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USPatent US8633206

Compile Data Set for Download or QSAR

Found 417 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113220
PNG
(US8633206, 139)
Show SMILES COCCOC1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H35N5O4S/c1-26(22-20-9-10-23-21(20)24-16-25-22)18-7-5-17(6-8-18)15-32(28,29)27-11-3-4-19(14-27)31-13-12-30-2/h9-10,16-19H,3-8,11-15H2,1-2H3,(H,23,24,25)/t17-,18-,19?
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US Patent
n/an/a 0.00125n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113219
PNG
(US8633206, 138)
Show SMILES CC(C)COC1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H37N5O3S/c1-17(2)14-31-20-5-4-12-28(13-20)32(29,30)15-18-6-8-19(9-7-18)27(3)23-21-10-11-24-22(21)25-16-26-23/h10-11,16-20H,4-9,12-15H2,1-3H3,(H,24,25,26)/t18-,19-,20?
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n/an/a 0.00133n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113216
PNG
(US8633206, 135)
Show SMILES C[C@H]1CN(C[C@@H]1CO)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H31N5O3S/c1-14-9-25(10-16(14)11-26)29(27,28)12-15-3-5-17(6-4-15)24(2)20-18-7-8-21-19(18)22-13-23-20/h7-8,13-17,26H,3-6,9-12H2,1-2H3,(H,21,22,23)/t14-,15-,16+,17-/m0/s1
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n/an/a 0.00199n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113220
PNG
(US8633206, 139)
Show SMILES COCCOC1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H35N5O4S/c1-26(22-20-9-10-23-21(20)24-16-25-22)18-7-5-17(6-8-18)15-32(28,29)27-11-3-4-19(14-27)31-13-12-30-2/h9-10,16-19H,3-8,11-15H2,1-2H3,(H,23,24,25)/t17-,18-,19?
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n/an/a 0.00405n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113214
PNG
(US8633206, 133)
Show SMILES C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H33N5O3S/c1-14-9-15(12-29(27,28)25-8-6-16(10-25)11-26)3-4-18(14)24(2)20-17-5-7-21-19(17)22-13-23-20/h5,7,13-16,18,26,29H,3-4,6,8-12H2,1-2H3,(H,27,28)(H,21,22,23)/t14-,15+,16+,18+/m1/s1
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n/an/a 0.00508n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113219
PNG
(US8633206, 138)
Show SMILES CC(C)COC1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H37N5O3S/c1-17(2)14-31-20-5-4-12-28(13-20)32(29,30)15-18-6-8-19(9-7-18)27(3)23-21-10-11-24-22(21)25-16-26-23/h10-11,16-20H,4-9,12-15H2,1-3H3,(H,24,25,26)/t18-,19-,20?
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n/an/a 0.00767n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113218
PNG
(US8633206, 137)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H29N5O3S/c1-19(25)8-10-24(12-19)28(26,27)11-14-3-5-15(6-4-14)23(2)18-16-7-9-20-17(16)21-13-22-18/h7,9,13-15,25H,3-6,8,10-12H2,1-2H3,(H,20,21,22)/t14-,15-,19?
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n/an/a 0.00777n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113216
PNG
(US8633206, 135)
Show SMILES C[C@H]1CN(C[C@@H]1CO)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H31N5O3S/c1-14-9-25(10-16(14)11-26)29(27,28)12-15-3-5-17(6-4-15)24(2)20-18-7-8-21-19(18)22-13-23-20/h7-8,13-17,26H,3-6,9-12H2,1-2H3,(H,21,22,23)/t14-,15-,16+,17-/m0/s1
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n/an/a 0.0165n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113214
PNG
(US8633206, 133)
Show SMILES C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H33N5O3S/c1-14-9-15(12-29(27,28)25-8-6-16(10-25)11-26)3-4-18(14)24(2)20-17-5-7-21-19(17)22-13-23-20/h5,7,13-16,18,26,29H,3-4,6,8-12H2,1-2H3,(H,27,28)(H,21,22,23)/t14-,15+,16+,18+/m1/s1
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n/an/a 0.0199n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113215
PNG
(US8633206, 134)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](C2)OC(=O)C(C)(C)C)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H37N5O4S/c1-24(2,3)23(30)33-19-6-5-13-29(14-19)34(31,32)15-17-7-9-18(10-8-17)28(4)22-20-11-12-25-21(20)26-16-27-22/h11-12,16-19H,5-10,13-15H2,1-4H3,(H,25,26,27)/t17-,18-,19-/m1/s1
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n/an/a 0.0227n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113221
PNG
(US8633206, 140)
Show SMILES CCOP(=O)(OCC)O[C@@H]1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H38N5O6PS/c1-4-32-35(29,33-5-2)34-20-7-6-14-28(15-20)36(30,31)16-18-8-10-19(11-9-18)27(3)23-21-12-13-24-22(21)25-17-26-23/h12-13,17-20H,4-11,14-16H2,1-3H3,(H,24,25,26)/t18-,19-,20-/m1/s1
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n/an/a 0.0235n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113217
PNG
(US8633206, 136)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCN(C)CC2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H30N6O2S/c1-23-9-11-25(12-10-23)28(26,27)13-15-3-5-16(6-4-15)24(2)19-17-7-8-20-18(17)21-14-22-19/h7-8,14-16H,3-6,9-13H2,1-2H3,(H,20,21,22)/t15-,16-
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n/an/a 0.0245n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113222
PNG
(US8633206, 141)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](C2)OP(O)(O)=O)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H30N5O6PS/c1-23(19-17-8-9-20-18(17)21-13-22-19)15-6-4-14(5-7-15)12-32(28,29)24-10-2-3-16(11-24)30-31(25,26)27/h8-9,13-16H,2-7,10-12H2,1H3,(H,20,21,22)(H2,25,26,27)/t14-,15-,16-/m1/s1
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n/an/a 0.0263n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113218
PNG
(US8633206, 137)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H29N5O3S/c1-19(25)8-10-24(12-19)28(26,27)11-14-3-5-15(6-4-14)23(2)18-16-7-9-20-17(16)21-13-22-18/h7,9,13-15,25H,3-6,8,10-12H2,1-2H3,(H,20,21,22)/t14-,15-,19?
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n/an/a 0.0366n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM113220
PNG
(US8633206, 139)
Show SMILES COCCOC1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H35N5O4S/c1-26(22-20-9-10-23-21(20)24-16-25-22)18-7-5-17(6-8-18)15-32(28,29)27-11-3-4-19(14-27)31-13-12-30-2/h9-10,16-19H,3-8,11-15H2,1-2H3,(H,23,24,25)/t17-,18-,19?
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n/an/a 0.0368n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM113214
PNG
(US8633206, 133)
Show SMILES C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H33N5O3S/c1-14-9-15(12-29(27,28)25-8-6-16(10-25)11-26)3-4-18(14)24(2)20-17-5-7-21-19(17)22-13-23-20/h5,7,13-16,18,26,29H,3-4,6,8-12H2,1-2H3,(H,27,28)(H,21,22,23)/t14-,15+,16+,18+/m1/s1
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n/an/a 0.0421n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113222
PNG
(US8633206, 141)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](C2)OP(O)(O)=O)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H30N5O6PS/c1-23(19-17-8-9-20-18(17)21-13-22-19)15-6-4-14(5-7-15)12-32(28,29)24-10-2-3-16(11-24)30-31(25,26)27/h8-9,13-16H,2-7,10-12H2,1H3,(H,20,21,22)(H2,25,26,27)/t14-,15-,16-/m1/s1
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n/an/a 0.106n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113217
PNG
(US8633206, 136)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCN(C)CC2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H30N6O2S/c1-23-9-11-25(12-10-23)28(26,27)13-15-3-5-16(6-4-15)24(2)19-17-7-8-20-18(17)21-14-22-19/h7-8,14-16H,3-6,9-13H2,1-2H3,(H,20,21,22)/t15-,16-
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n/an/a 0.109n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113221
PNG
(US8633206, 140)
Show SMILES CCOP(=O)(OCC)O[C@@H]1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H38N5O6PS/c1-4-32-35(29,33-5-2)34-20-7-6-14-28(15-20)36(30,31)16-18-8-10-19(11-9-18)27(3)23-21-12-13-24-22(21)25-17-26-23/h12-13,17-20H,4-11,14-16H2,1-3H3,(H,24,25,26)/t18-,19-,20-/m1/s1
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n/an/a 0.116n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM113215
PNG
(US8633206, 134)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](C2)OC(=O)C(C)(C)C)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H37N5O4S/c1-24(2,3)23(30)33-19-6-5-13-29(14-19)34(31,32)15-17-7-9-18(10-8-17)28(4)22-20-11-12-25-21(20)26-16-27-22/h11-12,16-19H,5-10,13-15H2,1-4H3,(H,25,26,27)/t17-,18-,19-/m1/s1
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n/an/a 0.129n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM113219
PNG
(US8633206, 138)
Show SMILES CC(C)COC1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H37N5O3S/c1-17(2)14-31-20-5-4-12-28(13-20)32(29,30)15-18-6-8-19(9-7-18)27(3)23-21-10-11-24-22(21)25-16-26-23/h10-11,16-20H,4-9,12-15H2,1-3H3,(H,24,25,26)/t18-,19-,20?
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n/an/a 0.132n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM113216
PNG
(US8633206, 135)
Show SMILES C[C@H]1CN(C[C@@H]1CO)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H31N5O3S/c1-14-9-25(10-16(14)11-26)29(27,28)12-15-3-5-17(6-4-15)24(2)20-18-7-8-21-19(18)22-13-23-20/h7-8,13-17,26H,3-6,9-12H2,1-2H3,(H,21,22,23)/t14-,15-,16+,17-/m0/s1
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n/an/a 0.198n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM113218
PNG
(US8633206, 137)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H29N5O3S/c1-19(25)8-10-24(12-19)28(26,27)11-14-3-5-15(6-4-14)23(2)18-16-7-9-20-17(16)21-13-22-18/h7,9,13-15,25H,3-6,8,10-12H2,1-2H3,(H,20,21,22)/t14-,15-,19?
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n/an/a 0.302n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM113222
PNG
(US8633206, 141)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](C2)OP(O)(O)=O)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H30N5O6PS/c1-23(19-17-8-9-20-18(17)21-13-22-19)15-6-4-14(5-7-15)12-32(28,29)24-10-2-3-16(11-24)30-31(25,26)27/h8-9,13-16H,2-7,10-12H2,1H3,(H,20,21,22)(H2,25,26,27)/t14-,15-,16-/m1/s1
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n/an/a 0.768n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113085
PNG
(US8633206, 3)
Show SMILES CCOC1CCCN(C1)S(=O)(=O)CC1CCC(CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H33N5O3S/c1-3-29-18-5-4-12-26(13-18)30(27,28)14-16-6-8-17(9-7-16)25(2)21-19-10-11-22-20(19)23-15-24-21/h10-11,15-18H,3-9,12-14H2,1-2H3,(H,22,23,24)
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM113217
PNG
(US8633206, 136)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCN(C)CC2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H30N6O2S/c1-23-9-11-25(12-10-23)28(26,27)13-15-3-5-16(6-4-15)24(2)19-17-7-8-20-18(17)21-14-22-19/h7-8,14-16H,3-6,9-13H2,1-2H3,(H,20,21,22)/t15-,16-
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n/an/a 1.29n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113179
PNG
(US8633206, 97)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@](O)(CSc3ccccn3)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H32N6O3S2/c1-29(23-20-9-12-26-22(20)27-17-28-23)19-7-5-18(6-8-19)14-35(32,33)30-13-10-24(31,15-30)16-34-21-4-2-3-11-25-21/h2-4,9,11-12,17-19,31H,5-8,10,13-16H2,1H3,(H,26,27,28)/t18-,19-,24-/m0/s1
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n/an/a 1.36n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113122
PNG
(US8633206, 40)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](O)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H29N5O3S/c1-23(19-17-8-9-20-18(17)21-13-22-19)15-6-4-14(5-7-15)12-28(26,27)24-10-2-3-16(25)11-24/h8-9,13-16,25H,2-7,10-12H2,1H3,(H,20,21,22)/t14-,15-,16-/m1/s1
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n/an/a 1.44n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113108
PNG
(US8633206, 26)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](C2)NC(=O)OC(C)(C)C)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H36N6O4S/c1-23(2,3)33-22(30)27-17-10-12-29(13-17)34(31,32)14-16-5-7-18(8-6-16)28(4)21-19-9-11-24-20(19)25-15-26-21/h9,11,15-18H,5-8,10,12-14H2,1-4H3,(H,27,30)(H,24,25,26)/t16-,17-,18-/m0/s1
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n/an/a 1.44n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113195
PNG
(US8633206, 113)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC(C2)c2nnn[nH]2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H25N9O2S/c1-26(18-15-6-7-19-17(15)20-11-21-18)14-4-2-12(3-5-14)10-30(28,29)27-8-13(9-27)16-22-24-25-23-16/h6-7,11-14H,2-5,8-10H2,1H3,(H,19,20,21)(H,22,23,24,25)/t12-,14-
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n/an/a 1.55n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113127
PNG
(US8633206, 45)
Show SMILES COCCC1(CCN(CC1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12)C(N)=O
Show InChI InChI=1S/C23H36N6O4S/c1-28(21-19-7-11-25-20(19)26-16-27-21)18-5-3-17(4-6-18)15-34(31,32)29-12-8-23(9-13-29,22(24)30)10-14-33-2/h7,11,16-18H,3-6,8-10,12-15H2,1-2H3,(H2,24,30)(H,25,26,27)/t17-,18-
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n/an/a 1.59n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113102
PNG
(US8633206, 20)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCCC(CNC(C)=O)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H34N6O3S/c1-16(29)24-12-18-4-3-11-28(13-18)32(30,31)14-17-5-7-19(8-6-17)27(2)22-20-9-10-23-21(20)25-15-26-22/h9-10,15,17-19H,3-8,11-14H2,1-2H3,(H,24,29)(H,23,25,26)/t17-,18?,19-
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n/an/a 1.66n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113155
PNG
(US8633206, 73)
Show SMILES COC[C@@H]1CCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H31N5O3S/c1-24(20-18-7-9-21-19(18)22-14-23-20)17-5-3-15(4-6-17)13-29(26,27)25-10-8-16(11-25)12-28-2/h7,9,14-17H,3-6,8,10-13H2,1-2H3,(H,21,22,23)/t15-,16-,17-/m1/s1
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n/an/a 1.69n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113210
PNG
(US8633206, 129)
Show SMILES C[C@@H]1C[C@@H](CS(=O)(=O)N2CCC[C@@H](O)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H31N5O3S/c1-14-10-15(12-29(27,28)25-9-3-4-16(26)11-25)5-6-18(14)24(2)20-17-7-8-21-19(17)22-13-23-20/h7-8,13-16,18,26H,3-6,9-12H2,1-2H3,(H,21,22,23)/t14-,15+,16-,18+/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113142
PNG
(US8633206, 60)
Show SMILES CO[C@@H]1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H31N5O3S/c1-24(20-18-9-10-21-19(18)22-14-23-20)16-7-5-15(6-8-16)13-29(26,27)25-11-3-4-17(12-25)28-2/h9-10,14-17H,3-8,11-13H2,1-2H3,(H,21,22,23)/t15-,16-,17-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113172
PNG
(US8633206, 90)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@](O)(Cn3cccn3)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H31N7O3S/c1-27(21-19-7-10-23-20(19)24-16-25-21)18-5-3-17(4-6-18)13-33(31,32)29-12-8-22(30,15-29)14-28-11-2-9-26-28/h2,7,9-11,16-18,30H,3-6,8,12-15H2,1H3,(H,23,24,25)/t17-,18-,22-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM113221
PNG
(US8633206, 140)
Show SMILES CCOP(=O)(OCC)O[C@@H]1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H38N5O6PS/c1-4-32-35(29,33-5-2)34-20-7-6-14-28(15-20)36(30,31)16-18-8-10-19(11-9-18)27(3)23-21-12-13-24-22(21)25-17-26-23/h12-13,17-20H,4-11,14-16H2,1-3H3,(H,24,25,26)/t18-,19-,20-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113173
PNG
(US8633206, 91)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@](O)(C2)c2ccccc2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H31N5O3S/c1-28(23-21-11-13-25-22(21)26-17-27-23)20-9-7-18(8-10-20)15-33(31,32)29-14-12-24(30,16-29)19-5-3-2-4-6-19/h2-6,11,13,17-18,20,30H,7-10,12,14-16H2,1H3,(H,25,26,27)/t18-,20-,24-/m0/s1
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n/an/a 1.92n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113098
PNG
(US8633206, 16)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCCC(C2)C(O)=O)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H29N5O4S/c1-24(19-17-8-9-21-18(17)22-13-23-19)16-6-4-14(5-7-16)12-30(28,29)25-10-2-3-15(11-25)20(26)27/h8-9,13-16H,2-7,10-12H2,1H3,(H,26,27)(H,21,22,23)/t14-,15?,16-
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n/an/a 2.13n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113144
PNG
(US8633206, 62)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](CO)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H31N5O3S/c1-24(20-18-8-9-21-19(18)22-14-23-20)17-6-4-15(5-7-17)13-29(27,28)25-10-2-3-16(11-25)12-26/h8-9,14-17,26H,2-7,10-13H2,1H3,(H,21,22,23)/t15-,16-,17-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113153
PNG
(US8633206, 71)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2C[C@H](O)[C@H](O)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H27N5O4S/c1-22(18-14-6-7-19-17(14)20-11-21-18)13-4-2-12(3-5-13)10-28(26,27)23-8-15(24)16(25)9-23/h6-7,11-13,15-16,24-25H,2-5,8-10H2,1H3,(H,19,20,21)/t12-,13-,15-,16+
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n/an/a 2.52n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113189
PNG
(US8633206, 107)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](C2)c2ccccn2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H30N6O2S/c1-28(23-20-9-12-25-22(20)26-16-27-23)19-7-5-17(6-8-19)15-32(30,31)29-13-10-18(14-29)21-4-2-3-11-24-21/h2-4,9,11-12,16-19H,5-8,10,13-15H2,1H3,(H,25,26,27)/t17-,18-,19-/m0/s1
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n/an/a 2.54n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113146
PNG
(US8633206, 64)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](C2)C#N)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H28N6O2S/c1-25(20-18-8-9-22-19(18)23-14-24-20)17-6-4-15(5-7-17)13-29(27,28)26-10-2-3-16(11-21)12-26/h8-9,14-17H,2-7,10,12-13H2,1H3,(H,22,23,24)/t15-,16-,17-/m1/s1
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n/an/a 2.71n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113163
PNG
(US8633206, 81)
Show SMILES CNS(=O)(=O)[C@H]1CCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H30N6O4S2/c1-20-31(28,29)16-8-10-25(11-16)30(26,27)12-14-3-5-15(6-4-14)24(2)19-17-7-9-21-18(17)22-13-23-19/h7,9,13-16,20H,3-6,8,10-12H2,1-2H3,(H,21,22,23)/t14-,15-,16-/m0/s1
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n/an/a 2.78n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113113
PNG
(US8633206, 31)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H29N5O3S/c1-23(19-17-6-8-20-18(17)21-13-22-19)16-4-2-14(3-5-16)12-28(26,27)24-9-7-15(10-24)11-25/h6,8,13-16,25H,2-5,7,9-12H2,1H3,(H,20,21,22)/t14-,15-,16-/m0/s1
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n/an/a 2.88n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113089
PNG
(US8633206, 7)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CCCC(C2)OCC(N)=O)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H32N6O4S/c1-26(21-18-8-9-23-20(18)24-14-25-21)16-6-4-15(5-7-16)13-32(29,30)27-10-2-3-17(11-27)31-12-19(22)28/h8-9,14-17H,2-7,10-13H2,1H3,(H2,22,28)(H,23,24,25)/t15-,16-,17?
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n/an/a 2.96n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113158
PNG
(US8633206, 76)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](C2)S(C)(=O)=O)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H29N5O4S2/c1-23(19-17-7-9-20-18(17)21-13-22-19)15-5-3-14(4-6-15)12-30(27,28)24-10-8-16(11-24)29(2,25)26/h7,9,13-16H,3-6,8,10-12H2,1-2H3,(H,20,21,22)/t14-,15-,16-/m0/s1
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n/an/a 2.98n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113162
PNG
(US8633206, 80)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2C[C@H](F)[C@@H](CO)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H28FN5O3S/c1-24(19-16-6-7-21-18(16)22-12-23-19)15-4-2-13(3-5-15)11-29(27,28)25-8-14(10-26)17(20)9-25/h6-7,12-15,17,26H,2-5,8-11H2,1H3,(H,21,22,23)/t13-,14-,15-,17+/m1/s1
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n/an/a 3.03n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113196
PNG
(US8633206, 114)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC(C2)S(=O)(=O)c2ccccc2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H29N5O4S2/c1-27(23-21-11-12-24-22(21)25-16-26-23)18-9-7-17(8-10-18)15-33(29,30)28-13-20(14-28)34(31,32)19-5-3-2-4-6-19/h2-6,11-12,16-18,20H,7-10,13-15H2,1H3,(H,24,25,26)/t17-,18-
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n/an/a 3.05n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM113112
PNG
(US8633206, 30)
Show SMILES CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](CO)C2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H29N5O3S/c1-23(19-17-6-8-20-18(17)21-13-22-19)16-4-2-14(3-5-16)12-28(26,27)24-9-7-15(10-24)11-25/h6,8,13-16,25H,2-5,7,9-12H2,1H3,(H,20,21,22)/t14-,15-,16-/m1/s1
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n/an/a 3.06n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...


US Patent US8633206 (2014)


BindingDB Entry DOI: 10.7270/Q2ZS2V44
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%