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PubMed code 9767642

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50403371
PNG
(Firazyr | HOE-140 | ICATIBANT)
Show SMILES N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
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n/an/a 0.0900n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50403371
PNG
(Firazyr | HOE-140 | ICATIBANT)
Show SMILES N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
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n/an/a 0.0900n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067263
PNG
(5-{2-[({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1
Show InChI InChI=1S/C28H25BrCl2N6O4/c1-16-26(29)37-12-4-5-22(27(37)35-16)41-15-18-19(30)8-10-21(25(18)31)36(3)24(39)14-34-23(38)11-7-17-6-9-20(33-13-17)28(40)32-2/h4-13H,14-15H2,1-3H3,(H,32,40)(H,34,38)/b11-7+
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n/an/a 0.360n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067263
PNG
(5-{2-[({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1
Show InChI InChI=1S/C28H25BrCl2N6O4/c1-16-26(29)37-12-4-5-22(27(37)35-16)41-15-18-19(30)8-10-21(25(18)31)36(3)24(39)14-34-23(38)11-7-17-6-9-20(33-13-17)28(40)32-2/h4-13H,14-15H2,1-3H3,(H,32,40)(H,34,38)/b11-7+
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n/an/a 0.360n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067242
PNG
(3-(6-Acetylamino-pyridin-3-yl)-N-({[3-(3-bromo-2-m...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(NC(C)=O)nc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C28H25BrCl2N6O4/c1-16-27(29)37-12-4-5-22(28(37)34-16)41-15-19-20(30)8-9-21(26(19)31)36(3)25(40)14-33-24(39)11-7-18-6-10-23(32-13-18)35-17(2)38/h4-13H,14-15H2,1-3H3,(H,33,39)(H,32,35,38)/b11-7+
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n/an/a 0.380n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067242
PNG
(3-(6-Acetylamino-pyridin-3-yl)-N-({[3-(3-bromo-2-m...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(NC(C)=O)nc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C28H25BrCl2N6O4/c1-16-27(29)37-12-4-5-22(28(37)34-16)41-15-19-20(30)8-9-21(26(19)31)36(3)25(40)14-33-24(39)11-7-18-6-10-23(32-13-18)35-17(2)38/h4-13H,14-15H2,1-3H3,(H,33,39)(H,32,35,38)/b11-7+
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n/an/a 0.380n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067248
PNG
(5-{2-[({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CN(C)C(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1
Show InChI InChI=1S/C29H27BrCl2N6O4/c1-17-27(30)38-13-5-6-23(28(38)35-17)42-16-19-20(31)9-11-22(26(19)32)37(4)25(40)15-34-24(39)12-8-18-7-10-21(33-14-18)29(41)36(2)3/h5-14H,15-16H2,1-4H3,(H,34,39)/b12-8+
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n/an/a 0.440n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067247
PNG
(4-{(E)-2-[({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyr...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C29H26BrCl2N5O4/c1-17-27(30)37-14-4-5-23(28(37)35-17)41-16-20-21(31)11-12-22(26(20)32)36(3)25(39)15-34-24(38)13-8-18-6-9-19(10-7-18)29(40)33-2/h4-14H,15-16H2,1-3H3,(H,33,40)(H,34,38)/b13-8+
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Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067247
PNG
(4-{(E)-2-[({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyr...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C29H26BrCl2N5O4/c1-17-27(30)37-14-4-5-23(28(37)35-17)41-16-20-21(31)11-12-22(26(20)32)36(3)25(39)15-34-24(38)13-8-18-6-9-19(10-7-18)29(40)33-2/h4-14H,15-16H2,1-3H3,(H,33,40)(H,34,38)/b13-8+
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Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067253
PNG
((E)-3-(4-Acetylamino-phenyl)-N-({[3-(3-bromo-2-met...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(NC(C)=O)cc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C29H26BrCl2N5O4/c1-17-28(30)37-14-4-5-24(29(37)34-17)41-16-21-22(31)11-12-23(27(21)32)36(3)26(40)15-33-25(39)13-8-19-6-9-20(10-7-19)35-18(2)38/h4-14H,15-16H2,1-3H3,(H,33,39)(H,35,38)/b13-8+
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n/an/a 0.550n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067240
PNG
((E)-N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(cc1)N1CCCC1=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C31H28BrCl2N5O4/c1-19-30(32)39-16-3-5-25(31(39)36-19)43-18-22-23(33)12-13-24(29(22)34)37(2)28(42)17-35-26(40)14-9-20-7-10-21(11-8-20)38-15-4-6-27(38)41/h3,5,7-14,16H,4,6,15,17-18H2,1-2H3,(H,35,40)/b14-9+
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n/an/a 0.590n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067240
PNG
((E)-N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(cc1)N1CCCC1=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C31H28BrCl2N5O4/c1-19-30(32)39-16-3-5-25(31(39)36-19)43-18-22-23(33)12-13-24(29(22)34)37(2)28(42)17-35-26(40)14-9-20-7-10-21(11-8-20)38-15-4-6-27(38)41/h3,5,7-14,16H,4,6,15,17-18H2,1-2H3,(H,35,40)/b14-9+
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Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067251
PNG
(4-{(E)-2-[({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyr...)
Show SMILES CN(C)C(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C30H28BrCl2N5O4/c1-18-28(31)38-15-5-6-24(29(38)35-18)42-17-21-22(32)12-13-23(27(21)33)37(4)26(40)16-34-25(39)14-9-19-7-10-20(11-8-19)30(41)36(2)3/h5-15H,16-17H2,1-4H3,(H,34,39)/b14-9+
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n/an/a 0.660n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067257
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES CN(C)C(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C28H27BrCl2N6O4/c1-16-25(29)37-12-6-9-22(26(37)33-16)41-15-19-20(30)10-11-21(24(19)31)36(4)23(38)14-32-28(40)34-18-8-5-7-17(13-18)27(39)35(2)3/h5-13H,14-15H2,1-4H3,(H2,32,34,40)
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n/an/a 0.760n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067264
PNG
((Z)-N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CN(C(=O)CNC(=O)\C=C/c1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C27H23BrCl2N4O3/c1-17-26(28)34-14-6-9-22(27(34)32-17)37-16-19-20(29)11-12-21(25(19)30)33(2)24(36)15-31-23(35)13-10-18-7-4-3-5-8-18/h3-14H,15-16H2,1-2H3,(H,31,35)/b13-10-
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n/an/a 0.780n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067235
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES COCCNC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C29H29BrCl2N6O5/c1-17-26(30)38-12-5-8-23(27(38)35-17)43-16-20-21(31)9-10-22(25(20)32)37(2)24(39)15-34-29(41)36-19-7-4-6-18(14-19)28(40)33-11-13-42-3/h4-10,12,14H,11,13,15-16H2,1-3H3,(H,33,40)(H2,34,36,41)
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n/an/a 0.790n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067235
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES COCCNC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C29H29BrCl2N6O5/c1-17-26(30)38-12-5-8-23(27(38)35-17)43-16-20-21(31)9-10-22(25(20)32)37(2)24(39)15-34-29(41)36-19-7-4-6-18(14-19)28(40)33-11-13-42-3/h4-10,12,14H,11,13,15-16H2,1-3H3,(H,33,40)(H2,34,36,41)
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n/an/a 0.790n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067233
PNG
(2-[3-(3-Acetyl-phenyl)-ureido]-N-[3-(3-bromo-2-met...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(c1)C(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C27H24BrCl2N5O4/c1-15-25(28)35-11-5-8-22(26(35)32-15)39-14-19-20(29)9-10-21(24(19)30)34(3)23(37)13-31-27(38)33-18-7-4-6-17(12-18)16(2)36/h4-12H,13-14H2,1-3H3,(H2,31,33,38)
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n/an/a 0.790n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067258
PNG
((E)-N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CNC(=O)Nc1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C29H27BrCl2N6O4/c1-17-27(30)38-14-4-5-23(28(38)35-17)42-16-20-21(31)11-12-22(26(20)32)37(3)25(40)15-34-24(39)13-8-18-6-9-19(10-7-18)36-29(41)33-2/h4-14H,15-16H2,1-3H3,(H,34,39)(H2,33,36,41)/b13-8+
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n/an/a 0.890n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067236
PNG
((E)-3-[4-(Acetyl-methyl-amino)-phenyl]-N-({[3-(3-b...)
Show SMILES CN(C(C)=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C30H28BrCl2N5O4/c1-18-29(31)38-15-5-6-25(30(38)35-18)42-17-22-23(32)12-13-24(28(22)33)37(4)27(41)16-34-26(40)14-9-20-7-10-21(11-8-20)36(3)19(2)39/h5-15H,16-17H2,1-4H3,(H,34,40)/b14-9+
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n/an/a 1.10n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067256
PNG
(CHEMBL559195 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C25H22BrCl2N5O3/c1-15-23(26)33-12-6-9-20(24(33)30-15)36-14-17-18(27)10-11-19(22(17)28)32(2)21(34)13-29-25(35)31-16-7-4-3-5-8-16/h3-12H,13-14H2,1-2H3,(H2,29,31,35)
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n/an/a 1.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067239
PNG
(CHEMBL555556 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(c1)C#N)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H21BrCl2N6O3/c1-15-24(27)35-10-4-7-21(25(35)32-15)38-14-18-19(28)8-9-20(23(18)29)34(2)22(36)13-31-26(37)33-17-6-3-5-16(11-17)12-30/h3-11H,13-14H2,1-2H3,(H2,31,33,37)
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n/an/a 1.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067251
PNG
(4-{(E)-2-[({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyr...)
Show SMILES CN(C)C(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C30H28BrCl2N5O4/c1-18-28(31)38-15-5-6-24(29(38)35-18)42-17-21-22(32)12-13-23(27(21)33)37(4)26(40)16-34-25(39)14-9-19-7-10-20(11-8-19)30(41)36(2)3/h5-15H,16-17H2,1-4H3,(H,34,39)/b14-9+
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n/an/a 1.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067260
PNG
(CHEMBL130452 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C(=O)CNC(=O)CCc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C27H25BrCl2N4O3/c1-17-26(28)34-14-6-9-22(27(34)32-17)37-16-19-20(29)11-12-21(25(19)30)33(2)24(36)15-31-23(35)13-10-18-7-4-3-5-8-18/h3-9,11-12,14H,10,13,15-16H2,1-2H3,(H,31,35)
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n/an/a 1.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067239
PNG
(CHEMBL555556 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(c1)C#N)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H21BrCl2N6O3/c1-15-24(27)35-10-4-7-21(25(35)32-15)38-14-18-19(28)8-9-20(23(18)29)34(2)22(36)13-31-26(37)33-17-6-3-5-16(11-17)12-30/h3-11H,13-14H2,1-2H3,(H2,31,33,37)
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n/an/a 1.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067253
PNG
((E)-3-(4-Acetylamino-phenyl)-N-({[3-(3-bromo-2-met...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(NC(C)=O)cc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C29H26BrCl2N5O4/c1-17-28(30)37-14-4-5-24(29(37)34-17)41-16-21-22(31)11-12-23(27(21)32)36(3)26(40)15-33-25(39)13-8-19-6-9-20(10-7-19)35-18(2)38/h4-14H,15-16H2,1-3H3,(H,33,39)(H,35,38)/b13-8+
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n/an/a 1.60n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067238
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES CCOC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C28H26BrCl2N5O5/c1-4-40-27(38)17-7-5-8-18(13-17)34-28(39)32-14-23(37)35(3)21-11-10-20(30)19(24(21)31)15-41-22-9-6-12-36-25(29)16(2)33-26(22)36/h5-13H,4,14-15H2,1-3H3,(H2,32,34,39)
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n/an/a 2.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067238
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES CCOC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C28H26BrCl2N5O5/c1-4-40-27(38)17-7-5-8-18(13-17)34-28(39)32-14-23(37)35(3)21-11-10-20(30)19(24(21)31)15-41-22-9-6-12-36-25(29)16(2)33-26(22)36/h5-13H,4,14-15H2,1-3H3,(H2,32,34,39)
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n/an/a 2.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067245
PNG
(CHEMBL542473 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES COc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C26H24BrCl2N5O4/c1-15-24(27)34-11-5-8-21(25(34)31-15)38-14-18-19(28)9-10-20(23(18)29)33(2)22(35)13-30-26(36)32-16-6-4-7-17(12-16)37-3/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 2.30n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062860
PNG
(CHEMBL132620 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C)CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H24BrCl2N5O3/c1-13-21(23)30-9-5-6-17(22(30)27-13)33-12-14-15(24)7-8-16(20(14)25)29(4)19(32)10-26-18(31)11-28(2)3/h5-9H,10-12H2,1-4H3,(H,26,31)
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n/an/a 2.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50062860
PNG
(CHEMBL132620 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C)CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H24BrCl2N5O3/c1-13-21(23)30-9-5-6-17(22(30)27-13)33-12-14-15(24)7-8-16(20(14)25)29(4)19(32)10-26-18(31)11-28(2)3/h5-9H,10-12H2,1-4H3,(H,26,31)
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n/an/a 2.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067258
PNG
((E)-N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CNC(=O)Nc1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C29H27BrCl2N6O4/c1-17-27(30)38-14-4-5-23(28(38)35-17)42-16-20-21(31)11-12-22(26(20)32)37(3)25(40)15-34-24(39)13-8-18-6-9-19(10-7-18)36-29(41)33-2/h4-14H,15-16H2,1-3H3,(H,34,39)(H2,33,36,41)/b13-8+
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n/an/a 2.60n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067241
PNG
(CHEMBL543188 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(C)c1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-15-6-4-7-17(12-15)32-26(36)30-13-22(35)33(3)20-10-9-19(28)18(23(20)29)14-37-21-8-5-11-34-24(27)16(2)31-25(21)34/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 2.70n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067246
PNG
(CHEMBL130660 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES COCC(=O)Nc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C28H27BrCl2N6O5/c1-16-26(29)37-11-5-8-22(27(37)33-16)42-14-19-20(30)9-10-21(25(19)31)36(2)24(39)13-32-28(40)35-18-7-4-6-17(12-18)34-23(38)15-41-3/h4-12H,13-15H2,1-3H3,(H,34,38)(H2,32,35,40)
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n/an/a 2.70n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067241
PNG
(CHEMBL543188 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(C)c1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-15-6-4-7-17(12-15)32-26(36)30-13-22(35)33(3)20-10-9-19(28)18(23(20)29)14-37-21-8-5-11-34-24(27)16(2)31-25(21)34/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 2.70n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067248
PNG
(5-{2-[({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CN(C)C(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1
Show InChI InChI=1S/C29H27BrCl2N6O4/c1-17-27(30)38-13-5-6-23(28(38)35-17)42-16-19-20(31)9-11-22(26(19)32)37(4)25(40)15-34-24(39)12-8-18-7-10-21(33-14-18)29(41)36(2)3/h5-14H,15-16H2,1-4H3,(H,34,39)/b12-8+
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n/an/a 3.70n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067261
PNG
(CHEMBL556816 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(Cl)c1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C25H21BrCl3N5O3/c1-14-23(26)34-10-4-7-20(24(34)31-14)37-13-17-18(28)8-9-19(22(17)29)33(2)21(35)12-30-25(36)32-16-6-3-5-15(27)11-16/h3-11H,12-13H2,1-2H3,(H2,30,32,36)
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n/an/a 3.80n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067261
PNG
(CHEMBL556816 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(Cl)c1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C25H21BrCl3N5O3/c1-14-23(26)34-10-4-7-20(24(34)31-14)37-13-17-18(28)8-9-19(22(17)29)33(2)21(35)12-30-25(36)32-16-6-3-5-15(27)11-16/h3-11H,12-13H2,1-2H3,(H2,30,32,36)
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n/an/a 3.80n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067250
PNG
((E)-N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(NS(C)(=O)=O)cc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C28H26BrCl2N5O5S/c1-17-27(29)36-14-4-5-23(28(36)33-17)41-16-20-21(30)11-12-22(26(20)31)35(2)25(38)15-32-24(37)13-8-18-6-9-19(10-7-18)34-42(3,39)40/h4-14,34H,15-16H2,1-3H3,(H,32,37)/b13-8+
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n/an/a 3.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067259
PNG
(CHEMBL130196 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C(=O)CNC(=O)COc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H23BrCl2N4O4/c1-16-25(27)33-12-6-9-21(26(33)31-16)37-14-18-19(28)10-11-20(24(18)29)32(2)23(35)13-30-22(34)15-36-17-7-4-3-5-8-17/h3-12H,13-15H2,1-2H3,(H,30,34)
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n/an/a 4.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067244
PNG
(CHEMBL545765 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(c1)[N+]([O-])=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C25H21BrCl2N6O5/c1-14-23(26)33-10-4-7-20(24(33)30-14)39-13-17-18(27)8-9-19(22(17)28)32(2)21(35)12-29-25(36)31-15-5-3-6-16(11-15)34(37)38/h3-11H,12-13H2,1-2H3,(H2,29,31,36)
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n/an/a 4.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067244
PNG
(CHEMBL545765 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(c1)[N+]([O-])=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C25H21BrCl2N6O5/c1-14-23(26)33-10-4-7-20(24(33)30-14)39-13-17-18(27)8-9-19(22(17)28)32(2)21(35)12-29-25(36)31-15-5-3-6-16(11-15)34(37)38/h3-11H,12-13H2,1-2H3,(H2,29,31,36)
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n/an/a 4.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067250
PNG
((E)-N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(NS(C)(=O)=O)cc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C28H26BrCl2N5O5S/c1-17-27(29)36-14-4-5-23(28(36)33-17)41-16-20-21(30)11-12-22(26(20)31)35(2)25(38)15-32-24(37)13-8-18-6-9-19(10-7-18)34-42(3,39)40/h4-14,34H,15-16H2,1-3H3,(H,32,37)/b13-8+
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n/an/a 4.80n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067249
PNG
(CHEMBL544600 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C(=O)CNC(=O)Cc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H23BrCl2N4O3/c1-16-25(27)33-12-6-9-21(26(33)31-16)36-15-18-19(28)10-11-20(24(18)29)32(2)23(35)14-30-22(34)13-17-7-4-3-5-8-17/h3-12H,13-15H2,1-2H3,(H,30,34)
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n/an/a 5.30n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067252
PNG
(CHEMBL338682 | Hexanoic acid ({[3-(3-bromo-2-methy...)
Show SMILES CCCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C24H27BrCl2N4O3/c1-4-5-6-9-20(32)28-13-21(33)30(3)18-11-10-17(26)16(22(18)27)14-34-19-8-7-12-31-23(25)15(2)29-24(19)31/h7-8,10-12H,4-6,9,13-14H2,1-3H3,(H,28,32)
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n/an/a 5.60n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067255
PNG
(CHEMBL130438 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C(=O)CNC(=O)CCCc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C28H27BrCl2N4O3/c1-18-27(29)35-15-7-11-23(28(35)33-18)38-17-20-21(30)13-14-22(26(20)31)34(2)25(37)16-32-24(36)12-6-10-19-8-4-3-5-9-19/h3-5,7-9,11,13-15H,6,10,12,16-17H2,1-2H3,(H,32,36)
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n/an/a 8.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067255
PNG
(CHEMBL130438 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C(=O)CNC(=O)CCCc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C28H27BrCl2N4O3/c1-18-27(29)35-15-7-11-23(28(35)33-18)38-17-20-21(30)13-14-22(26(20)31)34(2)25(37)16-32-24(36)12-6-10-19-8-4-3-5-9-19/h3-5,7-9,11,13-15H,6,10,12,16-17H2,1-2H3,(H,32,36)
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n/an/a 8.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062878
PNG
(CHEMBL131517 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H23BrCl2N4O3/c1-4-6-18(30)26-11-19(31)28(3)16-9-8-15(24)14(20(16)25)12-32-17-7-5-10-29-21(23)13(2)27-22(17)29/h5,7-10H,4,6,11-12H2,1-3H3,(H,26,30)
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n/an/a 8.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50062878
PNG
(CHEMBL131517 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C22H23BrCl2N4O3/c1-4-6-18(30)26-11-19(31)28(3)16-9-8-15(24)14(20(16)25)12-32-17-7-5-10-29-21(23)13(2)27-22(17)29/h5,7-10H,4,6,11-12H2,1-3H3,(H,26,30)
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n/an/a 8.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062864
PNG
(CHEMBL336116 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C21H22BrCl2N5O3/c1-4-25-21(31)26-10-17(30)28(3)15-8-7-14(23)13(18(15)24)11-32-16-6-5-9-29-19(22)12(2)27-20(16)29/h5-9H,4,10-11H2,1-3H3,(H2,25,26,31)
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n/an/a 9n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067243
PNG
(2-(3-Benzyl-ureido)-N-[3-(3-bromo-2-methyl-imidazo...)
Show SMILES CN(C(=O)CNC(=O)NCc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-16-24(27)34-12-6-9-21(25(34)32-16)37-15-18-19(28)10-11-20(23(18)29)33(2)22(35)14-31-26(36)30-13-17-7-4-3-5-8-17/h3-12H,13-15H2,1-2H3,(H2,30,31,36)
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n/an/a 11n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067243
PNG
(2-(3-Benzyl-ureido)-N-[3-(3-bromo-2-methyl-imidazo...)
Show SMILES CN(C(=O)CNC(=O)NCc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-16-24(27)34-12-6-9-21(25(34)32-16)37-15-18-19(28)10-11-20(23(18)29)33(2)22(35)14-31-26(36)30-13-17-7-4-3-5-8-17/h3-12H,13-15H2,1-2H3,(H2,30,31,36)
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n/an/a 11n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067265
PNG
(CHEMBL542472 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1ccc(C)cc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-15-6-8-17(9-7-15)32-26(36)30-13-22(35)33(3)20-11-10-19(28)18(23(20)29)14-37-21-5-4-12-34-24(27)16(2)31-25(21)34/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 12n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067266
PNG
(2-[3-(3-Amino-phenyl)-ureido]-N-[3-(3-bromo-2-meth...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(N)c1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C25H23BrCl2N6O3/c1-14-23(26)34-10-4-7-20(24(34)31-14)37-13-17-18(27)8-9-19(22(17)28)33(2)21(35)12-30-25(36)32-16-6-3-5-15(29)11-16/h3-11H,12-13,29H2,1-2H3,(H2,30,32,36)
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n/an/a 15n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067266
PNG
(2-[3-(3-Amino-phenyl)-ureido]-N-[3-(3-bromo-2-meth...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(N)c1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C25H23BrCl2N6O3/c1-14-23(26)34-10-4-7-20(24(34)31-14)37-13-17-18(27)8-9-19(22(17)28)33(2)21(35)12-30-25(36)32-16-6-3-5-15(29)11-16/h3-11H,12-13,29H2,1-2H3,(H2,30,32,36)
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n/an/a 15n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067236
PNG
((E)-3-[4-(Acetyl-methyl-amino)-phenyl]-N-({[3-(3-b...)
Show SMILES CN(C(C)=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C30H28BrCl2N5O4/c1-18-29(31)38-15-5-6-25(30(38)35-18)42-17-22-23(32)12-13-24(28(22)33)37(4)27(41)16-34-26(40)14-9-20-7-10-21(11-8-20)36(3)19(2)39/h5-15H,16-17H2,1-4H3,(H,34,40)/b14-9+
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n/an/a 16n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50062863
PNG
(2-Acetylamino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a...)
Show SMILES CN(C(=O)CNC(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C20H19BrCl2N4O3/c1-11-19(21)27-8-4-5-16(20(27)25-11)30-10-13-14(22)6-7-15(18(13)23)26(3)17(29)9-24-12(2)28/h4-8H,9-10H2,1-3H3,(H,24,28)
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n/an/a 16n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067257
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES CN(C)C(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C28H27BrCl2N6O4/c1-16-25(29)37-12-6-9-22(26(37)33-16)41-15-19-20(30)10-11-21(24(19)31)36(4)23(38)14-32-28(40)34-18-8-5-7-17(13-18)27(39)35(2)3/h5-13H,14-15H2,1-4H3,(H2,32,34,40)
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n/an/a 20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067233
PNG
(2-[3-(3-Acetyl-phenyl)-ureido]-N-[3-(3-bromo-2-met...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(c1)C(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C27H24BrCl2N5O4/c1-15-25(28)35-11-5-8-22(26(35)32-15)39-14-19-20(29)9-10-21(24(19)30)34(3)23(37)13-31-27(38)33-18-7-4-6-17(12-18)16(2)36/h4-12H,13-14H2,1-3H3,(H2,31,33,38)
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n/an/a 61n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067254
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(c1)C(O)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H22BrCl2N5O5/c1-14-23(27)34-10-4-7-20(24(34)31-14)39-13-17-18(28)8-9-19(22(17)29)33(2)21(35)12-30-26(38)32-16-6-3-5-15(11-16)25(36)37/h3-11H,12-13H2,1-2H3,(H,36,37)(H2,30,32,38)
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n/an/a 63n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067254
PNG
(3-[3-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-...)
Show SMILES CN(C(=O)CNC(=O)Nc1cccc(c1)C(O)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H22BrCl2N5O5/c1-14-23(27)34-10-4-7-20(24(34)31-14)39-13-17-18(28)8-9-19(22(17)29)33(2)21(35)12-30-26(38)32-16-6-3-5-15(11-16)25(36)37/h3-11H,12-13H2,1-2H3,(H,36,37)(H2,30,32,38)
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n/an/a 63n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067246
PNG
(CHEMBL130660 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES COCC(=O)Nc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C28H27BrCl2N6O5/c1-16-26(29)37-11-5-8-22(27(37)33-16)42-14-19-20(30)9-10-21(25(19)31)36(2)24(39)13-32-28(40)35-18-7-4-6-17(12-18)34-23(38)15-41-3/h4-12H,13-15H2,1-3H3,(H,34,38)(H2,32,35,40)
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n/an/a 75n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067237
PNG
(CHEMBL336209 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1ccccc1C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-15-7-4-5-8-19(15)32-26(36)30-13-22(35)33(3)20-11-10-18(28)17(23(20)29)14-37-21-9-6-12-34-24(27)16(2)31-25(21)34/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 83n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067264
PNG
((Z)-N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin...)
Show SMILES CN(C(=O)CNC(=O)\C=C/c1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C27H23BrCl2N4O3/c1-17-26(28)34-14-6-9-22(27(34)32-17)37-16-19-20(29)11-12-21(25(19)30)33(2)24(36)15-31-23(35)13-10-18-7-4-3-5-8-18/h3-14H,15-16H2,1-2H3,(H,31,35)/b13-10-
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n/an/a 120n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067237
PNG
(CHEMBL336209 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1ccccc1C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-15-7-4-5-8-19(15)32-26(36)30-13-22(35)33(3)20-11-10-18(28)17(23(20)29)14-37-21-9-6-12-34-24(27)16(2)31-25(21)34/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 150n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067256
PNG
(CHEMBL559195 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C25H22BrCl2N5O3/c1-15-23(26)33-12-6-9-20(24(33)30-15)36-14-17-18(27)10-11-19(22(17)28)32(2)21(34)13-29-25(35)31-16-7-4-3-5-8-16/h3-12H,13-14H2,1-2H3,(H2,29,31,35)
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n/an/a 150n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067245
PNG
(CHEMBL542473 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES COc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1
Show InChI InChI=1S/C26H24BrCl2N5O4/c1-15-24(27)34-11-5-8-21(25(34)31-15)38-14-18-19(28)9-10-20(23(18)29)33(2)22(35)13-30-26(36)32-16-6-4-7-17(12-16)37-3/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 200n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067252
PNG
(CHEMBL338682 | Hexanoic acid ({[3-(3-bromo-2-methy...)
Show SMILES CCCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C24H27BrCl2N4O3/c1-4-5-6-9-20(32)28-13-21(33)30(3)18-11-10-17(26)16(22(18)27)14-34-19-8-7-12-31-23(25)15(2)29-24(19)31/h7-8,10-12H,4-6,9,13-14H2,1-3H3,(H,28,32)
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n/an/a 240n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067265
PNG
(CHEMBL542472 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CN(C(=O)CNC(=O)Nc1ccc(C)cc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H24BrCl2N5O3/c1-15-6-8-17(9-7-15)32-26(36)30-13-22(35)33(3)20-11-10-19(28)18(23(20)29)14-37-21-5-4-12-34-24(27)16(2)31-25(21)34/h4-12H,13-14H2,1-3H3,(H2,30,32,36)
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n/an/a 260n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067234
PNG
(2-(3-Benzoyl-ureido)-N-[3-(3-bromo-2-methyl-imidaz...)
Show SMILES CN(C(=O)CNC(=O)NC(=O)c1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H22BrCl2N5O4/c1-15-23(27)34-12-6-9-20(24(34)31-15)38-14-17-18(28)10-11-19(22(17)29)33(2)21(35)13-30-26(37)32-25(36)16-7-4-3-5-8-16/h3-12H,13-14H2,1-2H3,(H2,30,32,36,37)
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n/an/a 340n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067234
PNG
(2-(3-Benzoyl-ureido)-N-[3-(3-bromo-2-methyl-imidaz...)
Show SMILES CN(C(=O)CNC(=O)NC(=O)c1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H22BrCl2N5O4/c1-15-23(27)34-12-6-9-20(24(34)31-15)38-14-17-18(28)10-11-19(22(17)29)33(2)21(35)13-30-26(37)32-25(36)16-7-4-3-5-8-16/h3-12H,13-14H2,1-2H3,(H2,30,32,36,37)
MMDB

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n/an/a 340n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067260
PNG
(CHEMBL130452 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C(=O)CNC(=O)CCc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C27H25BrCl2N4O3/c1-17-26(28)34-14-6-9-22(27(34)32-17)37-16-19-20(29)11-12-21(25(19)30)33(2)24(36)15-31-23(35)13-10-18-7-4-3-5-8-18/h3-9,11-12,14H,10,13,15-16H2,1-2H3,(H,31,35)
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n/an/a 350n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067259
PNG
(CHEMBL130196 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C(=O)CNC(=O)COc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H23BrCl2N4O4/c1-16-25(27)33-12-6-9-21(26(33)31-16)37-14-18-19(28)10-11-20(24(18)29)32(2)23(35)13-30-22(34)15-36-17-7-4-3-5-8-17/h3-12H,13-15H2,1-2H3,(H,30,34)
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n/an/a 510n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067249
PNG
(CHEMBL544600 | N-({[3-(3-Bromo-2-methyl-imidazo[1,...)
Show SMILES CN(C(=O)CNC(=O)Cc1ccccc1)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C26H23BrCl2N4O3/c1-16-25(27)33-12-6-9-21(26(33)31-16)36-15-18-19(28)10-11-20(24(18)29)32(2)23(35)14-30-22(34)13-17-7-4-3-5-8-17/h3-12H,13-15H2,1-2H3,(H,30,34)
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n/an/a 670n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50062864
PNG
(CHEMBL336116 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-...)
Show SMILES CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C21H22BrCl2N5O3/c1-4-25-21(31)26-10-17(30)28(3)15-8-7-14(23)13(18(15)24)11-32-16-6-5-9-29-19(22)12(2)27-20(16)29/h5-9H,4,10-11H2,1-3H3,(H2,25,26,31)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50062863
PNG
(2-Acetylamino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a...)
Show SMILES CN(C(=O)CNC(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Show InChI InChI=1S/C20H19BrCl2N4O3/c1-11-19(21)27-8-4-5-16(20(27)25-11)30-10-13-14(22)6-7-15(18(13)23)26(3)17(29)9-24-12(2)28/h4-8H,9-10H2,1-3H3,(H,24,28)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B...


J Med Chem 41: 4053-61 (1998)


Article DOI: 10.1021/jm980214f
BindingDB Entry DOI: 10.7270/Q2WQ04GV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%