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PubMed code 9513604

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Homo sapiens (Human))
BDBM50063292
PNG
(CHEMBL349426 | {4-[2-(4-Phenyl-piperazin-1-yl)-eth...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccccc12
Show InChI InChI=1S/C26H33N5/c1-2-6-23(7-3-1)31-18-16-30(17-19-31)15-14-21-10-12-22(13-11-21)29-26-24-8-4-5-9-25(24)27-20-28-26/h1-9,20-22H,10-19H2,(H,27,28,29)/t21-,22-
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0.0200n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063279
PNG
(CHEMBL309623 | Cyclohexanecarboxylic acid {4-[2-(4...)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)C1CCCCC1
Show InChI InChI=1S/C25H39N3O/c29-25(22-7-3-1-4-8-22)26-23-13-11-21(12-14-23)15-16-27-17-19-28(20-18-27)24-9-5-2-6-10-24/h2,5-6,9-10,21-23H,1,3-4,7-8,11-20H2,(H,26,29)/t21-,23-
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0.140n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063281
PNG
((4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}...)
Show SMILES COc1ccccc1N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H33N5O/c1-29-22-6-3-2-5-21(22)28-17-15-27(16-18-28)14-11-19-7-9-20(10-8-19)26-23-24-12-4-13-25-23/h2-6,12-13,19-20H,7-11,14-18H2,1H3,(H,24,25,26)/t19-,20-
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0.5n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063291
PNG
(CHEMBL78791 | Thiophene-2-carboxylic acid {4-[2-(4...)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)c1cccs1
Show InChI InChI=1S/C23H31N3OS/c27-23(22-7-4-18-28-22)24-20-10-8-19(9-11-20)12-13-25-14-16-26(17-15-25)21-5-2-1-3-6-21/h1-7,18-20H,8-17H2,(H,24,27)/t19-,20-
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0.800n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063282
PNG
(CHEMBL2110308 | {4-[2-(4-Phenyl-piperazin-1-yl)-et...)
Show SMILES C1CC(CCC1Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H27N5/c1-2-5-18(6-3-1)24-13-15-25(16-14-24)19-9-7-17(8-10-19)23-20-21-11-4-12-22-20/h1-6,11-12,17,19H,7-10,13-16H2,(H,21,22,23)
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1.90n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50455438
PNG
(CHEMBL3084971)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C22H31N5/c1-2-5-21(6-3-1)27-17-15-26(16-18-27)14-11-19-7-9-20(10-8-19)25-22-23-12-4-13-24-22/h1-6,12-13,19-20H,7-11,14-18H2,(H,23,24,25)/t19-,20+
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1.90n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063280
PNG
(CHEMBL355371 | {4-[2-(4-Pyridin-2-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1ccccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-2-10-22-20(4-1)27-16-14-26(15-17-27)13-9-18-5-7-19(8-6-18)25-21-23-11-3-12-24-21/h1-4,10-12,18-19H,5-9,13-17H2,(H,23,24,25)/t18-,19-
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2.20n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063281
PNG
((4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}...)
Show SMILES COc1ccccc1N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H33N5O/c1-29-22-6-3-2-5-21(22)28-17-15-27(16-18-28)14-11-19-7-9-20(10-8-19)26-23-24-12-4-13-25-23/h2-6,12-13,19-20H,7-11,14-18H2,1H3,(H,24,25,26)/t19-,20-
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3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063292
PNG
(CHEMBL349426 | {4-[2-(4-Phenyl-piperazin-1-yl)-eth...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccccc12
Show InChI InChI=1S/C26H33N5/c1-2-6-23(7-3-1)31-18-16-30(17-19-31)15-14-21-10-12-22(13-11-21)29-26-24-8-4-5-9-25(24)27-20-28-26/h1-9,20-22H,10-19H2,(H,27,28,29)/t21-,22-
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3.20n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063291
PNG
(CHEMBL78791 | Thiophene-2-carboxylic acid {4-[2-(4...)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)c1cccs1
Show InChI InChI=1S/C23H31N3OS/c27-23(22-7-4-18-28-22)24-20-10-8-19(9-11-20)12-13-25-14-16-26(17-15-25)21-5-2-1-3-6-21/h1-7,18-20H,8-17H2,(H,24,27)/t19-,20-
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3.40n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063296
PNG
(CHEMBL165679 | {4-[2-(4-Phenyl-piperazin-1-yl)-eth...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C22H31N5/c1-2-5-21(6-3-1)27-17-15-26(16-18-27)14-11-19-7-9-20(10-8-19)25-22-23-12-4-13-24-22/h1-6,12-13,19-20H,7-11,14-18H2,(H,23,24,25)/t19-,20-
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3.5n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063276
PNG
(CHEMBL164604 | {4-[2-(4-Phenyl-3,6-dihydro-2H-pyri...)
Show SMILES C(CN1CCC(=CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C23H30N4/c1-2-5-20(6-3-1)21-12-17-27(18-13-21)16-11-19-7-9-22(10-8-19)26-23-24-14-4-15-25-23/h1-6,12,14-15,19,22H,7-11,13,16-18H2,(H,24,25,26)/t19-,22-
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3.70n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063276
PNG
(CHEMBL164604 | {4-[2-(4-Phenyl-3,6-dihydro-2H-pyri...)
Show SMILES C(CN1CCC(=CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C23H30N4/c1-2-5-20(6-3-1)21-12-17-27(18-13-21)16-11-19-7-9-22(10-8-19)26-23-24-14-4-15-25-23/h1-6,12,14-15,19,22H,7-11,13,16-18H2,(H,24,25,26)/t19-,22-
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3.90n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063277
PNG
((4-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C22H30FN5/c23-19-4-8-21(9-5-19)28-16-14-27(15-17-28)13-10-18-2-6-20(7-3-18)26-22-24-11-1-12-25-22/h1,4-5,8-9,11-12,18,20H,2-3,6-7,10,13-17H2,(H,24,25,26)/t18-,20-
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4.5n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063276
PNG
(CHEMBL164604 | {4-[2-(4-Phenyl-3,6-dihydro-2H-pyri...)
Show SMILES C(CN1CCC(=CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C23H30N4/c1-2-5-20(6-3-1)21-12-17-27(18-13-21)16-11-19-7-9-22(10-8-19)26-23-24-14-4-15-25-23/h1-6,12,14-15,19,22H,7-11,13,16-18H2,(H,24,25,26)/t19-,22-
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4.70n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063286
PNG
(CHEMBL164723 | {4-[2-(4-Pyridin-3-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1cccnc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-3-20(17-22-9-1)27-15-13-26(14-16-27)12-8-18-4-6-19(7-5-18)25-21-23-10-2-11-24-21/h1-3,9-11,17-19H,4-8,12-16H2,(H,23,24,25)/t18-,19-
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4.70n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063288
PNG
(CHEMBL165047 | Methyl-{4-[2-(4-phenyl-piperazin-1-...)
Show SMILES CN([C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)c1ncccn1
Show InChI InChI=1S/C23H33N5/c1-26(23-24-13-5-14-25-23)21-10-8-20(9-11-21)12-15-27-16-18-28(19-17-27)22-6-3-2-4-7-22/h2-7,13-14,20-21H,8-12,15-19H2,1H3/t20-,21-
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4.70n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063288
PNG
(CHEMBL165047 | Methyl-{4-[2-(4-phenyl-piperazin-1-...)
Show SMILES CN([C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)c1ncccn1
Show InChI InChI=1S/C23H33N5/c1-26(23-24-13-5-14-25-23)21-10-8-20(9-11-21)12-15-27-16-18-28(19-17-27)22-6-3-2-4-7-22/h2-7,13-14,20-21H,8-12,15-19H2,1H3/t20-,21-
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4.80n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063298
PNG
((4-{2-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-eth...)
Show SMILES Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)Nc3ncccn3)CC2)c1Cl
Show InChI InChI=1S/C22H29Cl2N5/c23-19-3-1-4-20(21(19)24)29-15-13-28(14-16-29)12-9-17-5-7-18(8-6-17)27-22-25-10-2-11-26-22/h1-4,10-11,17-18H,5-9,12-16H2,(H,25,26,27)/t17-,18-
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5n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063296
PNG
(CHEMBL165679 | {4-[2-(4-Phenyl-piperazin-1-yl)-eth...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C22H31N5/c1-2-5-21(6-3-1)27-17-15-26(16-18-27)14-11-19-7-9-20(10-8-19)25-22-23-12-4-13-24-22/h1-6,12-13,19-20H,7-11,14-18H2,(H,23,24,25)/t19-,20-
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5.20n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063295
PNG
(CHEMBL165664 | [4-(4-Phenyl-piperazin-1-ylmethyl)-...)
Show SMILES C([C@H]1CC[C@@H](CC1)Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H29N5/c1-2-5-20(6-3-1)26-15-13-25(14-16-26)17-18-7-9-19(10-8-18)24-21-22-11-4-12-23-21/h1-6,11-12,18-19H,7-10,13-17H2,(H,22,23,24)/t18-,19-
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5.70n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063283
PNG
((4-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}...)
Show SMILES COc1ccc(cc1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H33N5O/c1-29-22-9-7-21(8-10-22)28-17-15-27(16-18-28)14-11-19-3-5-20(6-4-19)26-23-24-12-2-13-25-23/h2,7-10,12-13,19-20H,3-6,11,14-18H2,1H3,(H,24,25,26)/t19-,20-
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6n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063285
PNG
(CHEMBL165056 | Pyrimidin-2-yl-(4-{2-[4-(3-trifluor...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H30F3N5/c24-23(25,26)19-3-1-4-21(17-19)31-15-13-30(14-16-31)12-9-18-5-7-20(8-6-18)29-22-27-10-2-11-28-22/h1-4,10-11,17-18,20H,5-9,12-16H2,(H,27,28,29)/t18-,20-
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6n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063289
PNG
(CHEMBL165140 | {4-[3-(4-Phenyl-piperazin-1-yl)-pro...)
Show SMILES C(C[C@H]1CC[C@@H](CC1)Nc1ncccn1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H33N5/c1-2-7-22(8-3-1)28-18-16-27(17-19-28)15-4-6-20-9-11-21(12-10-20)26-23-24-13-5-14-25-23/h1-3,5,7-8,13-14,20-21H,4,6,9-12,15-19H2,(H,24,25,26)/t20-,21-
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7.40n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063277
PNG
((4-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C22H30FN5/c23-19-4-8-21(9-5-19)28-16-14-27(15-17-28)13-10-18-2-6-20(7-3-18)26-22-24-11-1-12-25-22/h1,4-5,8-9,11-12,18,20H,2-3,6-7,10,13-17H2,(H,24,25,26)/t18-,20-
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8.5n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063294
PNG
(CHEMBL349980 | Pyrimidin-2-yl-{4-[2-(4-pyrimidin-2...)
Show SMILES C(CN1CCN(CC1)c1ncccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-8-21-19(22-9-1)25-18-5-3-17(4-6-18)7-12-26-13-15-27(16-14-26)20-23-10-2-11-24-20/h1-2,8-11,17-18H,3-7,12-16H2,(H,21,22,25)/t17-,18-
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8.60n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063286
PNG
(CHEMBL164723 | {4-[2-(4-Pyridin-3-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1cccnc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-3-20(17-22-9-1)27-15-13-26(14-16-27)12-8-18-4-6-19(7-5-18)25-21-23-10-2-11-24-21/h1-3,9-11,17-19H,4-8,12-16H2,(H,23,24,25)/t18-,19-
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9.5n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063297
PNG
(CHEMBL166252 | Pyrimidin-2-yl-{4-[2-(4-thiazol-2-y...)
Show SMILES C(CN1CCN(CC1)c1nccs1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C19H28N6S/c1-7-20-18(21-8-1)23-17-4-2-16(3-5-17)6-10-24-11-13-25(14-12-24)19-22-9-15-26-19/h1,7-9,15-17H,2-6,10-14H2,(H,20,21,23)/t16-,17-
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10n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063281
PNG
((4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}...)
Show SMILES COc1ccccc1N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H33N5O/c1-29-22-6-3-2-5-21(22)28-17-15-27(16-18-28)14-11-19-7-9-20(10-8-19)26-23-24-12-4-13-25-23/h2-6,12-13,19-20H,7-11,14-18H2,1H3,(H,24,25,26)/t19-,20-
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11n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063298
PNG
((4-{2-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-eth...)
Show SMILES Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)Nc3ncccn3)CC2)c1Cl
Show InChI InChI=1S/C22H29Cl2N5/c23-19-3-1-4-20(21(19)24)29-15-13-28(14-16-29)12-9-17-5-7-18(8-6-17)27-22-25-10-2-11-26-22/h1-4,10-11,17-18H,5-9,12-16H2,(H,25,26,27)/t17-,18-
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11n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063280
PNG
(CHEMBL355371 | {4-[2-(4-Pyridin-2-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1ccccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-2-10-22-20(4-1)27-16-14-26(15-17-27)13-9-18-5-7-19(8-6-18)25-21-23-11-3-12-24-21/h1-4,10-12,18-19H,5-9,13-17H2,(H,23,24,25)/t18-,19-
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12n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063283
PNG
((4-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}...)
Show SMILES COc1ccc(cc1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H33N5O/c1-29-22-9-7-21(8-10-22)28-17-15-27(16-18-28)14-11-19-3-5-20(6-4-19)26-23-24-12-2-13-25-23/h2,7-10,12-13,19-20H,3-6,11,14-18H2,1H3,(H,24,25,26)/t19-,20-
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13n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063285
PNG
(CHEMBL165056 | Pyrimidin-2-yl-(4-{2-[4-(3-trifluor...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H30F3N5/c24-23(25,26)19-3-1-4-21(17-19)31-15-13-30(14-16-31)12-9-18-5-7-20(8-6-18)29-22-27-10-2-11-28-22/h1-4,10-11,17-18,20H,5-9,12-16H2,(H,27,28,29)/t18-,20-
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13n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063296
PNG
(CHEMBL165679 | {4-[2-(4-Phenyl-piperazin-1-yl)-eth...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C22H31N5/c1-2-5-21(6-3-1)27-17-15-26(16-18-27)14-11-19-7-9-20(10-8-19)25-22-23-12-4-13-24-22/h1-6,12-13,19-20H,7-11,14-18H2,(H,23,24,25)/t19-,20-
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13.7n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063289
PNG
(CHEMBL165140 | {4-[3-(4-Phenyl-piperazin-1-yl)-pro...)
Show SMILES C(C[C@H]1CC[C@@H](CC1)Nc1ncccn1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H33N5/c1-2-7-22(8-3-1)28-18-16-27(17-19-28)15-4-6-20-9-11-21(12-10-20)26-23-24-13-5-14-25-23/h1-3,5,7-8,13-14,20-21H,4,6,9-12,15-19H2,(H,24,25,26)/t20-,21-
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16n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063288
PNG
(CHEMBL165047 | Methyl-{4-[2-(4-phenyl-piperazin-1-...)
Show SMILES CN([C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)c1ncccn1
Show InChI InChI=1S/C23H33N5/c1-26(23-24-13-5-14-25-23)21-10-8-20(9-11-21)12-15-27-16-18-28(19-17-27)22-6-3-2-4-7-22/h2-7,13-14,20-21H,8-12,15-19H2,1H3/t20-,21-
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24n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063286
PNG
(CHEMBL164723 | {4-[2-(4-Pyridin-3-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1cccnc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-3-20(17-22-9-1)27-15-13-26(14-16-27)12-8-18-4-6-19(7-5-18)25-21-23-10-2-11-24-21/h1-3,9-11,17-19H,4-8,12-16H2,(H,23,24,25)/t18-,19-
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25n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063280
PNG
(CHEMBL355371 | {4-[2-(4-Pyridin-2-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1ccccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-2-10-22-20(4-1)27-16-14-26(15-17-27)13-9-18-5-7-19(8-6-18)25-21-23-11-3-12-24-21/h1-4,10-12,18-19H,5-9,13-17H2,(H,23,24,25)/t18-,19-
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26n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50455438
PNG
(CHEMBL3084971)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C22H31N5/c1-2-5-21(6-3-1)27-17-15-26(16-18-27)14-11-19-7-9-20(10-8-19)25-22-23-12-4-13-24-22/h1-6,12-13,19-20H,7-11,14-18H2,(H,23,24,25)/t19-,20+
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28n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063282
PNG
(CHEMBL2110308 | {4-[2-(4-Phenyl-piperazin-1-yl)-et...)
Show SMILES C1CC(CCC1Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H27N5/c1-2-5-18(6-3-1)24-13-15-25(16-14-24)19-9-7-17(8-10-19)23-20-21-11-4-12-22-20/h1-6,11-12,17,19H,7-10,13-16H2,(H,21,22,23)
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28n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063282
PNG
(CHEMBL2110308 | {4-[2-(4-Phenyl-piperazin-1-yl)-et...)
Show SMILES C1CC(CCC1Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H27N5/c1-2-5-18(6-3-1)24-13-15-25(16-14-24)19-9-7-17(8-10-19)23-20-21-11-4-12-22-20/h1-6,11-12,17,19H,7-10,13-16H2,(H,21,22,23)
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29n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063293
PNG
(CHEMBL165689 | Pyrimidin-2-yl-{4-[2-(2,3,5,6-tetra...)
Show SMILES C(CN1CCN(CC1)c1cnccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-7-23-20(24-8-1)25-18-4-2-17(3-5-18)6-11-26-12-14-27(15-13-26)19-16-21-9-10-22-19/h1,7-10,16-18H,2-6,11-15H2,(H,23,24,25)/t17-,18-
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29n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50455438
PNG
(CHEMBL3084971)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C22H31N5/c1-2-5-21(6-3-1)27-17-15-26(16-18-27)14-11-19-7-9-20(10-8-19)25-22-23-12-4-13-24-22/h1-6,12-13,19-20H,7-11,14-18H2,(H,23,24,25)/t19-,20+
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29n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063283
PNG
((4-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}...)
Show SMILES COc1ccc(cc1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H33N5O/c1-29-22-9-7-21(8-10-22)28-17-15-27(16-18-28)14-11-19-3-5-20(6-4-19)26-23-24-12-2-13-25-23/h2,7-10,12-13,19-20H,3-6,11,14-18H2,1H3,(H,24,25,26)/t19-,20-
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32n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063285
PNG
(CHEMBL165056 | Pyrimidin-2-yl-(4-{2-[4-(3-trifluor...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H30F3N5/c24-23(25,26)19-3-1-4-21(17-19)31-15-13-30(14-16-31)12-9-18-5-7-20(8-6-18)29-22-27-10-2-11-28-22/h1-4,10-11,17-18,20H,5-9,12-16H2,(H,27,28,29)/t18-,20-
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32n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063279
PNG
(CHEMBL309623 | Cyclohexanecarboxylic acid {4-[2-(4...)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)C1CCCCC1
Show InChI InChI=1S/C25H39N3O/c29-25(22-7-3-1-4-8-22)26-23-13-11-21(12-14-23)15-16-27-17-19-28(20-18-27)24-9-5-2-6-10-24/h2,5-6,9-10,21-23H,1,3-4,7-8,11-20H2,(H,26,29)/t21-,23-
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38n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063287
PNG
(CHEMBL164979 | {4-[2-(Methyl-phenethyl-amino)-ethy...)
Show SMILES CN(CC[C@H]1CC[C@@H](CC1)Nc1ncccn1)CCc1ccccc1
Show InChI InChI=1S/C21H30N4/c1-25(16-12-18-6-3-2-4-7-18)17-13-19-8-10-20(11-9-19)24-21-22-14-5-15-23-21/h2-7,14-15,19-20H,8-13,16-17H2,1H3,(H,22,23,24)/t19-,20-
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39n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063278
PNG
(CHEMBL165440 | {4-[2-(3,4-Dihydro-1H-isoquinolin-2...)
Show SMILES C(CN1CCc2ccccc2C1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H28N4/c1-2-5-19-16-25(15-11-18(19)4-1)14-10-17-6-8-20(9-7-17)24-21-22-12-3-13-23-21/h1-5,12-13,17,20H,6-11,14-16H2,(H,22,23,24)/t17-,20-
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40n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063295
PNG
(CHEMBL165664 | [4-(4-Phenyl-piperazin-1-ylmethyl)-...)
Show SMILES C([C@H]1CC[C@@H](CC1)Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H29N5/c1-2-5-20(6-3-1)26-15-13-25(14-16-26)17-18-7-9-19(10-8-18)24-21-22-11-4-12-23-21/h1-6,11-12,18-19H,7-10,13-17H2,(H,22,23,24)/t18-,19-
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41n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063278
PNG
(CHEMBL165440 | {4-[2-(3,4-Dihydro-1H-isoquinolin-2...)
Show SMILES C(CN1CCc2ccccc2C1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H28N4/c1-2-5-19-16-25(15-11-18(19)4-1)14-10-17-6-8-20(9-7-17)24-21-22-12-3-13-23-21/h1-5,12-13,17,20H,6-11,14-16H2,(H,22,23,24)/t17-,20-
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44n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063297
PNG
(CHEMBL166252 | Pyrimidin-2-yl-{4-[2-(4-thiazol-2-y...)
Show SMILES C(CN1CCN(CC1)c1nccs1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C19H28N6S/c1-7-20-18(21-8-1)23-17-4-2-16(3-5-17)6-10-24-11-13-25(14-12-24)19-22-9-15-26-19/h1,7-9,15-17H,2-6,10-14H2,(H,20,21,23)/t16-,17-
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46n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063277
PNG
((4-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C22H30FN5/c23-19-4-8-21(9-5-19)28-16-14-27(15-17-28)13-10-18-2-6-20(7-3-18)26-22-24-11-1-12-25-22/h1,4-5,8-9,11-12,18,20H,2-3,6-7,10,13-17H2,(H,24,25,26)/t18-,20-
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48n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063289
PNG
(CHEMBL165140 | {4-[3-(4-Phenyl-piperazin-1-yl)-pro...)
Show SMILES C(C[C@H]1CC[C@@H](CC1)Nc1ncccn1)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H33N5/c1-2-7-22(8-3-1)28-18-16-27(17-19-28)15-4-6-20-9-11-21(12-10-20)26-23-24-13-5-14-25-23/h1-3,5,7-8,13-14,20-21H,4,6,9-12,15-19H2,(H,24,25,26)/t20-,21-
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54n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063291
PNG
(CHEMBL78791 | Thiophene-2-carboxylic acid {4-[2-(4...)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)c1cccs1
Show InChI InChI=1S/C23H31N3OS/c27-23(22-7-4-18-28-22)24-20-10-8-19(9-11-20)12-13-25-14-16-26(17-15-25)21-5-2-1-3-6-21/h1-7,18-20H,8-17H2,(H,24,27)/t19-,20-
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57n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063292
PNG
(CHEMBL349426 | {4-[2-(4-Phenyl-piperazin-1-yl)-eth...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccccc12
Show InChI InChI=1S/C26H33N5/c1-2-6-23(7-3-1)31-18-16-30(17-19-31)15-14-21-10-12-22(13-11-21)29-26-24-8-4-5-9-25(24)27-20-28-26/h1-9,20-22H,10-19H2,(H,27,28,29)/t21-,22-
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74n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063298
PNG
((4-{2-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-eth...)
Show SMILES Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)Nc3ncccn3)CC2)c1Cl
Show InChI InChI=1S/C22H29Cl2N5/c23-19-3-1-4-20(21(19)24)29-15-13-28(14-16-29)12-9-17-5-7-18(8-6-17)27-22-25-10-2-11-26-22/h1-4,10-11,17-18H,5-9,12-16H2,(H,25,26,27)/t17-,18-
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76n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063282
PNG
(CHEMBL2110308 | {4-[2-(4-Phenyl-piperazin-1-yl)-et...)
Show SMILES C1CC(CCC1Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H27N5/c1-2-5-18(6-3-1)24-13-15-25(16-14-24)19-9-7-17(8-10-19)23-20-21-11-4-12-22-20/h1-6,11-12,17,19H,7-10,13-16H2,(H,21,22,23)
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83n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063295
PNG
(CHEMBL165664 | [4-(4-Phenyl-piperazin-1-ylmethyl)-...)
Show SMILES C([C@H]1CC[C@@H](CC1)Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H29N5/c1-2-5-20(6-3-1)26-15-13-25(14-16-26)17-18-7-9-19(10-8-18)24-21-22-11-4-12-23-21/h1-6,11-12,18-19H,7-10,13-17H2,(H,22,23,24)/t18-,19-
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89n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063287
PNG
(CHEMBL164979 | {4-[2-(Methyl-phenethyl-amino)-ethy...)
Show SMILES CN(CC[C@H]1CC[C@@H](CC1)Nc1ncccn1)CCc1ccccc1
Show InChI InChI=1S/C21H30N4/c1-25(16-12-18-6-3-2-4-7-18)17-13-19-8-10-20(11-9-19)24-21-22-14-5-15-23-21/h2-7,14-15,19-20H,8-13,16-17H2,1H3,(H,22,23,24)/t19-,20-
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91n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063278
PNG
(CHEMBL165440 | {4-[2-(3,4-Dihydro-1H-isoquinolin-2...)
Show SMILES C(CN1CCc2ccccc2C1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H28N4/c1-2-5-19-16-25(15-11-18(19)4-1)14-10-17-6-8-20(9-7-17)24-21-22-12-3-13-23-21/h1-5,12-13,17,20H,6-11,14-16H2,(H,22,23,24)/t17-,20-
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110n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063293
PNG
(CHEMBL165689 | Pyrimidin-2-yl-{4-[2-(2,3,5,6-tetra...)
Show SMILES C(CN1CCN(CC1)c1cnccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-7-23-20(24-8-1)25-18-4-2-17(3-5-18)6-11-26-12-14-27(15-13-26)19-16-21-9-10-22-19/h1,7-10,16-18H,2-6,11-15H2,(H,23,24,25)/t17-,18-
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180n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063293
PNG
(CHEMBL165689 | Pyrimidin-2-yl-{4-[2-(2,3,5,6-tetra...)
Show SMILES C(CN1CCN(CC1)c1cnccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-7-23-20(24-8-1)25-18-4-2-17(3-5-18)6-11-26-12-14-27(15-13-26)19-16-21-9-10-22-19/h1,7-10,16-18H,2-6,11-15H2,(H,23,24,25)/t17-,18-
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210n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063294
PNG
(CHEMBL349980 | Pyrimidin-2-yl-{4-[2-(4-pyrimidin-2...)
Show SMILES C(CN1CCN(CC1)c1ncccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-8-21-19(22-9-1)25-18-5-3-17(4-6-18)7-12-26-13-15-27(16-14-26)20-23-10-2-11-24-20/h1-2,8-11,17-18H,3-7,12-16H2,(H,21,22,25)/t17-,18-
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240n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063282
PNG
(CHEMBL2110308 | {4-[2-(4-Phenyl-piperazin-1-yl)-et...)
Show SMILES C1CC(CCC1Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H27N5/c1-2-5-18(6-3-1)24-13-15-25(16-14-24)19-9-7-17(8-10-19)23-20-21-11-4-12-22-20/h1-6,11-12,17,19H,7-10,13-16H2,(H,21,22,23)
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320n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063294
PNG
(CHEMBL349980 | Pyrimidin-2-yl-{4-[2-(4-pyrimidin-2...)
Show SMILES C(CN1CCN(CC1)c1ncccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C20H29N7/c1-8-21-19(22-9-1)25-18-5-3-17(4-6-18)7-12-26-13-15-27(16-14-26)20-23-10-2-11-24-20/h1-2,8-11,17-18H,3-7,12-16H2,(H,21,22,25)/t17-,18-
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590n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063282
PNG
(CHEMBL2110308 | {4-[2-(4-Phenyl-piperazin-1-yl)-et...)
Show SMILES C1CC(CCC1Nc1ncccn1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C20H27N5/c1-2-5-18(6-3-1)24-13-15-25(16-14-24)19-9-7-17(8-10-19)23-20-21-11-4-12-22-20/h1-6,11-12,17,19H,7-10,13-16H2,(H,21,22,23)
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610n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063290
PNG
(CHEMBL166151 | {4-[2-(4-Pyridin-4-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1ccncc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-9-23-21(24-10-1)25-19-4-2-18(3-5-19)8-13-26-14-16-27(17-15-26)20-6-11-22-12-7-20/h1,6-7,9-12,18-19H,2-5,8,13-17H2,(H,23,24,25)/t18-,19-
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730n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063299
PNG
(CHEMBL165381 | [4-(2-Dipropylamino-ethyl)-cyclohex...)
Show SMILES CCCN(CCC)CC[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C18H32N4/c1-3-13-22(14-4-2)15-10-16-6-8-17(9-7-16)21-18-19-11-5-12-20-18/h5,11-12,16-17H,3-4,6-10,13-15H2,1-2H3,(H,19,20,21)/t16-,17-
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800n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50063290
PNG
(CHEMBL166151 | {4-[2-(4-Pyridin-4-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1ccncc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-9-23-21(24-10-1)25-19-4-2-18(3-5-19)8-13-26-14-16-27(17-15-26)20-6-11-22-12-7-20/h1,6-7,9-12,18-19H,2-5,8,13-17H2,(H,23,24,25)/t18-,19-
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2.30E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring displacement of [3H]-spiperone from cloned Human Dopamine receptor D3 in CHO-K1 cells


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063299
PNG
(CHEMBL165381 | [4-(2-Dipropylamino-ethyl)-cyclohex...)
Show SMILES CCCN(CCC)CC[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C18H32N4/c1-3-13-22(14-4-2)15-10-16-6-8-17(9-7-16)21-18-19-11-5-12-20-18/h5,11-12,16-17H,3-4,6-10,13-15H2,1-2H3,(H,19,20,21)/t16-,17-
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2.40E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063290
PNG
(CHEMBL166151 | {4-[2-(4-Pyridin-4-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1ccncc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-9-23-21(24-10-1)25-19-4-2-18(3-5-19)8-13-26-14-16-27(17-15-26)20-6-11-22-12-7-20/h1,6-7,9-12,18-19H,2-5,8,13-17H2,(H,23,24,25)/t18-,19-
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4.80E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity determined by measuring its ability to displace [3H]-N-0437 radioligand in CHO-K1 cells on Cloned Human Dopamine receptor D2


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50063279
PNG
(CHEMBL309623 | Cyclohexanecarboxylic acid {4-[2-(4...)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccc2)CC1)C1CCCCC1
Show InChI InChI=1S/C25H39N3O/c29-25(22-7-3-1-4-8-22)26-23-13-11-21(12-14-23)15-16-27-17-19-28(20-18-27)24-9-5-2-6-10-24/h2,5-6,9-10,21-23H,1,3-4,7-8,11-20H2,(H,26,29)/t21-,23-
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5.30E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The binding affinity of the compound was determined by measuring its ability to displace [3H]-8-OH-DPAT radioligand in 5-hydroxytryptamine 1A recepto...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063281
PNG
((4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}...)
Show SMILES COc1ccccc1N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C23H33N5O/c1-29-22-6-3-2-5-21(22)28-17-15-27(16-18-28)14-11-19-7-9-20(10-8-19)26-23-24-12-4-13-25-23/h2-6,12-13,19-20H,7-11,14-18H2,1H3,(H,24,25,26)/t19-,20-
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n/an/a 9.90n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The in vitro intrinsic activity was measured at DA D2 receptor by measuring its ability to increase [3H]-thymidine uptake in CHO-K1 cells transfected...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063277
PNG
((4-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Fc1ccc(cc1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1
Show InChI InChI=1S/C22H30FN5/c23-19-4-8-21(9-5-19)28-16-14-27(15-17-28)13-10-18-2-6-20(7-3-18)26-22-24-11-1-12-25-22/h1,4-5,8-9,11-12,18,20H,2-3,6-7,10,13-17H2,(H,24,25,26)/t18-,20-
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n/an/a 79n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The in vitro intrinsic activity was measured at DA D2 receptor by measuring its ability to increase [3H]-thymidine uptake in CHO-K1 cells transfected...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063280
PNG
(CHEMBL355371 | {4-[2-(4-Pyridin-2-yl-piperazin-1-y...)
Show SMILES C(CN1CCN(CC1)c1ccccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C21H30N6/c1-2-10-22-20(4-1)27-16-14-26(15-17-27)13-9-18-5-7-19(8-6-18)25-21-23-11-3-12-24-21/h1-4,10-12,18-19H,5-9,13-17H2,(H,23,24,25)/t18-,19-
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n/an/an/an/a 28n/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The in vitro intrinsic activity was measured at DA D2 receptor by measuring its ability to increase [3H]-thymidine uptake in CHO-K1 cells transfected...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50063296
PNG
(CHEMBL165679 | {4-[2-(4-Phenyl-piperazin-1-yl)-eth...)
Show SMILES C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1
Show InChI InChI=1S/C22H31N5/c1-2-5-21(6-3-1)27-17-15-26(16-18-27)14-11-19-7-9-20(10-8-19)25-22-23-12-4-13-24-22/h1-6,12-13,19-20H,7-11,14-18H2,(H,23,24,25)/t19-,20-
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n/an/an/an/a 29n/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
The in vitro intrinsic activity was measured at DA D2 receptor by measuring its ability to increase [3H]-thymidine uptake in CHO-K1 cells transfected...


J Med Chem 41: 760-71 (1998)


Article DOI: 10.1021/jm9707378
BindingDB Entry DOI: 10.7270/Q20G3J97
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%