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PubMed code 7932569

Compile data set for download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(MOUSE)
BDBM50037492
PNG
(CHEMBL113995 | [(S)-2-(2-{(S)-2-[(S)-2-Amino-3-(4-...)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C25H31N5O7/c1-15(29-24(36)19(26)11-17-7-9-18(31)10-8-17)23(35)27-13-21(32)30-20(25(37)28-14-22(33)34)12-16-5-3-2-4-6-16/h2-10,15,19-20,31H,11-14,26H2,1H3,(H,27,35)(H,28,37)(H,29,36)(H,30,32)(H,33,34)/t15-,19-,20-/m0/s1
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0.460n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor by displacing radioligand [3H]DAMGO


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(MOUSE)
BDBM50381677
PNG
(CHEMBL1256748 | U-69593)
Show SMILES CN([C@H]1C[C@@]2(CCCO2)CC[C@@H]1N1CCCC1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)20-17-22(11-7-15-26-22)12-10-19(20)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22+/m0/s1
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1.20n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor by displacing radioligand [3HlU69,593


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037478
PNG
((6S,11R)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037489
PNG
((6S,11S)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21+/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037478
PNG
((6S,11R)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m0/s1
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2n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037476
PNG
((6R,11S)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037484
PNG
((6S,11S)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22+/m1/s1
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2.80n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(MOUSE)
BDBM50001683
PNG
(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O
Show InChI InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21+,23-,24-/m0/s1
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3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity against opioid receptor by displacing radioligand [3H]DPDPE


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037482
PNG
((6S,11R)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m0/s1
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3.40n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037480
PNG
((6R,11S)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m1/s1
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3.80n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037469
PNG
((6S,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m0/s1
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4.20n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50035131
PNG
((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CC=C(C)C
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m1/s1
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4.40n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity against sigma receptor was determined


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037475
PNG
((6S,11R)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m0/s1
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4.70n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037482
PNG
((6S,11R)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m0/s1
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4.90n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037472
PNG
((6R,11S)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m1/s1
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6n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037478
PNG
((6S,11R)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m0/s1
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7.60n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037487
PNG
((6S,11R)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21-/m0/s1
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8.80n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037469
PNG
((6S,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m0/s1
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11n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037486
PNG
((6S,11S)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23+/m1/s1
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12n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037482
PNG
((6S,11R)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m0/s1
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13n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037485
PNG
((6S,11R)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m0/s1
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15n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037479
PNG
((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m0/s1
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16n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037479
PNG
((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m0/s1
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16n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037485
PNG
((6S,11R)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m0/s1
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16n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037469
PNG
((6S,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m0/s1
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17n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037483
PNG
((+)-cis-N-Normetazocine | (6S,11R)-6,11-Dimethyl-1...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m0/s1
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23n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037485
PNG
((6S,11R)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m0/s1
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23n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037487
PNG
((6S,11R)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21-/m0/s1
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27n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037470
PNG
((6S,11R)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22-/m0/s1
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30n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037473
PNG
((6S,11R)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23-/m0/s1
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32n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037479
PNG
((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m0/s1
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32n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037487
PNG
((6S,11R)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21-/m0/s1
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32n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037470
PNG
((6S,11R)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22-/m0/s1
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35n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037478
PNG
((6S,11R)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m0/s1
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37n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037477
PNG
((6S,11R)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24-/m0/s1
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38n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037475
PNG
((6S,11R)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m0/s1
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39n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037475
PNG
((6S,11R)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m0/s1
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40n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037474
PNG
((6R,11S)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m1/s1
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43n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037475
PNG
((6S,11R)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m0/s1
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43n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037485
PNG
((6S,11R)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m0/s1
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45n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037487
PNG
((6S,11R)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21-/m0/s1
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49n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037483
PNG
((+)-cis-N-Normetazocine | (6S,11R)-6,11-Dimethyl-1...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m0/s1
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54n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037487
PNG
((6S,11R)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21-/m0/s1
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57n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037470
PNG
((6S,11R)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22-/m0/s1
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59n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037475
PNG
((6S,11R)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m0/s1
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67n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037488
PNG
((6S,11S)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24+/m1/s1
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69n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037470
PNG
((6S,11R)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22-/m0/s1
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77n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037482
PNG
((6S,11R)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m0/s1
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78n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037485
PNG
((6S,11R)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m0/s1
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98n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037482
PNG
((6S,11R)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m0/s1
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104n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037483
PNG
((+)-cis-N-Normetazocine | (6S,11R)-6,11-Dimethyl-1...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m0/s1
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113n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037470
PNG
((6S,11R)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22-/m0/s1
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114n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037486
PNG
((6S,11S)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23+/m1/s1
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126n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037473
PNG
((6S,11R)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23-/m0/s1
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151n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037469
PNG
((6S,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m0/s1
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152n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037479
PNG
((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m0/s1
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158n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037484
PNG
((6S,11S)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22+/m1/s1
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160n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037473
PNG
((6S,11R)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23-/m0/s1
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183n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037489
PNG
((6S,11S)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21+/m1/s1
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243n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037489
PNG
((6S,11S)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21+/m1/s1
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259n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037476
PNG
((6R,11S)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m1/s1
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318n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037483
PNG
((+)-cis-N-Normetazocine | (6S,11R)-6,11-Dimethyl-1...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m0/s1
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449n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037474
PNG
((6R,11S)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m1/s1
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452n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037473
PNG
((6S,11R)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23-/m0/s1
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464n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037481
PNG
((-)-cis-Normetazocine | (6R,11S)-6,11-Dimethyl-1,2...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m1/s1
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470n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037477
PNG
((6S,11R)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24-/m0/s1
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507n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037484
PNG
((6S,11S)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22+/m1/s1
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522n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037473
PNG
((6S,11R)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23-/m0/s1
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709n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037489
PNG
((6S,11S)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21+/m1/s1
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723n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037480
PNG
((6R,11S)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m1/s1
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738n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037478
PNG
((6S,11R)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m0/s1
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739n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037488
PNG
((6S,11S)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24+/m1/s1
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756n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037480
PNG
((6R,11S)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m1/s1
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776n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037472
PNG
((6R,11S)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m1/s1
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783n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037476
PNG
((6R,11S)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m1/s1
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788n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037476
PNG
((6R,11S)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m1/s1
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795n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037474
PNG
((6R,11S)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m1/s1
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943n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037477
PNG
((6S,11R)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24-/m0/s1
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997n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037490
PNG
((6R,11S)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m1/s1
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1.09E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037472
PNG
((6R,11S)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m1/s1
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1.24E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037471
PNG
((6R,11S)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m1/s1
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1.33E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037471
PNG
((6R,11S)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m1/s1
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1.38E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037486
PNG
((6S,11S)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23+/m1/s1
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1.38E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037484
PNG
((6S,11S)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22+/m1/s1
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1.59E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037481
PNG
((-)-cis-Normetazocine | (6R,11S)-6,11-Dimethyl-1,2...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m1/s1
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1.72E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037480
PNG
((6R,11S)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m1/s1
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1.74E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037486
PNG
((6S,11S)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23+/m1/s1
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2.27E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037488
PNG
((6S,11S)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24+/m1/s1
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2.27E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037477
PNG
((6S,11R)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24-/m0/s1
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2.27E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037484
PNG
((6S,11S)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C22H35NO/c1-4-5-6-7-8-9-13-23-14-12-22(3)17(2)21(23)15-18-10-11-19(24)16-20(18)22/h10-11,16-17,21,24H,4-9,12-15H2,1-3H3/t17-,21?,22+/m1/s1
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2.27E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037476
PNG
((6R,11S)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C20H31NO/c1-4-5-6-7-11-21-12-10-20(3)15(2)19(21)13-16-8-9-17(22)14-18(16)20/h8-9,14-15,19,22H,4-7,10-13H2,1-3H3/t15-,19?,20-/m1/s1
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2.27E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037477
PNG
((6S,11R)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24-/m0/s1
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2.58E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037481
PNG
((-)-cis-Normetazocine | (6R,11S)-6,11-Dimethyl-1,2...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m1/s1
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2.73E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037472
PNG
((6R,11S)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m1/s1
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2.88E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037486
PNG
((6S,11S)-6,11-Dimethyl-3-nonyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C23H37NO/c1-4-5-6-7-8-9-10-14-24-15-13-23(3)18(2)22(24)16-19-11-12-20(25)17-21(19)23/h11-12,17-18,22,25H,4-10,13-16H2,1-3H3/t18-,22?,23+/m1/s1
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2.93E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037481
PNG
((-)-cis-Normetazocine | (6R,11S)-6,11-Dimethyl-1,2...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m1/s1
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3.78E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037471
PNG
((6R,11S)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m1/s1
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3.78E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50037490
PNG
((6R,11S)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m1/s1
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3.78E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50037490
PNG
((6R,11S)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m1/s1
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4.19E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037488
PNG
((6S,11S)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24+/m1/s1
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4.20E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50368882
PNG
(CHEMBL147585 | SK&F-10047 | SK-10047)
Show SMILES CC1C2Cc3ccc(O)cc3C1CCN2CC=C
Show InChI InChI=1S/C16H21NO/c1-3-7-17-8-6-14-11(2)16(17)9-12-4-5-13(18)10-15(12)14/h3-5,10-11,14,16,18H,1,6-9H2,2H3
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4.30E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity against sigma receptor was determined


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50368882
PNG
(CHEMBL147585 | SK&F-10047 | SK-10047)
Show SMILES CC1C2Cc3ccc(O)cc3C1CCN2CC=C
Show InChI InChI=1S/C16H21NO/c1-3-7-17-8-6-14-11(2)16(17)9-12-4-5-13(18)10-15(12)14/h3-5,10-11,14,16,18H,1,6-9H2,2H3
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4.30E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity against sigma receptor was determined


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037488
PNG
((6S,11S)-3-Decyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C24H39NO/c1-4-5-6-7-8-9-10-11-15-25-16-14-24(3)19(2)23(25)17-20-12-13-21(26)18-22(20)24/h12-13,18-19,23,26H,4-11,14-17H2,1-3H3/t19-,23?,24+/m1/s1
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4.62E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037471
PNG
((6R,11S)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m1/s1
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4.97E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037474
PNG
((6R,11S)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m1/s1
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5.22E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037483
PNG
((+)-cis-N-Normetazocine | (6S,11R)-6,11-Dimethyl-1...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m0/s1
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6.75E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037481
PNG
((-)-cis-Normetazocine | (6R,11S)-6,11-Dimethyl-1,2...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2
Show InChI InChI=1S/C14H19NO/c1-9-13-7-10-3-4-11(16)8-12(10)14(9,2)5-6-15-13/h3-4,8-9,13,15-16H,5-7H2,1-2H3/t9-,13?,14-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037471
PNG
((6R,11S)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037489
PNG
((6S,11S)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCCCN1CC[C@@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C21H33NO/c1-4-5-6-7-8-12-22-13-11-21(3)16(2)20(22)14-17-9-10-18(23)15-19(17)21/h9-10,15-16,20,23H,4-8,11-14H2,1-3H3/t16-,20?,21+/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037490
PNG
((6R,11S)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037472
PNG
((6R,11S)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C18H27NO/c1-4-5-9-19-10-8-18(3)13(2)17(19)11-14-6-7-15(20)12-16(14)18/h6-7,12-13,17,20H,4-5,8-11H2,1-3H3/t13-,17?,18-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037480
PNG
((6R,11S)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C19H29NO/c1-4-5-6-10-20-11-9-19(3)14(2)18(20)12-15-7-8-16(21)13-17(15)19/h7-8,13-14,18,21H,4-6,9-12H2,1-3H3/t14-,18?,19-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50037474
PNG
((6R,11S)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Show SMILES CCCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17/h5-6,11-12,16,19H,4,7-10H2,1-3H3/t12-,16?,17-/m1/s1
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7.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50037490
PNG
((6R,11S)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@]2(C)[C@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037479
PNG
((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Show SMILES CCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21
Show InChI InChI=1S/C16H23NO/c1-4-17-8-7-16(3)11(2)15(17)9-12-5-6-13(18)10-14(12)16/h5-6,10-11,15,18H,4,7-9H2,1-3H3/t11-,15?,16-/m0/s1
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1.66E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50037469
PNG
((6S,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Show SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2C
Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3/t10-,14?,15-/m0/s1
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1.81E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum


J Med Chem 37: 3408-18 (1994)


Article DOI: 10.1021/jm00046a026
BindingDB Entry DOI: 10.7270/Q2M32WD4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%