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USPatent US10029993

Compile data set for download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280297
PNG
(US10029993, Example 86)
Show SMILES Cc1ccccc1-c1cnnc(n1)N1CCN(CC(=O)Nc2cccnc2)CC1
Show InChI InChI=1S/C21H23N7O/c1-16-5-2-3-7-18(16)19-14-23-26-21(25-19)28-11-9-27(10-12-28)15-20(29)24-17-6-4-8-22-13-17/h2-8,13-14H,9-12,15H2,1H3,(H,24,29)
PDB

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UniChem
US Patent
n/an/a 0.5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280316
PNG
(US10029993, Example 183)
Show SMILES Cc1ccccc1-c1cnnc(n1)N1CCC(CCCO)CC1
Show InChI InChI=1S/C18H24N4O/c1-14-5-2-3-7-16(14)17-13-19-21-18(20-17)22-10-8-15(9-11-22)6-4-12-23/h2-3,5,7,13,15,23H,4,6,8-12H2,1H3
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280305
PNG
(US10029993, Example 154)
Show SMILES Cc1nc[nH]c1CN1CCC(CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H32ClN9O/c1-18-23(28-17-27-18)15-33-8-6-21(7-9-33)30-24(36)16-34-10-12-35(13-11-34)25-31-22(14-29-32-25)19-2-4-20(26)5-3-19/h2-5,14,17,21H,6-13,15-16H2,1H3,(H,27,28)(H,30,36)
PDB

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UniChem
US Patent
n/an/a 1.10n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280326
PNG
(US10029993, Example 221)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H23F3N6O/c1-13(2)24-17(29)12-27-7-9-28(10-8-27)18-25-16(11-23-26-18)14-3-5-15(6-4-14)19(20,21)22/h3-6,11,13H,7-10,12H2,1-2H3,(H,24,29)
PDB

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UniChem
US Patent
n/an/a 2.40n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280321
PNG
(US10029993, Example 211)
Show SMILES Cn1c(cc2ccccc12)-c1cnnc(n1)N1CCOCC1
Show InChI InChI=1S/C16H17N5O/c1-20-14-5-3-2-4-12(14)10-15(20)13-11-17-19-16(18-13)21-6-8-22-9-7-21/h2-5,10-11H,6-9H2,1H3
PDB

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UniChem
US Patent
n/an/a 2.40n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280292
PNG
(US10029993, Example 81)
Show SMILES CNC(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C21H24ClN9O2/c1-23-19(32)14-31-12-17(10-25-31)26-20(33)13-29-6-8-30(9-7-29)21-27-18(11-24-28-21)15-2-4-16(22)5-3-15/h2-5,10-12H,6-9,13-14H2,1H3,(H,23,32)(H,26,33)
PDB

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UniChem
US Patent
n/an/a 2.70n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280324
PNG
(US10029993, Example 219)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C20H26N6O2/c1-14(2)22-19(27)13-25-6-8-26(9-7-25)20-23-17(12-21-24-20)15-3-4-18-16(11-15)5-10-28-18/h3-4,11-12,14H,5-10,13H2,1-2H3,(H,22,27)
PDB

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PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280291
PNG
(US10029993, Example 80)
Show SMILES CNC(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(F)cc2)cn1
Show InChI InChI=1S/C21H24FN9O2/c1-23-19(32)14-31-12-17(10-25-31)26-20(33)13-29-6-8-30(9-7-29)21-27-18(11-24-28-21)15-2-4-16(22)5-3-15/h2-5,10-12H,6-9,13-14H2,1H3,(H,23,32)(H,26,33)
PDB

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UniChem
US Patent
n/an/a 4.5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280289
PNG
(US10029993, Example 76)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C22H26ClN9O2/c1-29(2)21(34)15-32-13-18(11-25-32)26-20(33)14-30-7-9-31(10-8-30)22-27-19(12-24-28-22)16-3-5-17(23)6-4-16/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,26,33)
PDB

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UniChem
US Patent
n/an/a 4.5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280290
PNG
(US10029993, Example 79)
Show SMILES CNC(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(C)cc2)cn1
Show InChI InChI=1S/C22H27N9O2/c1-16-3-5-17(6-4-16)19-12-24-28-22(27-19)30-9-7-29(8-10-30)14-21(33)26-18-11-25-31(13-18)15-20(32)23-2/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,23,32)(H,26,33)
PDB

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US Patent
n/an/a 4.5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280277
PNG
(US10029993, Example 40)
Show SMILES CN([C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1)C(C)=O
Show InChI InChI=1S/C24H32FN7O2/c1-17(33)30(2)21-9-7-20(8-10-21)27-23(34)16-31-11-13-32(14-12-31)24-28-22(15-26-29-24)18-3-5-19(25)6-4-18/h3-6,15,20-21H,7-14,16H2,1-2H3,(H,27,34)/t20-,21-
PDB

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UniChem
US Patent
n/an/a 4.90n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280314
PNG
(US10029993, Example 178)
Show SMILES Clc1ccc(cc1)-c1cnnc(n1)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C18H22ClN5O/c19-15-3-1-14(2-4-15)17-13-20-22-18(21-17)24-9-7-23(8-10-24)16-5-11-25-12-6-16/h1-4,13,16H,5-12H2
PDB

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US Patent
n/an/a 5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280311
PNG
(US10029993, Example 166a)
Show SMILES O[C@@H]1COCC[C@@H]1NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H25ClN6O3/c21-15-3-1-14(2-4-15)17-11-22-25-20(24-17)27-8-6-26(7-9-27)12-19(29)23-16-5-10-30-13-18(16)28/h1-4,11,16,18,28H,5-10,12-13H2,(H,23,29)/t16-,18+/m0/s1
PDB

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n/an/a 5.60n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280317
PNG
(US10029993, Example 188)
Show SMILES Cc1ccccc1-c1cnnc(n1)N1CC[C@H](C1)Oc1ccncc1
Show InChI InChI=1S/C19H19N5O/c1-14-4-2-3-5-17(14)18-12-21-23-19(22-18)24-11-8-16(13-24)25-15-6-9-20-10-7-15/h2-7,9-10,12,16H,8,11,13H2,1H3/t16-/m1/s1
PDB

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US Patent
n/an/a 6n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280315
PNG
(US10029993, Example 180)
Show SMILES CC(C)NC(=O)NC1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H23FN6O/c1-12(2)21-18(26)22-15-7-9-25(10-8-15)17-23-16(11-20-24-17)13-3-5-14(19)6-4-13/h3-6,11-12,15H,7-10H2,1-2H3,(H2,21,22,26)
PDB

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PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280309
PNG
(US10029993, Example 161)
Show SMILES C[C@H]1COCCC1NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H27ClN6O2/c1-15-14-30-11-6-18(15)24-20(29)13-27-7-9-28(10-8-27)21-25-19(12-23-26-21)16-2-4-17(22)5-3-16/h2-5,12,15,18H,6-11,13-14H2,1H3,(H,24,29)/t15-,18?/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280287
PNG
(US10029993, Example 71)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(F)cc2)cn1
Show InChI InChI=1S/C22H26FN9O2/c1-29(2)21(34)15-32-13-18(11-25-32)26-20(33)14-30-7-9-31(10-8-30)22-27-19(12-24-28-22)16-3-5-17(23)6-4-16/h3-6,11-13H,7-10,14-15H2,1-2H3,(H,26,33)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280298
PNG
(US10029993, Example 115)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NN2CCCC2)CC1
Show InChI InChI=1S/C19H24FN7O/c20-16-5-3-15(4-6-16)17-13-21-23-19(22-17)26-11-9-25(10-12-26)14-18(28)24-27-7-1-2-8-27/h3-6,13H,1-2,7-12,14H2,(H,24,28)
PDB

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US Patent
n/an/a 6.30n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280281
PNG
(US10029993, Example 50)
Show SMILES Cc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)N[C@H]2CC[C@@H](CC2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H32N6O3S/c1-17-3-5-18(6-4-17)21-15-24-27-23(26-21)29-13-11-28(12-14-29)16-22(30)25-19-7-9-20(10-8-19)33(2,31)32/h3-6,15,19-20H,7-14,16H2,1-2H3,(H,25,30)/t19-,20-
PDB

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UniChem
US Patent
n/an/a 6.30n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280267
PNG
(US10029993, Example 12)
Show SMILES Cc1ccccc1-c1cnnc(n1)N1CCN(CC(=O)NC2CC[C@@](C)(O)CC2)CC1
Show InChI InChI=1S/C23H32N6O2/c1-17-5-3-4-6-19(17)20-15-24-27-22(26-20)29-13-11-28(12-14-29)16-21(30)25-18-7-9-23(2,31)10-8-18/h3-6,15,18,31H,7-14,16H2,1-2H3,(H,25,30)/t18?,23-
PDB

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PC sid
UniChem
US Patent
n/an/a 6.90n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280282
PNG
(US10029993, Example 54)
Show SMILES CN1CC[C@@H](CC1=O)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H26ClN7O2/c1-27-7-6-17(12-20(27)31)24-19(30)14-28-8-10-29(11-9-28)21-25-18(13-23-26-21)15-2-4-16(22)5-3-15/h2-5,13,17H,6-12,14H2,1H3,(H,24,30)/t17-/m0/s1
PDB

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PC sid
UniChem
US Patent
n/an/a 7.20n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280331
PNG
(US10029993, Example 251)
Show SMILES CC(C)CC(=O)NN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H23ClN6O/c1-13(2)11-17(26)23-25-9-7-24(8-10-25)18-21-16(12-20-22-18)14-3-5-15(19)6-4-14/h3-6,12-13H,7-11H2,1-2H3,(H,23,26)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 7.5n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280294
PNG
(US10029993, Example 83)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1cc(F)ccc1F
Show InChI InChI=1S/C23H31F2N7O/c1-30(2)18-6-4-17(5-7-18)27-22(33)15-31-9-11-32(12-10-31)23-28-21(14-26-29-23)19-13-16(24)3-8-20(19)25/h3,8,13-14,17-18H,4-7,9-12,15H2,1-2H3,(H,27,33)/t17-,18-
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n/an/a 7.60n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280288
PNG
(US10029993, Example 75)
Show SMILES CN(C)C(=O)Cn1cc(NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(C)cc2)cn1
Show InChI InChI=1S/C23H29N9O2/c1-17-4-6-18(7-5-17)20-13-24-28-23(27-20)31-10-8-30(9-11-31)15-21(33)26-19-12-25-32(14-19)16-22(34)29(2)3/h4-7,12-14H,8-11,15-16H2,1-3H3,(H,26,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280307
PNG
(US10029993, Example 159a)
Show SMILES CN1CCO[C@@H](CNC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(F)cc2)C1
Show InChI InChI=1S/C21H28FN7O2/c1-27-10-11-31-18(14-27)12-23-20(30)15-28-6-8-29(9-7-28)21-25-19(13-24-26-21)16-2-4-17(22)5-3-16/h2-5,13,18H,6-12,14-15H2,1H3,(H,23,30)/t18-/m0/s1
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n/an/a 7.70n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280269
PNG
(US10029993, Example 18)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H32ClN7O/c1-29(2)20-9-7-19(8-10-20)26-22(32)16-30-11-13-31(14-12-30)23-27-21(15-25-28-23)17-3-5-18(24)6-4-17/h3-6,15,19-20H,7-14,16H2,1-2H3,(H,26,32)/t19-,20-
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n/an/a 7.90n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280274
PNG
(US10029993, Example 28)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)N[C@H]2CC[C@@H](CC2)N2CCOCC2)CC1
Show InChI InChI=1S/C25H34FN7O2/c26-20-3-1-19(2-4-20)23-17-27-30-25(29-23)33-11-9-31(10-12-33)18-24(34)28-21-5-7-22(8-6-21)32-13-15-35-16-14-32/h1-4,17,21-22H,5-16,18H2,(H,28,34)/t21-,22-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280272
PNG
(US10029993, Example 26)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)N[C@H]2CC[C@@H](CC2)N2CCNC(=O)C2)CC1
Show InChI InChI=1S/C25H33FN8O2/c26-19-3-1-18(2-4-19)22-15-28-31-25(30-22)33-13-11-32(12-14-33)16-24(36)29-20-5-7-21(8-6-20)34-10-9-27-23(35)17-34/h1-4,15,20-21H,5-14,16-17H2,(H,27,35)(H,29,36)/t20-,21-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280283
PNG
(US10029993, Example 55)
Show SMILES CNC(=O)CO[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H32FN7O3/c1-26-23(34)16-35-20-8-6-19(7-9-20)28-22(33)15-31-10-12-32(13-11-31)24-29-21(14-27-30-24)17-2-4-18(25)5-3-17/h2-5,14,19-20H,6-13,15-16H2,1H3,(H,26,34)(H,28,33)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280280
PNG
(US10029993, Example 48)
Show SMILES CC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H33N7O2/c1-17-3-5-19(6-4-17)22-15-25-29-24(28-22)31-13-11-30(12-14-31)16-23(33)27-21-9-7-20(8-10-21)26-18(2)32/h3-6,15,20-21H,7-14,16H2,1-2H3,(H,26,32)(H,27,33)/t20-,21-
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n/an/a 9n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280323
PNG
(US10029993, Example 218)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1cccc2CCOCc12
Show InChI InChI=1S/C21H28N6O2/c1-15(2)23-20(28)13-26-7-9-27(10-8-26)21-24-19(12-22-25-21)17-5-3-4-16-6-11-29-14-18(16)17/h3-5,12,15H,6-11,13-14H2,1-2H3,(H,23,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280296
PNG
(US10029993, Example 85)
Show SMILES CNC(=O)CN1CCC(CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H34N8O2/c1-18-3-5-19(6-4-18)21-15-26-29-24(28-21)32-13-11-31(12-14-32)17-23(34)27-20-7-9-30(10-8-20)16-22(33)25-2/h3-6,15,20H,7-14,16-17H2,1-2H3,(H,25,33)(H,27,34)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280285
PNG
(US10029993, Example 62)
Show SMILES Cc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NC2CCN(CCNS(C)(=O)=O)CC2)CC1
Show InChI InChI=1S/C24H36N8O3S/c1-19-3-5-20(6-4-19)22-17-25-29-24(28-22)32-15-13-31(14-16-32)18-23(33)27-21-7-10-30(11-8-21)12-9-26-36(2,34)35/h3-6,17,21,26H,7-16,18H2,1-2H3,(H,27,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280301
PNG
(US10029993, Example 141)
Show SMILES OC1(CC1)C(=O)N1CC(C1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H26FN7O3/c23-16-3-1-15(2-4-16)18-11-24-27-21(26-18)29-9-7-28(8-10-29)14-19(31)25-17-12-30(13-17)20(32)22(33)5-6-22/h1-4,11,17,33H,5-10,12-14H2,(H,25,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280312
PNG
(US10029993, Example 167a)
Show SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN7O2/c1-16(32)26-19-3-2-4-20(13-19)27-22(33)15-30-9-11-31(12-10-30)23-28-21(14-25-29-23)17-5-7-18(24)8-6-17/h5-8,14,19-20H,2-4,9-13,15H2,1H3,(H,26,32)(H,27,33)/t19-,20+/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280330
PNG
(US10029993, Example 244)
Show SMILES Cc1ccccc1-c1cnnc(n1)C1CCCN(C1)c1cnccn1
Show InChI InChI=1S/C19H20N6/c1-14-5-2-3-7-16(14)17-11-22-24-19(23-17)15-6-4-10-25(13-15)18-12-20-8-9-21-18/h2-3,5,7-9,11-12,15H,4,6,10,13H2,1H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280279
PNG
(US10029993, Example 47)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NCCN2CCS(=O)(=O)CC2)CC1
Show InChI InChI=1S/C21H28FN7O3S/c22-18-3-1-17(2-4-18)19-15-24-26-21(25-19)29-9-7-28(8-10-29)16-20(30)23-5-6-27-11-13-33(31,32)14-12-27/h1-4,15H,5-14,16H2,(H,23,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280293
PNG
(US10029993, Example 82)
Show SMILES CN1CCNC(=O)[C@@]11CCC(CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H33FN8O2/c1-32-11-10-27-23(36)25(32)8-6-20(7-9-25)29-22(35)17-33-12-14-34(15-13-33)24-30-21(16-28-31-24)18-2-4-19(26)5-3-18/h2-5,16,20H,6-15,17H2,1H3,(H,27,36)(H,29,35)/t20?,25-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280300
PNG
(US10029993, Example 135)
Show SMILES CC[C@@H](O)C(=O)N1CCC(CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H32FN7O3/c1-2-21(33)23(35)31-9-7-19(8-10-31)27-22(34)16-30-11-13-32(14-12-30)24-28-20(15-26-29-24)17-3-5-18(25)6-4-17/h3-6,15,19,21,33H,2,7-14,16H2,1H3,(H,27,34)/t21-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280320
PNG
(US10029993, Example 199)
Show SMILES O=C1NCC2(CCN(CC2)c2nncc(n2)-c2ccc3ccccc3c2)O1
Show InChI InChI=1S/C20H19N5O2/c26-19-21-13-20(27-19)7-9-25(10-8-20)18-23-17(12-22-24-18)16-6-5-14-3-1-2-4-15(14)11-16/h1-6,11-12H,7-10,13H2,(H,21,26)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280334
PNG
(US10029993, Example 257)
Show SMILES Clc1ccc(CNc2cnnc(n2)N2CCOCC2)cc1
Show InChI InChI=1S/C14H16ClN5O/c15-12-3-1-11(2-4-12)9-16-13-10-17-19-14(18-13)20-5-7-21-8-6-20/h1-4,10H,5-9H2,(H,16,18,19)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280273
PNG
(US10029993, Example 27)
Show SMILES Clc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NC2CCS(=O)(=O)CC2)CC1
Show InChI InChI=1S/C20H25ClN6O3S/c21-16-3-1-15(2-4-16)18-13-22-25-20(24-18)27-9-7-26(8-10-27)14-19(28)23-17-5-11-31(29,30)12-6-17/h1-4,13,17H,5-12,14H2,(H,23,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280308
PNG
(US10029993, Example 160)
Show SMILES CN(C)[C@@H]1CCC[C@@H](C1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H32FN7O/c1-29(2)20-5-3-4-19(14-20)26-22(32)16-30-10-12-31(13-11-30)23-27-21(15-25-28-23)17-6-8-18(24)9-7-17/h6-9,15,19-20H,3-5,10-14,16H2,1-2H3,(H,26,32)/t19-,20+/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280276
PNG
(US10029993, Example 38)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NC2CCN(CC(=O)N3CCOCC3)CC2)CC1
Show InChI InChI=1S/C26H35FN8O3/c27-21-3-1-20(2-4-21)23-17-28-31-26(30-23)35-11-9-33(10-12-35)18-24(36)29-22-5-7-32(8-6-22)19-25(37)34-13-15-38-16-14-34/h1-4,17,22H,5-16,18-19H2,(H,29,36)
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US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280306
PNG
(US10029993, Example 157a)
Show SMILES OC1C2COCC1CC(C2)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H29F3N6O3/c25-24(26,27)18-3-1-15(2-4-18)20-11-28-31-23(30-20)33-7-5-32(6-8-33)12-21(34)29-19-9-16-13-36-14-17(10-19)22(16)35/h1-4,11,16-17,19,22,35H,5-10,12-14H2,(H,29,34)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280332
PNG
(US10029993, Example 252)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)C(O)C1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H33FN6O2/c1-30(2)20-9-7-19(8-10-20)27-23(33)22(32)17-11-13-31(14-12-17)24-28-21(15-26-29-24)16-3-5-18(25)6-4-16/h3-6,15,17,19-20,22,32H,7-14H2,1-2H3,(H,27,33)/t19-,20-,22?
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n/an/a 15n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280299
PNG
(US10029993, Example 124)
Show SMILES C[C@H]1CC[C@@H](CC1)c1cnnc(n1)N1CCN(CC(=O)N[C@H]2CC[C@@H](CC2)N(C)C)CC1
Show InChI InChI=1S/C24H41N7O/c1-18-4-6-19(7-5-18)22-16-25-28-24(27-22)31-14-12-30(13-15-31)17-23(32)26-20-8-10-21(11-9-20)29(2)3/h16,18-21H,4-15,17H2,1-3H3,(H,26,32)/t18-,19-,20-,21-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280268
PNG
(US10029993, Example 16)
Show SMILES CC(C)[C@@H](CO)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H27F3N6O2/c1-14(2)18(13-31)26-19(32)12-29-7-9-30(10-8-29)20-27-17(11-25-28-20)15-3-5-16(6-4-15)21(22,23)24/h3-6,11,14,18,31H,7-10,12-13H2,1-2H3,(H,26,32)/t18-/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280310
PNG
(US10029993, Example 164a)
Show SMILES O[C@H]1COC[C@H]1NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H23F3N6O3/c21-20(22,23)14-3-1-13(2-4-14)15-9-24-27-19(26-15)29-7-5-28(6-8-29)10-18(31)25-16-11-32-12-17(16)30/h1-4,9,16-17,30H,5-8,10-12H2,(H,25,31)/t16-,17+/m1/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280303
PNG
(US10029993, Example 151)
Show SMILES Fc1ccc(cc1)-c1cnnc(n1)N1CCN(CC(=O)NC2CCN(CC3=NCCN3)CC2)CC1
Show InChI InChI=1S/C24H32FN9O/c25-19-3-1-18(2-4-19)21-15-28-31-24(30-21)34-13-11-33(12-14-34)17-23(35)29-20-5-9-32(10-6-20)16-22-26-7-8-27-22/h1-4,15,20H,5-14,16-17H2,(H,26,27)(H,29,35)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280278
PNG
(US10029993, Example 44)
Show SMILES CNC(=O)CN1CCC(CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H31FN8O2/c1-25-21(33)15-30-8-6-19(7-9-30)27-22(34)16-31-10-12-32(13-11-31)23-28-20(14-26-29-23)17-2-4-18(24)5-3-17/h2-5,14,19H,6-13,15-16H2,1H3,(H,25,33)(H,27,34)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280270
PNG
(US10029993, Example 19)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2n(C)ncc2c1
Show InChI InChI=1S/C24H32N8O2/c1-30-22-8-3-17(13-18(22)14-26-30)21-15-25-29-24(28-21)32-11-9-31(10-12-32)16-23(33)27-19-4-6-20(34-2)7-5-19/h3,8,13-15,19-20H,4-7,9-12,16H2,1-2H3,(H,27,33)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280271
PNG
(US10029993, Example 22)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H32FN7O/c1-29(2)20-9-7-19(8-10-20)26-22(32)16-30-11-13-31(14-12-30)23-27-21(15-25-28-23)17-3-5-18(24)6-4-17/h3-6,15,19-20H,7-14,16H2,1-2H3,(H,26,32)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280304
PNG
(US10029993, Example 153)
Show SMILES Cc1nc[nH]c1CN1CCC(CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H32FN9O/c1-18-23(28-17-27-18)15-33-8-6-21(7-9-33)30-24(36)16-34-10-12-35(13-11-34)25-31-22(14-29-32-25)19-2-4-20(26)5-3-19/h2-5,14,17,21H,6-13,15-16H2,1H3,(H,27,28)(H,30,36)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280275
PNG
(US10029993, Example 29)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccccc1C
Show InChI InChI=1S/C24H35N7O/c1-18-6-4-5-7-21(18)22-16-25-28-24(27-22)31-14-12-30(13-15-31)17-23(32)26-19-8-10-20(11-9-19)29(2)3/h4-7,16,19-20H,8-15,17H2,1-3H3,(H,26,32)/t19-,20-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280302
PNG
(US10029993, Example 147)
Show SMILES Cc1ncc(CN2CCC(CC2)NC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(F)cc2)[nH]1
Show InChI InChI=1S/C25H32FN9O/c1-18-27-14-22(29-18)16-33-8-6-21(7-9-33)30-24(36)17-34-10-12-35(13-11-34)25-31-23(15-28-32-25)19-2-4-20(26)5-3-19/h2-5,14-15,21H,6-13,16-17H2,1H3,(H,27,29)(H,30,36)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280284
PNG
(US10029993, Example 59)
Show SMILES NC(=O)N1CCC(O)(CNC(=O)CN2CCN(CC2)c2nncc(n2)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C22H29ClN8O3/c23-17-3-1-16(2-4-17)18-13-26-28-21(27-18)31-11-9-29(10-12-31)14-19(32)25-15-22(34)5-7-30(8-6-22)20(24)33/h1-4,13,34H,5-12,14-15H2,(H2,24,33)(H,25,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280286
PNG
(US10029993, Example 64)
Show SMILES OC1CCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H36FN7O2/c27-20-3-1-19(2-4-20)24-17-28-31-26(30-24)34-15-13-32(14-16-34)18-25(36)29-21-5-7-22(8-6-21)33-11-9-23(35)10-12-33/h1-4,17,21-23,35H,5-16,18H2,(H,29,36)/t21-,22-
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280325
PNG
(US10029993, Example 220)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H23N7OS/c1-13(2)22-18(27)11-25-5-7-26(8-6-25)19-23-16(10-21-24-19)14-3-4-15-17(9-14)28-12-20-15/h3-4,9-10,12-13H,5-8,11H2,1-2H3,(H,22,27)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280328
PNG
(US10029993, Example 233)
Show SMILES C(C1CCCCC1)c1cnnc(n1)N1CCOCC1
Show InChI InChI=1S/C14H22N4O/c1-2-4-12(5-3-1)10-13-11-15-17-14(16-13)18-6-8-19-9-7-18/h11-12H,1-10H2
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280329
PNG
(US10029993, Example 236)
Show SMILES Cc1ccccc1-c1cnnc(n1)N(Cc1ccccn1)S(C)(=O)=O
Show InChI InChI=1S/C17H17N5O2S/c1-13-7-3-4-9-15(13)16-11-19-21-17(20-16)22(25(2,23)24)12-14-8-5-6-10-18-14/h3-11H,12H2,1-2H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280313
PNG
(US10029993, Example 170)
Show SMILES Cc1ccccc1-c1cnnc(n1)N1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN5/c1-15-4-2-3-5-18(15)19-14-22-24-20(23-19)26-12-10-25(11-13-26)17-8-6-16(21)7-9-17/h2-9,14H,10-13H2,1H3
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280295
PNG
(US10029993, Example 84)
Show SMILES CN1CC[C@@H](CC1=O)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2COCc2c1
Show InChI InChI=1S/C23H29N7O3/c1-28-5-4-19(11-22(28)32)25-21(31)13-29-6-8-30(9-7-29)23-26-20(12-24-27-23)16-2-3-17-14-33-15-18(17)10-16/h2-3,10,12,19H,4-9,11,13-15H2,1H3,(H,25,31)/t19-/m0/s1
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280333
PNG
(US10029993, Example 256)
Show SMILES C(Oc1cnnc(n1)N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C14H16N4O2/c1-2-4-12(5-3-1)11-20-13-10-15-17-14(16-13)18-6-8-19-9-7-18/h1-5,10H,6-9,11H2
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280327
PNG
(US10029993, Example 222)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc2N(C)NCc2c1
Show InChI InChI=1S/C20H28N8O/c1-14(2)23-19(29)13-27-6-8-28(9-7-27)20-24-17(12-21-25-20)15-4-5-18-16(10-15)11-22-26(18)3/h4-5,10,12,14,22H,6-9,11,13H2,1-3H3,(H,23,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280322
PNG
(US10029993, Example 215)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1nncc(n1)-c1ccc(nc1)C#N
Show InChI InChI=1S/C18H22N8O/c1-13(2)22-17(27)12-25-5-7-26(8-6-25)18-23-16(11-21-24-18)14-3-4-15(9-19)20-10-14/h3-4,10-11,13H,5-8,12H2,1-2H3,(H,22,27)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280318
PNG
(US10029993, Example 192)
Show SMILES CN(CCCS(C)(=O)=O)c1nncc(n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C18H20N4O2S/c1-22(10-5-11-25(2,23)24)18-20-17(13-19-21-18)16-9-8-14-6-3-4-7-15(14)12-16/h3-4,6-9,12-13H,5,10-11H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2)


(Homo sapiens (Human))
BDBM280319
PNG
(US10029993, Example 196)
Show SMILES CC(=O)N1CCC(CNc2nncc(n2)-c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C21H23N5O/c1-15(27)26-10-8-16(9-11-26)13-22-21-24-20(14-23-25-21)19-7-6-17-4-2-3-5-18(17)12-19/h2-7,12,14,16H,8-11,13H2,1H3,(H,22,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 67n/an/an/an/a7.425



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
The pcDNA3.1-human CYP11B2 plasmid was transfected into a Chinese hamster lung fibroblast V79 cell line to produce a cell line stably expressing huma...


US Patent US10029993 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%