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PubMed code 9857090

Compile data set for download or QSAR
Found 158 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
EDNRA


(RAT)
BDBM50068673
PNG
(2'-Formylaminomethyl-4'-isobutyl-biphenyl-2-sulfon...)
Show SMILES CC(C)Cc1ccc(c(CNC=O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H27N3O4S/c1-15(2)11-18-9-10-20(19(12-18)13-24-14-27)21-7-5-6-8-22(21)31(28,29)26-23-16(3)17(4)25-30-23/h5-10,12,14-15,26H,11,13H2,1-4H3,(H,24,27)
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2n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068706
PNG
(6-(2-Hydroxy-ethoxy)-4'-isobutyl-biphenyl-2-sulfon...)
Show SMILES CC(C)Cc1ccc(cc1)-c1c(OCCO)cccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H28N2O5S/c1-15(2)14-18-8-10-19(11-9-18)22-20(29-13-12-26)6-5-7-21(22)31(27,28)25-23-16(3)17(4)24-30-23/h5-11,15,25-26H,12-14H2,1-4H3
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2.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068674
PNG
(2'-Amino-4'-isobutyl-biphenyl-2-sulfonic acid (3,4...)
Show SMILES CC(C)Cc1ccc(c(N)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H25N3O3S/c1-13(2)11-16-9-10-17(19(22)12-16)18-7-5-6-8-20(18)28(25,26)24-21-14(3)15(4)23-27-21/h5-10,12-13,24H,11,22H2,1-4H3
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4.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068713
PNG
(4'-Isobutyl-2'-methyl-biphenyl-2-sulfonic acid (3,...)
Show SMILES CC(C)Cc1ccc(c(C)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O3S/c1-14(2)12-18-10-11-19(15(3)13-18)20-8-6-7-9-21(20)28(25,26)24-22-16(4)17(5)23-27-22/h6-11,13-14,24H,12H2,1-5H3
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5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068720
PNG
(6-Hydroxy-4'-isobutyl-biphenyl-2-sulfonic acid (3,...)
Show SMILES CC(C)Cc1ccc(cc1)-c1c(O)cccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O4S/c1-13(2)12-16-8-10-17(11-9-16)20-18(24)6-5-7-19(20)28(25,26)23-21-14(3)15(4)22-27-21/h5-11,13,23-24H,12H2,1-4H3
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5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068740
PNG
(2'-Ethylamino-4'-isobutyl-biphenyl-2-sulfonic acid...)
Show SMILES CCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H29N3O3S/c1-6-24-21-14-18(13-15(2)3)11-12-19(21)20-9-7-8-10-22(20)30(27,28)26-23-16(4)17(5)25-29-23/h7-12,14-15,24,26H,6,13H2,1-5H3
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6.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068697
PNG
(2'-(2-Hydroxy-ethylamino)-4'-isobutyl-biphenyl-2-s...)
Show SMILES CC(C)Cc1ccc(c(NCCO)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H29N3O4S/c1-15(2)13-18-9-10-19(21(14-18)24-11-12-27)20-7-5-6-8-22(20)31(28,29)26-23-16(3)17(4)25-30-23/h5-10,14-15,24,26-27H,11-13H2,1-4H3
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6.40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068736
PNG
(2'-Hydroxy-4'-isobutyl-biphenyl-2-sulfonic acid (3...)
Show SMILES CC(C)Cc1ccc(c(O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O4S/c1-13(2)11-16-9-10-17(19(24)12-16)18-7-5-6-8-20(18)28(25,26)23-21-14(3)15(4)22-27-21/h5-10,12-13,23-24H,11H2,1-4H3
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8n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068685
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4,5-dimethyl...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-14(2)13-17-9-11-18(12-10-17)19-7-5-6-8-20(19)27(24,25)23-21-15(3)16(4)26-22-21/h5-12,14H,13H2,1-4H3,(H,22,23)
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13n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068704
PNG
(4'-Isobutyl-2'-methylamino-biphenyl-2-sulfonic aci...)
Show SMILES CNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H27N3O3S/c1-14(2)12-17-10-11-18(20(13-17)23-5)19-8-6-7-9-21(19)29(26,27)25-22-15(3)16(4)24-28-22/h6-11,13-14,23,25H,12H2,1-5H3
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14n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068722
PNG
(5-Amino-4'-isobutyl-biphenyl-2-sulfonic acid (3,4-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(N)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H25N3O3S/c1-13(2)11-16-5-7-17(8-6-16)19-12-18(22)9-10-20(19)28(25,26)24-21-14(3)15(4)23-27-21/h5-10,12-13,24H,11,22H2,1-4H3
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14n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068719
PNG
(4'-Isobutyl-6-methoxy-biphenyl-2-sulfonic acid (3,...)
Show SMILES COc1cccc(c1-c1ccc(CC(C)C)cc1)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O4S/c1-14(2)13-17-9-11-18(12-10-17)21-19(27-5)7-6-8-20(21)29(25,26)24-22-15(3)16(4)23-28-22/h6-12,14,24H,13H2,1-5H3
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16n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068716
PNG
(2'-Amino-biphenyl-2-sulfonic acid (3,4-dimethyl-is...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N)c1C
Show InChI InChI=1S/C17H17N3O3S/c1-11-12(2)19-23-17(11)20-24(21,22)16-10-6-4-8-14(16)13-7-3-5-9-15(13)18/h3-10,20H,18H2,1-2H3
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16n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068717
PNG
(2'-Formylamino-4'-isobutyl-biphenyl-2-sulfonic aci...)
Show SMILES CC(C)Cc1ccc(c(NC=O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H25N3O4S/c1-14(2)11-17-9-10-18(20(12-17)23-13-26)19-7-5-6-8-21(19)30(27,28)25-22-15(3)16(4)24-29-22/h5-10,12-14,25H,11H2,1-4H3,(H,23,26)
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17n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068676
PNG
(4'-Isopropoxy-biphenyl-2-sulfonic acid (3,4-dimeth...)
Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O4S/c1-13(2)25-17-11-9-16(10-12-17)18-7-5-6-8-19(18)27(23,24)22-20-14(3)15(4)21-26-20/h5-13,22H,1-4H3
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17n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068742
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-14(2)13-17-9-11-18(12-10-17)19-7-5-6-8-20(19)27(24,25)23-21-15(3)16(4)22-26-21/h5-12,14,23H,13H2,1-4H3
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18n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068729
PNG
(2'-Fluoro-4'-isobutyl-biphenyl-2-sulfonic acid (3,...)
Show SMILES CC(C)Cc1ccc(c(F)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H23FN2O3S/c1-13(2)11-16-9-10-17(19(22)12-16)18-7-5-6-8-20(18)28(25,26)24-21-14(3)15(4)23-27-21/h5-10,12-13,24H,11H2,1-4H3
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20n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068698
PNG
(2'-Hydroxymethyl-4'-isobutyl-biphenyl-2-sulfonic a...)
Show SMILES CC(C)Cc1ccc(c(CO)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O4S/c1-14(2)11-17-9-10-19(18(12-17)13-25)20-7-5-6-8-21(20)29(26,27)24-22-15(3)16(4)23-28-22/h5-10,12,14,24-25H,11,13H2,1-4H3
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20n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068694
PNG
(4'-Propyl-biphenyl-2-sulfonic acid (3,4-dimethyl-i...)
Show SMILES CCCc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O3S/c1-4-7-16-10-12-17(13-11-16)18-8-5-6-9-19(18)26(23,24)22-20-14(2)15(3)21-25-20/h5-6,8-13,22H,4,7H2,1-3H3
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28n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068677
PNG
(4'-Isobutyl-2'-propylamino-biphenyl-2-sulfonic aci...)
Show SMILES CCCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C24H31N3O3S/c1-6-13-25-22-15-19(14-16(2)3)11-12-20(22)21-9-7-8-10-23(21)31(28,29)27-24-17(4)18(5)26-30-24/h7-12,15-16,25,27H,6,13-14H2,1-5H3
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29n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068686
PNG
(4'-Isobutoxy-biphenyl-2-sulfonic acid (3,4-dimethy...)
Show SMILES CC(C)COc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O4S/c1-14(2)13-26-18-11-9-17(10-12-18)19-7-5-6-8-20(19)28(24,25)23-21-15(3)16(4)22-27-21/h5-12,14,23H,13H2,1-4H3
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32n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068746
PNG
(4'-Methoxy-biphenyl-2-sulfonic acid (3,4-dimethyl-...)
Show SMILES COc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C18H18N2O4S/c1-12-13(2)19-24-18(12)20-25(21,22)17-7-5-4-6-16(17)14-8-10-15(23-3)11-9-14/h4-11,20H,1-3H3
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33n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068738
PNG
(4'-Isobutyl-2'-isopropylamino-biphenyl-2-sulfonic ...)
Show SMILES CC(C)Cc1ccc(c(NC(C)C)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C24H31N3O3S/c1-15(2)13-19-11-12-20(22(14-19)25-16(3)4)21-9-7-8-10-23(21)31(28,29)27-24-17(5)18(6)26-30-24/h7-12,14-16,25,27H,13H2,1-6H3
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34n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068735
PNG
(4'-Butyl-biphenyl-2-sulfonic acid (3,4-dimethyl-is...)
Show SMILES CCCCc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-4-5-8-17-11-13-18(14-12-17)19-9-6-7-10-20(19)27(24,25)23-21-15(2)16(3)22-26-21/h6-7,9-14,23H,4-5,8H2,1-3H3
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37n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068731
PNG
(4'-Isopropylsulfanyl-biphenyl-2-sulfonic acid (3,4...)
Show SMILES CC(C)Sc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O3S2/c1-13(2)26-17-11-9-16(10-12-17)18-7-5-6-8-19(18)27(23,24)22-20-14(3)15(4)21-25-20/h5-13,22H,1-4H3
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39n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068703
PNG
(2'-Hydroxymethyl-biphenyl-2-sulfonic acid (3,4-dim...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2CO)c1C
Show InChI InChI=1S/C18H18N2O4S/c1-12-13(2)19-24-18(12)20-25(22,23)17-10-6-5-9-16(17)15-8-4-3-7-14(15)11-21/h3-10,20-21H,11H2,1-2H3
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40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50329850
PNG
((R)-3-Amino-4-[(S)-2-((R)-1-{(S)-1-[(R)-1-(1H-indo...)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C
Show InChI InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23-,24-,26+/m0/s1
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40n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068691
PNG
(CHEMBL149152 | Lithium; [6-(3,4-dimethyl-isoxazol-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1c(OCC([O-])=O)cccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H26N2O6S/c1-14(2)12-17-8-10-18(11-9-17)22-19(30-13-21(26)27)6-5-7-20(22)32(28,29)25-23-15(3)16(4)24-31-23/h5-11,14,25H,12-13H2,1-4H3,(H,26,27)/p-1
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42n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068710
PNG
(4'-Isobutyl-2'-(3-methyl-ureido)-biphenyl-2-sulfon...)
Show SMILES CNC(=O)Nc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H28N4O4S/c1-14(2)12-17-10-11-18(20(13-17)25-23(28)24-5)19-8-6-7-9-21(19)32(29,30)27-22-15(3)16(4)26-31-22/h6-11,13-14,27H,12H2,1-5H3,(H2,24,25,28)
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43n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068705
PNG
(4'-Isopropyl-biphenyl-2-sulfonic acid (3,4-dimethy...)
Show SMILES CC(C)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O3S/c1-13(2)16-9-11-17(12-10-16)18-7-5-6-8-19(18)26(23,24)22-20-14(3)15(4)21-25-20/h5-13,22H,1-4H3
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50n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068727
PNG
(4'-Isopropylamino-biphenyl-2-sulfonic acid (3,4-di...)
Show SMILES CC(C)Nc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H23N3O3S/c1-13(2)21-17-11-9-16(10-12-17)18-7-5-6-8-19(18)27(24,25)23-20-14(3)15(4)22-26-20/h5-13,21,23H,1-4H3
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50n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068682
PNG
(4'-Dimethylamino-biphenyl-2-sulfonic acid (3,4-dim...)
Show SMILES CN(C)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C19H21N3O3S/c1-13-14(2)20-25-19(13)21-26(23,24)18-8-6-5-7-17(18)15-9-11-16(12-10-15)22(3)4/h5-12,21H,1-4H3
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54n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50034435
PNG
(5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C17H19N3O3S/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4/h5-10,19H,1-4H3
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55n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068701
PNG
(4'-Methyl-biphenyl-2-sulfonic acid (3,4-dimethyl-i...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C)cc2)c1C
Show InChI InChI=1S/C18H18N2O3S/c1-12-8-10-15(11-9-12)16-6-4-5-7-17(16)24(21,22)20-18-13(2)14(3)19-23-18/h4-11,20H,1-3H3
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55n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068683
PNG
(4'-(Isopropyl-methyl-amino)-biphenyl-2-sulfonic ac...)
Show SMILES CC(C)N(C)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H25N3O3S/c1-14(2)24(5)18-12-10-17(11-13-18)19-8-6-7-9-20(19)28(25,26)23-21-15(3)16(4)22-27-21/h6-14,23H,1-5H3
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60n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068687
PNG
(4'-tert-Butyl-biphenyl-2-sulfonic acid (3,4-dimeth...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)C(C)(C)C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-14-15(2)22-26-20(14)23-27(24,25)19-9-7-6-8-18(19)16-10-12-17(13-11-16)21(3,4)5/h6-13,23H,1-5H3
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61n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068680
PNG
(3'-Amino-biphenyl-2-sulfonic acid (3,4-dimethyl-is...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N)c2)c1C
Show InChI InChI=1S/C17H17N3O3S/c1-11-12(2)19-23-17(11)20-24(21,22)16-9-4-3-8-15(16)13-6-5-7-14(18)10-13/h3-10,20H,18H2,1-2H3
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62n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068743
PNG
(4'-Isobutyl-2'-methoxy-biphenyl-2-sulfonic acid (3...)
Show SMILES COc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O4S/c1-14(2)12-17-10-11-18(20(13-17)27-5)19-8-6-7-9-21(19)29(25,26)24-22-15(3)16(4)23-28-22/h6-11,13-14,24H,12H2,1-5H3
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74n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068726
PNG
(4'-(3-Methyl-butyl)-biphenyl-2-sulfonic acid (3,4-...)
Show SMILES CC(C)CCc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O3S/c1-15(2)9-10-18-11-13-19(14-12-18)20-7-5-6-8-21(20)28(25,26)24-22-16(3)17(4)23-27-22/h5-8,11-15,24H,9-10H2,1-4H3
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80n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068688
PNG
(CHEMBL357823 | [2'-(3,4-Dimethyl-isoxazol-5-ylsulf...)
Show SMILES CC(C)Cc1ccc(c(NCC(O)=O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H27N3O5S/c1-14(2)11-17-9-10-18(20(12-17)24-13-22(27)28)19-7-5-6-8-21(19)32(29,30)26-23-15(3)16(4)25-31-23/h5-10,12,14,24,26H,11,13H2,1-4H3,(H,27,28)
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89n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068700
PNG
(Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C
Show InChI InChI=1S/C17H16N2O3S/c1-12-13(2)18-22-17(12)19-23(20,21)16-11-7-6-10-15(16)14-8-4-3-5-9-14/h3-11,19H,1-2H3
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90n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068692
PNG
(2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-isobuty...)
Show SMILES CC(C)Cc1ccc(c(c1)C(N)=O)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H25N3O4S/c1-13(2)11-16-9-10-17(19(12-16)21(23)26)18-7-5-6-8-20(18)30(27,28)25-22-14(3)15(4)24-29-22/h5-10,12-13,25H,11H2,1-4H3,(H2,23,26)
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100n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068690
PNG
(2'-Aminomethyl-4'-isobutyl-biphenyl-2-sulfonic aci...)
Show SMILES CC(C)Cc1ccc(c(CN)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H27N3O3S/c1-14(2)11-17-9-10-19(18(12-17)13-23)20-7-5-6-8-21(20)29(26,27)25-22-15(3)16(4)24-28-22/h5-10,12,14,25H,11,13,23H2,1-4H3
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100n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068741
PNG
(2'-Dimethylamino-biphenyl-2-sulfonic acid (3,4-dim...)
Show SMILES CN(C)c1ccccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C19H21N3O3S/c1-13-14(2)20-25-19(13)21-26(23,24)18-12-8-6-10-16(18)15-9-5-7-11-17(15)22(3)4/h5-12,21H,1-4H3
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103n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068695
PNG
(4'-(2,2-Dimethyl-propyl)-biphenyl-2-sulfonic acid ...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)(C)C)cc2)c1C
Show InChI InChI=1S/C22H26N2O3S/c1-15-16(2)23-27-21(15)24-28(25,26)20-9-7-6-8-19(20)18-12-10-17(11-13-18)14-22(3,4)5/h6-13,24H,14H2,1-5H3
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110n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068733
PNG
(4'-(Propane-2-sulfonyl)-biphenyl-2-sulfonic acid (...)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O5S2/c1-13(2)28(23,24)17-11-9-16(10-12-17)18-7-5-6-8-19(18)29(25,26)22-20-14(3)15(4)21-27-20/h5-13,22H,1-4H3
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110n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068748
PNG
(3'-Dimethylamino-biphenyl-2-sulfonic acid (3,4-dim...)
Show SMILES CN(C)c1cccc(c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C19H21N3O3S/c1-13-14(2)20-25-19(13)21-26(23,24)18-11-6-5-10-17(18)15-8-7-9-16(12-15)22(3)4/h5-12,21H,1-4H3
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112n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068707
PNG
(2'-Nitro-biphenyl-2-sulfonic acid (3,4-dimethyl-is...)
Show SMILES Cc1[n-][o+]c(NS(=O)(=O)c2ccccc2-c2ccccc2[N+]([O-])=O)c1C
Show InChI InChI=1S/C17H15N3O5S/c1-11-12(2)18-25-17(11)19-26(23,24)16-10-6-4-8-14(16)13-7-3-5-9-15(13)20(21)22/h3-10,19H,1-2H3
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140n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068678
PNG
(3'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl...)
Show SMILES CC(C)Cc1cccc(c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-14(2)12-17-8-7-9-18(13-17)19-10-5-6-11-20(19)27(24,25)23-21-15(3)16(4)22-26-21/h5-11,13-14,23H,12H2,1-4H3
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190n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068681
PNG
(4'-Benzyloxy-biphenyl-2-sulfonic acid (3,4-dimethy...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCc3ccccc3)cc2)c1C
Show InChI InChI=1S/C24H22N2O4S/c1-17-18(2)25-30-24(17)26-31(27,28)23-11-7-6-10-22(23)20-12-14-21(15-13-20)29-16-19-8-4-3-5-9-19/h3-15,26H,16H2,1-2H3
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190n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50068708
PNG
(CHEMBL148637 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-py...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2cccnc2)c1C
Show InChI InChI=1S/C16H15N3O3S/c1-11-12(2)18-22-16(11)19-23(20,21)15-8-4-3-7-14(15)13-6-5-9-17-10-13/h3-10,19H,1-2H3
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260n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068709
PNG
(2'-Dimethylamino-4'-isobutyl-biphenyl-2-sulfonic a...)
Show SMILES CC(C)Cc1ccc(c(c1)N(C)C)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H29N3O3S/c1-15(2)13-18-11-12-19(21(14-18)26(5)6)20-9-7-8-10-22(20)30(27,28)25-23-16(3)17(4)24-29-23/h7-12,14-15,25H,13H2,1-6H3
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330n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50068696
PNG
(CHEMBL148967 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-(1...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2cc3ccccc3[nH]2)c1C
Show InChI InChI=1S/C19H17N3O3S/c1-12-13(2)21-25-19(12)22-26(23,24)18-10-6-4-8-15(18)17-11-14-7-3-5-9-16(14)20-17/h3-11,20,22H,1-2H3
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340n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068711
PNG
(4'-Isobutyl-5-methoxy-biphenyl-2-sulfonic acid (3,...)
Show SMILES COc1ccc(c(c1)-c1ccc(CC(C)C)cc1)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O4S/c1-14(2)12-17-6-8-18(9-7-17)20-13-19(27-5)10-11-21(20)29(25,26)24-22-15(3)16(4)23-28-22/h6-11,13-14,24H,12H2,1-5H3
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370n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068732
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (6-chloro-pyr...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1ccc(Cl)nn1
Show InChI InChI=1S/C20H20ClN3O2S/c1-14(2)13-15-7-9-16(10-8-15)17-5-3-4-6-18(17)27(25,26)24-20-12-11-19(21)22-23-20/h3-12,14H,13H2,1-2H3,(H,23,24)
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400n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068730
PNG
(4-Hydroxy-4'-isobutyl-biphenyl-2-sulfonic acid (3,...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccc(O)cc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O4S/c1-13(2)11-16-5-7-17(8-6-16)19-10-9-18(24)12-20(19)28(25,26)23-21-14(3)15(4)22-27-21/h5-10,12-13,23-24H,11H2,1-4H3
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500n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50068679
PNG
(CHEMBL357331 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-(1...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2c[nH]c3ccccc23)c1C
Show InChI InChI=1S/C19H17N3O3S/c1-12-13(2)21-25-19(12)22-26(23,24)18-10-6-4-8-15(18)16-11-20-17-9-5-3-7-14(16)17/h3-11,20,22H,1-2H3
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520n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068670
PNG
(CHEMBL358461 | [6-(3,4-Dimethyl-isoxazol-5-ylsulfa...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(NCC(O)=O)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H27N3O5S/c1-14(2)11-17-5-7-18(8-6-17)20-12-19(24-13-22(27)28)9-10-21(20)32(29,30)26-23-15(3)16(4)25-31-23/h5-10,12,14,24,26H,11,13H2,1-4H3,(H,27,28)
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550n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068702
PNG
(Biphenyl-2,4'-disulfonic acid 4'-dimethylamide 2-[...)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C19H21N3O5S2/c1-13-14(2)20-27-19(13)21-28(23,24)18-8-6-5-7-17(18)15-9-11-16(12-10-15)29(25,26)22(3)4/h5-12,21H,1-4H3
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560n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068747
PNG
(CHEMBL342498 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-is...)
Show SMILES CC(C)c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C14H18N2O3S/c1-9(2)12-7-5-6-8-13(12)20(17,18)16-14-10(3)11(4)15-19-14/h5-9,16H,1-4H3
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600n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068728
PNG
(CHEMBL150697 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-tr...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2C(F)(F)F)c1C
Show InChI InChI=1S/C12H11F3N2O3S/c1-7-8(2)16-20-11(7)17-21(18,19)10-6-4-3-5-9(10)12(13,14)15/h3-6,17H,1-2H3
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700n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50068689
PNG
(CHEMBL149018 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-py...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccn2)c1C
Show InChI InChI=1S/C16H15N3O3S/c1-11-12(2)18-22-16(11)19-23(20,21)15-9-4-3-7-13(15)14-8-5-6-10-17-14/h3-10,19H,1-2H3
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820n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50068718
PNG
(CHEMBL151819 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-th...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccsc2)c1C
Show InChI InChI=1S/C15H14N2O3S2/c1-10-11(2)16-20-15(10)17-22(18,19)14-6-4-3-5-13(14)12-7-8-21-9-12/h3-9,17H,1-2H3
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900n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068720
PNG
(6-Hydroxy-4'-isobutyl-biphenyl-2-sulfonic acid (3,...)
Show SMILES CC(C)Cc1ccc(cc1)-c1c(O)cccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O4S/c1-13(2)12-16-8-10-17(11-9-16)20-18(24)6-5-7-19(20)28(25,26)23-21-14(3)15(4)22-27-21/h5-11,13,23-24H,12H2,1-4H3
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940n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50068712
PNG
(CHEMBL357789 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-th...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2cccs2)c1C
Show InChI InChI=1S/C15H14N2O3S2/c1-10-11(2)16-20-15(10)17-22(18,19)14-8-4-3-6-12(14)13-7-5-9-21-13/h3-9,17H,1-2H3
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950n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068671
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4-methyl-iso...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1oncc1C
Show InChI InChI=1S/C20H22N2O3S/c1-14(2)12-16-8-10-17(11-9-16)18-6-4-5-7-19(18)26(23,24)22-20-15(3)13-21-25-20/h4-11,13-14,22H,12H2,1-3H3
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970n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068673
PNG
(2'-Formylaminomethyl-4'-isobutyl-biphenyl-2-sulfon...)
Show SMILES CC(C)Cc1ccc(c(CNC=O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H27N3O4S/c1-15(2)11-18-9-10-20(19(12-18)13-24-14-27)21-7-5-6-8-22(21)31(28,29)26-23-16(3)17(4)25-30-23/h5-10,12,14-15,26H,11,13H2,1-4H3,(H,24,27)
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1.20E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068684
PNG
(2-Amino-N-[6-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(NC(=O)CN)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H28N4O4S/c1-14(2)11-17-5-7-18(8-6-17)20-12-19(25-22(28)13-24)9-10-21(20)32(29,30)27-23-15(3)16(4)26-31-23/h5-10,12,14,27H,11,13,24H2,1-4H3,(H,25,28)
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1.20E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068698
PNG
(2'-Hydroxymethyl-4'-isobutyl-biphenyl-2-sulfonic a...)
Show SMILES CC(C)Cc1ccc(c(CO)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O4S/c1-14(2)11-17-9-10-19(18(12-17)13-25)20-7-5-6-8-21(20)29(26,27)24-22-15(3)16(4)23-28-22/h5-10,12,14,24-25H,11,13H2,1-4H3
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1.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068714
PNG
(4'-Isobutyl-3-methyl-biphenyl-2-sulfonic acid (3,4...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cccc(C)c1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O3S/c1-14(2)13-18-9-11-19(12-10-18)20-8-6-7-15(3)21(20)28(25,26)24-22-16(4)17(5)23-27-22/h6-12,14,24H,13H2,1-5H3
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1.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068740
PNG
(2'-Ethylamino-4'-isobutyl-biphenyl-2-sulfonic acid...)
Show SMILES CCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H29N3O3S/c1-6-24-21-14-18(13-15(2)3)11-12-19(21)20-9-7-8-10-22(20)30(27,28)26-23-16(4)17(5)25-29-23/h7-12,14-15,24,26H,6,13H2,1-5H3
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1.40E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068672
PNG
(2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-isobuty...)
Show SMILES CC(C)Cc1ccc(c(c1)C(O)=O)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H24N2O5S/c1-13(2)11-16-9-10-17(19(12-16)22(25)26)18-7-5-6-8-20(18)30(27,28)24-21-14(3)15(4)23-29-21/h5-10,12-13,24H,11H2,1-4H3,(H,25,26)
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1.50E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068676
PNG
(4'-Isopropoxy-biphenyl-2-sulfonic acid (3,4-dimeth...)
Show SMILES CC(C)Oc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O4S/c1-13(2)25-17-11-9-16(10-12-17)18-7-5-6-8-19(18)27(23,24)22-20-14(3)15(4)21-26-20/h5-13,22H,1-4H3
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1.50E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068697
PNG
(2'-(2-Hydroxy-ethylamino)-4'-isobutyl-biphenyl-2-s...)
Show SMILES CC(C)Cc1ccc(c(NCCO)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H29N3O4S/c1-15(2)13-18-9-10-19(21(14-18)24-11-12-27)20-7-5-6-8-22(20)31(28,29)26-23-16(3)17(4)25-30-23/h5-10,14-15,24,26-27H,11-13H2,1-4H3
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1.60E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068742
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-14(2)13-17-9-11-18(12-10-17)19-7-5-6-8-20(19)27(24,25)23-21-15(3)16(4)22-26-21/h5-12,14,23H,13H2,1-4H3
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1.70E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068674
PNG
(2'-Amino-4'-isobutyl-biphenyl-2-sulfonic acid (3,4...)
Show SMILES CC(C)Cc1ccc(c(N)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H25N3O3S/c1-13(2)11-16-9-10-17(19(22)12-16)18-7-5-6-8-20(18)28(25,26)24-21-14(3)15(4)23-27-21/h5-10,12-13,24H,11,22H2,1-4H3
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1.70E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068735
PNG
(4'-Butyl-biphenyl-2-sulfonic acid (3,4-dimethyl-is...)
Show SMILES CCCCc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-4-5-8-17-11-13-18(14-12-17)19-9-6-7-10-20(19)27(24,25)23-21-15(2)16(3)22-26-21/h6-7,9-14,23H,4-5,8H2,1-3H3
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1.90E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068670
PNG
(CHEMBL358461 | [6-(3,4-Dimethyl-isoxazol-5-ylsulfa...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(NCC(O)=O)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H27N3O5S/c1-14(2)11-17-5-7-18(8-6-17)20-12-19(24-13-22(27)28)9-10-21(20)32(29,30)26-23-15(3)16(4)25-31-23/h5-10,12,14,24,26H,11,13H2,1-4H3,(H,27,28)
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1.90E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068719
PNG
(4'-Isobutyl-6-methoxy-biphenyl-2-sulfonic acid (3,...)
Show SMILES COc1cccc(c1-c1ccc(CC(C)C)cc1)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O4S/c1-14(2)13-17-9-11-18(12-10-17)21-19(27-5)7-6-8-20(21)29(25,26)24-22-15(3)16(4)23-28-22/h6-12,14,24H,13H2,1-5H3
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2.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068685
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4,5-dimethyl...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-14(2)13-17-9-11-18(12-10-17)19-7-5-6-8-20(19)27(24,25)23-21-15(3)16(4)26-22-21/h5-12,14H,13H2,1-4H3,(H,22,23)
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2.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068722
PNG
(5-Amino-4'-isobutyl-biphenyl-2-sulfonic acid (3,4-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(N)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H25N3O3S/c1-13(2)11-16-5-7-17(8-6-16)19-12-18(22)9-10-20(19)28(25,26)24-21-14(3)15(4)23-27-21/h5-10,12-13,24H,11,22H2,1-4H3
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2.10E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068715
PNG
(CHEMBL147007 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-ph...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2Oc2ccccc2)c1C
Show InChI InChI=1S/C17H16N2O4S/c1-12-13(2)18-23-17(12)19-24(20,21)16-11-7-6-10-15(16)22-14-8-4-3-5-9-14/h3-11,19H,1-2H3
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2.10E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068704
PNG
(4'-Isobutyl-2'-methylamino-biphenyl-2-sulfonic aci...)
Show SMILES CNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H27N3O3S/c1-14(2)12-17-10-11-18(20(13-17)23-5)19-8-6-7-9-21(19)29(26,27)25-22-15(3)16(4)24-28-22/h6-11,13-14,23,25H,12H2,1-5H3
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2.20E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068706
PNG
(6-(2-Hydroxy-ethoxy)-4'-isobutyl-biphenyl-2-sulfon...)
Show SMILES CC(C)Cc1ccc(cc1)-c1c(OCCO)cccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H28N2O5S/c1-15(2)14-18-8-10-19(11-9-18)22-20(29-13-12-26)6-5-7-21(22)31(27,28)25-23-16(3)17(4)24-30-23/h5-11,15,25-26H,12-14H2,1-4H3
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2.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068739
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (3-methyl-4-n...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1[o+][n-]c(C)c1[N+]([O-])=O
Show InChI InChI=1S/C20H21N3O5S/c1-13(2)12-15-8-10-16(11-9-15)17-6-4-5-7-18(17)29(26,27)22-20-19(23(24)25)14(3)21-28-20/h4-11,13,22H,12H2,1-3H3
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2.50E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068721
PNG
(CHEMBL150269 | N-[6-(3,4-Dimethyl-isoxazol-5-ylsul...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(NC(C)=O)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H27N3O4S/c1-14(2)12-18-6-8-19(9-7-18)21-13-20(24-17(5)27)10-11-22(21)31(28,29)26-23-15(3)16(4)25-30-23/h6-11,13-14,26H,12H2,1-5H3,(H,24,27)
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2.80E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068686
PNG
(4'-Isobutoxy-biphenyl-2-sulfonic acid (3,4-dimethy...)
Show SMILES CC(C)COc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O4S/c1-14(2)13-26-18-11-9-17(10-12-18)19-7-5-6-8-20(19)28(24,25)23-21-15(3)16(4)22-27-21/h5-12,14,23H,13H2,1-4H3
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2.80E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068738
PNG
(4'-Isobutyl-2'-isopropylamino-biphenyl-2-sulfonic ...)
Show SMILES CC(C)Cc1ccc(c(NC(C)C)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C24H31N3O3S/c1-15(2)13-19-11-12-20(22(14-19)25-16(3)4)21-9-7-8-10-23(21)31(28,29)27-24-17(5)18(6)26-30-24/h7-12,14-16,25,27H,13H2,1-6H3
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2.90E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068744
PNG
(CHEMBL151545 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-ni...)
Show SMILES Cc1[n-][o+]c(NS(=O)(=O)c2ccccc2[N+]([O-])=O)c1C
Show InChI InChI=1S/C11H11N3O5S/c1-7-8(2)12-19-11(7)13-20(17,18)10-6-4-3-5-9(10)14(15)16/h3-6,13H,1-2H3
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3.50E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068677
PNG
(4'-Isobutyl-2'-propylamino-biphenyl-2-sulfonic aci...)
Show SMILES CCCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C24H31N3O3S/c1-6-13-25-22-15-19(14-16(2)3)11-12-20(22)21-9-7-8-10-23(21)31(28,29)27-24-17(4)18(5)26-30-24/h7-12,15-16,25,27H,6,13-14H2,1-5H3
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3.70E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068749
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4,6-dimethox...)
Show SMILES COc1cc(OC)nc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)n1
Show InChI InChI=1S/C22H25N3O4S/c1-15(2)13-16-9-11-17(12-10-16)18-7-5-6-8-19(18)30(26,27)25-22-23-20(28-3)14-21(24-22)29-4/h5-12,14-15H,13H2,1-4H3,(H,23,24,25)
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3.90E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068691
PNG
(CHEMBL149152 | Lithium; [6-(3,4-dimethyl-isoxazol-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1c(OCC([O-])=O)cccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H26N2O6S/c1-14(2)12-17-8-10-18(11-9-17)22-19(30-13-21(26)27)6-5-7-20(22)32(28,29)25-23-15(3)16(4)24-31-23/h5-11,14,25H,12-13H2,1-4H3,(H,26,27)/p-1
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4.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068695
PNG
(4'-(2,2-Dimethyl-propyl)-biphenyl-2-sulfonic acid ...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)(C)C)cc2)c1C
Show InChI InChI=1S/C22H26N2O3S/c1-15-16(2)23-27-21(15)24-28(25,26)20-9-7-6-8-19(20)18-12-10-17(11-13-18)14-22(3,4)5/h6-13,24H,14H2,1-5H3
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4.10E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068699
PNG
(2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)C(O)=O)c1C
Show InChI InChI=1S/C18H16N2O5S/c1-11-12(2)19-25-17(11)20-26(23,24)16-6-4-3-5-15(16)13-7-9-14(10-8-13)18(21)22/h3-10,20H,1-2H3,(H,21,22)
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4.40E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068745
PNG
(CHEMBL78499 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-flu...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2F)c1C
Show InChI InChI=1S/C11H11FN2O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-6-4-3-5-9(10)12/h3-6,14H,1-2H3
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4.70E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068710
PNG
(4'-Isobutyl-2'-(3-methyl-ureido)-biphenyl-2-sulfon...)
Show SMILES CNC(=O)Nc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H28N4O4S/c1-14(2)12-17-10-11-18(20(13-17)25-23(28)24-5)19-8-6-7-9-21(19)32(29,30)27-22-15(3)16(4)26-31-22/h6-11,13-14,27H,12H2,1-5H3,(H2,24,25,28)
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5.40E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068678
PNG
(3'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl...)
Show SMILES CC(C)Cc1cccc(c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-14(2)12-17-8-7-9-18(13-17)19-10-5-6-11-20(19)27(24,25)23-21-15(3)16(4)22-26-21/h5-11,13-14,23H,12H2,1-4H3
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5.60E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068731
PNG
(4'-Isopropylsulfanyl-biphenyl-2-sulfonic acid (3,4...)
Show SMILES CC(C)Sc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O3S2/c1-13(2)26-17-11-9-16(10-12-17)18-7-5-6-8-19(18)27(23,24)22-20-14(3)15(4)21-25-20/h5-13,22H,1-4H3
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5.70E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068734
PNG
(CHEMBL343477 | N-[6-(3,4-Dimethyl-isoxazol-5-ylsul...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(NC(=O)c2ccccc2)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C28H29N3O4S/c1-18(2)16-21-10-12-22(13-11-21)25-17-24(29-27(32)23-8-6-5-7-9-23)14-15-26(25)36(33,34)31-28-19(3)20(4)30-35-28/h5-15,17-18,31H,16H2,1-4H3,(H,29,32)
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5.80E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068750
PNG
(2-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2N)c1C
Show InChI InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-6-4-3-5-9(10)12/h3-6,14H,12H2,1-2H3
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5.90E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068682
PNG
(4'-Dimethylamino-biphenyl-2-sulfonic acid (3,4-dim...)
Show SMILES CN(C)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C19H21N3O3S/c1-13-14(2)20-25-19(13)21-26(23,24)18-8-6-5-7-17(18)15-9-11-16(12-10-15)22(3)4/h5-12,21H,1-4H3
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6.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068711
PNG
(4'-Isobutyl-5-methoxy-biphenyl-2-sulfonic acid (3,...)
Show SMILES COc1ccc(c(c1)-c1ccc(CC(C)C)cc1)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O4S/c1-14(2)12-17-6-8-18(9-7-17)20-13-19(27-5)10-11-21(20)29(25,26)24-22-15(3)16(4)23-28-22/h6-11,13-14,24H,12H2,1-5H3
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6.20E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068693
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4-benzyl-3-m...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1Cc1ccccc1
Show InChI InChI=1S/C27H28N2O3S/c1-19(2)17-22-13-15-23(16-14-22)24-11-7-8-12-26(24)33(30,31)29-27-25(20(3)28-32-27)18-21-9-5-4-6-10-21/h4-16,19,29H,17-18H2,1-3H3
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6.40E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068717
PNG
(2'-Formylamino-4'-isobutyl-biphenyl-2-sulfonic aci...)
Show SMILES CC(C)Cc1ccc(c(NC=O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H25N3O4S/c1-14(2)11-17-9-10-18(20(12-17)23-13-26)19-7-5-6-8-21(19)30(27,28)25-22-15(3)16(4)24-29-22/h5-10,12-14,25H,11H2,1-4H3,(H,23,26)
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6.90E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068724
PNG
(5-(4'-Isobutyl-biphenyl-2-sulfonylamino)-3-methyl-...)
Show SMILES CCOC(=O)c1c(C)noc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1
Show InChI InChI=1S/C23H26N2O5S/c1-5-29-23(26)21-16(4)24-30-22(21)25-31(27,28)20-9-7-6-8-19(20)18-12-10-17(11-13-18)14-15(2)3/h6-13,15,25H,5,14H2,1-4H3
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7.20E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068684
PNG
(2-Amino-N-[6-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(NC(=O)CN)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H28N4O4S/c1-14(2)11-17-5-7-18(8-6-17)20-12-19(25-22(28)13-24)9-10-21(20)32(29,30)27-23-15(3)16(4)26-31-23/h5-10,12,14,27H,11,13,24H2,1-4H3,(H,25,28)
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7.40E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068725
PNG
(2-Bromo-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C
Show InChI InChI=1S/C11H11BrN2O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-6-4-3-5-9(10)12/h3-6,14H,1-2H3
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8.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by rad...


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068681
PNG
(4'-Benzyloxy-biphenyl-2-sulfonic acid (3,4-dimethy...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCc3ccccc3)cc2)c1C
Show InChI InChI=1S/C24H22N2O4S/c1-17-18(2)25-30-24(17)26-31(27,28)23-11-7-6-10-22(23)20-12-14-21(15-13-20)29-16-19-8-4-3-5-9-19/h3-15,26H,16H2,1-2H3
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8.40E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


()
BDBM50068737
PNG
(CHEMBL357678 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-py...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ncccn2)c1C
Show InChI InChI=1S/C15H14N4O3S/c1-10-11(2)18-22-15(10)19-23(20,21)13-7-4-3-6-12(13)14-16-8-5-9-17-14/h3-9,19H,1-2H3
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8.80E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068690
PNG
(2'-Aminomethyl-4'-isobutyl-biphenyl-2-sulfonic aci...)
Show SMILES CC(C)Cc1ccc(c(CN)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H27N3O3S/c1-14(2)11-17-9-10-19(18(12-17)13-23)20-7-5-6-8-21(20)29(26,27)25-22-15(3)16(4)24-28-22/h5-10,12,14,25H,11,13,23H2,1-4H3
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9.60E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068736
PNG
(2'-Hydroxy-4'-isobutyl-biphenyl-2-sulfonic acid (3...)
Show SMILES CC(C)Cc1ccc(c(O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O4S/c1-13(2)11-16-9-10-17(19(24)12-16)18-7-5-6-8-20(18)28(25,26)23-21-14(3)15(4)22-27-21/h5-10,12-13,23-24H,11H2,1-4H3
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9.80E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068721
PNG
(CHEMBL150269 | N-[6-(3,4-Dimethyl-isoxazol-5-ylsul...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(NC(C)=O)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H27N3O4S/c1-14(2)12-18-6-8-19(9-7-18)21-13-20(24-17(5)27)10-11-22(21)31(28,29)26-23-15(3)16(4)25-30-23/h6-11,13-14,26H,12H2,1-5H3,(H,24,27)
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9.80E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068688
PNG
(CHEMBL357823 | [2'-(3,4-Dimethyl-isoxazol-5-ylsulf...)
Show SMILES CC(C)Cc1ccc(c(NCC(O)=O)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H27N3O5S/c1-14(2)11-17-9-10-18(20(12-17)24-13-22(27)28)19-7-5-6-8-21(19)32(29,30)26-23-15(3)16(4)25-31-23/h5-10,12,14,24,26H,11,13H2,1-4H3,(H,27,28)
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1.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068692
PNG
(2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-isobuty...)
Show SMILES CC(C)Cc1ccc(c(c1)C(N)=O)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H25N3O4S/c1-13(2)11-16-9-10-17(19(12-16)21(23)26)18-7-5-6-8-20(18)30(27,28)25-22-14(3)15(4)24-29-22/h5-10,12-13,25H,11H2,1-4H3,(H2,23,26)
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1.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068729
PNG
(2'-Fluoro-4'-isobutyl-biphenyl-2-sulfonic acid (3,...)
Show SMILES CC(C)Cc1ccc(c(F)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H23FN2O3S/c1-13(2)11-16-9-10-17(19(22)12-16)18-7-5-6-8-20(18)28(25,26)24-21-14(3)15(4)23-27-21/h5-10,12-13,24H,11H2,1-4H3
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1.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068687
PNG
(4'-tert-Butyl-biphenyl-2-sulfonic acid (3,4-dimeth...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)C(C)(C)C)c1C
Show InChI InChI=1S/C21H24N2O3S/c1-14-15(2)22-26-20(14)23-27(24,25)19-9-7-6-8-18(19)16-10-12-17(13-11-16)21(3,4)5/h6-13,23H,1-5H3
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1.50E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068694
PNG
(4'-Propyl-biphenyl-2-sulfonic acid (3,4-dimethyl-i...)
Show SMILES CCCc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O3S/c1-4-7-16-10-12-17(13-11-16)18-8-5-6-9-19(18)26(23,24)22-20-14(2)15(3)21-25-20/h5-6,8-13,22H,4,7H2,1-3H3
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1.50E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068727
PNG
(4'-Isopropylamino-biphenyl-2-sulfonic acid (3,4-di...)
Show SMILES CC(C)Nc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H23N3O3S/c1-13(2)21-17-11-9-16(10-12-17)18-7-5-6-8-19(18)27(24,25)23-20-14(3)15(4)22-26-20/h5-13,21,23H,1-4H3
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1.70E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068714
PNG
(4'-Isobutyl-3-methyl-biphenyl-2-sulfonic acid (3,4...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cccc(C)c1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O3S/c1-14(2)13-18-9-11-19(12-10-18)20-8-6-7-15(3)21(20)28(25,26)24-22-16(4)17(5)23-27-22/h6-12,14,24H,13H2,1-5H3
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1.90E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068705
PNG
(4'-Isopropyl-biphenyl-2-sulfonic acid (3,4-dimethy...)
Show SMILES CC(C)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O3S/c1-13(2)16-9-11-17(12-10-16)18-7-5-6-8-19(18)26(23,24)22-20-14(3)15(4)21-25-20/h5-13,22H,1-4H3
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1.90E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068713
PNG
(4'-Isobutyl-2'-methyl-biphenyl-2-sulfonic acid (3,...)
Show SMILES CC(C)Cc1ccc(c(C)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O3S/c1-14(2)12-18-10-11-19(15(3)13-18)20-8-6-7-9-21(20)28(25,26)24-22-16(4)17(5)23-27-22/h6-11,13-14,24H,12H2,1-5H3
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1.90E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068683
PNG
(4'-(Isopropyl-methyl-amino)-biphenyl-2-sulfonic ac...)
Show SMILES CC(C)N(C)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H25N3O3S/c1-14(2)24(5)18-12-10-17(11-13-18)19-8-6-7-9-20(19)28(25,26)23-21-15(3)16(4)22-27-21/h6-14,23H,1-5H3
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2.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068723
PNG
(4-Benzyloxy-4'-isobutyl-biphenyl-2-sulfonic acid (...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccc(OCc2ccccc2)cc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C28H30N2O4S/c1-19(2)16-22-10-12-24(13-11-22)26-15-14-25(33-18-23-8-6-5-7-9-23)17-27(26)35(31,32)30-28-20(3)21(4)29-34-28/h5-15,17,19,30H,16,18H2,1-4H3
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>2.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068701
PNG
(4'-Methyl-biphenyl-2-sulfonic acid (3,4-dimethyl-i...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C)cc2)c1C
Show InChI InChI=1S/C18H18N2O3S/c1-12-8-10-15(11-9-12)16-6-4-5-7-17(16)24(21,22)20-18-13(2)14(3)19-23-18/h4-11,20H,1-3H3
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2.30E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068730
PNG
(4-Hydroxy-4'-isobutyl-biphenyl-2-sulfonic acid (3,...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccc(O)cc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C21H24N2O4S/c1-13(2)11-16-5-7-17(8-6-16)19-10-9-18(24)12-20(19)28(25,26)23-21-14(3)15(4)22-27-21/h5-10,12-13,23-24H,11H2,1-4H3
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2.40E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRA


(RAT)
BDBM50068675
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4,5,6,7-tetr...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc2CCCCc12
Show InChI InChI=1S/C23H26N2O3S/c1-16(2)15-17-11-13-18(14-12-17)19-7-4-6-10-22(19)29(26,27)25-23-20-8-3-5-9-21(20)24-28-23/h4,6-7,10-14,16,25H,3,5,8-9,15H2,1-2H3
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2.40E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068672
PNG
(2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-4-isobuty...)
Show SMILES CC(C)Cc1ccc(c(c1)C(O)=O)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H24N2O5S/c1-13(2)11-16-9-10-17(19(12-16)22(25)26)18-7-5-6-8-20(18)30(27,28)24-21-14(3)15(4)23-29-21/h5-10,12-13,24H,11H2,1-4H3,(H,25,26)
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2.60E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068726
PNG
(4'-(3-Methyl-butyl)-biphenyl-2-sulfonic acid (3,4-...)
Show SMILES CC(C)CCc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O3S/c1-15(2)9-10-18-11-13-19(14-12-18)20-7-5-6-8-21(20)28(25,26)24-22-16(3)17(4)23-27-22/h5-8,11-15,24H,9-10H2,1-4H3
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3.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068739
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (3-methyl-4-n...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1[o+][n-]c(C)c1[N+]([O-])=O
Show InChI InChI=1S/C20H21N3O5S/c1-13(2)12-15-8-10-16(11-9-15)17-6-4-5-7-18(17)29(26,27)22-20-19(23(24)25)14(3)21-28-20/h4-11,13,22H,12H2,1-3H3
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3.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50329850
PNG
((R)-3-Amino-4-[(S)-2-((R)-1-{(S)-1-[(R)-1-(1H-indo...)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C
Show InChI InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23-,24-,26+/m0/s1
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3.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068734
PNG
(CHEMBL343477 | N-[6-(3,4-Dimethyl-isoxazol-5-ylsul...)
Show SMILES CC(C)Cc1ccc(cc1)-c1cc(NC(=O)c2ccccc2)ccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C28H29N3O4S/c1-18(2)16-21-10-12-22(13-11-21)25-17-24(29-27(32)23-8-6-5-7-9-23)14-15-26(25)36(33,34)31-28-19(3)20(4)30-35-28/h5-15,17-18,31H,16H2,1-4H3,(H,29,32)
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3.80E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068724
PNG
(5-(4'-Isobutyl-biphenyl-2-sulfonylamino)-3-methyl-...)
Show SMILES CCOC(=O)c1c(C)noc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1
Show InChI InChI=1S/C23H26N2O5S/c1-5-29-23(26)21-16(4)24-30-22(21)25-31(27,28)20-9-7-6-8-19(20)18-12-10-17(11-13-18)14-15(2)3/h6-13,15,25H,5,14H2,1-4H3
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4.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068732
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (6-chloro-pyr...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1ccc(Cl)nn1
Show InChI InChI=1S/C20H20ClN3O2S/c1-14(2)13-15-7-9-16(10-8-15)17-5-3-4-6-18(17)27(25,26)24-20-12-11-19(21)22-23-20/h3-12,14H,13H2,1-2H3,(H,23,24)
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4.40E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068749
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4,6-dimethox...)
Show SMILES COc1cc(OC)nc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)n1
Show InChI InChI=1S/C22H25N3O4S/c1-15(2)13-16-9-11-17(12-10-16)18-7-5-6-8-19(18)30(26,27)25-22-23-20(28-3)14-21(24-22)29-4/h5-12,14-15H,13H2,1-4H3,(H,23,24,25)
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5.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068743
PNG
(4'-Isobutyl-2'-methoxy-biphenyl-2-sulfonic acid (3...)
Show SMILES COc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C22H26N2O4S/c1-14(2)12-17-10-11-18(20(13-17)27-5)19-8-6-7-9-21(19)29(25,26)24-22-15(3)16(4)23-28-22/h6-11,13-14,24H,12H2,1-5H3
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5.40E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(HUMAN)
BDBM50068696
PNG
(CHEMBL148967 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-(1...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2cc3ccccc3[nH]2)c1C
Show InChI InChI=1S/C19H17N3O3S/c1-12-13(2)21-25-19(12)22-26(23,24)18-10-6-4-8-15(18)17-11-14-7-3-5-9-16(14)20-17/h3-11,20,22H,1-2H3
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6.60E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit ET-1 induced contractions in rabbit carotid artery rings (Endothelin B receptor) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068709
PNG
(2'-Dimethylamino-4'-isobutyl-biphenyl-2-sulfonic a...)
Show SMILES CC(C)Cc1ccc(c(c1)N(C)C)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C23H29N3O3S/c1-15(2)13-18-11-12-19(21(14-18)26(5)6)20-9-7-8-10-22(20)30(27,28)25-23-16(3)17(4)24-29-23/h7-12,14-15,25H,13H2,1-6H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068671
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4-methyl-iso...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1oncc1C
Show InChI InChI=1S/C20H22N2O3S/c1-14(2)12-16-8-10-17(11-9-16)18-6-4-5-7-19(18)26(23,24)22-20-15(3)13-21-25-20/h4-11,13-14,22H,12H2,1-3H3
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1.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068733
PNG
(4'-(Propane-2-sulfonyl)-biphenyl-2-sulfonic acid (...)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C20H22N2O5S2/c1-13(2)28(23,24)17-11-9-16(10-12-17)18-7-5-6-8-19(18)29(25,26)22-20-14(3)15(4)21-27-20/h5-13,22H,1-4H3
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1.70E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(HUMAN)
BDBM50068718
PNG
(CHEMBL151819 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-th...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccsc2)c1C
Show InChI InChI=1S/C15H14N2O3S2/c1-10-11(2)16-20-15(10)17-22(18,19)14-6-4-3-5-13(14)12-7-8-21-9-12/h3-9,17H,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit ET-1 induced contractions in rabbit carotid artery rings (Endothelin B receptor) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50034435
PNG
(5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C17H19N3O3S/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4/h5-10,19H,1-4H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068741
PNG
(2'-Dimethylamino-biphenyl-2-sulfonic acid (3,4-dim...)
Show SMILES CN(C)c1ccccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C19H21N3O3S/c1-13-14(2)20-25-19(13)21-26(23,24)18-12-8-6-10-16(18)15-9-5-7-11-17(15)22(3)4/h5-12,21H,1-4H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068693
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4-benzyl-3-m...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1Cc1ccccc1
Show InChI InChI=1S/C27H28N2O3S/c1-19(2)17-22-13-15-23(16-14-22)24-11-7-8-12-26(24)33(30,31)29-27-25(20(3)28-32-27)18-21-9-5-4-6-10-21/h4-16,19,29H,17-18H2,1-3H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068723
PNG
(4-Benzyloxy-4'-isobutyl-biphenyl-2-sulfonic acid (...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccc(OCc2ccccc2)cc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C28H30N2O4S/c1-19(2)16-22-10-12-24(13-11-22)26-15-14-25(33-18-23-8-6-5-7-9-23)17-27(26)35(31,32)30-28-20(3)21(4)29-34-28/h5-15,17,19,30H,16,18H2,1-4H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068748
PNG
(3'-Dimethylamino-biphenyl-2-sulfonic acid (3,4-dim...)
Show SMILES CN(C)c1cccc(c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C19H21N3O3S/c1-13-14(2)20-25-19(13)21-26(23,24)18-11-6-5-10-17(18)15-8-7-9-16(12-15)22(3)4/h5-12,21H,1-4H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068675
PNG
(4'-Isobutyl-biphenyl-2-sulfonic acid (4,5,6,7-tetr...)
Show SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc2CCCCc12
Show InChI InChI=1S/C23H26N2O3S/c1-16(2)15-17-11-13-18(14-12-17)19-7-4-6-10-22(19)29(26,27)25-23-20-8-3-5-9-21(20)24-28-23/h4,6-7,10-14,16,25H,3,5,8-9,15H2,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068680
PNG
(3'-Amino-biphenyl-2-sulfonic acid (3,4-dimethyl-is...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N)c2)c1C
Show InChI InChI=1S/C17H17N3O3S/c1-11-12(2)19-23-17(11)20-24(21,22)16-9-4-3-8-15(16)13-6-5-7-14(18)10-13/h3-10,20H,18H2,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068716
PNG
(2'-Amino-biphenyl-2-sulfonic acid (3,4-dimethyl-is...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N)c1C
Show InChI InChI=1S/C17H17N3O3S/c1-11-12(2)19-23-17(11)20-24(21,22)16-10-6-4-8-14(16)13-7-3-5-9-15(13)18/h3-10,20H,18H2,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(HUMAN)
BDBM50068679
PNG
(CHEMBL357331 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-(1...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2c[nH]c3ccccc23)c1C
Show InChI InChI=1S/C19H17N3O3S/c1-12-13(2)21-25-19(12)22-26(23,24)18-10-6-4-8-15(18)16-11-20-17-9-5-3-7-14(16)17/h3-11,20,22H,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit ET-1 induced contractions in rabbit carotid artery rings (Endothelin B receptor) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068703
PNG
(2'-Hydroxymethyl-biphenyl-2-sulfonic acid (3,4-dim...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2CO)c1C
Show InChI InChI=1S/C18H18N2O4S/c1-12-13(2)19-24-18(12)20-25(22,23)17-10-6-5-9-16(17)15-8-4-3-7-14(15)11-21/h3-10,20-21H,11H2,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068699
PNG
(2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)C(O)=O)c1C
Show InChI InChI=1S/C18H16N2O5S/c1-11-12(2)19-25-17(11)20-26(23,24)16-6-4-3-5-15(16)13-7-9-14(10-8-13)18(21)22/h3-10,20H,1-2H3,(H,21,22)
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(HUMAN)
BDBM50068712
PNG
(CHEMBL357789 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-th...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2cccs2)c1C
Show InChI InChI=1S/C15H14N2O3S2/c1-10-11(2)16-20-15(10)17-22(18,19)14-8-4-3-6-12(14)13-7-5-9-21-13/h3-9,17H,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit ET-1 induced contractions in rabbit carotid artery rings (Endothelin B receptor) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068707
PNG
(2'-Nitro-biphenyl-2-sulfonic acid (3,4-dimethyl-is...)
Show SMILES Cc1[n-][o+]c(NS(=O)(=O)c2ccccc2-c2ccccc2[N+]([O-])=O)c1C
Show InChI InChI=1S/C17H15N3O5S/c1-11-12(2)18-25-17(11)19-26(23,24)16-10-6-4-8-14(16)13-7-3-5-9-15(13)20(21)22/h3-10,19H,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068700
PNG
(Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C
Show InChI InChI=1S/C17H16N2O3S/c1-12-13(2)18-22-17(12)19-23(20,21)16-11-7-6-10-15(16)14-8-4-3-5-9-14/h3-11,19H,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068702
PNG
(Biphenyl-2,4'-disulfonic acid 4'-dimethylamide 2-[...)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C19H21N3O5S2/c1-13-14(2)20-27-19(13)21-28(23,24)18-8-6-5-7-17(18)15-9-11-16(12-10-15)29(25,26)22(3)4/h5-12,21H,1-4H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(HUMAN)
BDBM50068708
PNG
(CHEMBL148637 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-py...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2cccnc2)c1C
Show InChI InChI=1S/C16H15N3O3S/c1-11-12(2)18-22-16(11)19-23(20,21)15-8-4-3-7-14(15)13-6-5-9-17-10-13/h3-10,19H,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit ET-1 induced contractions in rabbit carotid artery rings (Endothelin B receptor) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(HUMAN)
BDBM50068737
PNG
(CHEMBL357678 | N-(3,4-Dimethyl-isoxazol-5-yl)-2-py...)
Show SMILES Cc1noc(NS(=O)(=O)c2ccccc2-c2ncccn2)c1C
Show InChI InChI=1S/C15H14N4O3S/c1-10-11(2)18-22-15(10)19-23(20,21)13-7-4-3-6-12(13)14-16-8-5-9-17-14/h3-9,19H,1-2H3
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>2.00E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit ET-1 induced contractions in rabbit carotid artery rings (Endothelin B receptor) was determined in an in vitro functional assay.


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
EDNRB


(RAT)
BDBM50068746
PNG
(4'-Methoxy-biphenyl-2-sulfonic acid (3,4-dimethyl-...)
Show SMILES COc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C18H18N2O4S/c1-12-13(2)19-24-18(12)20-25(21,22)17-7-5-4-6-16(17)14-8-10-15(23-3)11-9-14/h4-11,20H,1-3H3
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2.50E+5n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)


J Med Chem 41: 5198-218 (1999)


Article DOI: 10.1021/jm970872k
BindingDB Entry DOI: 10.7270/Q2J9672R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%