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PubMed code 8027992

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038991
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-chloro-quinazolin-4...)
Show SMILES Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)
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PubMed
n/an/a 19n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038975
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quin...)
Show SMILES CSc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O2S/c1-23-12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)22-10-21-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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PubMed
n/an/a 31n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038992
PNG
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazolin...)
Show SMILES N#Cc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H12N4O2/c18-7-11-1-3-14-13(5-11)17(21-9-20-14)19-8-12-2-4-15-16(6-12)23-10-22-15/h1-6,9H,8,10H2,(H,19,20,21)
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n/an/a 90n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038973
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methyl-quinazolin-4...)
Show SMILES Cc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O2/c1-11-2-4-14-13(6-11)17(20-9-19-14)18-8-12-3-5-15-16(7-12)22-10-21-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a 100n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038982
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methoxy-quinazolin-...)
Show SMILES COc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O3/c1-21-12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)23-10-22-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a 230n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038979
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(7-methoxy-6-methylsul...)
Show SMILES COc1cc2ncnc(NCc3ccc4OCOc4c3)c2cc1SC
Show InChI InChI=1S/C18H17N3O3S/c1-22-16-7-13-12(6-17(16)25-2)18(21-9-20-13)19-8-11-3-4-14-15(5-11)24-10-23-14/h3-7,9H,8,10H2,1-2H3,(H,19,20,21)
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n/an/a 350n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 360n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited PDE 3 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038988
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methanesulfinyl-qui...)
Show SMILES CS(=O)c1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O3S/c1-24(21)12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)23-10-22-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a 380n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038995
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-ethoxy-quinazolin-4...)
Show SMILES CCOc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C18H17N3O3/c1-2-22-13-4-5-15-14(8-13)18(21-10-20-15)19-9-12-3-6-16-17(7-12)24-11-23-16/h3-8,10H,2,9,11H2,1H3,(H,19,20,21)
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n/an/a 380n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038986
PNG
(3-Benzo[1,3]dioxol-5-ylmethyl-6,7,8-trimethoxy-3H-...)
Show SMILES COc1cc2c(ncn(Cc3ccc4OCOc4c3)c2=O)c(OC)c1OC
Show InChI InChI=1S/C19H18N2O6/c1-23-15-7-12-16(18(25-3)17(15)24-2)20-9-21(19(12)22)8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3
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n/an/a 530n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038998
PNG
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazolin...)
Show SMILES CCOC(=O)c1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C19H17N3O4/c1-2-24-19(23)13-4-5-15-14(8-13)18(22-10-21-15)20-9-12-3-6-16-17(7-12)26-11-25-16/h3-8,10H,2,9,11H2,1H3,(H,20,21,22)
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n/an/a 620n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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n/an/a 720n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50039001
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(5,6-dimethoxy-quinazo...)
Show SMILES COc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1OC
Show InChI InChI=1S/C18H17N3O4/c1-22-14-6-4-12-16(17(14)23-2)18(21-9-20-12)19-8-11-3-5-13-15(7-11)25-10-24-13/h3-7,9H,8,10H2,1-2H3,(H,19,20,21)
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n/an/a 730n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 740n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038976
PNG
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazolin...)
Show SMILES NC(=O)c1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H14N4O3/c18-16(22)11-2-3-13-12(6-11)17(21-8-20-13)19-7-10-1-4-14-15(5-10)24-9-23-14/h1-6,8H,7,9H2,(H2,18,22)(H,19,20,21)
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n/an/a 770n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038999
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methanesulfonyl-qui...)
Show SMILES CS(=O)(=O)c1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O4S/c1-25(21,22)12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)24-10-23-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a 810n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038989
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,8-dimethoxy-quinazo...)
Show SMILES COc1cc(OC)c2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C18H17N3O4/c1-22-12-6-13-17(16(7-12)23-2)20-9-21-18(13)19-8-11-3-4-14-15(5-11)25-10-24-14/h3-7,9H,8,10H2,1-2H3,(H,19,20,21)
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n/an/a 810n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038977
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7-dimethoxy-quinazo...)
Show SMILES COc1cc2ncnc(NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C18H17N3O4/c1-22-15-6-12-13(7-16(15)23-2)20-9-21-18(12)19-8-11-3-4-14-17(5-11)25-10-24-14/h3-7,9H,8,10H2,1-2H3,(H,19,20,21)
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n/an/a 840n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038974
PNG
(CHEMBL68337 | {4-[(Benzo[1,3]dioxol-5-ylmethyl)-am...)
Show SMILES OCc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O3/c21-8-12-1-3-14-13(5-12)17(20-9-19-14)18-7-11-2-4-15-16(6-11)23-10-22-15/h1-6,9,21H,7-8,10H2,(H,18,19,20)
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n/an/a 930n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038996
PNG
(4-(Benzo[1,3]dioxol-5-ylmethoxy)-6,7,8-trimethoxy-...)
Show SMILES COc1cc2c(OCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H18N2O6/c1-22-15-7-12-16(18(24-3)17(15)23-2)20-9-21-19(12)25-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038981
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(7-chloro-quinazolin-4...)
Show SMILES Clc1ccc2c(NCc3ccc4OCOc4c3)ncnc2c1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-2-3-12-13(6-11)19-8-20-16(12)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038987
PNG
(4-(Benzo[1,3]dioxol-5-ylmethoxy)-6-methylsulfanyl-...)
Show SMILES CSc1ccc2ncnc(OCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H14N2O3S/c1-23-12-3-4-14-13(7-12)17(19-9-18-14)20-8-11-2-5-15-16(6-11)22-10-21-15/h2-7,9H,8,10H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038980
PNG
(Benzo[1,3]dioxol-5-ylmethyl-[1,3]dioxolo[4,5-g]qui...)
Show SMILES C(Nc1ncnc2cc3OCOc3cc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C17H13N3O4/c1-2-13-14(22-8-21-13)3-10(1)6-18-17-11-4-15-16(24-9-23-15)5-12(11)19-7-20-17/h1-5,7H,6,8-9H2,(H,18,19,20)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038985
PNG
(3-Benzo[1,3]dioxol-5-ylmethyl-6-methylsulfanyl-3H-...)
Show SMILES CSc1ccc2ncn(Cc3ccc4OCOc4c3)c(=O)c2c1
Show InChI InChI=1S/C17H14N2O3S/c1-23-12-3-4-14-13(7-12)17(20)19(9-18-14)8-11-2-5-15-16(6-11)22-10-21-15/h2-7,9H,8,10H2,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038994
PNG
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazolin...)
Show SMILES CN(C)C(=O)c1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C19H18N4O3/c1-23(2)19(24)13-4-5-15-14(8-13)18(22-10-21-15)20-9-12-3-6-16-17(7-12)26-11-25-16/h3-8,10H,9,11H2,1-2H3,(H,20,21,22)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50039000
PNG
(CHEMBL304277 | {4-[(Benzo[1,3]dioxol-5-ylmethyl)-a...)
Show SMILES O=C(N1CCOCC1)c1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C21H20N4O4/c26-21(25-5-7-27-8-6-25)15-2-3-17-16(10-15)20(24-12-23-17)22-11-14-1-4-18-19(9-14)29-13-28-18/h1-4,9-10,12H,5-8,11,13H2,(H,22,23,24)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038993
PNG
(3-Benzo[1,3]dioxol-5-ylmethyl-7-methoxy-6-methylsu...)
Show SMILES COc1cc2ncn(Cc3ccc4OCOc4c3)c(=O)c2cc1SC
Show InChI InChI=1S/C18H16N2O4S/c1-22-16-7-13-12(6-17(16)25-2)18(21)20(9-19-13)8-11-3-4-14-15(5-11)24-10-23-14/h3-7,9H,8,10H2,1-2H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038983
PNG
(Benzo[1,3]dioxol-5-ylmethyl-quinazolin-4-yl-amine ...)
Show SMILES C(Nc1ncnc2ccccc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C16H13N3O2/c1-2-4-13-12(3-1)16(19-9-18-13)17-8-11-5-6-14-15(7-11)21-10-20-14/h1-7,9H,8,10H2,(H,17,18,19)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038990
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(8-methoxy-quinazolin-...)
Show SMILES COc1cccc2c(NCc3ccc4OCOc4c3)ncnc12
Show InChI InChI=1S/C17H15N3O3/c1-21-14-4-2-3-12-16(14)19-9-20-17(12)18-8-11-5-6-13-15(7-11)23-10-22-13/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038984
PNG
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazolin...)
Show SMILES OC(=O)c1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H13N3O4/c21-17(22)11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)24-9-23-14/h1-6,8H,7,9H2,(H,21,22)(H,18,19,20)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50038997
PNG
(3-Benzo[1,3]dioxol-5-ylmethyl-7-chloro-3H-quinazol...)
Show SMILES Clc1ccc2c(c1)ncn(Cc1ccc3OCOc3c1)c2=O
Show InChI InChI=1S/C16H11ClN2O3/c17-11-2-3-12-13(6-11)18-8-19(16(12)20)7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2
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n/an/a 8.70E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against cGMP-phosphodiesterase from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a 8.70E+3n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP stimulated-PDE 2 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific-PDE 4 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038982
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methoxy-quinazolin-...)
Show SMILES COc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O3/c1-21-12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)23-10-22-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP stimulated-PDE 2 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038992
PNG
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazolin...)
Show SMILES N#Cc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H12N4O2/c18-7-11-1-3-14-13(5-11)17(21-9-20-14)19-8-12-2-4-15-16(6-12)23-10-22-15/h1-6,9H,8,10H2,(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP stimulated-PDE 2 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038973
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methyl-quinazolin-4...)
Show SMILES Cc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O2/c1-11-2-4-14-13(6-11)17(20-9-19-14)18-8-12-3-5-15-16(7-12)22-10-21-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited PDE 3 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038991
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-chloro-quinazolin-4...)
Show SMILES Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific-PDE 4 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038975
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quin...)
Show SMILES CSc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O2S/c1-23-12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)22-10-21-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific-PDE 4 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038978
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6,7,8-trimethoxy-quin...)
Show SMILES COc1cc2c(NCc3ccc4OCOc4c3)ncnc2c(OC)c1OC
Show InChI InChI=1S/C19H19N3O5/c1-23-15-7-12-16(18(25-3)17(15)24-2)21-9-22-19(12)20-8-11-4-5-13-14(6-11)27-10-26-13/h4-7,9H,8,10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited PDE 3 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038975
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quin...)
Show SMILES CSc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O2S/c1-23-12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)22-10-21-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited PDE 3 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038992
PNG
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazolin...)
Show SMILES N#Cc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H12N4O2/c18-7-11-1-3-14-13(5-11)17(21-9-20-14)19-8-12-2-4-15-16(6-12)23-10-22-15/h1-6,9H,8,10H2,(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific-PDE 4 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038975
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quin...)
Show SMILES CSc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O2S/c1-23-12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)22-10-21-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP stimulated-PDE 2 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038992
PNG
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazolin...)
Show SMILES N#Cc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H12N4O2/c18-7-11-1-3-14-13(5-11)17(21-9-20-14)19-8-12-2-4-15-16(6-12)23-10-22-15/h1-6,9H,8,10H2,(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited PDE 3 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038982
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methoxy-quinazolin-...)
Show SMILES COc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O3/c1-21-12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)23-10-22-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific-PDE 4 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 3A


(Sus scrofa)
BDBM50038991
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-chloro-quinazolin-4...)
Show SMILES Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP-inhibited PDE 3 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038973
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methyl-quinazolin-4...)
Show SMILES Cc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O2/c1-11-2-4-14-13(6-11)17(20-9-19-14)18-8-12-3-5-15-16(7-12)22-10-21-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP stimulated-PDE 2 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038982
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methoxy-quinazolin-...)
Show SMILES COc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O3/c1-21-12-3-4-14-13(7-12)17(20-9-19-14)18-8-11-2-5-15-16(6-11)23-10-22-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific-PDE 4 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50038991
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-chloro-quinazolin-4...)
Show SMILES Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cGMP stimulated-PDE 2 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50038973
PNG
(Benzo[1,3]dioxol-5-ylmethyl-(6-methyl-quinazolin-4...)
Show SMILES Cc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C17H15N3O2/c1-11-2-4-14-13(6-11)17(20-9-19-14)18-8-12-3-5-15-16(7-12)22-10-21-15/h2-7,9H,8,10H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Eisai Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cAMP specific-PDE 4 from porcine aorta


J Med Chem 37: 2106-11 (1994)


Article DOI: 10.1021/jm00039a024
BindingDB Entry DOI: 10.7270/Q2Q52NPF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%