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PubMed code 8978834

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055122
PNG
(CHEMBL358775 | bicyclic N-hydroxy urea derivatives)
Show SMILES Cc1c2C(CCn2c2ccc(Oc3ccccc3)cc12)N(O)C(N)=O
Show InChI InChI=1S/C19H19N3O3/c1-12-15-11-14(25-13-5-3-2-4-6-13)7-8-16(15)21-10-9-17(18(12)21)22(24)19(20)23/h2-8,11,17,24H,9-10H2,1H3,(H2,20,23)
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n/an/a 450n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055127
PNG
(CHEMBL148298 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1CCCc2cc(OCc3ccc4ccccc4c3)ccc12
Show InChI InChI=1S/C22H22N2O3/c23-22(25)24(26)21-7-3-6-18-13-19(10-11-20(18)21)27-14-15-8-9-16-4-1-2-5-17(16)12-15/h1-2,4-5,8-13,21,26H,3,6-7,14H2,(H2,23,25)
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n/an/a 500n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055118
PNG
(CHEMBL356563 | N-Hydroxy-N-[1,2,3,4-tetrahydro-6-(...)
Show SMILES COc1ccc(COc2cccc3C(CCCc23)N(O)C(N)=O)cc1
Show InChI InChI=1S/C19H22N2O4/c1-24-14-10-8-13(9-11-14)12-25-18-7-3-4-15-16(18)5-2-6-17(15)21(23)19(20)22/h3-4,7-11,17,23H,2,5-6,12H2,1H3,(H2,20,22)
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n/an/a 500n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055142
PNG
(CHEMBL148096 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1CCn2c1cc1cc(Oc3ccccc3)ccc21
Show InChI InChI=1S/C18H17N3O3/c19-18(22)21(23)16-8-9-20-15-7-6-14(10-12(15)11-17(16)20)24-13-4-2-1-3-5-13/h1-7,10-11,16,23H,8-9H2,(H2,19,22)
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n/an/a 520n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055119
PNG
(CHEMBL344114 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1CCCc2cc(CCc3ccccc3)ccc12
Show InChI InChI=1S/C19H22N2O2/c20-19(22)21(23)18-8-4-7-16-13-15(11-12-17(16)18)10-9-14-5-2-1-3-6-14/h1-3,5-6,11-13,18,23H,4,7-10H2,(H2,20,22)
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n/an/a 600n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055126
PNG
((+)-N-Hydroxy-N-[2,3-dihydro-5-(benzyloxy)-1H-inde...)
Show SMILES NC(=O)N(O)C1CCc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C17H18N2O3/c18-17(20)19(21)16-9-6-13-10-14(7-8-15(13)16)22-11-12-4-2-1-3-5-12/h1-5,7-8,10,16,21H,6,9,11H2,(H2,18,20)
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n/an/a 620n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055143
PNG
(CHEMBL149384 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1CCn2c1cc1cc(OCc3ccccc3)ccc21
Show InChI InChI=1S/C19H19N3O3/c20-19(23)22(24)17-8-9-21-16-7-6-15(10-14(16)11-18(17)21)25-12-13-4-2-1-3-5-13/h1-7,10-11,17,24H,8-9,12H2,(H2,20,23)
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n/an/a 650n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055125
PNG
(CHEMBL148400 | N-Hydroxy-N-[1,2,3,4-tetrahydro-6-(...)
Show SMILES NC(=O)N(O)C1CCCc2c(Oc3ccccc3)cccc12
Show InChI InChI=1S/C17H18N2O3/c18-17(20)19(21)15-10-4-9-14-13(15)8-5-11-16(14)22-12-6-2-1-3-7-12/h1-3,5-8,11,15,21H,4,9-10H2,(H2,18,20)
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n/an/a 840n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055128
PNG
(CHEMBL355899 | N-Hydroxy-N-[2,3-dihydro-5-(phenoxy...)
Show SMILES NC(=O)N(O)C1CCc2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C16H16N2O3/c17-16(19)18(20)15-9-6-11-10-13(7-8-14(11)15)21-12-4-2-1-3-5-12/h1-5,7-8,10,15,20H,6,9H2,(H2,17,19)
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n/an/a 850n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055126
PNG
((+)-N-Hydroxy-N-[2,3-dihydro-5-(benzyloxy)-1H-inde...)
Show SMILES NC(=O)N(O)C1CCc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C17H18N2O3/c18-17(20)19(21)16-9-6-13-10-14(7-8-15(13)16)22-11-12-4-2-1-3-5-12/h1-5,7-8,10,16,21H,6,9,11H2,(H2,18,20)
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n/an/a 880n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055136
PNG
(CHEMBL358414 | N-Hydroxy-N-[1,2,3,4-tetrahydro-5-(...)
Show SMILES NC(=O)N(O)C1CCCc2c(OCc3ccccc3)cccc12
Show InChI InChI=1S/C18H20N2O3/c19-18(21)20(22)16-10-4-9-15-14(16)8-5-11-17(15)23-12-13-6-2-1-3-7-13/h1-3,5-8,11,16,22H,4,9-10,12H2,(H2,19,21)
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n/an/a 910n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055139
PNG
(CHEMBL146093 | N-Hydroxy-N-[1,2,3,4-tetrahydro-7-(...)
Show SMILES NC(=O)N(O)C1CCCc2ccc(OCc3ccccc3)cc12
Show InChI InChI=1S/C18H20N2O3/c19-18(21)20(22)17-8-4-7-14-9-10-15(11-16(14)17)23-12-13-5-2-1-3-6-13/h1-3,5-6,9-11,17,22H,4,7-8,12H2,(H2,19,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055115
PNG
(1-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl...)
Show SMILES NC(=O)N(O)C1CCCc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C18H20N2O3/c19-18(21)20(22)17-8-4-7-14-11-15(9-10-16(14)17)23-12-13-5-2-1-3-6-13/h1-3,5-6,9-11,17,22H,4,7-8,12H2,(H2,19,21)
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n/an/a 1.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055134
PNG
(CHEMBL148844 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1CCn2c1cc1cc(Cl)ccc21
Show InChI InChI=1S/C12H12ClN3O2/c13-8-1-2-9-7(5-8)6-11-10(3-4-15(9)11)16(18)12(14)17/h1-2,5-6,10,18H,3-4H2,(H2,14,17)
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SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055115
PNG
(1-(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl...)
Show SMILES NC(=O)N(O)C1CCCc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C18H20N2O3/c19-18(21)20(22)17-8-4-7-14-11-15(9-10-16(14)17)23-12-13-5-2-1-3-6-13/h1-3,5-6,9-11,17,22H,4,7-8,12H2,(H2,19,21)
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n/an/a 1.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055132
PNG
(CHEMBL146715 | N-Hydroxy-N-[2,3-dihydro-5-(4-metho...)
Show SMILES COc1ccc(COc2ccc3C(CCc3c2)N(O)C(N)=O)cc1
Show InChI InChI=1S/C18H20N2O4/c1-23-14-5-2-12(3-6-14)11-24-15-7-8-16-13(10-15)4-9-17(16)20(22)18(19)21/h2-3,5-8,10,17,22H,4,9,11H2,1H3,(H2,19,21)
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n/an/a 1.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055141
PNG
(CHEMBL346172 | bicyclic N-hydroxy urea derivatives)
Show SMILES CC(C)c1ccc2n3CCC(N(O)C(N)=O)c3c(C)c2c1
Show InChI InChI=1S/C16H21N3O2/c1-9(2)11-4-5-13-12(8-11)10(3)15-14(6-7-18(13)15)19(21)16(17)20/h4-5,8-9,14,21H,6-7H2,1-3H3,(H2,17,20)
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n/an/a 1.70E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055131
PNG
(CHEMBL422666 | bicyclic N-hydroxy urea derivatives)
Show SMILES CCc1ccc2n3CCC(N(O)C(N)=O)c3cc2c1
Show InChI InChI=1S/C14H17N3O2/c1-2-9-3-4-11-10(7-9)8-13-12(5-6-16(11)13)17(19)14(15)18/h3-4,7-8,12,19H,2,5-6H2,1H3,(H2,15,18)
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n/an/a 1.70E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055133
PNG
(CHEMBL146537 | N-Hydroxy-N-[1,2,3,4-tetrahydro-6-(...)
Show SMILES NC(=O)N(O)C1CCCc2cc(OCc3ccc(Cl)cc3)ccc12
Show InChI InChI=1S/C18H19ClN2O3/c19-14-6-4-12(5-7-14)11-24-15-8-9-16-13(10-15)2-1-3-17(16)21(23)18(20)22/h4-10,17,23H,1-3,11H2,(H2,20,22)
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n/an/a 2.20E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055120
PNG
((+)-N-Hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofur...)
Show SMILES NC(=O)N(O)C1COc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C16H16N2O4/c17-16(19)18(20)14-10-22-15-8-12(6-7-13(14)15)21-9-11-4-2-1-3-5-11/h1-8,14,20H,9-10H2,(H2,17,19)
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SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055120
PNG
((+)-N-Hydroxy-N-[2,3-dihydro-6-(benzyloxy)benzofur...)
Show SMILES NC(=O)N(O)C1COc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C16H16N2O4/c17-16(19)18(20)14-10-22-15-8-12(6-7-13(14)15)21-9-11-4-2-1-3-5-11/h1-8,14,20H,9-10H2,(H2,17,19)
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n/an/a 2.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055121
PNG
(CHEMBL145821 | N-Hydroxy-N-[2,3-dihydro-6-(4-metho...)
Show SMILES COc1ccc(COc2ccc3C(COc3c2)N(O)C(N)=O)cc1
Show InChI InChI=1S/C17H18N2O5/c1-22-12-4-2-11(3-5-12)9-23-13-6-7-14-15(19(21)17(18)20)10-24-16(14)8-13/h2-8,15,21H,9-10H2,1H3,(H2,18,20)
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n/an/a 2.70E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055129
PNG
(CHEMBL148845 | N-Hydroxy-N-[1,2,3,4-tetrahydro-6-(...)
Show SMILES NC(=O)N(O)C1CCCc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C17H18N2O2/c18-17(20)19(21)16-8-4-7-14-11-13(9-10-15(14)16)12-5-2-1-3-6-12/h1-3,5-6,9-11,16,21H,4,7-8H2,(H2,18,20)
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n/an/a 3.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50000541
PNG
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Show SMILES CC(N(O)C(N)=O)c1cc2ccccc2s1
Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
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n/an/a 3.20E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055117
PNG
(CHEMBL148799 | N-Hydroxy-N-[2,3-dihydro-6-(phenoxy...)
Show SMILES NC(=O)N(O)C1COc2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C15H14N2O4/c16-15(18)17(19)13-9-20-14-8-11(6-7-12(13)14)21-10-4-2-1-3-5-10/h1-8,13,19H,9H2,(H2,16,18)
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n/an/a 3.30E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055124
PNG
(CHEMBL148739 | N-Hydroxy-N-[2,3-dihydro-7-(benzylo...)
Show SMILES NC(=O)N(O)C1COc2ccc(Oc3ccccc3)cc12
Show InChI InChI=1S/C15H14N2O4/c16-15(18)17(19)13-9-20-14-7-6-11(8-12(13)14)21-10-4-2-1-3-5-10/h1-8,13,19H,9H2,(H2,16,18)
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n/an/a 3.50E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055140
PNG
(CHEMBL424122 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1COc2c1ccc1ccccc21
Show InChI InChI=1S/C13H12N2O3/c14-13(16)15(17)11-7-18-12-9-4-2-1-3-8(9)5-6-10(11)12/h1-6,11,17H,7H2,(H2,14,16)
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n/an/a 4.20E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055123
PNG
(CHEMBL358858 | N-Hydroxy-N-[2,3-dihydro-7-(phenoxy...)
Show SMILES NC(=O)N(O)C1CCc2cccc(Oc3ccccc3)c12
Show InChI InChI=1S/C16H16N2O3/c17-16(19)18(20)13-10-9-11-5-4-8-14(15(11)13)21-12-6-2-1-3-7-12/h1-8,13,20H,9-10H2,(H2,17,19)
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n/an/a 5.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055135
PNG
(CHEMBL343008 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1CCCc2c1ccc1ccccc21
Show InChI InChI=1S/C15H16N2O2/c16-15(18)17(19)14-7-3-6-12-11-5-2-1-4-10(11)8-9-13(12)14/h1-2,4-5,8-9,14,19H,3,6-7H2,(H2,16,18)
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n/an/a 5.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055130
PNG
(CHEMBL145933 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1COc2ccc3ccccc3c12
Show InChI InChI=1S/C13H12N2O3/c14-13(16)15(17)10-7-18-11-6-5-8-3-1-2-4-9(8)12(10)11/h1-6,10,17H,7H2,(H2,14,16)
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n/an/a 8.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055137
PNG
(CHEMBL149926 | bicyclic N-hydroxy urea derivatives)
Show SMILES NC(=O)N(O)C1CCn2c1cc1ccccc21
Show InChI InChI=1S/C12H13N3O2/c13-12(16)15(17)10-5-6-14-9-4-2-1-3-8(9)7-11(10)14/h1-4,7,10,17H,5-6H2,(H2,13,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055138
PNG
(CHEMBL148497 | N-Hydroxy-N-[1,2,3,4-tetrahydro-1-n...)
Show SMILES NC(=O)N(O)C1CCCc2ccccc12
Show InChI InChI=1S/C11H14N2O2/c12-11(14)13(15)10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10,15H,3,5,7H2,(H2,12,14)
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n/an/a 2.90E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50055116
PNG
(CHEMBL146017 | N-Hydroxy-N-[1,2,3,4-tetrahydro-6-(...)
Show SMILES COc1ccc2C(CCCc2c1)N(O)C(N)=O
Show InChI InChI=1S/C12H16N2O3/c1-17-9-5-6-10-8(7-9)3-2-4-11(10)14(16)12(13)15/h5-7,11,16H,2-4H2,1H3,(H2,13,15)
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n/an/a 4.80E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against rat 5-lipoxygenase by using continuous oxygen consumption assay.


J Med Chem 39: 5035-46 (1997)


Article DOI: 10.1021/jm960271d
BindingDB Entry DOI: 10.7270/Q2Q23ZB1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%