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PubMed code 9871673

Compile data set for download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50061669
PNG
((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Show SMILES Oc1ccc2CC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C17H19NO2/c19-15-8-6-14-7-9-16(20-17(14)10-15)12-18-11-13-4-2-1-3-5-13/h1-6,8,10,16,18-19H,7,9,11-12H2/t16-/m1/s1
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0.160n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50061642
PNG
((S)-3-(Benzylamino-methyl)-2,3-dihydro-benzo[1,4]d...)
Show SMILES Oc1ccc2OC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C16H17NO3/c18-13-6-7-15-16(8-13)20-14(11-19-15)10-17-9-12-4-2-1-3-5-12/h1-8,14,17-18H,9-11H2/t14-/m0/s1
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0.350n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50061642
PNG
((S)-3-(Benzylamino-methyl)-2,3-dihydro-benzo[1,4]d...)
Show SMILES Oc1ccc2OC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C16H17NO3/c18-13-6-7-15-16(8-13)20-14(11-19-15)10-17-9-12-4-2-1-3-5-12/h1-8,14,17-18H,9-11H2/t14-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069921
PNG
(CHEMBL99913 | N-[5-(2-Benzylamino-ethoxy)-2-chloro...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2ccccc2)ccc1Cl
Show InChI InChI=1S/C16H19ClN2O3S/c1-23(20,21)19-16-11-14(7-8-15(16)17)22-10-9-18-12-13-5-3-2-4-6-13/h2-8,11,18-19H,9-10,12H2,1H3
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1.60n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50061669
PNG
((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Show SMILES Oc1ccc2CC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C17H19NO2/c19-15-8-6-14-7-9-16(20-17(14)10-15)12-18-11-13-4-2-1-3-5-13/h1-6,8,10,16,18-19H,7,9,11-12H2/t16-/m1/s1
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2.40n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069908
PNG
(CHEMBL102490 | N-(2-Chloro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1Cl
Show InChI InChI=1S/C14H17ClN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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2.60n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069921
PNG
(CHEMBL99913 | N-[5-(2-Benzylamino-ethoxy)-2-chloro...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2ccccc2)ccc1Cl
Show InChI InChI=1S/C16H19ClN2O3S/c1-23(20,21)19-16-11-14(7-8-15(16)17)22-10-9-18-12-13-5-3-2-4-6-13/h2-8,11,18-19H,9-10,12H2,1H3
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3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50061669
PNG
((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Show SMILES Oc1ccc2CC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C17H19NO2/c19-15-8-6-14-7-9-16(20-17(14)10-15)12-18-11-13-4-2-1-3-5-13/h1-6,8,10,16,18-19H,7,9,11-12H2/t16-/m1/s1
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3.30n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069914
PNG
(3-(2-Benzylamino-ethoxy)-phenol | CHEMBL64508)
Show SMILES Oc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
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3.60n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069918
PNG
(CHEMBL99849 | N-[3-(2-Benzylamino-ethoxy)-phenyl]-...)
Show SMILES CS(=O)(=O)Nc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C16H20N2O3S/c1-22(19,20)18-15-8-5-9-16(12-15)21-11-10-17-13-14-6-3-2-4-7-14/h2-9,12,17-18H,10-11,13H2,1H3
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4.40n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50061642
PNG
((S)-3-(Benzylamino-methyl)-2,3-dihydro-benzo[1,4]d...)
Show SMILES Oc1ccc2OC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C16H17NO3/c18-13-6-7-15-16(8-13)20-14(11-19-15)10-17-9-12-4-2-1-3-5-12/h1-8,14,17-18H,9-11H2/t14-/m0/s1
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4.80n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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5.5n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069908
PNG
(CHEMBL102490 | N-(2-Chloro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1Cl
Show InChI InChI=1S/C14H17ClN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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6n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50061642
PNG
((S)-3-(Benzylamino-methyl)-2,3-dihydro-benzo[1,4]d...)
Show SMILES Oc1ccc2OC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C16H17NO3/c18-13-6-7-15-16(8-13)20-14(11-19-15)10-17-9-12-4-2-1-3-5-12/h1-8,14,17-18H,9-11H2/t14-/m0/s1
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7.20n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069912
PNG
(CHEMBL323118 | N-[5-(2-Benzylamino-ethoxy)-2-fluor...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2ccccc2)ccc1F
Show InChI InChI=1S/C16H19FN2O3S/c1-23(20,21)19-16-11-14(7-8-15(16)17)22-10-9-18-12-13-5-3-2-4-6-13/h2-8,11,18-19H,9-10,12H2,1H3
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7.90n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069908
PNG
(CHEMBL102490 | N-(2-Chloro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1Cl
Show InChI InChI=1S/C14H17ClN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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9n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069906
PNG
(2-(2-Benzylamino-ethoxy)-phenol | CHEMBL101285)
Show SMILES Oc1ccccc1OCCNCc1ccccc1
Show InChI InChI=1S/C15H17NO2/c17-14-8-4-5-9-15(14)18-11-10-16-12-13-6-2-1-3-7-13/h1-9,16-17H,10-12H2
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9.60n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50061669
PNG
((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Show SMILES Oc1ccc2CC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C17H19NO2/c19-15-8-6-14-7-9-16(20-17(14)10-15)12-18-11-13-4-2-1-3-5-13/h1-6,8,10,16,18-19H,7,9,11-12H2/t16-/m1/s1
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10n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069921
PNG
(CHEMBL99913 | N-[5-(2-Benzylamino-ethoxy)-2-chloro...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2ccccc2)ccc1Cl
Show InChI InChI=1S/C16H19ClN2O3S/c1-23(20,21)19-16-11-14(7-8-15(16)17)22-10-9-18-12-13-5-3-2-4-6-13/h2-8,11,18-19H,9-10,12H2,1H3
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11n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069914
PNG
(3-(2-Benzylamino-ethoxy)-phenol | CHEMBL64508)
Show SMILES Oc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
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11n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069913
PNG
(CHEMBL101910 | N-(2-Fluoro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1F
Show InChI InChI=1S/C14H17FN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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12n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069919
PNG
(1-Benzyl-4-phenyl-piperazine | CHEMBL101032)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H20N2/c1-3-7-16(8-4-1)15-18-11-13-19(14-12-18)17-9-5-2-6-10-17/h1-10H,11-15H2
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16n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50061642
PNG
((S)-3-(Benzylamino-methyl)-2,3-dihydro-benzo[1,4]d...)
Show SMILES Oc1ccc2OC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C16H17NO3/c18-13-6-7-15-16(8-13)20-14(11-19-15)10-17-9-12-4-2-1-3-5-12/h1-8,14,17-18H,9-11H2/t14-/m0/s1
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17n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069913
PNG
(CHEMBL101910 | N-(2-Fluoro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1F
Show InChI InChI=1S/C14H17FN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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20n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069912
PNG
(CHEMBL323118 | N-[5-(2-Benzylamino-ethoxy)-2-fluor...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2ccccc2)ccc1F
Show InChI InChI=1S/C16H19FN2O3S/c1-23(20,21)19-16-11-14(7-8-15(16)17)22-10-9-18-12-13-5-3-2-4-6-13/h2-8,11,18-19H,9-10,12H2,1H3
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24n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069920
PNG
(5-(2-Benzylamino-ethoxy)-2-chloro-phenylamine | CH...)
Show SMILES Nc1cc(OCCNCc2ccccc2)ccc1Cl
Show InChI InChI=1S/C15H17ClN2O/c16-14-7-6-13(10-15(14)17)19-9-8-18-11-12-4-2-1-3-5-12/h1-7,10,18H,8-9,11,17H2
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27n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD4.4) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069908
PNG
(CHEMBL102490 | N-(2-Chloro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1Cl
Show InChI InChI=1S/C14H17ClN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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28n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069918
PNG
(CHEMBL99849 | N-[3-(2-Benzylamino-ethoxy)-phenyl]-...)
Show SMILES CS(=O)(=O)Nc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C16H20N2O3S/c1-22(19,20)18-15-8-5-9-16(12-15)21-11-10-17-13-14-6-3-2-4-7-14/h2-9,12,17-18H,10-11,13H2,1H3
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29n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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29n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069918
PNG
(CHEMBL99849 | N-[3-(2-Benzylamino-ethoxy)-phenyl]-...)
Show SMILES CS(=O)(=O)Nc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C16H20N2O3S/c1-22(19,20)18-15-8-5-9-16(12-15)21-11-10-17-13-14-6-3-2-4-7-14/h2-9,12,17-18H,10-11,13H2,1H3
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38n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069918
PNG
(CHEMBL99849 | N-[3-(2-Benzylamino-ethoxy)-phenyl]-...)
Show SMILES CS(=O)(=O)Nc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C16H20N2O3S/c1-22(19,20)18-15-8-5-9-16(12-15)21-11-10-17-13-14-6-3-2-4-7-14/h2-9,12,17-18H,10-11,13H2,1H3
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43n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069916
PNG
(2-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL100952)
Show SMILES Oc1ccccc1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-9-5-4-8-16(17)19-12-10-18(11-13-19)14-15-6-2-1-3-7-15/h1-9,20H,10-14H2
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65n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069917
PNG
(Benzyl-(2-phenoxy-ethyl)-amine | CHEMBL103951)
Show SMILES C(COc1ccccc1)NCc1ccccc1
Show InChI InChI=1S/C15H17NO/c1-3-7-14(8-4-1)13-16-11-12-17-15-9-5-2-6-10-15/h1-10,16H,11-13H2
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68n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069914
PNG
(3-(2-Benzylamino-ethoxy)-phenol | CHEMBL64508)
Show SMILES Oc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
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76n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069921
PNG
(CHEMBL99913 | N-[5-(2-Benzylamino-ethoxy)-2-chloro...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2ccccc2)ccc1Cl
Show InChI InChI=1S/C16H19ClN2O3S/c1-23(20,21)19-16-11-14(7-8-15(16)17)22-10-9-18-12-13-5-3-2-4-6-13/h2-8,11,18-19H,9-10,12H2,1H3
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76n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069914
PNG
(3-(2-Benzylamino-ethoxy)-phenol | CHEMBL64508)
Show SMILES Oc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
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81n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD4.4) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069910
PNG
(4-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL103900)
Show SMILES Oc1ccc(cc1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-6-16(7-9-17)19-12-10-18(11-13-19)14-15-4-2-1-3-5-15/h1-9,20H,10-14H2
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92n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069917
PNG
(Benzyl-(2-phenoxy-ethyl)-amine | CHEMBL103951)
Show SMILES C(COc1ccccc1)NCc1ccccc1
Show InChI InChI=1S/C15H17NO/c1-3-7-14(8-4-1)13-16-11-12-17-15-9-5-2-6-10-15/h1-10,16H,11-13H2
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94n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD4.4) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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95n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069914
PNG
(3-(2-Benzylamino-ethoxy)-phenol | CHEMBL64508)
Show SMILES Oc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
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101n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069909
PNG
(4-(2-Benzylamino-ethoxy)-phenol | CHEMBL100461)
Show SMILES Oc1ccc(OCCNCc2ccccc2)cc1
Show InChI InChI=1S/C15H17NO2/c17-14-6-8-15(9-7-14)18-11-10-16-12-13-4-2-1-3-5-13/h1-9,16-17H,10-12H2
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113n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50061669
PNG
((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Show SMILES Oc1ccc2CC[C@H](CNCc3ccccc3)Oc2c1
Show InChI InChI=1S/C17H19NO2/c19-15-8-6-14-7-9-16(20-17(14)10-15)12-18-11-13-4-2-1-3-5-13/h1-6,8,10,16,18-19H,7,9,11-12H2/t16-/m1/s1
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116n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069916
PNG
(2-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL100952)
Show SMILES Oc1ccccc1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-9-5-4-8-16(17)19-12-10-18(11-13-19)14-15-6-2-1-3-7-15/h1-9,20H,10-14H2
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118n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069910
PNG
(4-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL103900)
Show SMILES Oc1ccc(cc1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-6-16(7-9-17)19-12-10-18(11-13-19)14-15-4-2-1-3-5-15/h1-9,20H,10-14H2
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120n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069919
PNG
(1-Benzyl-4-phenyl-piperazine | CHEMBL101032)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H20N2/c1-3-7-16(8-4-1)15-18-11-13-19(14-12-18)17-9-5-2-6-10-17/h1-10H,11-15H2
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124n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069908
PNG
(CHEMBL102490 | N-(2-Chloro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1Cl
Show InChI InChI=1S/C14H17ClN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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137n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD4.4) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069906
PNG
(2-(2-Benzylamino-ethoxy)-phenol | CHEMBL101285)
Show SMILES Oc1ccccc1OCCNCc1ccccc1
Show InChI InChI=1S/C15H17NO2/c17-14-8-4-5-9-15(14)18-11-10-16-12-13-6-2-1-3-7-13/h1-9,16-17H,10-12H2
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191n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50069920
PNG
(5-(2-Benzylamino-ethoxy)-2-chloro-phenylamine | CH...)
Show SMILES Nc1cc(OCCNCc2ccccc2)ccc1Cl
Show InChI InChI=1S/C15H17ClN2O/c16-14-7-6-13(10-15(14)17)19-9-8-18-11-12-4-2-1-3-5-12/h1-7,10,18H,8-9,11,17H2
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237n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50069917
PNG
(Benzyl-(2-phenoxy-ethyl)-amine | CHEMBL103951)
Show SMILES C(COc1ccccc1)NCc1ccccc1
Show InChI InChI=1S/C15H17NO/c1-3-7-14(8-4-1)13-16-11-12-17-15-9-5-2-6-10-15/h1-10,16H,11-13H2
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241n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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246n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069919
PNG
(1-Benzyl-4-phenyl-piperazine | CHEMBL101032)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H20N2/c1-3-7-16(8-4-1)15-18-11-13-19(14-12-18)17-9-5-2-6-10-17/h1-10H,11-15H2
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267n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069909
PNG
(4-(2-Benzylamino-ethoxy)-phenol | CHEMBL100461)
Show SMILES Oc1ccc(OCCNCc2ccccc2)cc1
Show InChI InChI=1S/C15H17NO2/c17-14-6-8-15(9-7-14)18-11-10-16-12-13-4-2-1-3-5-13/h1-9,16-17H,10-12H2
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277n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD4.4) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069906
PNG
(2-(2-Benzylamino-ethoxy)-phenol | CHEMBL101285)
Show SMILES Oc1ccccc1OCCNCc1ccccc1
Show InChI InChI=1S/C15H17NO2/c17-14-8-4-5-9-15(14)18-11-10-16-12-13-6-2-1-3-7-13/h1-9,16-17H,10-12H2
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282n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069906
PNG
(2-(2-Benzylamino-ethoxy)-phenol | CHEMBL101285)
Show SMILES Oc1ccccc1OCCNCc1ccccc1
Show InChI InChI=1S/C15H17NO2/c17-14-8-4-5-9-15(14)18-11-10-16-12-13-6-2-1-3-7-13/h1-9,16-17H,10-12H2
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297n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD4.4) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069910
PNG
(4-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL103900)
Show SMILES Oc1ccc(cc1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-6-16(7-9-17)19-12-10-18(11-13-19)14-15-4-2-1-3-5-15/h1-9,20H,10-14H2
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>300n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069913
PNG
(CHEMBL101910 | N-(2-Fluoro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1F
Show InChI InChI=1S/C14H17FN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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>300n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069919
PNG
(1-Benzyl-4-phenyl-piperazine | CHEMBL101032)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H20N2/c1-3-7-16(8-4-1)15-18-11-13-19(14-12-18)17-9-5-2-6-10-17/h1-10H,11-15H2
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>300n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069917
PNG
(Benzyl-(2-phenoxy-ethyl)-amine | CHEMBL103951)
Show SMILES C(COc1ccccc1)NCc1ccccc1
Show InChI InChI=1S/C15H17NO/c1-3-7-14(8-4-1)13-16-11-12-17-15-9-5-2-6-10-15/h1-10,16H,11-13H2
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>300n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069916
PNG
(2-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL100952)
Show SMILES Oc1ccccc1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-9-5-4-8-16(17)19-12-10-18(11-13-19)14-15-6-2-1-3-7-15/h1-9,20H,10-14H2
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>300n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069916
PNG
(2-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL100952)
Show SMILES Oc1ccccc1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-9-5-4-8-16(17)19-12-10-18(11-13-19)14-15-6-2-1-3-7-15/h1-9,20H,10-14H2
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069919
PNG
(1-Benzyl-4-phenyl-piperazine | CHEMBL101032)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H20N2/c1-3-7-16(8-4-1)15-18-11-13-19(14-12-18)17-9-5-2-6-10-17/h1-10H,11-15H2
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069913
PNG
(CHEMBL101910 | N-(2-Fluoro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1F
Show InChI InChI=1S/C14H17FN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069917
PNG
(Benzyl-(2-phenoxy-ethyl)-amine | CHEMBL103951)
Show SMILES C(COc1ccccc1)NCc1ccccc1
Show InChI InChI=1S/C15H17NO/c1-3-7-14(8-4-1)13-16-11-12-17-15-9-5-2-6-10-15/h1-10,16H,11-13H2
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069913
PNG
(CHEMBL101910 | N-(2-Fluoro-5-{2-[(thiophen-2-ylmet...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2cccs2)ccc1F
Show InChI InChI=1S/C14H17FN2O3S2/c1-22(18,19)17-14-9-11(4-5-13(14)15)20-7-6-16-10-12-3-2-8-21-12/h2-5,8-9,16-17H,6-7,10H2,1H3
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069910
PNG
(4-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL103900)
Show SMILES Oc1ccc(cc1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-6-16(7-9-17)19-12-10-18(11-13-19)14-15-4-2-1-3-5-15/h1-9,20H,10-14H2
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069916
PNG
(2-(4-Benzyl-piperazin-1-yl)-phenol | CHEMBL100952)
Show SMILES Oc1ccccc1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-9-5-4-8-16(17)19-12-10-18(11-13-19)14-15-6-2-1-3-7-15/h1-9,20H,10-14H2
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069906
PNG
(2-(2-Benzylamino-ethoxy)-phenol | CHEMBL101285)
Show SMILES Oc1ccccc1OCCNCc1ccccc1
Show InChI InChI=1S/C15H17NO2/c17-14-8-4-5-9-15(14)18-11-10-16-12-13-6-2-1-3-7-13/h1-9,16-17H,10-12H2
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456n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50069918
PNG
(CHEMBL99849 | N-[3-(2-Benzylamino-ethoxy)-phenyl]-...)
Show SMILES CS(=O)(=O)Nc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C16H20N2O3S/c1-22(19,20)18-15-8-5-9-16(12-15)21-11-10-17-13-14-6-3-2-4-7-14/h2-9,12,17-18H,10-11,13H2,1H3
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500n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD4.4) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-1


(HUMAN-Homo sapiens (Human))
BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Agonistic activity towards dopamine D2 receptor using radioligand [3H]-quinpirole in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5HT1A)


(Mus musculus (Mouse))
BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069920
PNG
(5-(2-Benzylamino-ethoxy)-2-chloro-phenylamine | CH...)
Show SMILES Nc1cc(OCCNCc2ccccc2)ccc1Cl
Show InChI InChI=1S/C15H17ClN2O/c16-14-7-6-13(10-15(14)17)19-9-8-18-11-12-4-2-1-3-5-12/h1-7,10,18H,8-9,11,17H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069920
PNG
(5-(2-Benzylamino-ethoxy)-2-chloro-phenylamine | CH...)
Show SMILES Nc1cc(OCCNCc2ccccc2)ccc1Cl
Show InChI InChI=1S/C15H17ClN2O/c16-14-7-6-13(10-15(14)17)19-9-8-18-11-12-4-2-1-3-5-12/h1-7,10,18H,8-9,11,17H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5HT1A)


(Mus musculus (Mouse))
BDBM50069914
PNG
(3-(2-Benzylamino-ethoxy)-phenol | CHEMBL64508)
Show SMILES Oc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
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PubMed
1.78E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069912
PNG
(CHEMBL323118 | N-[5-(2-Benzylamino-ethoxy)-2-fluor...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2ccccc2)ccc1F
Show InChI InChI=1S/C16H19FN2O3S/c1-23(20,21)19-16-11-14(7-8-15(16)17)22-10-9-18-12-13-5-3-2-4-6-13/h2-8,11,18-19H,9-10,12H2,1H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50069909
PNG
(4-(2-Benzylamino-ethoxy)-phenol | CHEMBL100461)
Show SMILES Oc1ccc(OCCNCc2ccccc2)cc1
Show InChI InChI=1S/C15H17NO2/c17-14-6-8-15(9-7-14)18-11-10-16-12-13-4-2-1-3-5-13/h1-9,16-17H,10-12H2
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>5.00E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]-spiperone as radioligand


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-1


(HUMAN-Homo sapiens (Human))
BDBM50069914
PNG
(3-(2-Benzylamino-ethoxy)-phenol | CHEMBL64508)
Show SMILES Oc1cccc(OCCNCc2ccccc2)c1
Show InChI InChI=1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
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PubMed
5.29E+3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity towards dopamine D2 receptor using radioligand [3H]-spiperone in rat striatal membranes


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069909
PNG
(4-(2-Benzylamino-ethoxy)-phenol | CHEMBL100461)
Show SMILES Oc1ccc(OCCNCc2ccccc2)cc1
Show InChI InChI=1S/C15H17NO2/c17-14-6-8-15(9-7-14)18-11-10-16-12-13-4-2-1-3-5-13/h1-9,16-17H,10-12H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50069912
PNG
(CHEMBL323118 | N-[5-(2-Benzylamino-ethoxy)-2-fluor...)
Show SMILES CS(=O)(=O)Nc1cc(OCCNCc2ccccc2)ccc1F
Show InChI InChI=1S/C16H19FN2O3S/c1-23(20,21)19-16-11-14(7-8-15(16)17)22-10-9-18-12-13-5-3-2-4-6-13/h2-8,11,18-19H,9-10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human cloned dopamine (hD2s) receptors expressed in CHO cell membranes using [3H]-spiperone


Bioorg Med Chem Lett 8: 295-300 (1999)


Article DOI: 10.1016/s0960-894x(98)00014-6
BindingDB Entry DOI: 10.7270/Q28W3CG1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%