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USPatent US9156852

Compile data set for download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM185584
PNG
(US9156852, 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM185584
PNG
(US9156852, 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM185589
PNG
(US9156852, 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM185585
PNG
(US9156852, 16)
Show SMILES COc1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C24H20N6O2S/c1-13-3-8-17-16(9-10-26-23(17)29-14-4-6-15(32-2)7-5-14)19(13)30-24(31)18-11-33-21-20(18)27-12-28-22(21)25/h3-12H,1-2H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM185586
PNG
(US9156852, 38)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-5-6-16-15(7-8-26-22(16)29-14-4-2-3-13(24)9-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM185589
PNG
(US9156852, 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens)
BDBM185584
PNG
(US9156852, 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM185589
PNG
(US9156852, 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM185591
PNG
(US9156852, 116)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM185588
PNG
(US9156852, 59)
Show SMILES CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl
Show InChI InChI=1S/C26H24ClN7OS/c1-14-4-6-18-17(21(14)33-26(35)19-12-36-23-22(19)30-13-31-24(23)28)8-9-29-25(18)32-16-5-7-20(27)15(10-16)11-34(2)3/h4-10,12-13H,11H2,1-3H3,(H,29,32)(H,33,35)(H2,28,30,31)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM185588
PNG
(US9156852, 59)
Show SMILES CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl
Show InChI InChI=1S/C26H24ClN7OS/c1-14-4-6-18-17(21(14)33-26(35)19-12-36-23-22(19)30-13-31-24(23)28)8-9-29-25(18)32-16-5-7-20(27)15(10-16)11-34(2)3/h4-10,12-13H,11H2,1-3H3,(H,29,32)(H,33,35)(H2,28,30,31)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM185589
PNG
(US9156852, 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM185591
PNG
(US9156852, 116)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM185586
PNG
(US9156852, 38)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-5-6-16-15(7-8-26-22(16)29-14-4-2-3-13(24)9-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM185591
PNG
(US9156852, 116)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens)
BDBM185589
PNG
(US9156852, 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM185589
PNG
(US9156852, 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM185590
PNG
(US9156852, 105)
Show SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-2-4-14-13(6-7-27-22(14)30-12-3-5-17(25)16(24)8-12)18(11)31-23(32)15-9-33-20-19(15)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM185585
PNG
(US9156852, 16)
Show SMILES COc1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C24H20N6O2S/c1-13-3-8-17-16(9-10-26-23(17)29-14-4-6-15(32-2)7-5-14)19(13)30-24(31)18-11-33-21-20(18)27-12-28-22(21)25/h3-12H,1-2H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM185584
PNG
(US9156852, 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM185584
PNG
(US9156852, 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM185591
PNG
(US9156852, 116)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM185587
PNG
(US9156852, 50)
Show SMILES Cc1ccc2c(Nc3ccc(OC(F)F)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C24H18F2N6O2S/c1-12-2-7-16-15(8-9-28-22(16)31-13-3-5-14(6-4-13)34-24(25)26)18(12)32-23(33)17-10-35-20-19(17)29-11-30-21(20)27/h2-11,24H,1H3,(H,28,31)(H,32,33)(H2,27,29,30)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM185590
PNG
(US9156852, 105)
Show SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-2-4-14-13(6-7-27-22(14)30-12-3-5-17(25)16(24)8-12)18(11)31-23(32)15-9-33-20-19(15)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM185587
PNG
(US9156852, 50)
Show SMILES Cc1ccc2c(Nc3ccc(OC(F)F)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C24H18F2N6O2S/c1-12-2-7-16-15(8-9-28-22(16)31-13-3-5-14(6-4-13)34-24(25)26)18(12)32-23(33)17-10-35-20-19(17)29-11-30-21(20)27/h2-11,24H,1H3,(H,28,31)(H,32,33)(H2,27,29,30)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM185585
PNG
(US9156852, 16)
Show SMILES COc1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C24H20N6O2S/c1-13-3-8-17-16(9-10-26-23(17)29-14-4-6-15(32-2)7-5-14)19(13)30-24(31)18-11-33-21-20(18)27-12-28-22(21)25/h3-12H,1-2H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM185586
PNG
(US9156852, 38)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-5-6-16-15(7-8-26-22(16)29-14-4-2-3-13(24)9-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM185588
PNG
(US9156852, 59)
Show SMILES CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl
Show InChI InChI=1S/C26H24ClN7OS/c1-14-4-6-18-17(21(14)33-26(35)19-12-36-23-22(19)30-13-31-24(23)28)8-9-29-25(18)32-16-5-7-20(27)15(10-16)11-34(2)3/h4-10,12-13H,11H2,1-3H3,(H,29,32)(H,33,35)(H2,28,30,31)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens)
BDBM185591
PNG
(US9156852, 116)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM185590
PNG
(US9156852, 105)
Show SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-2-4-14-13(6-7-27-22(14)30-12-3-5-17(25)16(24)8-12)18(11)31-23(32)15-9-33-20-19(15)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM185591
PNG
(US9156852, 116)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM185586
PNG
(US9156852, 38)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-5-6-16-15(7-8-26-22(16)29-14-4-2-3-13(24)9-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM185586
PNG
(US9156852, 38)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-5-6-16-15(7-8-26-22(16)29-14-4-2-3-13(24)9-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM185590
PNG
(US9156852, 105)
Show SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-2-4-14-13(6-7-27-22(14)30-12-3-5-17(25)16(24)8-12)18(11)31-23(32)15-9-33-20-19(15)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens)
BDBM185586
PNG
(US9156852, 38)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-5-6-16-15(7-8-26-22(16)29-14-4-2-3-13(24)9-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM185584
PNG
(US9156852, 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM185587
PNG
(US9156852, 50)
Show SMILES Cc1ccc2c(Nc3ccc(OC(F)F)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C24H18F2N6O2S/c1-12-2-7-16-15(8-9-28-22(16)31-13-3-5-14(6-4-13)34-24(25)26)18(12)32-23(33)17-10-35-20-19(17)29-11-30-21(20)27/h2-11,24H,1H3,(H,28,31)(H,32,33)(H2,27,29,30)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM185590
PNG
(US9156852, 105)
Show SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-2-4-14-13(6-7-27-22(14)30-12-3-5-17(25)16(24)8-12)18(11)31-23(32)15-9-33-20-19(15)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens)
BDBM185590
PNG
(US9156852, 105)
Show SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-2-4-14-13(6-7-27-22(14)30-12-3-5-17(25)16(24)8-12)18(11)31-23(32)15-9-33-20-19(15)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%