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USPatent US10093663

Compile data set for download or QSAR
Found 110 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM159970
PNG
(US10093663, Example 20a | US9682968, Example-20a)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC[C@@H](C)C[C@H]1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O3/c1-15-9-11-26(21(12-15)17-4-6-18(7-5-17)24(27)28)14-20-19-8-10-25-23(19)16(2)13-22(20)29-3/h4-8,10,13,15,21,25H,9,11-12,14H2,1-3H3,(H,27,28)/t15-,21+/m1/s1
PDB

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n/an/a 9n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289502
PNG
(US10093663, Example 27-4a)
Show SMILES CCOC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H32N2O3/c1-3-32-21-11-13-29(25(15-21)19-6-8-20(9-7-19)27(30)31)16-24-22-10-12-28-26(22)17(2)14-23(24)18-4-5-18/h6-10,12,14,18,21,25,28H,3-5,11,13,15-16H2,1-2H3,(H,30,31)/t21?,25-/m0/s1
PDB

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n/an/a 9n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160475
PNG
(US10093663, Example 26b | US9682968, Example-26a)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O4/c1-4-31-19-10-12-27(22(14-19)17-5-7-18(8-6-17)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3/h5-9,11,13,19,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29)/t19-,22-/m0/s1
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n/an/a 10n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159938
PNG
(US10093663, Example 17-29 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC2(CC2)CC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H28N2O3/c1-16-13-22(30-2)20(19-7-11-26-23(16)19)15-27-12-10-25(8-9-25)14-21(27)17-3-5-18(6-4-17)24(28)29/h3-7,11,13,21,26H,8-10,12,14-15H2,1-2H3,(H,28,29)
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n/an/a 11n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159545
PNG
(US10093663, Example 17-30 | US9682968, Example-17-...)
Show SMILES CCC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O3/c1-4-17-10-12-27(22(14-17)18-5-7-19(8-6-18)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3/h5-9,11,13,17,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29)
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n/an/a 13n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289488
PNG
(US10093663, Example 22-2b)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC(C)(C)C[C@@H]1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O3/c1-16-13-22(30-4)20(19-9-11-26-23(16)19)15-27-12-10-25(2,3)14-21(27)17-5-7-18(8-6-17)24(28)29/h5-9,11,13,21,26H,10,12,14-15H2,1-4H3,(H,28,29)/t21-/m1/s1
PDB

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n/an/a 13n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289500
PNG
(US10093663, Example 27-3a)
Show SMILES COC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H30N2O3/c1-16-13-22(17-3-4-17)23(21-9-11-27-25(16)21)15-28-12-10-20(31-2)14-24(28)18-5-7-19(8-6-18)26(29)30/h5-9,11,13,17,20,24,27H,3-4,10,12,14-15H2,1-2H3,(H,29,30)/t20?,24-/m0/s1
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n/an/a 14n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289498
PNG
(US10093663, Example 27-2a)
Show SMILES CCOC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O3/c1-4-30-20-10-12-27(23(14-20)18-5-7-19(8-6-18)25(28)29)15-22-16(2)13-17(3)24-21(22)9-11-26-24/h5-9,11,13,20,23,26H,4,10,12,14-15H2,1-3H3,(H,28,29)/t20?,23-/m0/s1
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n/an/a 15n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159486
PNG
(US10093663, Example 17-11 | US9682968, Example-17-...)
Show SMILES CCCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H32N2O4/c1-4-13-32-20-10-12-28(23(15-20)18-5-7-19(8-6-18)26(29)30)16-22-21-9-11-27-25(21)17(2)14-24(22)31-3/h5-9,11,14,20,23,27H,4,10,12-13,15-16H2,1-3H3,(H,29,30)/t20-,23-/m0/s1
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n/an/a 15n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289485
PNG
(US10093663, Example 22-1a)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C24H29N3O4/c1-4-31-17-8-10-27(21(12-17)16-5-6-20(24(28)29)26-13-16)14-19-18-7-9-25-23(18)15(2)11-22(19)30-3/h5-7,9,11,13,17,21,25H,4,8,10,12,14H2,1-3H3,(H,28,29)/t17?,21-/m0/s1
PDB

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n/an/a 19n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159312
PNG
(US10093663, Example 17-1 | US9682968, Example-17-1)
Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(cc2)C(O)=O)c2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-16-14-21(17-5-6-17)22(20-11-12-26-24(16)20)15-27-13-3-2-4-23(27)18-7-9-19(10-8-18)25(28)29/h7-12,14,17,23,26H,2-6,13,15H2,1H3,(H,28,29)/t23-/m0/s1
PDB

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n/an/a 19n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160036
PNG
(US10093663, Example 21a | US9682968, Example-21a)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O4/c1-15-12-22(30-3)20(19-8-10-25-23(15)19)14-26-11-9-18(29-2)13-21(26)16-4-6-17(7-5-16)24(27)28/h4-8,10,12,18,21,25H,9,11,13-14H2,1-3H3,(H,27,28)/t18-,21-/m0/s1
PDB

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n/an/a 19n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160499
PNG
(US10093663, Example 36 | US9682968, Example-36)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)-c1nn[nH]n1
Show InChI InChI=1S/C25H30N6O2/c1-4-33-19-10-12-31(15-21-20-9-11-26-24(20)16(2)13-23(21)32-3)22(14-19)17-5-7-18(8-6-17)25-27-29-30-28-25/h5-9,11,13,19,22,26H,4,10,12,14-15H2,1-3H3,(H,27,28,29,30)
PDB

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n/an/a 20n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160500
PNG
(US10093663, Example 37 | US9682968, Example-37)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C26H33N3O5S/c1-5-34-20-11-13-29(16-22-21-10-12-27-25(21)17(2)14-24(22)33-3)23(15-20)18-6-8-19(9-7-18)26(30)28-35(4,31)32/h6-10,12,14,20,23,27H,5,11,13,15-16H2,1-4H3,(H,28,30)/t20-,23-/m0/s1
PDB

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n/an/a 22n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289497
PNG
(US10093663, Example 27-1b)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O3/c1-15-12-16(2)23-20(8-10-25-23)21(15)14-26-11-9-19(29-3)13-22(26)17-4-6-18(7-5-17)24(27)28/h4-8,10,12,19,22,25H,9,11,13-14H2,1-3H3,(H,27,28)/t19?,22-/m1/s1
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n/an/a 22n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159545
PNG
(US10093663, Example 17-30 | US9682968, Example-17-...)
Show SMILES CCC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O3/c1-4-17-10-12-27(22(14-17)18-5-7-19(8-6-18)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3/h5-9,11,13,17,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29)
PDB

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n/an/a 23n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159566
PNG
(US10093663, Example 17-18 | US9682968, Example-17-...)
Show SMILES COC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C25H29N3O3/c1-15-11-20(16-3-4-16)21(19-7-9-26-24(15)19)14-28-10-8-18(31-2)12-23(28)17-5-6-22(25(29)30)27-13-17/h5-7,9,11,13,16,18,23,26H,3-4,8,10,12,14H2,1-2H3,(H,29,30)
PDB

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n/an/a 27n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289450
PNG
(US10093663, Example 17-2 | US10093663, Example 17-...)
Show SMILES Cc1cc(C2CC2)c(CN2CCCCC2c2ccc(cc2)C(O)=O)c2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-16-14-21(17-5-6-17)22(20-11-12-26-24(16)20)15-27-13-3-2-4-23(27)18-7-9-19(10-8-18)25(28)29/h7-12,14,17,23,26H,2-6,13,15H2,1H3,(H,28,29)
PDB

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n/an/a 30n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159311
PNG
(US10093663, Example 16 | US9682968, Example-16)
Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(C(O)=O)c(F)c2)c2cc[nH]c12
Show InChI InChI=1S/C25H27FN2O2/c1-15-12-20(16-5-6-16)21(18-9-10-27-24(15)18)14-28-11-3-2-4-23(28)17-7-8-19(25(29)30)22(26)13-17/h7-10,12-13,16,23,27H,2-6,11,14H2,1H3,(H,29,30)/t23-/m0/s1
PDB

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n/an/a 30n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159873
PNG
(US10093663, Example 17-24 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1)-c1cc[nH]n1
Show InChI InChI=1S/C25H28N4O/c1-17-15-24(30-2)21(20-10-12-26-25(17)20)16-29-14-4-3-5-23(29)19-8-6-18(7-9-19)22-11-13-27-28-22/h6-13,15,23,26H,3-5,14,16H2,1-2H3,(H,27,28)/t23-/m0/s1
PDB

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US Patent
n/an/a 35n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159289
PNG
(US10093663, Example 5-12 | US9682968, Example-5-12)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)-c1nn[nH]n1
Show InChI InChI=1S/C23H26N6/c1-15-13-16(2)22-19(10-11-24-22)20(15)14-29-12-4-3-5-21(29)17-6-8-18(9-7-17)23-25-27-28-26-23/h6-11,13,21,24H,3-5,12,14H2,1-2H3,(H,25,26,27,28)
PDB

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US Patent
n/an/a 37n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289451
PNG
(US10093663, Example 17-3)
Show SMILES Cc1cc(C2CC2)c(CN2CCCCC2c2ccc(nc2)C(O)=O)c2cc[nH]c12
Show InChI InChI=1S/C24H27N3O2/c1-15-12-19(16-5-6-16)20(18-9-10-25-23(15)18)14-27-11-3-2-4-22(27)17-7-8-21(24(28)29)26-13-17/h7-10,12-13,16,22,25H,2-6,11,14H2,1H3,(H,28,29)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159920
PNG
(US10093663, Example 17-25 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(O)=O)c2ccccc12
Show InChI InChI=1S/C27H28N2O3/c1-17-15-25(32-2)23(21-12-13-28-26(17)21)16-29-14-6-5-9-24(29)20-10-11-22(27(30)31)19-8-4-3-7-18(19)20/h3-4,7-8,10-13,15,24,28H,5-6,9,14,16H2,1-2H3,(H,30,31)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160473
PNG
(US10093663, Example 25b | US9682968, Example-25a (...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O2/c1-15-13-16(2)22-19(10-11-24-22)20(15)14-25-12-4-3-5-21(25)17-6-8-18(9-7-17)23(26)27/h6-11,13,21,24H,3-5,12,14H2,1-2H3,(H,26,27)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160506
PNG
(US10093663, Example 40 | US9682968, Example-40)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(cc1)C1CCCCN1Cc1c(cc(C)c2[nH]ccc12)C1CC1
Show InChI InChI=1S/C26H31N3O3S/c1-17-15-23(19-6-7-19)24(22-12-13-27-26(17)22)16-29-14-4-3-5-25(29)20-8-10-21(11-9-20)33(31,32)28-18(2)30/h8-13,15,19,25,27H,3-7,14,16H2,1-2H3,(H,28,30)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159509
PNG
(US10093663, Example 17-13 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1C)C(O)=O
Show InChI InChI=1S/C24H28N2O3/c1-15-12-17(24(27)28)7-8-18(15)21-6-4-5-11-26(21)14-20-19-9-10-25-23(19)16(2)13-22(20)29-3/h7-10,12-13,21,25H,4-6,11,14H2,1-3H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159379
PNG
(US10093663, Example 17-8 | US9682968, Example-17-8)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1F)C(O)=O
Show InChI InChI=1S/C23H25FN2O3/c1-14-11-21(29-2)18(16-8-9-25-22(14)16)13-26-10-4-3-5-20(26)17-7-6-15(23(27)28)12-19(17)24/h6-9,11-12,20,25H,3-5,10,13H2,1-2H3,(H,27,28)/t20-/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289452
PNG
(US10093663, Example 17-4)
Show SMILES COc1cc(ccc1C1CCCCN1Cc1c(cc(C)c2[nH]ccc12)C1CC1)C(O)=O
Show InChI InChI=1S/C26H30N2O3/c1-16-13-21(17-6-7-17)22(19-10-11-27-25(16)19)15-28-12-4-3-5-23(28)20-9-8-18(26(29)30)14-24(20)31-2/h8-11,13-14,17,23,27H,3-7,12,15H2,1-2H3,(H,29,30)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159841
PNG
(US10093663, Example 17-22 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCCC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O3/c1-16-14-22(29-2)20(19-11-12-25-23(16)19)15-26-13-5-3-4-6-21(26)17-7-9-18(10-8-17)24(27)28/h7-12,14,21,25H,3-6,13,15H2,1-2H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159382
PNG
(US10093663, Example 17-10 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cn1)C(O)=O
Show InChI InChI=1S/C22H25N3O3/c1-14-11-20(28-2)17(16-8-9-23-21(14)16)13-25-10-4-3-5-19(25)18-7-6-15(12-24-18)22(26)27/h6-9,11-12,19,23H,3-5,10,13H2,1-2H3,(H,26,27)/t19-/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289450
PNG
(US10093663, Example 17-2 | US10093663, Example 17-...)
Show SMILES Cc1cc(C2CC2)c(CN2CCCCC2c2ccc(cc2)C(O)=O)c2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-16-14-21(17-5-6-17)22(20-11-12-26-24(16)20)15-27-13-3-2-4-23(27)18-7-9-19(10-8-18)25(28)29/h7-12,14,17,23,26H,2-6,13,15H2,1H3,(H,28,29)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160501
PNG
(US10093663, Example 38 | US9682968, Example-38)
Show SMILES CNC(=O)c1ccc(cc1)[C@@H]1C[C@H](CCN1Cc1c(OC)cc(C)c2[nH]ccc12)OC
Show InChI InChI=1S/C25H31N3O3/c1-16-13-23(31-4)21(20-9-11-27-24(16)20)15-28-12-10-19(30-3)14-22(28)17-5-7-18(8-6-17)25(29)26-2/h5-9,11,13,19,22,27H,10,12,14-15H2,1-4H3,(H,26,29)/t19-,22-/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159303
PNG
(US10093663, Example 13 | US9682968, Example-13)
Show SMILES Cc1cc(Cl)c(CN2CCCCC2c2ccc(cc2)C(O)=O)c2cc[nH]c12
Show InChI InChI=1S/C22H23ClN2O2/c1-14-12-19(23)18(17-9-10-24-21(14)17)13-25-11-3-2-4-20(25)15-5-7-16(8-6-15)22(26)27/h5-10,12,20,24H,2-4,11,13H2,1H3,(H,26,27)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159932
PNG
(US10093663, Example 17-28 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(O)=O)c(OC)c1
Show InChI InChI=1S/C24H28N2O4/c1-15-12-21(29-2)19(17-9-10-25-23(15)17)14-26-11-5-4-6-20(26)16-7-8-18(24(27)28)22(13-16)30-3/h7-10,12-13,20,25H,4-6,11,14H2,1-3H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289524
PNG
(Ethyl 4-((2S,4R)-1-((5-methoxy-7-methyl-1H-indol-4...)
Show SMILES CCOC(=O)c1ccc(cc1)[C@@H]1C[C@H](C)CCN1Cc1c(OC)cc(C)c2[nH]ccc12
Show InChI InChI=1S/C26H32N2O3/c1-5-31-26(29)20-8-6-19(7-9-20)23-14-17(2)11-13-28(23)16-22-21-10-12-27-25(21)18(3)15-24(22)30-4/h6-10,12,15,17,23,27H,5,11,13-14,16H2,1-4H3/t17-,23+/m1/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159157
PNG
(US10093663, Example 5-4 | US9682968, Example-5-4)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C22H27N3O2S/c1-15-13-16(2)22-19(10-11-24-22)20(15)14-25-12-4-3-5-21(25)17-6-8-18(9-7-17)28(23,26)27/h6-11,13,21,24H,3-5,12,14H2,1-2H3,(H2,23,26,27)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159302
PNG
(US10093663, Example 12 | US9682968, Example-12)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O3/c1-14-11-15(2)22-19(7-9-24-22)20(14)13-25-10-8-18(26)12-21(25)16-3-5-17(6-4-16)23(27)28/h3-7,9,11,18,21,24,26H,8,10,12-13H2,1-2H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160508
PNG
(US10093663, Example 42 | US9682968, Example-42)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)OCC
Show InChI InChI=1S/C27H34N2O4/c1-5-32-21-12-14-29(17-23-22-11-13-28-26(22)18(3)15-25(23)31-4)24(16-21)19-7-9-20(10-8-19)27(30)33-6-2/h7-11,13,15,21,24,28H,5-6,12,14,16-17H2,1-4H3/t21-,24-/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160504
PNG
(US10093663, Example 39-3 | US9682968, Example-39-3)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)NCCO
Show InChI InChI=1S/C26H33N3O4/c1-17-14-24(33-3)22(21-8-10-27-25(17)21)16-29-12-9-20(32-2)15-23(29)18-4-6-19(7-5-18)26(31)28-11-13-30/h4-8,10,14,20,23,27,30H,9,11-13,15-16H2,1-3H3,(H,28,31)/t20-,23-/m0/s1
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159976
PNG
(US10093663, Example 20b | US9682968, Example-20b)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC[C@H](C)C[C@@H]1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O3/c1-15-9-11-26(21(12-15)17-4-6-18(7-5-17)24(27)28)14-20-19-8-10-25-23(19)16(2)13-22(20)29-3/h4-8,10,13,15,21,25H,9,11-12,14H2,1-3H3,(H,27,28)/t15-,21+/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160505
PNG
(US10093663, Example 39-4 | US9682968, Example-39-4)
Show SMILES COCCNC(=O)c1ccc(cc1)[C@@H]1C[C@H](CCN1Cc1c(OC)cc(C)c2[nH]ccc12)OC
Show InChI InChI=1S/C27H35N3O4/c1-18-15-25(34-4)23(22-9-11-28-26(18)22)17-30-13-10-21(33-3)16-24(30)19-5-7-20(8-6-19)27(31)29-12-14-32-2/h5-9,11,15,21,24,28H,10,12-14,16-17H2,1-4H3,(H,29,31)/t21-,24-/m0/s1
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160495
PNG
(US10093663, Example 32-3 | US9682968, Example-32-3)
Show SMILES COC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(CO)cc1
Show InChI InChI=1S/C24H30N2O3/c1-16-12-23(29-3)21(20-8-10-25-24(16)20)14-26-11-9-19(28-2)13-22(26)18-6-4-17(15-27)5-7-18/h4-8,10,12,19,22,25,27H,9,11,13-15H2,1-3H3
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159506
PNG
(US10093663, Example 17-12 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC[C@H](O)C[C@H]1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O4/c1-14-11-21(29-2)19(18-7-9-24-22(14)18)13-25-10-8-17(26)12-20(25)15-3-5-16(6-4-15)23(27)28/h3-7,9,11,17,20,24,26H,8,10,12-13H2,1-2H3,(H,27,28)/t17-,20-/m0/s1
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159296
PNG
(US10093663, Example 9-2 | US9682968, Example-9-2)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C24H29N3O2/c1-15-12-16(2)23-20(8-10-26-23)21(15)14-27-11-9-19(29-3)13-22(27)17-4-6-18(7-5-17)24(25)28/h4-8,10,12,19,22,26H,9,11,13-14H2,1-3H3,(H2,25,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160051
PNG
(US10093663, Example 21b | US9682968, Example-21b)
Show SMILES CO[C@@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O4/c1-15-12-22(30-3)20(19-8-10-25-23(15)19)14-26-11-9-18(29-2)13-21(26)16-4-6-17(7-5-16)24(27)28/h4-8,10,12,18,21,25H,9,11,13-14H2,1-3H3,(H,27,28)/t18-,21-/m1/s1
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n/an/a 650n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159184
PNG
(US10093663, Example 5-6 | US9682968, Example-5-6)
Show SMILES CNS(=O)(=O)c1ccc(cc1)C1CCCCN1Cc1c(C)cc(C)c2[nH]ccc12
Show InChI InChI=1S/C23H29N3O2S/c1-16-14-17(2)23-20(11-12-25-23)21(16)15-26-13-5-4-6-22(26)18-7-9-19(10-8-18)29(27,28)24-3/h7-12,14,22,24-25H,4-6,13,15H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159294
PNG
(US10093663, Example 8 | US9682968, Example-8)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C23H27N3O/c1-15-13-16(2)22-19(10-11-25-22)20(15)14-26-12-4-3-5-21(26)17-6-8-18(9-7-17)23(24)27/h6-11,13,21,25H,3-5,12,14H2,1-2H3,(H2,24,27)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159102
PNG
(US10093663, Example 4b | US9682968, Example-3)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
Show InChI InChI=1S/C23H28N2O/c1-16-13-17(2)23-20(9-11-24-23)21(16)15-25-12-10-19(26-3)14-22(25)18-7-5-4-6-8-18/h4-9,11,13,19,22,24H,10,12,14-15H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289501
PNG
(US10093663, Example 27-3b)
Show SMILES COC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H30N2O3/c1-16-13-22(17-3-4-17)23(21-9-11-27-25(16)21)15-28-12-10-20(31-2)14-24(28)18-5-7-19(8-6-18)26(29)30/h5-9,11,13,17,20,24,27H,3-4,10,12,14-15H2,1-2H3,(H,29,30)/t20?,24-/m1/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159840
PNG
(US10093663, Example 17-21 | US9682968, Example-17-...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(c1)C(O)=O
Show InChI InChI=1S/C23H26N2O2/c1-15-12-16(2)22-19(9-10-24-22)20(15)14-25-11-4-3-8-21(25)17-6-5-7-18(13-17)23(26)27/h5-7,9-10,12-13,21,24H,3-4,8,11,14H2,1-2H3,(H,26,27)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160475
PNG
(US10093663, Example 26b | US9682968, Example-26a)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O4/c1-4-31-19-10-12-27(22(14-19)17-5-7-18(8-6-17)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3/h5-9,11,13,19,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29)/t19-,22-/m0/s1
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n/an/a 1.10E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160496
PNG
(US10093663, Example 33 | US9682968, Example-33)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C23H26N6/c1-15-12-16(2)22-19(9-10-24-22)20(15)14-29-11-4-3-8-21(29)17-6-5-7-18(13-17)23-25-27-28-26-23/h5-7,9-10,12-13,21,24H,3-4,8,11,14H2,1-2H3,(H,25,26,27,28)
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n/an/a 1.20E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160490
PNG
(US10093663, Example 30-3 | US9682968, Example-30-2...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(O)CCC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O4/c1-14-11-21(29-2)19(18-9-10-24-22(14)18)13-25-12-17(26)7-8-20(25)15-3-5-16(6-4-15)23(27)28/h3-6,9-11,17,20,24,26H,7-8,12-13H2,1-2H3,(H,27,28)
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n/an/a 1.30E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160490
PNG
(US10093663, Example 30-3 | US9682968, Example-30-2...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(O)CCC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O4/c1-14-11-21(29-2)19(18-9-10-24-22(14)18)13-25-12-17(26)7-8-20(25)15-3-5-16(6-4-15)23(27)28/h3-6,9-11,17,20,24,26H,7-8,12-13H2,1-2H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159288
PNG
(US10093663, Example 5-11 | US9682968, Example-5-11)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H28N2O2S/c1-16-14-17(2)23-20(11-12-24-23)21(16)15-25-13-5-4-6-22(25)18-7-9-19(10-8-18)28(3,26)27/h7-12,14,22,24H,4-6,13,15H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159287
PNG
(US10093663, Example 5-10 | US9682968, Example-5-10)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(CO)cc1
Show InChI InChI=1S/C23H28N2O/c1-16-13-17(2)23-20(10-11-24-23)21(16)14-25-12-4-3-5-22(25)19-8-6-18(15-26)7-9-19/h6-11,13,22,24,26H,3-5,12,14-15H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160487
PNG
(US10093663, Example 30-1 | US9682968, Example-28 |...)
Show SMILES COC1CCC(N(Cc2c(OC)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O4/c1-15-12-22(30-3)20(19-10-11-25-23(15)19)14-26-13-18(29-2)8-9-21(26)16-4-6-17(7-5-16)24(27)28/h4-7,10-12,18,21,25H,8-9,13-14H2,1-3H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160502
PNG
(US10093663, Example 39-1 | US9682968, Example-39-1)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)N(C)C
Show InChI InChI=1S/C26H33N3O3/c1-17-14-24(32-5)22(21-10-12-27-25(17)21)16-29-13-11-20(31-4)15-23(29)18-6-8-19(9-7-18)26(30)28(2)3/h6-10,12,14,20,23,27H,11,13,15-16H2,1-5H3/t20-,23-/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159309
PNG
(US10093663, Example 15 | US9682968, Example-14 | U...)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(=O)OC
Show InChI InChI=1S/C25H30N2O3/c1-16-13-17(2)24-21(9-11-26-24)22(16)15-27-12-10-20(29-3)14-23(27)18-5-7-19(8-6-18)25(28)30-4/h5-9,11,13,20,23,26H,10,12,14-15H2,1-4H3
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289503
PNG
(US10093663, Example 27-4b)
Show SMILES CCOC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H32N2O3/c1-3-32-21-11-13-29(25(15-21)19-6-8-20(9-7-19)27(30)31)16-24-22-10-12-28-26(22)17(2)14-23(24)18-4-5-18/h6-10,12,14,18,21,25,28H,3-5,11,13,15-16H2,1-2H3,(H,30,31)/t21?,25-/m1/s1
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159844
PNG
(US10093663, Example 17-23 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C25H28N4O/c1-17-13-24(30-2)22(21-10-11-26-25(17)21)16-29-12-4-3-5-23(29)19-8-6-18(7-9-19)20-14-27-28-15-20/h6-11,13-15,23,26H,3-5,12,16H2,1-2H3,(H,27,28)/t23-/m0/s1
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160293
PNG
(US10093663, Example 23b | US9682968, Example-23a (...)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H29N3O2/c1-4-30-20-10-12-28(23(14-20)19-7-5-18(15-26)6-8-19)16-22-21-9-11-27-25(21)17(2)13-24(22)29-3/h5-9,11,13,20,23,27H,4,10,12,14,16H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289462
PNG
(US10093663, Example 17-14)
Show SMILES CC1CCC(N(Cc2c(C)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O2/c1-15-4-9-22(18-5-7-19(8-6-18)24(27)28)26(13-15)14-21-16(2)12-17(3)23-20(21)10-11-25-23/h5-8,10-12,15,22,25H,4,9,13-14H2,1-3H3,(H,27,28)
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160503
PNG
(US10093663, Example 39-2 | US9682968, Example-39-2)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C28H35N3O4/c1-19-16-26(34-3)24(23-8-10-29-27(19)23)18-31-11-9-22(33-2)17-25(31)20-4-6-21(7-5-20)28(32)30-12-14-35-15-13-30/h4-8,10,16,22,25,29H,9,11-15,17-18H2,1-3H3/t22-,25-/m0/s1
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289486
PNG
(US10093663, Example 22-1b)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](C1)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C24H29N3O4/c1-4-31-17-8-10-27(21(12-17)16-5-6-20(24(28)29)26-13-16)14-19-18-7-9-25-23(18)15(2)11-22(19)30-3/h5-7,9,11,13,17,21,25H,4,8,10,12,14H2,1-3H3,(H,28,29)/t17?,21-/m1/s1
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159546
PNG
(US10093663, Example 17-16 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C24H28N2O3/c1-16-13-22(29-2)20(19-10-11-25-24(16)19)15-26-12-4-3-5-21(26)18-8-6-17(7-9-18)14-23(27)28/h6-11,13,21,25H,3-5,12,14-15H2,1-2H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159295
PNG
(US10093663, Example 9-1 | US9682968, Example-9-1)
Show SMILES Cc1cc(Cl)c(CN2CCCCC2c2ccc(cc2)C(N)=O)c2cc[nH]c12
Show InChI InChI=1S/C22H24ClN3O/c1-14-12-19(23)18(17-9-10-25-21(14)17)13-26-11-3-2-4-20(26)15-5-7-16(8-6-15)22(24)27/h5-10,12,20,25H,2-4,11,13H2,1H3,(H2,24,27)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159565
PNG
(US10093663, Example 17-17 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(CC(O)=O)c1
Show InChI InChI=1S/C24H28N2O3/c1-16-12-22(29-2)20(19-9-10-25-24(16)19)15-26-11-4-3-8-21(26)18-7-5-6-17(13-18)14-23(27)28/h5-7,9-10,12-13,21,25H,3-4,8,11,14-15H2,1-2H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289487
PNG
(US10093663, Example 22-2a)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC(C)(C)C[C@H]1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O3/c1-16-13-22(30-4)20(19-9-11-26-23(16)19)15-27-12-10-25(2,3)14-21(27)17-5-7-18(8-6-17)24(28)29/h5-9,11,13,21,26H,10,12,14-15H2,1-4H3,(H,28,29)/t21-/m0/s1
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n/an/a 2.20E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159302
PNG
(US10093663, Example 12 | US9682968, Example-12)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O3/c1-14-11-15(2)22-19(7-9-24-22)20(14)13-25-10-8-18(26)12-21(25)16-3-5-17(6-4-16)23(27)28/h3-7,9,11,18,21,24,26H,8,10,12-13H2,1-2H3,(H,27,28)
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n/an/a 2.30E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159149
PNG
(US10093663, Example 5-3 | US9682968, Example-5-2 |...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CO)CC1c1ccccc1
Show InChI InChI=1S/C23H28N2O/c1-16-12-17(2)23-20(8-10-24-23)21(16)14-25-11-9-18(15-26)13-22(25)19-6-4-3-5-7-19/h3-8,10,12,18,22,24,26H,9,11,13-15H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160498
PNG
(US10093663, Example 35 | US9682968, Example-35)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(CO)c1
Show InChI InChI=1S/C23H28N2O/c1-16-12-17(2)23-20(9-10-24-23)21(16)14-25-11-4-3-8-22(25)19-7-5-6-18(13-19)15-26/h5-7,9-10,12-13,22,24,26H,3-4,8,11,14-15H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159593
PNG
(US10093663, Example 17-20 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1nc(C)c(s1)C(O)=O
Show InChI InChI=1S/C21H25N3O3S/c1-12-10-17(27-3)15(14-7-8-22-18(12)14)11-24-9-5-4-6-16(24)20-23-13(2)19(28-20)21(25)26/h7-8,10,16,22H,4-6,9,11H2,1-3H3,(H,25,26)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159950
PNG
(US10093663, Example 19 | US9682968, Example-18 | U...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CC#N)CC1c1ccccc1
Show InChI InChI=1S/C24H27N3/c1-17-14-18(2)24-21(9-12-26-24)22(17)16-27-13-10-19(8-11-25)15-23(27)20-6-4-3-5-7-20/h3-7,9,12,14,19,23,26H,8,10,13,15-16H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160497
PNG
(US10093663, Example 34 | US9682968, Example-34)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(c1)C(N)=O
Show InChI InChI=1S/C23H27N3O/c1-15-12-16(2)22-19(9-10-25-22)20(15)14-26-11-4-3-8-21(26)17-6-5-7-18(13-17)23(24)27/h5-7,9-10,12-13,21,25H,3-4,8,11,14H2,1-2H3,(H2,24,27)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160487
PNG
(US10093663, Example 30-1 | US9682968, Example-28 |...)
Show SMILES COC1CCC(N(Cc2c(OC)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O4/c1-15-12-22(30-3)20(19-10-11-25-23(15)19)14-26-13-18(29-2)8-9-21(26)16-4-6-17(7-5-16)24(27)28/h4-7,10-12,18,21,25H,8-9,13-14H2,1-3H3,(H,27,28)
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n/an/a 3.40E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160487
PNG
(US10093663, Example 30-1 | US9682968, Example-28 |...)
Show SMILES COC1CCC(N(Cc2c(OC)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O4/c1-15-12-22(30-3)20(19-10-11-25-23(15)19)14-26-13-18(29-2)8-9-21(26)16-4-6-17(7-5-16)24(27)28/h4-7,10-12,18,21,25H,8-9,13-14H2,1-3H3,(H,27,28)
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n/an/a 3.40E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159161
PNG
(US10093663, Example 5-5 | US9682968, Example-5-5)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H27N3O2S/c1-15-12-16(2)22-19(9-10-24-22)20(15)14-25-11-4-3-8-21(25)17-6-5-7-18(13-17)28(23,26)27/h5-7,9-10,12-13,21,24H,3-4,8,11,14H2,1-2H3,(H2,23,26,27)
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n/an/a 3.50E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289496
PNG
(US10093663, Example 27-1a)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H28N2O3/c1-15-12-16(2)23-20(8-10-25-23)21(15)14-26-11-9-19(29-3)13-22(26)17-4-6-18(7-5-17)24(27)28/h4-8,10,12,19,22,25H,9,11,13-14H2,1-3H3,(H,27,28)/t19?,22-/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159322
PNG
(US10093663, Example 17-7 | US9682968, Example-17-7)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccnc1
Show InChI InChI=1S/C21H25N3O/c1-15-12-20(25-2)18(17-8-10-23-21(15)17)14-24-11-4-3-7-19(24)16-6-5-9-22-13-16/h5-6,8-10,12-13,19,23H,3-4,7,11,14H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159924
PNG
(US10093663, Example 17-27 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1C(N1CCCC[C@H]1c1ccc(cc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H25F3N2O3/c1-14-13-19(32-2)20(17-10-11-28-21(14)17)22(24(25,26)27)29-12-4-3-5-18(29)15-6-8-16(9-7-15)23(30)31/h6-11,13,18,22,28H,3-5,12H2,1-2H3,(H,30,31)/t18-,22?/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159381
PNG
(US10093663, Example 17-9 | US9682968, Example-17-9)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCOC[C@H]1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H24N2O4/c1-14-11-20(27-2)18(17-7-8-23-21(14)17)12-24-9-10-28-13-19(24)15-3-5-16(6-4-15)22(25)26/h3-8,11,19,23H,9-10,12-13H2,1-2H3,(H,25,26)/t19-/m0/s1
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159102
PNG
(US10093663, Example 4b | US9682968, Example-3)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
Show InChI InChI=1S/C23H28N2O/c1-16-13-17(2)23-20(9-11-24-23)21(16)15-25-12-10-19(26-3)14-22(25)18-7-5-4-6-8-18/h4-9,11,13,19,22,24H,10,12,14-15H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159320
PNG
(US10093663, Example 17-6 | US9682968, Example-17-6)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccncc1
Show InChI InChI=1S/C21H25N3O/c1-15-13-20(25-2)18(17-8-11-23-21(15)17)14-24-12-4-3-5-19(24)16-6-9-22-10-7-16/h6-11,13,19,23H,3-5,12,14H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160492
PNG
(BDBM160493 | US10093663, Example 32-1 | US9682968,...)
Show SMILES CNC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
Show InChI InChI=1S/C23H29N3/c1-16-13-17(2)23-20(9-11-25-23)21(16)15-26-12-10-19(24-3)14-22(26)18-7-5-4-6-8-18/h4-9,11,13,19,22,24-25H,10,12,14-15H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159270
PNG
(US10093663, Example 5-9 | US9682968, Example-5-9)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1(CO)c1ccccc1
Show InChI InChI=1S/C23H28N2O/c1-17-14-18(2)22-20(10-12-24-22)21(17)15-25-13-7-6-11-23(25,16-26)19-8-4-3-5-9-19/h3-5,8-10,12,14,24,26H,6-7,11,13,15-16H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159137
PNG
(US10093663, Example 5-1 | US9682968, Example-5-1)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccccc1
Show InChI InChI=1S/C22H26N2/c1-16-14-17(2)22-19(11-12-23-22)20(16)15-24-13-7-6-10-21(24)18-8-4-3-5-9-18/h3-5,8-9,11-12,14,21,23H,6-7,10,13,15H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159149
PNG
(US10093663, Example 5-3 | US9682968, Example-5-2 |...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CO)CC1c1ccccc1
Show InChI InChI=1S/C23H28N2O/c1-16-12-17(2)23-20(8-10-24-23)21(16)14-25-11-9-18(15-26)13-22(25)19-6-4-3-5-7-19/h3-8,10,12,18,22,24,26H,9,11,13-15H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM155872
PNG
(US10093663, Example 2b | US9682968, Example-1)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccccc1
Show InChI InChI=1S/C22H26N2O/c1-15-12-16(2)22-19(8-10-23-22)20(15)14-24-11-9-18(25)13-21(24)17-6-4-3-5-7-17/h3-8,10,12,18,21,23,25H,9,11,13-14H2,1-2H3
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n/an/a 7.90E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160490
PNG
(US10093663, Example 30-3 | US9682968, Example-30-2...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(O)CCC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O4/c1-14-11-21(29-2)19(18-9-10-24-22(14)18)13-25-12-17(26)7-8-20(25)15-3-5-16(6-4-15)23(27)28/h3-6,9-11,17,20,24,26H,7-8,12-13H2,1-2H3,(H,27,28)
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n/an/a 8.20E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160490
PNG
(US10093663, Example 30-3 | US9682968, Example-30-2...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(O)CCC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O4/c1-14-11-21(29-2)19(18-9-10-24-22(14)18)13-25-12-17(26)7-8-20(25)15-3-5-16(6-4-15)23(27)28/h3-6,9-11,17,20,24,26H,7-8,12-13H2,1-2H3,(H,27,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159192
PNG
(US10093663, Example 5-7 | US9682968, Example-5-7)
Show SMILES CNS(=O)(=O)c1cccc(c1)C1CCCCN1Cc1c(C)cc(C)c2[nH]ccc12
Show InChI InChI=1S/C23H29N3O2S/c1-16-13-17(2)23-20(10-11-25-23)21(16)15-26-12-5-4-9-22(26)18-7-6-8-19(14-18)29(27,28)24-3/h6-8,10-11,13-14,22,24-25H,4-5,9,12,15H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159309
PNG
(US10093663, Example 15 | US9682968, Example-14 | U...)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(=O)OC
Show InChI InChI=1S/C25H30N2O3/c1-16-13-17(2)24-21(9-11-26-24)22(16)15-27-12-10-20(29-3)14-23(27)18-5-7-19(8-6-18)25(28)30-4/h5-9,11,13,20,23,26H,10,12,14-15H2,1-4H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160472
PNG
(US10093663, Example 24 | US9682968, Example-24)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C25H31N3O3/c1-4-31-19-10-12-28(22(14-19)17-5-7-18(8-6-17)25(26)29)15-21-20-9-11-27-24(20)16(2)13-23(21)30-3/h5-9,11,13,19,22,27H,4,10,12,14-15H2,1-3H3,(H2,26,29)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159292
PNG
(US10093663, Example 7 | US9682968, Example-6 | US9...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(N)CC1c1ccccc1
Show InChI InChI=1S/C22H27N3/c1-15-12-16(2)22-19(8-10-24-22)20(15)14-25-11-9-18(23)13-21(25)17-6-4-3-5-7-17/h3-8,10,12,18,21,24H,9,11,13-14,23H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159300
PNG
(US10093663, Example 10 | US9682968, Example-10)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC(C)(CC1c1ccc(cc1)C(N)=O)OC
Show InChI InChI=1S/C25H31N3O3/c1-16-13-22(30-3)20(19-9-11-27-23(16)19)15-28-12-10-25(2,31-4)14-21(28)17-5-7-18(8-6-17)24(26)29/h5-9,11,13,21,27H,10,12,14-15H2,1-4H3,(H2,26,29)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159292
PNG
(US10093663, Example 7 | US9682968, Example-6 | US9...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(N)CC1c1ccccc1
Show InChI InChI=1S/C22H27N3/c1-15-12-16(2)22-19(8-10-24-22)20(15)14-25-11-9-18(23)13-21(25)17-6-4-3-5-7-17/h3-8,10,12,18,21,24H,9,11,13-14,23H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160473
PNG
(US10093663, Example 25b | US9682968, Example-25a (...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H26N2O2/c1-15-13-16(2)22-19(10-11-24-22)20(15)14-25-12-4-3-5-21(25)17-6-8-18(9-7-17)23(26)27/h6-11,13,21,24H,3-5,12,14H2,1-2H3,(H,26,27)
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n/an/a 1.50E+4n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM289499
PNG
(US10093663, Example 27-2b)
Show SMILES CCOC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](C1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N2O3/c1-4-30-20-10-12-27(23(14-20)18-5-7-19(8-6-18)25(28)29)15-22-16(2)13-17(3)24-21(22)9-11-26-24/h5-9,11,13,20,23,26H,4,10,12,14-15H2,1-3H3,(H,28,29)/t20?,23-/m1/s1
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n/an/a 1.60E+4n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159216
PNG
(US10093663, Example 5-8 | US9682968, Example-5-8)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(F)cc1
Show InChI InChI=1S/C23H27FN2O/c1-15-12-16(2)23-20(8-10-25-23)21(15)14-26-11-9-19(27-3)13-22(26)17-4-6-18(24)7-5-17/h4-8,10,12,19,22,25H,9,11,13-14H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159592
PNG
(US10093663, Example 17-19 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H23N3O3S/c1-12-9-17(26-2)14(13-6-7-21-18(12)13)10-23-8-4-3-5-16(23)19-22-15(11-27-19)20(24)25/h6-7,9,11,16,21H,3-5,8,10H2,1-2H3,(H,24,25)
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160488
PNG
(US10093663, Example 29 | US9682968, Example-29)
Show SMILES COC1CCC(N(Cc2c(OC)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C24H29N3O3/c1-15-12-22(30-3)20(19-10-11-26-23(15)19)14-27-13-18(29-2)8-9-21(27)16-4-6-17(7-5-16)24(25)28/h4-7,10-12,18,21,26H,8-9,13-14H2,1-3H3,(H2,25,28)
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160494
PNG
(US10093663, Example 32-2 | US9682968, Example-32-2)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(CN)cc1
Show InChI InChI=1S/C23H29N3/c1-16-13-17(2)23-20(10-11-25-23)21(16)15-26-12-4-3-5-22(26)19-8-6-18(14-24)7-9-19/h6-11,13,22,25H,3-5,12,14-15,24H2,1-2H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160492
PNG
(BDBM160493 | US10093663, Example 32-1 | US9682968,...)
Show SMILES CNC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
Show InChI InChI=1S/C23H29N3/c1-16-13-17(2)23-20(9-11-25-23)21(16)15-26-12-10-19(24-3)14-22(26)18-7-5-4-6-8-18/h4-9,11,13,19,22,24-25H,10,12,14-15H2,1-3H3
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159102
PNG
(US10093663, Example 4b | US9682968, Example-3)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
Show InChI InChI=1S/C23H28N2O/c1-16-13-17(2)23-20(9-11-24-23)21(16)15-25-12-10-19(26-3)14-22(25)18-7-5-4-6-8-18/h4-9,11,13,19,22,24H,10,12,14-15H2,1-3H3
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n/an/a 6.70E+4n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160293
PNG
(US10093663, Example 23b | US9682968, Example-23a (...)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H29N3O2/c1-4-30-20-10-12-28(23(14-20)19-7-5-18(15-26)6-8-19)16-22-21-9-11-27-25(21)17(2)13-24(22)29-3/h5-9,11,13,20,23,27H,4,10,12,14,16H2,1-3H3
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159950
PNG
(US10093663, Example 19 | US9682968, Example-18 | U...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CC#N)CC1c1ccccc1
Show InChI InChI=1S/C24H27N3/c1-17-14-18(2)24-21(9-12-26-24)22(17)16-27-13-10-19(8-11-25)15-23(27)20-6-4-3-5-7-20/h3-7,9,12,14,19,23,26H,8,10,13,15-16H2,1-2H3
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM155872
PNG
(US10093663, Example 2b | US9682968, Example-1)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccccc1
Show InChI InChI=1S/C22H26N2O/c1-15-12-16(2)22-19(8-10-23-22)20(15)14-24-11-9-18(25)13-21(24)17-6-4-3-5-7-17/h3-8,10,12,18,21,23,25H,9,11,13-14H2,1-2H3
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159924
PNG
(US10093663, Example 17-27 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1C(N1CCCC[C@H]1c1ccc(cc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C24H25F3N2O3/c1-14-13-19(32-2)20(17-10-11-28-21(14)17)22(24(25,26)27)29-12-4-3-5-18(29)15-6-8-16(9-7-15)23(30)31/h6-11,13,18,22,28H,3-5,12H2,1-2H3,(H,30,31)/t18-,22?/m0/s1
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM155872
PNG
(US10093663, Example 2b | US9682968, Example-1)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccccc1
Show InChI InChI=1S/C22H26N2O/c1-15-12-16(2)22-19(8-10-23-22)20(15)14-24-11-9-18(25)13-21(24)17-6-4-3-5-7-17/h3-8,10,12,18,21,23,25H,9,11,13-14H2,1-2H3
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US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US10093663 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%