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PubMed code 7837223

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50180894
PNG
(4-(4-Phenoxy-benzoyl)-benzoic acid | 4-(4-phenoxyb...)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H14O4/c21-19(14-6-8-16(9-7-14)20(22)23)15-10-12-18(13-11-15)24-17-4-2-1-3-5-17/h1-13H,(H,22,23)
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5n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407305
PNG
(CHEMBL36772)
Show SMILES COc1cc2cc(C(O)=O)n(C)c2cc1OCc1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-19-14-10-17(23-11-12-6-4-3-5-7-12)16(22-2)9-13(14)8-15(19)18(20)21/h3-10H,11H2,1-2H3,(H,20,21)
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10n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50009101
PNG
(4-Benzyloxy-1H-indole-2-carboxylic acid | CHEMBL23...)
Show SMILES OC(=O)c1cc2c(OCc3ccccc3)cccc2[nH]1
Show InChI InChI=1S/C16H13NO3/c18-16(19)14-9-12-13(17-14)7-4-8-15(12)20-10-11-5-2-1-3-6-11/h1-9,17H,10H2,(H,18,19)
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10n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50057467
PNG
(4-[4-(4-Methyl-benzoyl)-benzoyl]-benzoic acid | CH...)
Show SMILES Cc1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H16O4/c1-14-2-4-15(5-3-14)20(23)16-6-8-17(9-7-16)21(24)18-10-12-19(13-11-18)22(25)26/h2-13H,1H3,(H,25,26)
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10n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407304
PNG
(CHEMBL289822)
Show SMILES Cc1ccc(Cc2ccc(cc2)C(=O)c2ccc(cc2)C(O)=O)cc1
Show InChI InChI=1S/C22H18O3/c1-15-2-4-16(5-3-15)14-17-6-8-18(9-7-17)21(23)19-10-12-20(13-11-19)22(24)25/h2-13H,14H2,1H3,(H,24,25)
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15n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407307
PNG
(CHEMBL285651)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(Oc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C20H13NO6/c22-19(13-1-3-15(4-2-13)20(23)24)14-5-9-17(10-6-14)27-18-11-7-16(8-12-18)21(25)26/h1-12H,(H,23,24)
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20n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407316
PNG
(CHEMBL286372)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(O)cc1
Show InChI InChI=1S/C21H14O5/c22-18-11-9-16(10-12-18)20(24)14-3-1-13(2-4-14)19(23)15-5-7-17(8-6-15)21(25)26/h1-12,22H,(H,25,26)
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22n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407310
PNG
(CHEMBL37880)
Show SMILES COc1cc2cc([nH]c2cc1OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H15NO4/c1-21-15-8-12-7-14(17(19)20)18-13(12)9-16(15)22-10-11-5-3-2-4-6-11/h2-9,18H,10H2,1H3,(H,19,20)
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30n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407303
PNG
(CHEMBL36688)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(Cc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H15F3O3/c23-22(24,25)19-11-3-15(4-12-19)13-14-1-5-16(6-2-14)20(26)17-7-9-18(10-8-17)21(27)28/h1-12H,13H2,(H,27,28)
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30n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407311
PNG
(CHEMBL34847)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)C1CCCCC1
Show InChI InChI=1S/C21H20O4/c22-19(14-4-2-1-3-5-14)15-6-8-16(9-7-15)20(23)17-10-12-18(13-11-17)21(24)25/h6-14H,1-5H2,(H,24,25)
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30n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407308
PNG
(CHEMBL35176)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H13F3O4/c23-22(24,25)18-11-9-16(10-12-18)20(27)14-3-1-13(2-4-14)19(26)15-5-7-17(8-6-15)21(28)29/h1-12H,(H,28,29)
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30n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407324
PNG
(CHEMBL287996)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H13ClO4/c22-18-11-9-16(10-12-18)20(24)14-3-1-13(2-4-14)19(23)15-5-7-17(8-6-15)21(25)26/h1-12H,(H,25,26)
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35n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407320
PNG
(CHEMBL35884)
Show SMILES OC(=O)c1ccc(Cc2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C20H16O3/c21-20(22)17-10-6-15(7-11-17)14-16-8-12-19(13-9-16)23-18-4-2-1-3-5-18/h1-13H,14H2,(H,21,22)
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35n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407323
PNG
(CHEMBL37091)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H12Cl2O4/c22-16-9-10-17(18(23)11-16)20(25)14-3-1-12(2-4-14)19(24)13-5-7-15(8-6-13)21(26)27/h1-11H,(H,26,27)
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35n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407313
PNG
(CHEMBL34924)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H12Cl2O4/c22-17-10-9-16(11-18(17)23)20(25)14-3-1-12(2-4-14)19(24)13-5-7-15(8-6-13)21(26)27/h1-11H,(H,26,27)
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35n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407317
PNG
(CHEMBL36022)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H13F3O4/c23-22(24,25)18-3-1-2-17(12-18)20(27)15-6-4-13(5-7-15)19(26)14-8-10-16(11-9-14)21(28)29/h1-12H,(H,28,29)
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38n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50057498
PNG
(5-Benzyloxy-1H-indole-2-carboxylic acid | CHEMBL24...)
Show SMILES OC(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C16H13NO3/c18-16(19)15-9-12-8-13(6-7-14(12)17-15)20-10-11-4-2-1-3-5-11/h1-9,17H,10H2,(H,18,19)
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40n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407321
PNG
(CHEMBL264757)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C22H16O4/c23-20(14-15-4-2-1-3-5-15)16-6-8-17(9-7-16)21(24)18-10-12-19(13-11-18)22(25)26/h1-13H,14H2,(H,25,26)
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40n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407315
PNG
(CHEMBL37660)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccccc1
Show InChI InChI=1S/C21H14O4/c22-19(14-4-2-1-3-5-14)15-6-8-16(9-7-15)20(23)17-10-12-18(13-11-17)21(24)25/h1-13H,(H,24,25)
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40n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407322
PNG
(CHEMBL37254)
Show SMILES OC(=O)c1ccc(cc1)-c1ccc(cc1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C21H16O3/c22-20(14-15-4-2-1-3-5-15)18-10-6-16(7-11-18)17-8-12-19(13-9-17)21(23)24/h1-13H,14H2,(H,23,24)
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60n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407312
PNG
(CHEMBL286363)
Show SMILES OC(c1ccc(Oc2ccccc2)cc1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H16O4/c21-19(14-6-8-16(9-7-14)20(22)23)15-10-12-18(13-11-15)24-17-4-2-1-3-5-17/h1-13,19,21H,(H,22,23)
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60n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407314
PNG
(CHEMBL37348)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H12Cl2O3/c21-16-9-10-17(18(22)11-16)12-1-3-13(4-2-12)19(23)14-5-7-15(8-6-14)20(24)25/h1-11H,(H,24,25)
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85n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407319
PNG
(CHEMBL431904)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C21H13NO6/c23-19(15-5-7-17(8-6-15)21(25)26)13-1-3-14(4-2-13)20(24)16-9-11-18(12-10-16)22(27)28/h1-12H,(H,25,26)
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100n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407306
PNG
(CHEMBL36441)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H22O4/c1-25(2,3)21-14-12-19(13-15-21)23(27)17-6-4-16(5-7-17)22(26)18-8-10-20(11-9-18)24(28)29/h4-15H,1-3H3,(H,28,29)
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110n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407302
PNG
(CHEMBL36832)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C22H14O6/c23-20(14-5-7-16(8-6-14)22(25)26)13-1-3-15(4-2-13)21(24)17-9-10-18-19(11-17)28-12-27-18/h1-11H,12H2,(H,25,26)
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120n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50004955
PNG
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)
Show SMILES OC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12)
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230n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407309
PNG
(CHEMBL37725)
Show SMILES Cn1c(cc2cc(OCc3ccccc3)ccc12)C(O)=O
Show InChI InChI=1S/C17H15NO3/c1-18-15-8-7-14(9-13(15)10-16(18)17(19)20)21-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3,(H,19,20)
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310n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50407310
PNG
(CHEMBL37880)
Show SMILES COc1cc2cc([nH]c2cc1OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H15NO4/c1-21-15-8-12-7-14(17(19)20)18-13(12)9-16(15)22-10-11-5-3-2-4-6-11/h2-9,18H,10H2,1H3,(H,19,20)
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460n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Apparent inhibition constant against recombinant human Steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50407305
PNG
(CHEMBL36772)
Show SMILES COc1cc2cc(C(O)=O)n(C)c2cc1OCc1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-19-14-10-17(23-11-12-6-4-3-5-7-12)16(22-2)9-13(14)8-15(19)18(20)21/h3-10H,11H2,1-2H3,(H,20,21)
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500n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Apparent inhibition constant against recombinant human Steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
Steroid 5-alpha-reductase


(Homo sapiens (Human))
BDBM50407318
PNG
(CHEMBL35997)
Show SMILES OC(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H14O6/c23-19(15-5-9-17(10-6-15)21(25)26)13-1-2-14(4-3-13)20(24)16-7-11-18(12-8-16)22(27)28/h1-12H,(H,25,26)(H,27,28)
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1.00E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50057498
PNG
(5-Benzyloxy-1H-indole-2-carboxylic acid | CHEMBL24...)
Show SMILES OC(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C16H13NO3/c18-16(19)15-9-12-8-13(6-7-14(12)17-15)20-10-11-4-2-1-3-5-11/h1-9,17H,10H2,(H,18,19)
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>2.50E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Apparent inhibition constant against recombinant human Steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50407309
PNG
(CHEMBL37725)
Show SMILES Cn1c(cc2cc(OCc3ccccc3)ccc12)C(O)=O
Show InChI InChI=1S/C17H15NO3/c1-18-15-8-7-14(9-13(15)10-16(18)17(19)20)21-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3,(H,19,20)
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>2.50E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Apparent inhibition constant against recombinant human Steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
5α-Reductase 1 (5α-R1)


(Homo sapiens (Human))
BDBM50009101
PNG
(4-Benzyloxy-1H-indole-2-carboxylic acid | CHEMBL23...)
Show SMILES OC(=O)c1cc2c(OCc3ccccc3)cccc2[nH]1
Show InChI InChI=1S/C16H13NO3/c18-16(19)14-9-12-13(17-14)7-4-8-15(12)20-10-11-5-2-1-3-6-11/h1-9,17H,10H2,(H,18,19)
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>2.50E+3n/an/an/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Apparent inhibition constant against recombinant human Steroid 5-alpha-reductase type I expressed in CHO cells


J Med Chem 38: 13-5 (1995)


Article DOI: 10.1021/jm00001a004
BindingDB Entry DOI: 10.7270/Q2D50P5K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%