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USPatent US10035761

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202585
PNG
(US10035761, Compound 8j | US9238625, 8j)
Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1
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0.800n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202585
PNG
(US10035761, Compound 8j | US9238625, 8j)
Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1
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1.16n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202584
PNG
(US10035761, Compound 8h | US9238625, 8h)
Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1
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1.19n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202582
PNG
(US10035761, Compound 8a | US9238625, 8a)
Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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1.40n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202582
PNG
(US10035761, Compound 8a | US9238625, 8a)
Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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2.38n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202584
PNG
(US10035761, Compound 8h | US9238625, 8h)
Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1
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2.39n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202581
PNG
(US10035761, Compound 7g | US9238625, 7g)
Show SMILES CCOCCCCNC(CC(C)C)C1(CCC1)c1ccc(SC)cc1
Show InChI InChI=1S/C22H37NOS/c1-5-24-16-7-6-15-23-21(17-18(2)3)22(13-8-14-22)19-9-11-20(25-4)12-10-19/h9-12,18,21,23H,5-8,13-17H2,1-4H3
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2.99n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202587
PNG
(US10035761, Compound 12c | US9238625, 12c)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCSCC
Show InChI InChI=1S/C21H35NOS/c1-5-23-19-10-8-18(9-11-19)21(12-7-13-21)20(16-17(3)4)22-14-15-24-6-2/h8-11,17,20,22H,5-7,12-16H2,1-4H3
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3.31n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202583
PNG
(US10035761, Compound 8d | US9238625, 8d)
Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1
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3.80n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202583
PNG
(US10035761, Compound 8d | US9238625, 8d)
Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1
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5.45n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202585
PNG
(US10035761, Compound 8j | US9238625, 8j)
Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1
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11n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202584
PNG
(US10035761, Compound 8h | US9238625, 8h)
Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1
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12.7n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202588
PNG
(US10035761, Compound 13c | US9238625, 13c)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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14.8n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202588
PNG
(US10035761, Compound 13c | US9238625, 13c)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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17.1n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202586
PNG
(US10035761, Compound 12b | US9238625, 12b)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H34ClNS/c1-4-24-15-6-5-14-23-20(16-17(2)3)21(12-7-13-21)18-8-10-19(22)11-9-18/h8-11,17,20,23H,4-7,12-16H2,1-3H3
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18.8n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202588
PNG
(US10035761, Compound 13c | US9238625, 13c)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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23.9n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202591
PNG
(US10035761, Compound 17a | US9238625, 17a)
Show SMILES CCS(=O)(=O)CCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO2S/c1-4-27(25,26)13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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29.4n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202581
PNG
(US10035761, Compound 7g | US9238625, 7g)
Show SMILES CCOCCCCNC(CC(C)C)C1(CCC1)c1ccc(SC)cc1
Show InChI InChI=1S/C22H37NOS/c1-5-24-16-7-6-15-23-21(17-18(2)3)22(13-8-14-22)19-9-11-20(25-4)12-10-19/h9-12,18,21,23H,5-8,13-17H2,1-4H3
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37.2n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202591
PNG
(US10035761, Compound 17a | US9238625, 17a)
Show SMILES CCS(=O)(=O)CCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO2S/c1-4-27(25,26)13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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38.4n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202591
PNG
(US10035761, Compound 17a | US9238625, 17a)
Show SMILES CCS(=O)(=O)CCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO2S/c1-4-27(25,26)13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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44.7n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202582
PNG
(US10035761, Compound 8a | US9238625, 8a)
Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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46.7n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM279459
PNG
(Example 57 1-(1-(3,4-dichlorophenyl)cyclobutyl)-N-...)
Show SMILES CCSCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NS/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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49.2n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202589
PNG
(US10035761, Compound 13d | US9238625, 13d)
Show SMILES CCCCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H37Cl2NS/c1-4-5-14-27-15-7-6-13-26-22(16-18(2)3)23(11-8-12-23)19-9-10-20(24)21(25)17-19/h9-10,17-18,22,26H,4-8,11-16H2,1-3H3
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51n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202586
PNG
(US10035761, Compound 12b | US9238625, 12b)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H34ClNS/c1-4-24-15-6-5-14-23-20(16-17(2)3)21(12-7-13-21)18-8-10-19(22)11-9-18/h8-11,17,20,23H,4-7,12-16H2,1-3H3
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51.9n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM202589
PNG
(US10035761, Compound 13d | US9238625, 13d)
Show SMILES CCCCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H37Cl2NS/c1-4-5-14-27-15-7-6-13-26-22(16-18(2)3)23(11-8-12-23)19-9-10-20(24)21(25)17-19/h9-10,17-18,22,26H,4-8,11-16H2,1-3H3
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65.3n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202586
PNG
(US10035761, Compound 12b | US9238625, 12b)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H34ClNS/c1-4-24-15-6-5-14-23-20(16-17(2)3)21(12-7-13-21)18-8-10-19(22)11-9-18/h8-11,17,20,23H,4-7,12-16H2,1-3H3
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67.6n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202583
PNG
(US10035761, Compound 8d | US9238625, 8d)
Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1
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72n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202581
PNG
(US10035761, Compound 7g | US9238625, 7g)
Show SMILES CCOCCCCNC(CC(C)C)C1(CCC1)c1ccc(SC)cc1
Show InChI InChI=1S/C22H37NOS/c1-5-24-16-7-6-15-23-21(17-18(2)3)22(13-8-14-22)19-9-11-20(25-4)12-10-19/h9-12,18,21,23H,5-8,13-17H2,1-4H3
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92n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202589
PNG
(US10035761, Compound 13d | US9238625, 13d)
Show SMILES CCCCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H37Cl2NS/c1-4-5-14-27-15-7-6-13-26-22(16-18(2)3)23(11-8-12-23)19-9-10-20(24)21(25)17-19/h9-10,17-18,22,26H,4-8,11-16H2,1-3H3
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104n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Monoamine transporters; serotonin & dopamine


(Homo sapiens (Human))
BDBM202587
PNG
(US10035761, Compound 12c | US9238625, 12c)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCSCC
Show InChI InChI=1S/C21H35NOS/c1-5-23-19-10-8-18(9-11-19)21(12-7-13-21)20(16-17(3)4)22-14-15-24-6-2/h8-11,17,20,22H,5-7,12-16H2,1-4H3
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116n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM279459
PNG
(Example 57 1-(1-(3,4-dichlorophenyl)cyclobutyl)-N-...)
Show SMILES CCSCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NS/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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119n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))
BDBM279459
PNG
(Example 57 1-(1-(3,4-dichlorophenyl)cyclobutyl)-N-...)
Show SMILES CCSCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NS/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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224n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))
BDBM202587
PNG
(US10035761, Compound 12c | US9238625, 12c)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCSCC
Show InChI InChI=1S/C21H35NOS/c1-5-23-19-10-8-18(9-11-19)21(12-7-13-21)20(16-17(3)4)22-14-15-24-6-2/h8-11,17,20,22H,5-7,12-16H2,1-4H3
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1.42E+3n/an/an/an/an/an/an/an/a



Revivia Pharmaceuticals, Inc.

US Patent


Assay Description
The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...


US Patent US10035761 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%