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PubMed code 8831768

Compile data set for download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053650
PNG
(3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2
Show InChI InChI=1S/C18H23NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,14-17,19H,1,8-10H2,2-3H3
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n/an/a 0.600n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053635
PNG
(3-(4-Ethynyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#C)N2C
Show InChI InChI=1S/C18H21NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h1,5-8,14-17H,9-11H2,2-3H3
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n/an/a 1.20n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053637
PNG
(3-(4-Ethynyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#C)N2
Show InChI InChI=1S/C17H19NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h1,4-7,13-16,18H,8-10H2,2H3
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Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053641
PNG
(3-[((Z)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3-
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n/an/a 1.20n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053647
PNG
(8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2C
Show InChI InChI=1S/C18H23NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h4-8,14-17H,1,9-11H2,2-3H3
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Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053643
PNG
(3-[((E)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3+
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n/an/a 1.30n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053637
PNG
(3-(4-Ethynyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#C)N2
Show InChI InChI=1S/C17H19NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h1,4-7,13-16,18H,8-10H2,2H3
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n/an/a 1.60n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053653
PNG
(3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C17H21NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h3-7,13-16,18H,1,8-10H2,2H3
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Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053653
PNG
(3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C17H21NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h3-7,13-16,18H,1,8-10H2,2H3
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n/an/a 2.30n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053651
PNG
(8-Methyl-3-(4-prop-1-ynyl-phenyl)-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#CC)N2C
Show InChI InChI=1S/C19H23NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h6-9,15-18H,10-12H2,1-3H3
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Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053638
PNG
(3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C19H25NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,15-18H,1,9-11H2,2-4H3
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n/an/a 3.10n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053652
PNG
(3-(4-Prop-1-ynyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#CC)N2
Show InChI InChI=1S/C18H21NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h5-8,14-17,19H,9-11H2,1-2H3
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Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053635
PNG
(3-(4-Ethynyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#C)N2C
Show InChI InChI=1S/C18H21NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h1,5-8,14-17H,9-11H2,2-3H3
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n/an/a 4.40n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053639
PNG
(8-Methyl-3-[((E)-4-propenyl)-phenyl]-8-aza-bicyclo...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4-9,15-18H,10-12H2,1-3H3/b5-4+
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n/an/a 5.30n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053652
PNG
(3-(4-Prop-1-ynyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#CC)N2
Show InChI InChI=1S/C18H21NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h5-8,14-17,19H,9-11H2,1-2H3
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n/an/a 6.10n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053642
PNG
(3-(4-Allyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3,5-8,14-17,19H,1,4,9-11H2,2H3
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n/an/a 6.20n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053645
PNG
(8-Methyl-3-[((Z)-4-propenyl)-phenyl]-8-aza-bicyclo...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4-9,15-18H,10-12H2,1-3H3/b5-4-
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n/an/a 7.10n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053648
PNG
((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES CCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C17H23NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h4-7,13-16,18H,3,8-10H2,1-2H3
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n/an/a 8.10n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053647
PNG
(8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2C
Show InChI InChI=1S/C18H23NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h4-8,14-17H,1,9-11H2,2-3H3
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n/an/a 9.5n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053639
PNG
(8-Methyl-3-[((E)-4-propenyl)-phenyl]-8-aza-bicyclo...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4-9,15-18H,10-12H2,1-3H3/b5-4+
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n/an/a 11n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053638
PNG
(3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C19H25NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,15-18H,1,9-11H2,2-4H3
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n/an/a 14n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053653
PNG
(3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C17H21NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h3-7,13-16,18H,1,8-10H2,2H3
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n/an/a 15n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053644
PNG
(3-(4-Isopropyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2
Show InChI InChI=1S/C18H25NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,11,14-17,19H,8-10H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053645
PNG
(8-Methyl-3-[((Z)-4-propenyl)-phenyl]-8-aza-bicyclo...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4-9,15-18H,10-12H2,1-3H3/b5-4-
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n/an/a 15n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053651
PNG
(8-Methyl-3-(4-prop-1-ynyl-phenyl)-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#CC)N2C
Show InChI InChI=1S/C19H23NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h6-9,15-18H,10-12H2,1-3H3
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n/an/a 16n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053637
PNG
(3-(4-Ethynyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#C)N2
Show InChI InChI=1S/C17H19NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h1,4-7,13-16,18H,8-10H2,2H3
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n/an/a 22n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053650
PNG
(3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2
Show InChI InChI=1S/C18H23NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,14-17,19H,1,8-10H2,2-3H3
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n/an/a 23n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053654
PNG
(3-(4-Propyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-c...)
Show SMILES CCCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C18H25NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h5-8,14-17,19H,3-4,9-11H2,1-2H3
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n/an/a 26n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053646
PNG
(3-(4-Allyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4,6-9,15-18H,1,5,10-12H2,2-3H3
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n/an/a 28n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053655
PNG
((R)-3-(4-Ethyl-phenyl)-8-methyl-8-aza-bicyclo[3.2....)
Show SMILES CCc1ccc(cc1)C1CC2CCC(C1C(=O)OC)N2C
Show InChI InChI=1S/C18H25NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h5-8,14-17H,4,9-11H2,1-3H3
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n/an/a 28n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053643
PNG
(3-[((E)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3+
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n/an/a 29n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053641
PNG
(3-[((Z)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3-
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n/an/a 32n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053646
PNG
(3-(4-Allyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4,6-9,15-18H,1,5,10-12H2,2-3H3
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n/an/a 33n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053648
PNG
((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES CCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C17H23NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h4-7,13-16,18H,3,8-10H2,1-2H3
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n/an/a 50n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053643
PNG
(3-[((E)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3+
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n/an/a 54n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053655
PNG
((R)-3-(4-Ethyl-phenyl)-8-methyl-8-aza-bicyclo[3.2....)
Show SMILES CCc1ccc(cc1)C1CC2CCC(C1C(=O)OC)N2C
Show InChI InChI=1S/C18H25NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h5-8,14-17H,4,9-11H2,1-3H3
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n/an/a 55n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053642
PNG
(3-(4-Allyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3,5-8,14-17,19H,1,4,9-11H2,2H3
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n/an/a 57n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053649
PNG
(8-Methyl-3-(4-propyl-phenyl)-8-aza-bicyclo[3.2.1]o...)
Show SMILES CCCc1ccc(cc1)C1CC2CCC(C1C(=O)OC)N2C
Show InChI InChI=1S/C19H27NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h6-9,15-18H,4-5,10-12H2,1-3H3
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n/an/a 69n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053649
PNG
(8-Methyl-3-(4-propyl-phenyl)-8-aza-bicyclo[3.2.1]o...)
Show SMILES CCCc1ccc(cc1)C1CC2CCC(C1C(=O)OC)N2C
Show InChI InChI=1S/C19H27NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h6-9,15-18H,4-5,10-12H2,1-3H3
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n/an/a 70n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053647
PNG
(8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2C
Show InChI InChI=1S/C18H23NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h4-8,14-17H,1,9-11H2,2-3H3
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n/an/a 78n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053635
PNG
(3-(4-Ethynyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#C)N2C
Show InChI InChI=1S/C18H21NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h1,5-8,14-17H,9-11H2,2-3H3
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n/an/a 83n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50084717
PNG
((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1C(=O)Oc1ccccc1)N2C
Show InChI InChI=1S/C17H21NO4/c1-18-11-8-9-14(18)15(17(20)21-2)13(10-11)16(19)22-12-6-4-3-5-7-12/h3-7,11,13-15H,8-10H2,1-2H3/t11?,13-,14?,15-/m0/s1
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n/an/a 89n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053642
PNG
(3-(4-Allyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-ca...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3,5-8,14-17,19H,1,4,9-11H2,2H3
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Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053652
PNG
(3-(4-Prop-1-ynyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#CC)N2
Show InChI InChI=1S/C18H21NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h5-8,14-17,19H,9-11H2,1-2H3
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n/an/a 116n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053648
PNG
((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES CCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C17H23NO2/c1-3-11-4-6-12(7-5-11)14-10-13-8-9-15(18-13)16(14)17(19)20-2/h4-7,13-16,18H,3,8-10H2,1-2H3
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n/an/a 122n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50366600
PNG
(CHEMBL301281)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1OC(=O)c1ccccc1)N2
Show InChI InChI=1S/C16H19NO4/c1-20-16(19)14-12-8-7-11(17-12)9-13(14)21-15(18)10-5-3-2-4-6-10/h2-6,11-14,17H,7-9H2,1H3/t11?,12?,13-,14+/m0/s1
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n/an/a 127n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50366600
PNG
(CHEMBL301281)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1OC(=O)c1ccccc1)N2
Show InChI InChI=1S/C16H19NO4/c1-20-16(19)14-12-8-7-11(17-12)9-13(14)21-15(18)10-5-3-2-4-6-10/h2-6,11-14,17H,7-9H2,1H3/t11?,12?,13-,14+/m0/s1
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n/an/a 139n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053650
PNG
(3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]octan...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2
Show InChI InChI=1S/C18H23NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,14-17,19H,1,8-10H2,2-3H3
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n/an/a 144n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053641
PNG
(3-[((Z)-4-Propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2
Show InChI InChI=1S/C18H23NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h3-8,14-17,19H,9-11H2,1-2H3/b4-3-
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n/an/a 147n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50053636
PNG
(3-(4-Isopropyl-phenyl)-8-methyl-8-aza-bicyclo[3.2....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2C
Show InChI InChI=1S/C19H27NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,12,15-18H,9-11H2,1-4H3
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n/an/a 191n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50366600
PNG
(CHEMBL301281)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1OC(=O)c1ccccc1)N2
Show InChI InChI=1S/C16H19NO4/c1-20-16(19)14-12-8-7-11(17-12)9-13(14)21-15(18)10-5-3-2-4-6-10/h2-6,11-14,17H,7-9H2,1H3/t11?,12?,13-,14+/m0/s1
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n/an/a 206n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053654
PNG
(3-(4-Propyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-c...)
Show SMILES CCCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C18H25NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h5-8,14-17,19H,3-4,9-11H2,1-2H3
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n/an/a 212n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053644
PNG
(3-(4-Isopropyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2
Show InChI InChI=1S/C18H25NO2/c1-11(2)12-4-6-13(7-5-12)15-10-14-8-9-16(19-14)17(15)18(20)21-3/h4-7,11,14-17,19H,8-10H2,1-3H3
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n/an/a 320n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053654
PNG
(3-(4-Propyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-c...)
Show SMILES CCCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
Show InChI InChI=1S/C18H25NO2/c1-3-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)17(15)18(20)21-2/h5-8,14-17,19H,3-4,9-11H2,1-2H3
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n/an/a 532n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50053636
PNG
(3-(4-Isopropyl-phenyl)-8-methyl-8-aza-bicyclo[3.2....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2C
Show InChI InChI=1S/C19H27NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,12,15-18H,9-11H2,1-4H3
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n/an/a 597n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053651
PNG
(8-Methyl-3-(4-prop-1-ynyl-phenyl)-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C#CC)N2C
Show InChI InChI=1S/C19H23NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h6-9,15-18H,10-12H2,1-3H3
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n/an/a 820n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50084717
PNG
((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1C(=O)Oc1ccccc1)N2C
Show InChI InChI=1S/C17H21NO4/c1-18-11-8-9-14(18)15(17(20)21-2)13(10-11)16(19)22-12-6-4-3-5-7-12/h3-7,11,13-15H,8-10H2,1-2H3/t11?,13-,14?,15-/m0/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053638
PNG
(3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo[3....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C19H25NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,15-18H,1,9-11H2,2-4H3
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n/an/a 1.33E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053639
PNG
(8-Methyl-3-[((E)-4-propenyl)-phenyl]-8-aza-bicyclo...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C\C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4-9,15-18H,10-12H2,1-3H3/b5-4+
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n/an/a 1.59E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053646
PNG
(3-(4-Allyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oc...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(CC=C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4,6-9,15-18H,1,5,10-12H2,2-3H3
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n/an/a 2.48E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053645
PNG
(8-Methyl-3-[((Z)-4-propenyl)-phenyl]-8-aza-bicyclo...)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(\C=C/C)cc1)N2C
Show InChI InChI=1S/C19H25NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h4-9,15-18H,10-12H2,1-3H3/b5-4-
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n/an/a 2.80E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50084717
PNG
((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1C(=O)Oc1ccccc1)N2C
Show InChI InChI=1S/C17H21NO4/c1-18-11-8-9-14(18)15(17(20)21-2)13(10-11)16(19)22-12-6-4-3-5-7-12/h3-7,11,13-15H,8-10H2,1-2H3/t11?,13-,14?,15-/m0/s1
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n/an/a 3.30E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053649
PNG
(8-Methyl-3-(4-propyl-phenyl)-8-aza-bicyclo[3.2.1]o...)
Show SMILES CCCc1ccc(cc1)C1CC2CCC(C1C(=O)OC)N2C
Show InChI InChI=1S/C19H27NO2/c1-4-5-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)2)18(16)19(21)22-3/h6-9,15-18H,4-5,10-12H2,1-3H3
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n/an/a 3.92E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053655
PNG
((R)-3-(4-Ethyl-phenyl)-8-methyl-8-aza-bicyclo[3.2....)
Show SMILES CCc1ccc(cc1)C1CC2CCC(C1C(=O)OC)N2C
Show InChI InChI=1S/C18H25NO2/c1-4-12-5-7-13(8-6-12)15-11-14-9-10-16(19(14)2)17(15)18(20)21-3/h5-8,14-17H,4,9-11H2,1-3H3
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n/an/a 4.03E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50053636
PNG
(3-(4-Isopropyl-phenyl)-8-methyl-8-aza-bicyclo[3.2....)
Show SMILES COC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2C
Show InChI InChI=1S/C19H27NO2/c1-12(2)13-5-7-14(8-6-13)16-11-15-9-10-17(20(15)3)18(16)19(21)22-4/h5-8,12,15-18H,9-11H2,1-4H3
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UniChem

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Article
PubMed
n/an/a 7.50E+4n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.


J Med Chem 39: 4027-35 (1996)


Article DOI: 10.1021/jm960409s
BindingDB Entry DOI: 10.7270/Q22B8ZNT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%