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PubMed code 9804698

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067929
PNG
(4-(2-{[(E)-3-(4-Dimethylcarbamoyl-phenyl)-acryloyl...)
Show SMILES CN(C)C(=O)c1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(C(=O)N(C)C)c(COc3cccc4ccc(C)nc34)c2C(=O)N(C)C)cc1
Show InChI InChI=1S/C40H42N6O5/c1-26-13-17-28-10-8-12-34(37(28)42-26)51-25-32-31(39(49)44(4)5)20-21-33(36(32)40(50)45(6)7)46-23-9-11-30(46)24-41-35(47)22-16-27-14-18-29(19-15-27)38(48)43(2)3/h8-23H,24-25H2,1-7H3,(H,41,47)/b22-16+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067930
PNG
(4-[(E)-2-({1-[2,4-Dichloro-3-(2-methyl-quinolin-8-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C33H28Cl2N4O3/c1-21-8-12-23-5-3-7-29(32(23)38-21)42-20-26-27(34)15-16-28(31(26)35)39-18-4-6-25(39)19-37-30(40)17-11-22-9-13-24(14-10-22)33(41)36-2/h3-18H,19-20H2,1-2H3,(H,36,41)(H,37,40)/b17-11+
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n/an/a 0.260n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067923
PNG
(3-(6-Acetylamino-pyridin-3-yl)-N-{1-[2,4-bis-acety...)
Show SMILES CC(=O)Nc1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(NC(C)=O)c(COc3cccc4ccc(C)nc34)c2NC(C)=O)cn1
Show InChI InChI=1S/C36H35N7O5/c1-22-10-13-27-7-5-9-32(35(27)39-22)48-21-29-30(40-23(2)44)14-15-31(36(29)42-25(4)46)43-18-6-8-28(43)20-38-34(47)17-12-26-11-16-33(37-19-26)41-24(3)45/h5-19H,20-21H2,1-4H3,(H,38,47)(H,40,44)(H,42,46)(H,37,41,45)/b17-12+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067917
PNG
((E)-N-{1-[3-(2-Methyl-quinolin-8-yloxymethyl)-2,4-...)
Show SMILES Cc1ccc2cccc(OCc3c(ccc(c3N3CCCC3=O)-n3cccc3CNC(=O)\C=C\c3ccc(cc3)N3CCCC3=O)N3CCCC3=O)c2n1
Show InChI InChI=1S/C43H42N6O5/c1-29-13-17-31-7-2-9-37(42(31)45-29)54-28-34-35(48-25-5-11-40(48)52)20-21-36(43(34)49-26-6-12-41(49)53)46-23-3-8-33(46)27-44-38(50)22-16-30-14-18-32(19-15-30)47-24-4-10-39(47)51/h2-3,7-9,13-23H,4-6,10-12,24-28H2,1H3,(H,44,50)/b22-16+
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n/an/a 0.410n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to human recombinant Bradykinin receptor B2 expressed in CHO cells.


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067929
PNG
(4-(2-{[(E)-3-(4-Dimethylcarbamoyl-phenyl)-acryloyl...)
Show SMILES CN(C)C(=O)c1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(C(=O)N(C)C)c(COc3cccc4ccc(C)nc34)c2C(=O)N(C)C)cc1
Show InChI InChI=1S/C40H42N6O5/c1-26-13-17-28-10-8-12-34(37(28)42-26)51-25-32-31(39(49)44(4)5)20-21-33(36(32)40(50)45(6)7)46-23-9-11-30(46)24-41-35(47)22-16-27-14-18-29(19-15-27)38(48)43(2)3/h8-23H,24-25H2,1-7H3,(H,41,47)/b22-16+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to human recombinant Bradykinin receptor B2 expressed in CHO cells.


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067301
PNG
((E)-3-(6-Acetylamino-pyridin-3-yl)-N-({[2,4-dichlo...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(NC(C)=O)nc1)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl
Show InChI InChI=1S/C30H27Cl2N5O4/c1-18-7-10-21-5-4-6-25(30(21)35-18)41-17-22-23(31)11-12-24(29(22)32)37(3)28(40)16-34-27(39)14-9-20-8-13-26(33-15-20)36-19(2)38/h4-15H,16-17H2,1-3H3,(H,34,39)(H,33,36,38)/b14-9+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067915
PNG
((E)-N-({Methyl-[3-(2-methyl-quinolin-8-yloxymethyl...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(\C=C\c2ccncc2)nc1)c1ccc(\C=C\c2ccncc2)c(COc2cccc3ccc(C)nc23)c1\C=C\c1ccncc1
Show InChI InChI=1S/C49H41N7O3/c1-35-6-12-41-4-3-5-46(49(41)55-35)59-34-44-40(13-7-36-20-26-50-27-21-36)14-18-45(43(44)17-10-38-24-30-52-31-25-38)56(2)48(58)33-54-47(57)19-11-39-9-16-42(53-32-39)15-8-37-22-28-51-29-23-37/h3-32H,33-34H2,1-2H3,(H,54,57)/b13-7+,15-8+,17-10+,19-11+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067281
PNG
(4-{(E)-2-[({[2,4-Dichloro-3-(2-methyl-quinolin-8-y...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C31H28Cl2N4O4/c1-19-7-11-21-5-4-6-26(30(21)36-19)41-18-23-24(32)14-15-25(29(23)33)37(3)28(39)17-35-27(38)16-10-20-8-12-22(13-9-20)31(40)34-2/h4-16H,17-18H2,1-3H3,(H,34,40)(H,35,38)/b16-10+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067928
PNG
(CHEMBL544623 | N-{1-[3-(2-Methyl-quinolin-8-yloxym...)
Show SMILES Cc1ccc2cccc(OCc3c(\C=C\c4ccncc4)ccc(c3\C=C\c3ccncc3)-n3cccc3CNC(=O)\C=C\c3ccc(\C=C\c4ccncc4)nc3)c2n1
Show InChI InChI=1S/C51H41N7O2/c1-37-7-13-43-4-2-6-49(51(43)57-37)60-36-47-42(14-8-38-21-27-52-28-22-38)15-19-48(46(47)18-11-40-25-31-54-32-26-40)58-33-3-5-45(58)35-56-50(59)20-12-41-10-17-44(55-34-41)16-9-39-23-29-53-30-24-39/h2-34H,35-36H2,1H3,(H,56,59)/b14-8+,16-9+,18-11+,20-12+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to human recombinant Bradykinin receptor B2 expressed in CHO cells.


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067932
PNG
((E)-N-({Methyl-[3-(2-methyl-quinolin-8-yloxymethyl...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(cc1)N1CCCC1=O)c1ccc(N2CCCC2=O)c(COc2cccc3ccc(C)nc23)c1N1CCCC1=O
Show InChI InChI=1S/C41H42N6O6/c1-27-12-16-29-7-3-8-34(40(29)43-27)53-26-31-32(46-23-5-10-37(46)50)19-20-33(41(31)47-24-6-11-38(47)51)44(2)39(52)25-42-35(48)21-15-28-13-17-30(18-14-28)45-22-4-9-36(45)49/h3,7-8,12-21H,4-6,9-11,22-26H2,1-2H3,(H,42,48)/b21-15+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067923
PNG
(3-(6-Acetylamino-pyridin-3-yl)-N-{1-[2,4-bis-acety...)
Show SMILES CC(=O)Nc1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(NC(C)=O)c(COc3cccc4ccc(C)nc34)c2NC(C)=O)cn1
Show InChI InChI=1S/C36H35N7O5/c1-22-10-13-27-7-5-9-32(35(27)39-22)48-21-29-30(40-23(2)44)14-15-31(36(29)42-25(4)46)43-18-6-8-28(43)20-38-34(47)17-12-26-11-16-33(37-19-26)41-24(3)45/h5-19H,20-21H2,1-4H3,(H,38,47)(H,40,44)(H,42,46)(H,37,41,45)/b17-12+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067917
PNG
((E)-N-{1-[3-(2-Methyl-quinolin-8-yloxymethyl)-2,4-...)
Show SMILES Cc1ccc2cccc(OCc3c(ccc(c3N3CCCC3=O)-n3cccc3CNC(=O)\C=C\c3ccc(cc3)N3CCCC3=O)N3CCCC3=O)c2n1
Show InChI InChI=1S/C43H42N6O5/c1-29-13-17-31-7-2-9-37(42(31)45-29)54-28-34-35(48-25-5-11-40(48)52)20-21-36(43(34)49-26-6-12-41(49)53)46-23-3-8-33(46)27-44-38(50)22-16-30-14-18-32(19-15-30)47-24-4-10-39(47)51/h2-3,7-9,13-23H,4-6,10-12,24-28H2,1H3,(H,44,50)/b22-16+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067930
PNG
(4-[(E)-2-({1-[2,4-Dichloro-3-(2-methyl-quinolin-8-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C33H28Cl2N4O3/c1-21-8-12-23-5-3-7-29(32(23)38-21)42-20-26-27(34)15-16-28(31(26)35)39-18-4-6-25(39)19-37-30(40)17-11-22-9-13-24(14-10-22)33(41)36-2/h3-18H,19-20H2,1-2H3,(H,36,41)(H,37,40)/b17-11+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067922
PNG
(CHEMBL538784 | N*1*,N*3*-Dimethyl-4-(methyl-{2-[3-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1
Show InChI InChI=1S/C34H35N7O6/c1-20-9-12-22-7-6-8-27(31(22)40-20)47-19-24-23(32(44)35-2)13-15-26(30(24)34(46)37-4)41(5)29(43)18-39-28(42)16-11-21-10-14-25(38-17-21)33(45)36-3/h6-17H,18-19H2,1-5H3,(H,35,44)(H,36,45)(H,37,46)(H,39,42)/b16-11+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067915
PNG
((E)-N-({Methyl-[3-(2-methyl-quinolin-8-yloxymethyl...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(\C=C\c2ccncc2)nc1)c1ccc(\C=C\c2ccncc2)c(COc2cccc3ccc(C)nc23)c1\C=C\c1ccncc1
Show InChI InChI=1S/C49H41N7O3/c1-35-6-12-41-4-3-5-46(49(41)55-35)59-34-44-40(13-7-36-20-26-50-27-21-36)14-18-45(43(44)17-10-38-24-30-52-31-25-38)56(2)48(58)33-54-47(57)19-11-39-9-16-42(53-32-39)15-8-37-22-28-51-29-23-37/h3-32H,33-34H2,1-2H3,(H,54,57)/b13-7+,15-8+,17-10+,19-11+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067916
PNG
(CHEMBL555006 | N*1*,N*3*-Dimethyl-4-(2-{[3-(6-meth...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1
Show InChI InChI=1S/C36H35N7O5/c1-22-10-13-24-7-5-9-30(33(24)42-22)48-21-27-26(34(45)37-2)14-16-29(32(27)36(47)39-4)43-18-6-8-25(43)20-41-31(44)17-12-23-11-15-28(40-19-23)35(46)38-3/h5-19H,20-21H2,1-4H3,(H,37,45)(H,38,46)(H,39,47)(H,41,44)/b17-12+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067287
PNG
(4-{(E)-2-[({[2,4-Dimethyl-3-(2-methyl-quinolin-8-y...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C33H34N4O4/c1-21-9-17-28(23(3)27(21)20-41-29-8-6-7-25-14-10-22(2)36-32(25)29)37(5)31(39)19-35-30(38)18-13-24-11-15-26(16-12-24)33(40)34-4/h6-18H,19-20H2,1-5H3,(H,34,40)(H,35,38)/b18-13+
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n/an/a 0.970n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067281
PNG
(4-{(E)-2-[({[2,4-Dichloro-3-(2-methyl-quinolin-8-y...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C31H28Cl2N4O4/c1-19-7-11-21-5-4-6-26(30(21)36-19)41-18-23-24(32)14-15-25(29(23)33)37(3)28(39)17-35-27(38)16-10-20-8-12-22(13-9-20)31(40)34-2/h4-16H,17-18H2,1-3H3,(H,34,40)(H,35,38)/b16-10+
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n/an/a 1.10n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to human recombinant Bradykinin receptor B2 expressed in CHO cells.


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067927
PNG
(4-({2-[(E)-3-(4-Dimethylcarbamoyl-phenyl)-acryloyl...)
Show SMILES CN(C)C(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(C(=O)N(C)C)c(COc3cccc4ccc(C)nc34)c2C(=O)N(C)C)cc1
Show InChI InChI=1S/C38H42N6O6/c1-24-12-16-26-10-9-11-31(35(26)40-24)50-23-29-28(37(48)42(4)5)19-20-30(34(29)38(49)43(6)7)44(8)33(46)22-39-32(45)21-15-25-13-17-27(18-14-25)36(47)41(2)3/h9-21H,22-23H2,1-8H3,(H,39,45)/b21-15+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067301
PNG
((E)-3-(6-Acetylamino-pyridin-3-yl)-N-({[2,4-dichlo...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(NC(C)=O)nc1)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl
Show InChI InChI=1S/C30H27Cl2N5O4/c1-18-7-10-21-5-4-6-25(30(21)35-18)41-17-22-23(31)11-12-24(29(22)32)37(3)28(40)16-34-27(39)14-9-20-8-13-26(33-15-20)36-19(2)38/h4-15H,16-17H2,1-3H3,(H,34,39)(H,33,36,38)/b14-9+
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n/an/a 1.40n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067916
PNG
(CHEMBL555006 | N*1*,N*3*-Dimethyl-4-(2-{[3-(6-meth...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1
Show InChI InChI=1S/C36H35N7O5/c1-22-10-13-24-7-5-9-30(33(24)42-22)48-21-27-26(34(45)37-2)14-16-29(32(27)36(47)39-4)43-18-6-8-25(43)20-41-31(44)17-12-23-11-15-28(40-19-23)35(46)38-3/h5-19H,20-21H2,1-4H3,(H,37,45)(H,38,46)(H,39,47)(H,41,44)/b17-12+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067921
PNG
(4-((E)-2-{[2',4'-Dimethyl-3'-(2-methyl-quinolin-8-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCc2ccccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C37H35N3O3/c1-24-12-20-31(26(3)33(24)23-43-34-11-7-9-28-17-13-25(2)40-36(28)34)32-10-6-5-8-30(32)22-39-35(41)21-16-27-14-18-29(19-15-27)37(42)38-4/h5-21H,22-23H2,1-4H3,(H,38,42)(H,39,41)/b21-16+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067928
PNG
(CHEMBL544623 | N-{1-[3-(2-Methyl-quinolin-8-yloxym...)
Show SMILES Cc1ccc2cccc(OCc3c(\C=C\c4ccncc4)ccc(c3\C=C\c3ccncc3)-n3cccc3CNC(=O)\C=C\c3ccc(\C=C\c4ccncc4)nc3)c2n1
Show InChI InChI=1S/C51H41N7O2/c1-37-7-13-43-4-2-6-49(51(43)57-37)60-36-47-42(14-8-38-21-27-52-28-22-38)15-19-48(46(47)18-11-40-25-31-54-32-26-40)58-33-3-5-45(58)35-56-50(59)20-12-41-10-17-44(55-34-41)16-9-39-23-29-53-30-24-39/h2-34H,35-36H2,1H3,(H,56,59)/b14-8+,16-9+,18-11+,20-12+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067921
PNG
(4-((E)-2-{[2',4'-Dimethyl-3'-(2-methyl-quinolin-8-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCc2ccccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C37H35N3O3/c1-24-12-20-31(26(3)33(24)23-43-34-11-7-9-28-17-13-25(2)40-36(28)34)32-10-6-5-8-30(32)22-39-35(41)21-16-27-14-18-29(19-15-27)37(42)38-4/h5-21H,22-23H2,1-4H3,(H,38,42)(H,39,41)/b21-16+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to human recombinant Bradykinin receptor B2 expressed in CHO cells.


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067919
PNG
(4-[(E)-2-({3-[2,4-Dimethyl-3-(2-methyl-quinolin-8-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCc2sccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C35H33N3O3S/c1-22-8-16-28(24(3)30(22)21-41-31-7-5-6-26-13-9-23(2)38-34(26)31)29-18-19-42-32(29)20-37-33(39)17-12-25-10-14-27(15-11-25)35(40)36-4/h5-19H,20-21H2,1-4H3,(H,36,40)(H,37,39)/b17-12+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067932
PNG
((E)-N-({Methyl-[3-(2-methyl-quinolin-8-yloxymethyl...)
Show SMILES CN(C(=O)CNC(=O)\C=C\c1ccc(cc1)N1CCCC1=O)c1ccc(N2CCCC2=O)c(COc2cccc3ccc(C)nc23)c1N1CCCC1=O
Show InChI InChI=1S/C41H42N6O6/c1-27-12-16-29-7-3-8-34(40(29)43-27)53-26-31-32(46-23-5-10-37(46)50)19-20-33(41(31)47-24-6-11-38(47)51)44(2)39(52)25-42-35(48)21-15-28-13-17-30(18-14-28)45-22-4-9-36(45)49/h3,7-8,12-21H,4-6,9-11,22-26H2,1-2H3,(H,42,48)/b21-15+
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n/an/a 3.20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067927
PNG
(4-({2-[(E)-3-(4-Dimethylcarbamoyl-phenyl)-acryloyl...)
Show SMILES CN(C)C(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(C(=O)N(C)C)c(COc3cccc4ccc(C)nc34)c2C(=O)N(C)C)cc1
Show InChI InChI=1S/C38H42N6O6/c1-24-12-16-26-10-9-11-31(35(26)40-24)50-23-29-28(37(48)42(4)5)19-20-30(34(29)38(49)43(6)7)44(8)33(46)22-39-32(45)21-15-25-13-17-27(18-14-25)36(47)41(2)3/h9-21H,22-23H2,1-8H3,(H,39,45)/b21-15+
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n/an/a 3.90n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to human recombinant Bradykinin receptor B2 expressed in CHO cells.


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067922
PNG
(CHEMBL538784 | N*1*,N*3*-Dimethyl-4-(methyl-{2-[3-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1
Show InChI InChI=1S/C34H35N7O6/c1-20-9-12-22-7-6-8-27(31(22)40-20)47-19-24-23(32(44)35-2)13-15-26(30(24)34(46)37-4)41(5)29(43)18-39-28(42)16-11-21-10-14-25(38-17-21)33(45)36-3/h6-17H,18-19H2,1-5H3,(H,35,44)(H,36,45)(H,37,46)(H,39,42)/b16-11+
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n/an/a 4.60n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067287
PNG
(4-{(E)-2-[({[2,4-Dimethyl-3-(2-methyl-quinolin-8-y...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C33H34N4O4/c1-21-9-17-28(23(3)27(21)20-41-29-8-6-7-25-14-10-22(2)36-32(25)29)37(5)31(39)19-35-30(38)18-13-24-11-15-26(16-12-24)33(40)34-4/h6-18H,19-20H2,1-5H3,(H,34,40)(H,35,38)/b18-13+
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n/an/a 4.80n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067926
PNG
(4-{(E)-2-[({[4-Chloro-3-(2-methyl-quinolin-8-yloxy...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2)cc1
Show InChI InChI=1S/C31H29ClN4O4/c1-20-7-11-22-5-4-6-27(30(22)35-20)40-19-24-17-25(14-15-26(24)32)36(3)29(38)18-34-28(37)16-10-21-8-12-23(13-9-21)31(39)33-2/h4-17H,18-19H2,1-3H3,(H,33,39)(H,34,37)/b16-10+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067919
PNG
(4-[(E)-2-({3-[2,4-Dimethyl-3-(2-methyl-quinolin-8-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCc2sccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C35H33N3O3S/c1-22-8-16-28(24(3)30(22)21-41-31-7-5-6-26-13-9-23(2)38-34(26)31)29-18-19-42-32(29)20-37-33(39)17-12-25-10-14-27(15-11-25)35(40)36-4/h5-19H,20-21H2,1-4H3,(H,36,40)(H,37,39)/b17-12+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067925
PNG
(4-((E)-2-{(Z)-3-[2,4-Dichloro-3-(2-methyl-quinolin...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NC\C=C/c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C31H27Cl2N3O3/c1-20-8-12-23-5-3-7-27(30(23)36-20)39-19-25-26(32)16-15-22(29(25)33)6-4-18-35-28(37)17-11-21-9-13-24(14-10-21)31(38)34-2/h3-17H,18-19H2,1-2H3,(H,34,38)(H,35,37)/b6-4-,17-11+
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n/an/a 14n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067931
PNG
(CHEMBL342195 | N-Methyl-4-{(E)-2-[({methyl-[2-meth...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2cccc(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C32H32N4O4/c1-21-11-15-24-7-6-10-28(31(24)35-21)40-20-26-8-5-9-27(22(26)2)36(4)30(38)19-34-29(37)18-14-23-12-16-25(17-13-23)32(39)33-3/h5-18H,19-20H2,1-4H3,(H,33,39)(H,34,37)/b18-14+
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Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067924
PNG
(4-{(E)-2-[({[2,4-Dimethoxy-3-(2-methyl-quinolin-8-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(OC)c(COc3cccc4ccc(C)nc34)c2OC)cc1
Show InChI InChI=1S/C33H34N4O6/c1-21-9-13-23-7-6-8-28(31(23)36-21)43-20-25-27(41-4)17-16-26(32(25)42-5)37(3)30(39)19-35-29(38)18-12-22-10-14-24(15-11-22)33(40)34-2/h6-18H,19-20H2,1-5H3,(H,34,40)(H,35,38)/b18-12+
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n/an/a 17n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067925
PNG
(4-((E)-2-{(Z)-3-[2,4-Dichloro-3-(2-methyl-quinolin...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NC\C=C/c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C31H27Cl2N3O3/c1-20-8-12-23-5-3-7-27(30(23)36-20)39-19-25-26(32)16-15-22(29(25)33)6-4-18-35-28(37)17-11-21-9-13-24(14-10-21)31(38)34-2/h3-17H,18-19H2,1-2H3,(H,34,38)(H,35,37)/b6-4-,17-11+
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n/an/a 17n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067914
PNG
(4-{(E)-2-[2',4'-Dimethyl-3'-(2-methyl-quinolin-8-y...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)Nc2cccc(c2)-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C36H33N3O3/c1-23-11-19-31(25(3)32(23)22-42-33-10-6-7-27-16-12-24(2)38-35(27)33)29-8-5-9-30(21-29)39-34(40)20-15-26-13-17-28(18-14-26)36(41)37-4/h5-21H,22H2,1-4H3,(H,37,41)(H,39,40)/b20-15+
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n/an/a 94n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067926
PNG
(4-{(E)-2-[({[4-Chloro-3-(2-methyl-quinolin-8-yloxy...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2)cc1
Show InChI InChI=1S/C31H29ClN4O4/c1-20-7-11-22-5-4-6-27(30(22)35-20)40-19-24-17-25(14-15-26(24)32)36(3)29(38)18-34-28(37)16-10-21-8-12-23(13-9-21)31(39)33-2/h4-17H,18-19H2,1-3H3,(H,33,39)(H,34,37)/b16-10+
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n/an/a 110n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067931
PNG
(CHEMBL342195 | N-Methyl-4-{(E)-2-[({methyl-[2-meth...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2cccc(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C32H32N4O4/c1-21-11-15-24-7-6-10-28(31(24)35-21)40-20-26-8-5-9-27(22(26)2)36(4)30(38)19-34-29(37)18-14-23-12-16-25(17-13-23)32(39)33-3/h5-18H,19-20H2,1-4H3,(H,33,39)(H,34,37)/b18-14+
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n/an/a 150n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067924
PNG
(4-{(E)-2-[({[2,4-Dimethoxy-3-(2-methyl-quinolin-8-...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(OC)c(COc3cccc4ccc(C)nc34)c2OC)cc1
Show InChI InChI=1S/C33H34N4O6/c1-21-9-13-23-7-6-8-28(31(23)36-21)43-20-25-27(41-4)17-16-26(32(25)42-5)37(3)30(39)19-35-29(38)18-12-22-10-14-24(15-11-22)33(40)34-2/h6-18H,19-20H2,1-5H3,(H,34,40)(H,35,38)/b18-12+
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n/an/a 210n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50408663
PNG
(CHEMBL2111974)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NC\C=C\c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C31H27Cl2N3O3/c1-20-8-12-23-5-3-7-27(30(23)36-20)39-19-25-26(32)16-15-22(29(25)33)6-4-18-35-28(37)17-11-21-9-13-24(14-10-21)31(38)34-2/h3-17H,18-19H2,1-2H3,(H,34,38)(H,35,37)/b6-4+,17-11+
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n/an/a 220n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Cavia porcellus)
BDBM50067920
PNG
((E)-3-(6-Acetylamino-pyridin-3-yl)-N-{[2,4-dichlor...)
Show SMILES CC(=O)Nc1ccc(\C=C\C(=O)NCC(=O)Nc2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1
Show InChI InChI=1S/C29H25Cl2N5O4/c1-17-6-9-20-4-3-5-24(29(20)34-17)40-16-21-22(30)10-11-23(28(21)31)36-27(39)15-33-26(38)13-8-19-7-12-25(32-14-19)35-18(2)37/h3-14H,15-16H2,1-2H3,(H,33,38)(H,36,39)(H,32,35,37)/b13-8+
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n/an/a 280n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50408663
PNG
(CHEMBL2111974)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)NC\C=C\c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1
Show InChI InChI=1S/C31H27Cl2N3O3/c1-20-8-12-23-5-3-7-27(30(23)36-20)39-19-25-26(32)16-15-22(29(25)33)6-4-18-35-28(37)17-11-21-9-13-24(14-10-21)31(38)34-2/h3-17H,18-19H2,1-2H3,(H,34,38)(H,35,37)/b6-4+,17-11+
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n/an/a 710n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067920
PNG
((E)-3-(6-Acetylamino-pyridin-3-yl)-N-{[2,4-dichlor...)
Show SMILES CC(=O)Nc1ccc(\C=C\C(=O)NCC(=O)Nc2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1
Show InChI InChI=1S/C29H25Cl2N5O4/c1-17-6-9-20-4-3-5-24(29(20)34-17)40-16-21-22(30)10-11-23(28(21)31)36-27(39)15-33-26(38)13-8-19-7-12-25(32-14-19)35-18(2)37/h3-14H,15-16H2,1-2H3,(H,33,38)(H,36,39)(H,32,35,37)/b13-8+
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n/an/a 4.20E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to Bradykinin receptor B2 in guinea pig ileum membrane preparations


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
BDKRB2


(HUMAN)
BDBM50067914
PNG
(4-{(E)-2-[2',4'-Dimethyl-3'-(2-methyl-quinolin-8-y...)
Show SMILES CNC(=O)c1ccc(\C=C\C(=O)Nc2cccc(c2)-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1
Show InChI InChI=1S/C36H33N3O3/c1-23-11-19-31(25(3)32(23)22-42-33-10-6-7-27-16-12-24(2)38-35(27)33)29-8-5-9-30(21-29)39-34(40)20-15-26-13-17-28(18-14-26)36(41)37-4/h5-21H,22H2,1-4H3,(H,37,41)(H,39,40)/b20-15+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Fujisawa Pharmaceutical Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]BK to human recombinant Bradykinin receptor B2 expressed in CHO cells.


J Med Chem 41: 4587-98 (1998)


Article DOI: 10.1021/jm980330i
BindingDB Entry DOI: 10.7270/Q2ZK5HBR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%