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PubMed code 6991695

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydrofolate reductase


(Escherichia coli)
BDBM18069
PNG
(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
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n/an/a 5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50138701
PNG
(6-Methyl-5-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,...)
Show SMILES COc1cc(Cc2c(C)nc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C15H20N4O3/c1-8-10(14(16)19-15(17)18-8)5-9-6-11(20-2)13(22-4)12(7-9)21-3/h6-7H,5H2,1-4H3,(H4,16,17,18,19)
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Plasmodium berghei (strain Anka))
BDBM18069
PNG
(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
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n/an/a 120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibition against dihydrofolate reductase enzyme of Plasmodium berghei


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50404463
PNG
(CHEMBL339058)
Show SMILES COc1cc(Cc2c(C)nc(N)nc2N)cc(OC)c1O
Show InChI InChI=1S/C14H18N4O3/c1-7-9(13(15)18-14(16)17-7)4-8-5-10(20-2)12(19)11(6-8)21-3/h5-6,19H,4H2,1-3H3,(H4,15,16,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Plasmodium berghei (strain Anka))
BDBM50138701
PNG
(6-Methyl-5-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,...)
Show SMILES COc1cc(Cc2c(C)nc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C15H20N4O3/c1-8-10(14(16)19-15(17)18-8)5-9-6-11(20-2)13(22-4)12(7-9)21-3/h6-7H,5H2,1-4H3,(H4,16,17,18,19)
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n/an/a 340n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibition against dihydrofolate reductase enzyme of Plasmodium berghei


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Plasmodium berghei (strain Anka))
BDBM50404463
PNG
(CHEMBL339058)
Show SMILES COc1cc(Cc2c(C)nc(N)nc2N)cc(OC)c1O
Show InChI InChI=1S/C14H18N4O3/c1-7-9(13(15)18-14(16)17-7)4-8-5-10(20-2)12(19)11(6-8)21-3/h5-6,19H,4H2,1-3H3,(H4,15,16,17,18)
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TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibition against dihydrofolate reductase enzyme of Plasmodium berghei


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50421660
PNG
(CHEMBL149353)
Show SMILES CCCc1nc(N)nc(N)c1Cc1cc(OC)c(O)c(OC)c1
Show InChI InChI=1S/C16H22N4O3/c1-4-5-11-10(15(17)20-16(18)19-11)6-9-7-12(22-2)14(21)13(8-9)23-3/h7-8,21H,4-6H2,1-3H3,(H4,17,18,19,20)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Plasmodium berghei (strain Anka))
BDBM50421660
PNG
(CHEMBL149353)
Show SMILES CCCc1nc(N)nc(N)c1Cc1cc(OC)c(O)c(OC)c1
Show InChI InChI=1S/C16H22N4O3/c1-4-5-11-10(15(17)20-16(18)19-11)6-9-7-12(22-2)14(21)13(8-9)23-3/h7-8,21H,4-6H2,1-3H3,(H4,17,18,19,20)
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n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibition against dihydrofolate reductase enzyme of Plasmodium berghei


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50404479
PNG
(CHEMBL150543)
Show SMILES CCCc1nc(N)nc(N)c1Cc1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C17H24N4O3/c1-5-6-12-11(16(18)21-17(19)20-12)7-10-8-13(22-2)15(24-4)14(9-10)23-3/h8-9H,5-7H2,1-4H3,(H4,18,19,20,21)
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n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50404474
PNG
(CHEMBL357960)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2C(C)C)cc(OC)c1OC
Show InChI InChI=1S/C17H24N4O3/c1-9(2)14-11(16(18)21-17(19)20-14)6-10-7-12(22-3)15(24-5)13(8-10)23-4/h7-9H,6H2,1-5H3,(H4,18,19,20,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50421665
PNG
(CHEMBL150248)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2-c2ccccc2)cc(OC)c1O
Show InChI InChI=1S/C19H20N4O3/c1-25-14-9-11(10-15(26-2)17(14)24)8-13-16(12-6-4-3-5-7-12)22-19(21)23-18(13)20/h3-7,9-10,24H,8H2,1-2H3,(H4,20,21,22,23)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50421662
PNG
(CHEMBL358879)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2-c2ccccc2)cc(OC)c1OC
Show InChI InChI=1S/C20H22N4O3/c1-25-15-10-12(11-16(26-2)18(15)27-3)9-14-17(13-7-5-4-6-8-13)23-20(22)24-19(14)21/h4-8,10-11H,9H2,1-3H3,(H4,21,22,23,24)
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n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50404475
PNG
(CHEMBL149408)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C14H19N5O3/c1-20-9-5-7(6-10(21-2)11(9)22-3)4-8-12(15)18-14(17)19-13(8)16/h5-6H,4H2,1-3H3,(H6,15,16,17,18,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Plasmodium berghei (strain Anka))
BDBM50404477
PNG
(CHEMBL150538)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2SC)cc(OC)c1OC
Show InChI InChI=1S/C15H20N4O3S/c1-20-10-6-8(7-11(21-2)12(10)22-3)5-9-13(16)18-15(17)19-14(9)23-4/h6-7H,5H2,1-4H3,(H4,16,17,18,19)
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the inhibition of Plasmodium berghei dihydrofolate reductase enzyme


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50421664
PNG
(CHEMBL150683)
Show SMILES CCc1cc(Cc2c(N)nc(N)nc2SC)cc(CC)c1OC
Show InChI InChI=1S/C17H24N4OS/c1-5-11-7-10(8-12(6-2)14(11)22-3)9-13-15(18)20-17(19)21-16(13)23-4/h7-8H,5-6,9H2,1-4H3,(H4,18,19,20,21)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50421664
PNG
(CHEMBL150683)
Show SMILES CCc1cc(Cc2c(N)nc(N)nc2SC)cc(CC)c1OC
Show InChI InChI=1S/C17H24N4OS/c1-5-11-7-10(8-12(6-2)14(11)22-3)9-13-15(18)20-17(19)21-16(13)23-4/h7-8H,5-6,9H2,1-4H3,(H4,18,19,20,21)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50421665
PNG
(CHEMBL150248)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2-c2ccccc2)cc(OC)c1O
Show InChI InChI=1S/C19H20N4O3/c1-25-14-9-11(10-15(26-2)17(14)24)8-13-16(12-6-4-3-5-7-12)22-19(21)23-18(13)20/h3-7,9-10,24H,8H2,1-2H3,(H4,20,21,22,23)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50421663
PNG
(CHEMBL150863)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2Oc2ccccc2)cc(OC)c1OC
Show InChI InChI=1S/C20H22N4O4/c1-25-15-10-12(11-16(26-2)17(15)27-3)9-14-18(21)23-20(22)24-19(14)28-13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3,(H4,21,22,23,24)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50421663
PNG
(CHEMBL150863)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2Oc2ccccc2)cc(OC)c1OC
Show InChI InChI=1S/C20H22N4O4/c1-25-15-10-12(11-16(26-2)17(15)27-3)9-14-18(21)23-20(22)24-19(14)28-13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3,(H4,21,22,23,24)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50404478
PNG
(CHEMBL439995)
Show SMILES COc1c(cc(Cc2c(N)nc(N)nc2N)cc1C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C20H31N5O/c1-19(2,3)13-9-11(10-14(15(13)26-7)20(4,5)6)8-12-16(21)24-18(23)25-17(12)22/h9-10H,8H2,1-7H3,(H6,21,22,23,24,25)
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n/an/a 6.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50404473
PNG
(CHEMBL150700)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2OC)cc(OC)c1OC
Show InChI InChI=1S/C15H20N4O4/c1-20-10-6-8(7-11(21-2)12(10)22-3)5-9-13(16)18-15(17)19-14(9)23-4/h6-7H,5H2,1-4H3,(H4,16,17,18,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM18069
PNG
(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
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n/an/a 2.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50421662
PNG
(CHEMBL358879)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2-c2ccccc2)cc(OC)c1OC
Show InChI InChI=1S/C20H22N4O3/c1-25-15-10-12(11-16(26-2)18(15)27-3)9-14-17(13-7-5-4-6-8-13)23-20(22)24-19(14)21/h4-8,10-11H,9H2,1-3H3,(H4,21,22,23,24)
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n/an/a>4.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50138701
PNG
(6-Methyl-5-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,...)
Show SMILES COc1cc(Cc2c(C)nc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C15H20N4O3/c1-8-10(14(16)19-15(17)18-8)5-9-6-11(20-2)13(22-4)12(7-9)21-3/h6-7H,5H2,1-4H3,(H4,16,17,18,19)
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n/an/a>4.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50404477
PNG
(CHEMBL150538)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2SC)cc(OC)c1OC
Show InChI InChI=1S/C15H20N4O3S/c1-20-10-6-8(7-11(21-2)12(10)22-3)5-9-13(16)18-15(17)19-14(9)23-4/h6-7H,5H2,1-4H3,(H4,16,17,18,19)
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n/an/a>4.50E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50404477
PNG
(CHEMBL150538)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2SC)cc(OC)c1OC
Show InChI InChI=1S/C15H20N4O3S/c1-20-10-6-8(7-11(21-2)12(10)22-3)5-9-13(16)18-15(17)19-14(9)23-4/h6-7H,5H2,1-4H3,(H4,16,17,18,19)
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n/an/a>4.50E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50404473
PNG
(CHEMBL150700)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2OC)cc(OC)c1OC
Show InChI InChI=1S/C15H20N4O4/c1-20-10-6-8(7-11(21-2)12(10)22-3)5-9-13(16)18-15(17)19-14(9)23-4/h6-7H,5H2,1-4H3,(H4,16,17,18,19)
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n/an/a>4.50E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50404475
PNG
(CHEMBL149408)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C14H19N5O3/c1-20-9-5-7(6-10(21-2)11(9)22-3)4-8-12(15)18-14(17)19-13(8)16/h5-6H,4H2,1-3H3,(H6,15,16,17,18,19)
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n/an/a>9.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50404479
PNG
(CHEMBL150543)
Show SMILES CCCc1nc(N)nc(N)c1Cc1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C17H24N4O3/c1-5-6-12-11(16(18)21-17(19)20-12)7-10-8-13(22-2)15(24-4)14(9-10)23-3/h8-9H,5-7H2,1-4H3,(H4,18,19,20,21)
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n/an/a 1.50E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of rat liver


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50421661
PNG
(CHEMBL150017)
Show SMILES COc1cc(Cc2c(N)nc(N)nc2N(C)C)cc(OC)c1OC
Show InChI InChI=1S/C16H23N5O3/c1-21(2)15-10(14(17)19-16(18)20-15)6-9-7-11(22-3)13(24-5)12(8-9)23-4/h7-8H,6H2,1-5H3,(H4,17,18,19,20)
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n/an/a 4.50E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against dihydrofolate reductase enzyme of Escherichia coli


J Med Chem 23: 535-41 (1980)


Article DOI: 10.1021/jm00179a012
BindingDB Entry DOI: 10.7270/Q2TX3GJG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%