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PubMed code 9873487

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071235
PNG
(CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H24Cl2N4/c1-4-9-26(12-15-5-6-15)19-10-13(2)24-21-20(14(3)25-27(19)21)17-8-7-16(22)11-18(17)23/h7-8,10-11,15H,4-6,9,12H2,1-3H3
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3.20n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071234
PNG
(Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazo...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H24Cl2N4/c1-5-7-10-25(6-2)18-11-13(3)23-20-19(14(4)24-26(18)20)16-9-8-15(21)12-17(16)22/h8-9,11-12H,5-7,10H2,1-4H3
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5n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071238
PNG
(3-(2,4-Dichloro-phenyl)-2,5-dimethyl-7-(2-propyl-p...)
Show SMILES CCCC1CCCCN1c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H26Cl2N4/c1-4-7-17-8-5-6-11-27(17)20-12-14(2)25-22-21(15(3)26-28(20)22)18-10-9-16(23)13-19(18)24/h9-10,12-13,17H,4-8,11H2,1-3H3
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6.40n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071229
PNG
(CHEMBL302645 | [3-(2,4-Dichloro-phenyl)-2,5-dimeth...)
Show SMILES CCN(CCOC)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H22Cl2N4O/c1-5-24(8-9-26-4)17-10-12(2)22-19-18(13(3)23-25(17)19)15-7-6-14(20)11-16(15)21/h6-7,10-11H,5,8-9H2,1-4H3
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11n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071233
PNG
(Butyl-[3-(2-chloro-phenyl)-2,5-dimethyl-pyrazolo[1...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccccc1Cl
Show InChI InChI=1S/C20H25ClN4/c1-5-7-12-24(6-2)18-13-14(3)22-20-19(15(4)23-25(18)20)16-10-8-9-11-17(16)21/h8-11,13H,5-7,12H2,1-4H3
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15n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071226
PNG
(Butyl-[3-(2,4-dichloro-phenyl)-5-methyl-pyrazolo[1...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(cnn12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H22Cl2N4/c1-4-6-9-24(5-2)18-10-13(3)23-19-16(12-22-25(18)19)15-8-7-14(20)11-17(15)21/h7-8,10-12H,4-6,9H2,1-3H3
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40n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071232
PNG
(3-(2,4-Dichloro-phenyl)-2,5-dimethyl-7-piperidin-1...)
Show SMILES Cc1nn2c(cc(C)nc2c1-c1ccc(Cl)cc1Cl)N1CCCCC1
Show InChI InChI=1S/C19H20Cl2N4/c1-12-10-17(24-8-4-3-5-9-24)25-19(22-12)18(13(2)23-25)15-7-6-14(20)11-16(15)21/h6-7,10-11H,3-5,8-9H2,1-2H3
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41n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50058163
PNG
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3
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56n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071228
PNG
(Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazo...)
Show SMILES CCCCNc1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H20Cl2N4/c1-4-5-8-21-16-9-11(2)22-18-17(12(3)23-24(16)18)14-7-6-13(19)10-15(14)20/h6-7,9-10,21H,4-5,8H2,1-3H3
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69n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071237
PNG
(Butyl-[3-(4-chloro-phenyl)-2,5-dimethyl-pyrazolo[1...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H25ClN4/c1-5-7-12-24(6-2)18-13-14(3)22-20-19(15(4)23-25(18)20)16-8-10-17(21)11-9-16/h8-11,13H,5-7,12H2,1-4H3
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77n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071230
PNG
(Butyl-[2,5-dimethyl-3-(2,4,6-trichloro-phenyl)-pyr...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C20H23Cl3N4/c1-5-7-8-26(6-2)17-9-12(3)24-20-18(13(4)25-27(17)20)19-15(22)10-14(21)11-16(19)23/h9-11H,5-8H2,1-4H3
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93n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071227
PNG
(CHEMBL65574 | N-Butyl-N-[3-(2,4-dichloro-phenyl)-2...)
Show SMILES CCCCN(OC)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H22Cl2N4O/c1-5-6-9-24(26-4)17-10-12(2)22-19-18(13(3)23-25(17)19)15-8-7-14(20)11-16(15)21/h7-8,10-11H,5-6,9H2,1-4H3
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216n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071236
PNG
(3-(2,4-Dichloro-phenyl)-2,5-dimethyl-7-morpholin-4...)
Show SMILES Cc1nn2c(cc(C)nc2c1-c1ccc(Cl)cc1Cl)N1CCOCC1
Show InChI InChI=1S/C18H18Cl2N4O/c1-11-9-16(23-5-7-25-8-6-23)24-18(21-11)17(12(2)22-24)14-4-3-13(19)10-15(14)20/h3-4,9-10H,5-8H2,1-2H3
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310n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071231
PNG
(Butyl-(2,5-dimethyl-3-phenyl-pyrazolo[1,5-a]pyrimi...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccccc1
Show InChI InChI=1S/C20H26N4/c1-5-7-13-23(6-2)18-14-15(3)21-20-19(16(4)22-24(18)20)17-11-9-8-10-12-17/h8-12,14H,5-7,13H2,1-4H3
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511n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%