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USPatent US8846699

Compile Data Set for Download or QSAR

Found 346 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133709
PNG
(US8846699, 25)
Show SMILES CN(C)CC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C23H24BrFN6O3/c1-4-21(32)29-19-10-15-18(11-20(19)34-8-7-26-22(33)12-31(2)3)27-13-28-23(15)30-17-6-5-14(24)9-16(17)25/h4-6,9-11,13H,1,7-8,12H2,2-3H3,(H,26,33)(H,29,32)(H,27,28,30)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133696
PNG
(US8846699, 12)
Show SMILES CN(C)CC(=O)NCCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C24H26BrFN6O3/c1-4-22(33)30-20-11-16-19(12-21(20)35-9-5-8-27-23(34)13-32(2)3)28-14-29-24(16)31-18-7-6-15(25)10-17(18)26/h4,6-7,10-12,14H,1,5,8-9,13H2,2-3H3,(H,27,34)(H,30,33)(H,28,29,31)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133707
PNG
(US8846699, 23)
Show SMILES CCNC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H22BrFN6O3/c1-3-20(31)29-18-10-14-17(11-19(18)33-8-7-26-22(32)25-4-2)27-12-28-21(14)30-16-6-5-13(23)9-15(16)24/h3,5-6,9-12H,1,4,7-8H2,2H3,(H,29,31)(H2,25,26,32)(H,27,28,30)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133702
PNG
(US8846699, 18)
Show SMILES CC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H19BrFN5O3/c1-3-20(30)27-18-9-14-17(10-19(18)31-7-6-24-12(2)29)25-11-26-21(14)28-16-5-4-13(22)8-15(16)23/h3-5,8-11H,1,6-7H2,2H3,(H,24,29)(H,27,30)(H,25,26,28)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133689
PNG
(US8846699, 5)
Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCC3CCN(CC3)C(=O)C=C)c(NC(=O)C=C)cc12
Show InChI InChI=1S/C26H25BrFN5O3/c1-3-24(34)31-22-12-18-21(29-15-30-26(18)32-20-6-5-17(27)11-19(20)28)13-23(22)36-14-16-7-9-33(10-8-16)25(35)4-2/h3-6,11-13,15-16H,1-2,7-10,14H2,(H,31,34)(H,29,30,32)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133711
PNG
(US8846699, 27 | US8846699, 55)
Show SMILES CC(=O)CNCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H21BrFN5O3/c1-3-21(31)28-19-9-15-18(10-20(19)32-7-6-25-11-13(2)30)26-12-27-22(15)29-17-5-4-14(23)8-16(17)24/h3-5,8-10,12,25H,1,6-7,11H2,2H3,(H,28,31)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133685
PNG
(US8846699, 1)
Show SMILES CC(=O)N1CCC(COc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2NC(=O)C=C)CC1
Show InChI InChI=1S/C25H25BrFN5O3/c1-3-24(34)30-22-11-18-21(12-23(22)35-13-16-6-8-32(9-7-16)15(2)33)28-14-29-25(18)31-20-5-4-17(26)10-19(20)27/h3-5,10-12,14,16H,1,6-9,13H2,2H3,(H,30,34)(H,28,29,31)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133701
PNG
(US8846699, 17)
Show SMILES CNCCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H21BrFN5O2/c1-3-20(29)27-18-10-14-17(11-19(18)30-8-4-7-24-2)25-12-26-21(14)28-16-6-5-13(22)9-15(16)23/h3,5-6,9-12,24H,1,4,7-8H2,2H3,(H,27,29)(H,25,26,28)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133819
PNG
(US8846699, 137)
Show SMILES CC(=O)CNCCOc1cc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H20Cl2FN5O3/c1-3-21(32)29-19-6-13-17(9-20(19)33-5-4-26-10-12(2)31)27-11-28-22(13)30-18-8-15(24)14(23)7-16(18)25/h3,6-9,11,26H,1,4-5,10H2,2H3,(H,29,32)(H,27,28,30)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133697
PNG
(US8846699, 13)
Show SMILES CC(=O)NCCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H21BrFN5O3/c1-3-21(31)28-19-10-15-18(11-20(19)32-8-4-7-25-13(2)30)26-12-27-22(15)29-17-6-5-14(23)9-16(17)24/h3,5-6,9-12H,1,4,7-8H2,2H3,(H,25,30)(H,28,31)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133708
PNG
(US8846699, 24)
Show SMILES NC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C20H18BrFN6O3/c1-2-18(29)27-16-8-12-15(9-17(16)31-6-5-24-20(23)30)25-10-26-19(12)28-14-4-3-11(21)7-13(14)22/h2-4,7-10H,1,5-6H2,(H,27,29)(H3,23,24,30)(H,25,26,28)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133713
PNG
(US8846699, 29)
Show SMILES NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C19H17BrFN5O2/c1-2-18(27)25-16-8-12-15(9-17(16)28-6-5-22)23-10-24-19(12)26-14-4-3-11(20)7-13(14)21/h2-4,7-10H,1,5-6,22H2,(H,25,27)(H,23,24,26)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133706
PNG
(US8846699, 22)
Show SMILES FC(F)C(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H17BrF3N5O3/c1-2-18(31)29-16-8-12-15(9-17(16)33-6-5-26-21(32)19(24)25)27-10-28-20(12)30-14-4-3-11(22)7-13(14)23/h2-4,7-10,19H,1,5-6H2,(H,26,32)(H,29,31)(H,27,28,30)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133710
PNG
(US8846699, 26)
Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCCNC(=O)C=C)c(NC(=O)C=C)cc12
Show InChI InChI=1S/C22H19BrFN5O3/c1-3-20(30)25-7-8-32-19-11-17-14(10-18(19)28-21(31)4-2)22(27-12-26-17)29-16-6-5-13(23)9-15(16)24/h3-6,9-12H,1-2,7-8H2,(H,25,30)(H,28,31)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133803
PNG
(US8846699, 121)
Show SMILES CC(=O)NCCOc1cc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H18Cl2FN5O3/c1-3-20(31)28-18-6-12-16(9-19(18)32-5-4-25-11(2)30)26-10-27-21(12)29-17-8-14(23)13(22)7-15(17)24/h3,6-10H,1,4-5H2,2H3,(H,25,30)(H,28,31)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133694
PNG
(US8846699, 10)
Show SMILES CN(C)CC(=O)N1CCC(COc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2NC(=O)C=C)CC1
Show InChI InChI=1S/C27H30BrFN6O3/c1-4-25(36)32-23-12-19-22(30-16-31-27(19)33-21-6-5-18(28)11-20(21)29)13-24(23)38-15-17-7-9-35(10-8-17)26(37)14-34(2)3/h4-6,11-13,16-17H,1,7-10,14-15H2,2-3H3,(H,32,36)(H,30,31,33)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133783
PNG
(US8846699, 101)
Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCCNC(=O)CN3CCCCC3)c(NC(=O)C=C)cc12
Show InChI InChI=1S/C26H28BrFN6O3/c1-2-24(35)32-22-13-18-21(30-16-31-26(18)33-20-7-6-17(27)12-19(20)28)14-23(22)37-11-8-29-25(36)15-34-9-4-3-5-10-34/h2,6-7,12-14,16H,1,3-5,8-11,15H2,(H,29,36)(H,32,35)(H,30,31,33)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133826
PNG
(US8846699, 144)
Show SMILES CCN(CC)CCC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)c(Cl)c3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C26H29BrClFN6O3/c1-4-22(36)33-20-13-16-19(14-21(20)38-12-10-30-23(37)9-11-35(5-2)6-3)31-15-32-26(16)34-18-8-7-17(27)24(28)25(18)29/h4,7-8,13-15H,1,5-6,9-12H2,2-3H3,(H,30,37)(H,33,36)(H,31,32,34)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133848
PNG
(US8846699, 168)
Show SMILES CCNC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)c(Cl)c3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H21BrClFN6O3/c1-3-18(32)30-16-9-12-15(10-17(16)34-8-7-27-22(33)26-4-2)28-11-29-21(12)31-14-6-5-13(23)19(24)20(14)25/h3,5-6,9-11H,1,4,7-8H2,2H3,(H,30,32)(H2,26,27,33)(H,28,29,31)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133705
PNG
(US8846699, 21)
Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCCNC(=O)C3CC3)c(NC(=O)C=C)cc12
Show InChI InChI=1S/C23H21BrFN5O3/c1-2-21(31)29-19-10-15-18(11-20(19)33-8-7-26-23(32)13-3-4-13)27-12-28-22(15)30-17-6-5-14(24)9-16(17)25/h2,5-6,9-13H,1,3-4,7-8H2,(H,26,32)(H,29,31)(H,27,28,30)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133817
PNG
(US8846699, 135)
Show SMILES CN(C)CC(=O)NCCOc1cc2ncnc(Nc3cc(Cl)c(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C23H23BrClFN6O3/c1-4-21(33)30-19-7-13-17(10-20(19)35-6-5-27-22(34)11-32(2)3)28-12-29-23(13)31-18-9-15(25)14(24)8-16(18)26/h4,7-10,12H,1,5-6,11H2,2-3H3,(H,27,34)(H,30,33)(H,28,29,31)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133703
PNG
(US8846699, 19)
Show SMILES CN(C)CCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H21BrFN5O2/c1-4-20(29)26-18-10-14-17(11-19(18)30-8-7-28(2)3)24-12-25-21(14)27-16-6-5-13(22)9-15(16)23/h4-6,9-12H,1,7-8H2,2-3H3,(H,26,29)(H,24,25,27)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133822
PNG
(US8846699, 140)
Show SMILES CN(C)CC(=O)NCCOc1cc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C23H23Cl2FN6O3/c1-4-21(33)30-19-7-13-17(10-20(19)35-6-5-27-22(34)11-32(2)3)28-12-29-23(13)31-18-9-15(25)14(24)8-16(18)26/h4,7-10,12H,1,5-6,11H2,2-3H3,(H,27,34)(H,30,33)(H,28,29,31)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133745
PNG
(US8846699, 61)
Show SMILES CN(C)CCC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C24H26BrFN6O3/c1-4-22(33)30-20-12-16-19(13-21(20)35-10-8-27-23(34)7-9-32(2)3)28-14-29-24(16)31-18-6-5-15(25)11-17(18)26/h4-6,11-14H,1,7-10H2,2-3H3,(H,27,34)(H,30,33)(H,28,29,31)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133704
PNG
(US8846699, 20)
Show SMILES CC(=O)NCCCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C23H23BrFN5O3/c1-3-22(32)29-20-11-16-19(12-21(20)33-9-5-4-8-26-14(2)31)27-13-28-23(16)30-18-7-6-15(24)10-17(18)25/h3,6-7,10-13H,1,4-5,8-9H2,2H3,(H,26,31)(H,29,32)(H,27,28,30)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133700
PNG
(US8846699, 16)
Show SMILES CCNC(=O)NCCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C23H24BrFN6O3/c1-3-21(32)30-19-11-15-18(12-20(19)34-9-5-8-27-23(33)26-4-2)28-13-29-22(15)31-17-7-6-14(24)10-16(17)25/h3,6-7,10-13H,1,4-5,8-9H2,2H3,(H,30,32)(H2,26,27,33)(H,28,29,31)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133793
PNG
(US8846699, 111)
Show SMILES CC(=O)NCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H19ClFN5O3/c1-3-20(30)28-18-9-14-17(10-19(18)31-7-6-24-12(2)29)25-11-26-21(14)27-13-4-5-16(23)15(22)8-13/h3-5,8-11H,1,6-7H2,2H3,(H,24,29)(H,28,30)(H,25,26,27)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133801
PNG
(US8846699, 119)
Show SMILES CC(=O)NCCOc1cc2ncnc(Nc3cc(F)c(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H18BrF2N5O3/c1-3-20(31)28-18-6-12-16(9-19(18)32-5-4-25-11(2)30)26-10-27-21(12)29-17-8-14(23)13(22)7-15(17)24/h3,6-10H,1,4-5H2,2H3,(H,25,30)(H,28,31)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133784
PNG
(US8846699, 102)
Show SMILES CN1CCN(CC(=O)NCCOc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2NC(=O)C=C)CC1
Show InChI InChI=1S/C26H29BrFN7O3/c1-3-24(36)32-22-13-18-21(30-16-31-26(18)33-20-5-4-17(27)12-19(20)28)14-23(22)38-11-6-29-25(37)15-35-9-7-34(2)8-10-35/h3-5,12-14,16H,1,6-11,15H2,2H3,(H,29,37)(H,32,36)(H,30,31,33)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133838
PNG
(US8846699, 158 | US8846699, 163)
Show SMILES C[C@@H](COc1cc2ncnc(Nc3ccc(Br)c(Cl)c3F)c2cc1NC(=O)C=C)NC(=O)CN(C)C
Show InChI InChI=1S/C24H25BrClFN6O3/c1-5-20(34)31-18-8-14-17(9-19(18)36-11-13(2)30-21(35)10-33(3)4)28-12-29-24(14)32-16-7-6-15(25)22(26)23(16)27/h5-9,12-13H,1,10-11H2,2-4H3,(H,30,35)(H,31,34)(H,28,29,32)/t13-/m0/s1
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133829
PNG
(US8846699, 147)
Show SMILES Fc1c(Cl)c(Br)ccc1Nc1ncnc2cc(OCCNC(=O)CCN3CCCCC3)c(NC(=O)C=C)cc12
Show InChI InChI=1S/C27H29BrClFN6O3/c1-2-23(37)34-21-14-17-20(32-16-33-27(17)35-19-7-6-18(28)25(29)26(19)30)15-22(21)39-13-9-31-24(38)8-12-36-10-4-3-5-11-36/h2,6-7,14-16H,1,3-5,8-13H2,(H,31,38)(H,34,37)(H,32,33,35)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133778
PNG
(US8846699, 96)
Show SMILES CN1CCN(CC1)C(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C25H27BrFN7O3/c1-3-23(35)31-21-13-17-20(29-15-30-24(17)32-19-5-4-16(26)12-18(19)27)14-22(21)37-11-6-28-25(36)34-9-7-33(2)8-10-34/h3-5,12-15H,1,6-11H2,2H3,(H,28,36)(H,31,35)(H,29,30,32)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133692
PNG
(US8846699, 8)
Show SMILES CC(=O)N1CCC(COc2cc3ncnc(Nc4c(F)cc(Br)cc4F)c3cc2NC(=O)C=C)CC1
Show InChI InChI=1S/C25H24BrF2N5O3/c1-3-23(35)31-21-10-17-20(11-22(21)36-12-15-4-6-33(7-5-15)14(2)34)29-13-30-25(17)32-24-18(27)8-16(26)9-19(24)28/h3,8-11,13,15H,1,4-7,12H2,2H3,(H,31,35)(H,29,30,32)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133816
PNG
(US8846699, 134)
Show SMILES CC(=O)CNCCOc1cc2ncnc(Nc3cc(Cl)c(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H20BrClFN5O3/c1-3-21(32)29-19-6-13-17(9-20(19)33-5-4-26-10-12(2)31)27-11-28-22(13)30-18-8-15(24)14(23)7-16(18)25/h3,6-9,11,26H,1,4-5,10H2,2H3,(H,29,32)(H,27,28,30)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133823
PNG
(US8846699, 141)
Show SMILES CC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)c(Cl)c3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H18BrClFN5O3/c1-3-18(31)28-16-8-12-15(9-17(16)32-7-6-25-11(2)30)26-10-27-21(12)29-14-5-4-13(22)19(23)20(14)24/h3-5,8-10H,1,6-7H2,2H3,(H,25,30)(H,28,31)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133824
PNG
(US8846699, 142)
Show SMILES CC(=O)CNCCOc1cc2ncnc(Nc3ccc(Br)c(Cl)c3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H20BrClFN5O3/c1-3-19(32)29-17-8-13-16(9-18(17)33-7-6-26-10-12(2)31)27-11-28-22(13)30-15-5-4-14(23)20(24)21(15)25/h3-5,8-9,11,26H,1,6-7,10H2,2H3,(H,29,32)(H,27,28,30)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133839
PNG
(US8846699, 159 | US8846699, 164)
Show SMILES C[C@H](COc1cc2ncnc(Nc3ccc(Br)c(Cl)c3F)c2cc1NC(=O)C=C)NC(=O)CN(C)C
Show InChI InChI=1S/C24H25BrClFN6O3/c1-5-20(34)31-18-8-14-17(9-19(18)36-11-13(2)30-21(35)10-33(3)4)28-12-29-24(14)32-16-7-6-15(25)22(26)23(16)27/h5-9,12-13H,1,10-11H2,2-4H3,(H,30,35)(H,31,34)(H,28,29,32)/t13-/m1/s1
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133786
PNG
(US8846699, 104)
Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCCNC(=O)CCN3CCCCC3)c(NC(=O)C=C)cc12
Show InChI InChI=1S/C27H30BrFN6O3/c1-2-25(36)33-23-15-19-22(31-17-32-27(19)34-21-7-6-18(28)14-20(21)29)16-24(23)38-13-9-30-26(37)8-12-35-10-4-3-5-11-35/h2,6-7,14-17H,1,3-5,8-13H2,(H,30,37)(H,33,36)(H,31,32,34)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133728
PNG
(US8846699, 44)
Show SMILES COCC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H21BrFN5O4/c1-3-20(30)28-18-9-14-17(10-19(18)33-7-6-25-21(31)11-32-2)26-12-27-22(14)29-16-5-4-13(23)8-15(16)24/h3-5,8-10,12H,1,6-7,11H2,2H3,(H,25,31)(H,28,30)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133846
PNG
(US8846699, 166)
Show SMILES COc1cc(Nc2ncnc3cc(OCCNC(=O)CN(C)C)c(NC(=O)C=C)cc23)c(OC)cc1Cl
Show InChI InChI=1S/C25H29ClN6O5/c1-6-23(33)30-18-9-15-17(11-22(18)37-8-7-27-24(34)13-32(2)3)28-14-29-25(15)31-19-12-20(35-4)16(26)10-21(19)36-5/h6,9-12,14H,1,7-8,13H2,2-5H3,(H,27,34)(H,30,33)(H,28,29,31)
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n/an/a 14n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133695
PNG
(US8846699, 11)
Show SMILES CC(C)(C)NC(=O)N1CCC(COc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2NC(=O)C=C)CC1
Show InChI InChI=1S/C28H32BrFN6O3/c1-5-25(37)33-23-13-19-22(31-16-32-26(19)34-21-7-6-18(29)12-20(21)30)14-24(23)39-15-17-8-10-36(11-9-17)27(38)35-28(2,3)4/h5-7,12-14,16-17H,1,8-11,15H2,2-4H3,(H,33,37)(H,35,38)(H,31,32,34)
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n/an/a 14n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133800
PNG
(US8846699, 118)
Show SMILES CC(=O)NCCOc1cc2ncnc(Nc3ccc(F)c(F)c3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H18F3N5O3/c1-3-18(31)28-16-8-12-15(9-17(16)32-7-6-25-11(2)30)26-10-27-21(12)29-14-5-4-13(22)19(23)20(14)24/h3-5,8-10H,1,6-7H2,2H3,(H,25,30)(H,28,31)(H,26,27,29)
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n/an/a 14n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133815
PNG
(US8846699, 133)
Show SMILES CC(=O)NCCOc1cc2ncnc(Nc3cc(Cl)c(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H18BrClFN5O3/c1-3-20(31)28-18-6-12-16(9-19(18)32-5-4-25-11(2)30)26-10-27-21(12)29-17-8-14(23)13(22)7-15(17)24/h3,6-10H,1,4-5H2,2H3,(H,25,30)(H,28,31)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133688
PNG
(US8846699, 4)
Show SMILES NC(=O)N1CCC(COc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2NC(=O)C=C)CC1
Show InChI InChI=1S/C24H24BrFN6O3/c1-2-22(33)30-20-10-16-19(11-21(20)35-12-14-5-7-32(8-6-14)24(27)34)28-13-29-23(16)31-18-4-3-15(25)9-17(18)26/h2-4,9-11,13-14H,1,5-8,12H2,(H2,27,34)(H,30,33)(H,28,29,31)
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n/an/a 15n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133737
PNG
(US8846699, 53)
Show SMILES CN(C)CC=CC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C25H26BrFN6O3/c1-4-23(34)31-21-13-17-20(14-22(21)36-11-9-28-24(35)6-5-10-33(2)3)29-15-30-25(17)32-19-8-7-16(26)12-18(19)27/h4-8,12-15H,1,9-11H2,2-3H3,(H,28,35)(H,31,34)(H,29,30,32)/b6-5+
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133831
PNG
(US8846699, 149)
Show SMILES OCC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)c(Cl)c3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H18BrClFN5O4/c1-2-17(31)28-15-7-11-14(8-16(15)33-6-5-25-18(32)9-30)26-10-27-21(11)29-13-4-3-12(22)19(23)20(13)24/h2-4,7-8,10,30H,1,5-6,9H2,(H,25,32)(H,28,31)(H,26,27,29)
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Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133773
PNG
(US8846699, 91)
Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCC3CNC(=O)O3)c(NC(=O)C=C)cc12
Show InChI InChI=1S/C21H17BrFN5O4/c1-2-19(29)27-17-6-13-16(7-18(17)31-9-12-8-24-21(30)32-12)25-10-26-20(13)28-15-4-3-11(22)5-14(15)23/h2-7,10,12H,1,8-9H2,(H,24,30)(H,27,29)(H,25,26,28)
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n/an/a 17n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133794
PNG
(US8846699, 112)
Show SMILES CC(=O)NCCOc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C21H19ClFN5O3/c1-3-20(30)27-18-9-14-17(10-19(18)31-7-6-24-12(2)29)25-11-26-21(14)28-16-5-4-13(22)8-15(16)23/h3-5,8-11H,1,6-7H2,2H3,(H,24,29)(H,27,30)(H,25,26,28)
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n/an/a 18n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133853
PNG
(US8846699, 173)
Show SMILES CC(N)C(=O)NCCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C22H22BrFN6O3/c1-3-20(31)29-18-9-14-17(10-19(18)33-7-6-26-22(32)12(2)25)27-11-28-21(14)30-16-5-4-13(23)8-15(16)24/h3-5,8-12H,1,6-7,25H2,2H3,(H,26,32)(H,29,31)(H,27,28,30)
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n/an/a 18n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM133806
PNG
(US8846699, 124)
Show SMILES CN(C)CC(=O)NCCOc1cc2ncnc(Nc3ccc(Br)c(F)c3F)c2cc1NC(=O)C=C
Show InChI InChI=1S/C23H23BrF2N6O3/c1-4-19(33)30-17-9-13-16(10-18(17)35-8-7-27-20(34)11-32(2)3)28-12-29-23(13)31-15-6-5-14(24)21(25)22(15)26/h4-6,9-10,12H,1,7-8,11H2,2-3H3,(H,27,34)(H,30,33)(H,28,29,31)
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n/an/a 18n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd.

US Patent


Assay Description
EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...


US Patent US8846699 (2014)


BindingDB Entry DOI: 10.7270/Q2KW5DRK
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%