18-30)28(32)27-24-13-7-5-11-21(24)17-22-12-6-8-14-25(22)27/h2-14,23,26-27,31H,15-19H2,1H3/t23-,26+/m0/s1
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366361
PNG
(CHEMBL538802)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C27H28N2O3/c1-28(23(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-21-11-5-7-13-24(21)32-25-14-8-6-12-22(25)26/h2-14,20,23,26,30H,15-18H2,1H3/t20-,23+/m0/s1
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366355
PNG
(CHEMBL543476)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H28Cl2N2O2/c1-30(25(19-5-3-2-4-6-19)18-31-16-15-24(32)17-31)27(33)26(20-7-11-22(28)12-8-20)21-9-13-23(29)14-10-21/h2-14,24-26,32H,15-18H2,1H3/t24-,25+/m0/s1
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366360
PNG
(CHEMBL538063)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1cccc(N)c1)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H31N3O2/c1-29(25(19-30-16-15-24(31)18-30)22-13-8-14-23(28)17-22)27(32)26(20-9-4-2-5-10-20)21-11-6-3-7-12-21/h2-14,17,24-26,31H,15-16,18-19,28H2,1H3/t24-,25+/m0/s1
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6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366362
PNG
(CHEMBL540345)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1cccc(NC(C)=O)c1)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H33N3O3/c1-21(33)30-25-15-9-14-24(18-25)27(20-32-17-16-26(34)19-32)31(2)29(35)28(22-10-5-3-6-11-22)23-12-7-4-8-13-23/h3-15,18,26-28,34H,16-17,19-20H2,1-2H3,(H,30,33)/t26-,27+/m0/s1
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6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366359
PNG
(CHEMBL543948)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccc(O)cc1)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H30N2O3/c1-28(25(19-29-17-16-24(31)18-29)20-12-14-23(30)15-13-20)27(32)26(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-15,24-26,30-31H,16-19H2,1H3/t24-,25+/m0/s1
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6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366364
PNG
(CHEMBL543947)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C27H28N2O2/c1-28(25(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-23-13-7-5-11-21(23)22-12-6-8-14-24(22)26/h2-14,20,25-26,30H,15-18H2,1H3/t20-,25+/m0/s1
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6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366357
PNG
(CHEMBL542036)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H28F2N2O2/c1-30(25(19-5-3-2-4-6-19)18-31-16-15-24(32)17-31)27(33)26(20-7-11-22(28)12-8-20)21-9-13-23(29)14-10-21/h2-14,24-26,32H,15-18H2,1H3/t24-,25+/m0/s1
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7n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366365
PNG
(CHEMBL540335)
Show SMILES COc1ccc(cc1)[C@@H](CN1CC[C@H](O)C1)N(C)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H32N2O3/c1-29(28(32)27(22-9-5-3-6-10-22)23-11-7-4-8-12-23)26(20-30-18-17-24(31)19-30)21-13-15-25(33-2)16-14-21/h3-16,24,26-27,31H,17-20H2,1-2H3/t24-,26+/m0/s1
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7n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366350
PNG
(CHEMBL555800)
Show SMILES CC(C)C(C(=O)N(C)[C@H](CN1CC[C@H](O)C1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-18(2)23(20-12-8-5-9-13-20)24(28)25(3)22(19-10-6-4-7-11-19)17-26-15-14-21(27)16-26/h4-13,18,21-23,27H,14-17H2,1-3H3/t21-,22+,23?/m0/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366351
PNG
(CHEMBL545346)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-3,5-8,11-14,23-26,30H,4,9-10,15-20H2,1H3/t24-,25+,26?/m0/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366352
PNG
(CHEMBL553085)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C27H28N2O2S/c1-28(23(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-21-11-5-7-13-24(21)32-25-14-8-6-12-22(25)26/h2-14,20,23,26,30H,15-18H2,1H3/t20-,23+/m0/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366351
PNG
(CHEMBL545346)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-3,5-8,11-14,23-26,30H,4,9-10,15-20H2,1H3/t24-,25+,26?/m0/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366353
PNG
(CHEMBL552587)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C29H32N2O2/c1-30(27(23-11-3-2-4-12-23)20-31-18-17-24(32)19-31)29(33)28-25-13-7-5-9-21(25)15-16-22-10-6-8-14-26(22)28/h2-14,24,27-28,32H,15-20H2,1H3/t24-,27+/m0/s1
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20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366354
PNG
(CHEMBL553084)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(C)cc1)c1ccc(C)cc1
Show InChI InChI=1S/C29H34N2O2/c1-21-9-13-24(14-10-21)28(25-15-11-22(2)12-16-25)29(33)30(3)27(23-7-5-4-6-8-23)20-31-18-17-26(32)19-31/h4-16,26-28,32H,17-20H2,1-3H3/t26-,27+/m0/s1
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20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50366366
PNG
(CHEMBL539317)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1cccc(c1)[N+]([O-])=O)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H29N3O4/c1-28(27(32)26(20-9-4-2-5-10-20)21-11-6-3-7-12-21)25(19-29-16-15-24(31)18-29)22-13-8-14-23(17-22)30(33)34/h2-14,17,24-26,31H,15-16,18-19H2,1H3/t24-,25+/m0/s1
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20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366364
PNG
(CHEMBL543947)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C27H28N2O2/c1-28(25(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-23-13-7-5-11-21(23)22-12-6-8-14-24(22)26/h2-14,20,25-26,30H,15-18H2,1H3/t20-,25+/m0/s1
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40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366364
PNG
(CHEMBL543947)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C27H28N2O2/c1-28(25(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-23-13-7-5-11-21(23)22-12-6-8-14-24(22)26/h2-14,20,25-26,30H,15-18H2,1H3/t20-,25+/m0/s1
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60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366361
PNG
(CHEMBL538802)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C27H28N2O3/c1-28(23(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-21-11-5-7-13-24(21)32-25-14-8-6-12-22(25)26/h2-14,20,23,26,30H,15-18H2,1H3/t20-,23+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366353
PNG
(CHEMBL552587)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C29H32N2O2/c1-30(27(23-11-3-2-4-12-23)20-31-18-17-24(32)19-31)29(33)28-25-13-7-5-9-21(25)15-16-22-10-6-8-14-26(22)28/h2-14,24,27-28,32H,15-20H2,1H3/t24-,27+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366350
PNG
(CHEMBL555800)
Show SMILES CC(C)C(C(=O)N(C)[C@H](CN1CC[C@H](O)C1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-18(2)23(20-12-8-5-9-13-20)24(28)25(3)22(19-10-6-4-7-11-19)17-26-15-14-21(27)16-26/h4-13,18,21-23,27H,14-17H2,1-3H3/t21-,22+,23?/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366351
PNG
(CHEMBL545346)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-3,5-8,11-14,23-26,30H,4,9-10,15-20H2,1H3/t24-,25+,26?/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366349
PNG
(CHEMBL543707)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1cccs1)c1cccs1
Show InChI InChI=1S/C23H26N2O2S2/c1-24(23(27)22(20-9-5-13-28-20)21-10-6-14-29-21)19(17-7-3-2-4-8-17)16-25-12-11-18(26)15-25/h2-10,13-14,18-19,22,26H,11-12,15-16H2,1H3/t18-,19+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366361
PNG
(CHEMBL538802)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Oc2ccccc12
Show InChI InChI=1S/C27H28N2O3/c1-28(23(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-21-11-5-7-13-24(21)32-25-14-8-6-12-22(25)26/h2-14,20,23,26,30H,15-18H2,1H3/t20-,23+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366356
PNG
(ASIMADOLINE HYDROCHLORIDE | EMD-61753)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H30N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,24-26,30H,17-20H2,1H3/t24-,25+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366363
PNG
(CHEMBL543236)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C28H30N2O2/c1-29(26(20-9-3-2-4-10-20)19-30-16-15-23(31)18-30)28(32)27-24-13-7-5-11-21(24)17-22-12-6-8-14-25(22)27/h2-14,23,26-27,31H,15-19H2,1H3/t23-,26+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366350
PNG
(CHEMBL555800)
Show SMILES CC(C)C(C(=O)N(C)[C@H](CN1CC[C@H](O)C1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-18(2)23(20-12-8-5-9-13-20)24(28)25(3)22(19-10-6-4-7-11-19)17-26-15-14-21(27)16-26/h4-13,18,21-23,27H,14-17H2,1-3H3/t21-,22+,23?/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366350
PNG
(CHEMBL555800)
Show SMILES CC(C)C(C(=O)N(C)[C@H](CN1CC[C@H](O)C1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-18(2)23(20-12-8-5-9-13-20)24(28)25(3)22(19-10-6-4-7-11-19)17-26-15-14-21(27)16-26/h4-13,18,21-23,27H,14-17H2,1-3H3/t21-,22+,23?/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366351
PNG
(CHEMBL545346)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-3,5-8,11-14,23-26,30H,4,9-10,15-20H2,1H3/t24-,25+,26?/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366354
PNG
(CHEMBL553084)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(C)cc1)c1ccc(C)cc1
Show InChI InChI=1S/C29H34N2O2/c1-21-9-13-24(14-10-21)28(25-15-11-22(2)12-16-25)29(33)30(3)27(23-7-5-4-6-8-23)20-31-18-17-26(32)19-31/h4-16,26-28,32H,17-20H2,1-3H3/t26-,27+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366357
PNG
(CHEMBL542036)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H28F2N2O2/c1-30(25(19-5-3-2-4-6-19)18-31-16-15-24(32)17-31)27(33)26(20-7-11-22(28)12-8-20)21-9-13-23(29)14-10-21/h2-14,24-26,32H,15-18H2,1H3/t24-,25+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366355
PNG
(CHEMBL543476)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H28Cl2N2O2/c1-30(25(19-5-3-2-4-6-19)18-31-16-15-24(32)17-31)27(33)26(20-7-11-22(28)12-8-20)21-9-13-23(29)14-10-21/h2-14,24-26,32H,15-18H2,1H3/t24-,25+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366352
PNG
(CHEMBL553085)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C27H28N2O2S/c1-28(23(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-21-11-5-7-13-24(21)32-25-14-8-6-12-22(25)26/h2-14,20,23,26,30H,15-18H2,1H3/t20-,23+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366353
PNG
(CHEMBL552587)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C29H32N2O2/c1-30(27(23-11-3-2-4-12-23)20-31-18-17-24(32)19-31)29(33)28-25-13-7-5-9-21(25)15-16-22-10-6-8-14-26(22)28/h2-14,24,27-28,32H,15-20H2,1H3/t24-,27+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366363
PNG
(CHEMBL543236)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C28H30N2O2/c1-29(26(20-9-3-2-4-10-20)19-30-16-15-23(31)18-30)28(32)27-24-13-7-5-11-21(24)17-22-12-6-8-14-25(22)27/h2-14,23,26-27,31H,15-19H2,1H3/t23-,26+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366349
PNG
(CHEMBL543707)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1cccs1)c1cccs1
Show InChI InChI=1S/C23H26N2O2S2/c1-24(23(27)22(20-9-5-13-28-20)21-10-6-14-29-21)19(17-7-3-2-4-8-17)16-25-12-11-18(26)15-25/h2-10,13-14,18-19,22,26H,11-12,15-16H2,1H3/t18-,19+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366357
PNG
(CHEMBL542036)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H28F2N2O2/c1-30(25(19-5-3-2-4-6-19)18-31-16-15-24(32)17-31)27(33)26(20-7-11-22(28)12-8-20)21-9-13-23(29)14-10-21/h2-14,24-26,32H,15-18H2,1H3/t24-,25+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366358
PNG
(CHEMBL559010 | EMD-60400)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)Cc1ccccc1N
Show InChI InChI=1S/C21H27N3O2/c1-23(21(26)13-17-9-5-6-10-19(17)22)20(16-7-3-2-4-8-16)15-24-12-11-18(25)14-24/h2-10,18,20,25H,11-15,22H2,1H3/t18-,20+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366354
PNG
(CHEMBL553084)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(C)cc1)c1ccc(C)cc1
Show InChI InChI=1S/C29H34N2O2/c1-21-9-13-24(14-10-21)28(25-15-11-22(2)12-16-25)29(33)30(3)27(23-7-5-4-6-8-23)20-31-18-17-26(32)19-31/h4-16,26-28,32H,17-20H2,1-3H3/t26-,27+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366351
PNG
(CHEMBL545346)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-3,5-8,11-14,23-26,30H,4,9-10,15-20H2,1H3/t24-,25+,26?/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366350
PNG
(CHEMBL555800)
Show SMILES CC(C)C(C(=O)N(C)[C@H](CN1CC[C@H](O)C1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-18(2)23(20-12-8-5-9-13-20)24(28)25(3)22(19-10-6-4-7-11-19)17-26-15-14-21(27)16-26/h4-13,18,21-23,27H,14-17H2,1-3H3/t21-,22+,23?/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366358
PNG
(CHEMBL559010 | EMD-60400)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)Cc1ccccc1N
Show InChI InChI=1S/C21H27N3O2/c1-23(21(26)13-17-9-5-6-10-19(17)22)20(16-7-3-2-4-8-16)15-24-12-11-18(25)14-24/h2-10,18,20,25H,11-15,22H2,1H3/t18-,20+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366355
PNG
(CHEMBL543476)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H28Cl2N2O2/c1-30(25(19-5-3-2-4-6-19)18-31-16-15-24(32)17-31)27(33)26(20-7-11-22(28)12-8-20)21-9-13-23(29)14-10-21/h2-14,24-26,32H,15-18H2,1H3/t24-,25+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50366356
PNG
(ASIMADOLINE HYDROCHLORIDE | EMD-61753)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H30N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,24-26,30H,17-20H2,1H3/t24-,25+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to delta opioid receptor determined in the presence of [3H]- [D-Pen2,5]enkephalin using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366351
PNG
(CHEMBL545346)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-3,5-8,11-14,23-26,30H,4,9-10,15-20H2,1H3/t24-,25+,26?/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50366352
PNG
(CHEMBL553085)
Show SMILES CN([C@H](CN1CC[C@H](O)C1)c1ccccc1)C(=O)C1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C27H28N2O2S/c1-28(23(19-9-3-2-4-10-19)18-29-16-15-20(30)17-29)27(31)26-21-11-5-7-13-24(21)32-25-14-8-6-12-22(25)26/h2-14,20,23,26,30H,15-18H2,1H3/t20-,23+/m0/s1
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>100n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Affinity to mu opioid receptor determined in the presence of [3H]- PL 017 using membranes prepared from rat cerebrum


Bioorg Med Chem Lett 4: 677-682 (1994)


Article DOI: 10.1016/S0960-894X(01)80179-7
BindingDB Entry DOI: 10.7270/Q28C9WRX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%