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USPatent US9163007

Compile data set for download or QSAR
Found 94 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50388878
PNG
(CHEMBL1999931 | US9163007, 73)
Show SMILES O=C(Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1)c1ccccc1
Show InChI InChI=1S/C23H18N6O/c30-23(17-9-5-2-6-10-17)24-22-19-13-18(11-12-20(19)25-27-22)21-15-29(28-26-21)14-16-7-3-1-4-8-16/h1-13,15H,14H2,(H2,24,25,27,30)
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0.400n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185854
PNG
(US9163007, 185)
Show SMILES CN(C)c1ccc(cc1)-c1c(nnn1Cc1ccccc1)-c1ccc2[nH]nc(N)c2c1
Show InChI InChI=1S/C24H23N7/c1-30(2)19-11-8-17(9-12-19)23-22(18-10-13-21-20(14-18)24(25)28-26-21)27-29-31(23)15-16-6-4-3-5-7-16/h3-14H,15H2,1-2H3,(H3,25,26,28)
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0.400n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185901
PNG
(US9163007, 408)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C23H18FN5/c1-15-20-13-18(9-12-21(20)26-25-15)22-23(17-7-10-19(24)11-8-17)29(28-27-22)14-16-5-3-2-4-6-16/h2-13H,14H2,1H3,(H,25,26)
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0.428n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185888
PNG
(US9163007, 395)
Show SMILES Fc1cccc(c1)C(=O)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C23H17FN6O/c24-18-8-4-7-17(11-18)23(31)25-22-19-12-16(9-10-20(19)26-28-22)21-14-30(29-27-21)13-15-5-2-1-3-6-15/h1-12,14H,13H2,(H2,25,26,28,31)
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0.5n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185899
PNG
(US9163007, 406)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1cccs1
Show InChI InChI=1S/C20H16N6S/c21-20-15-11-14(8-9-16(15)22-24-20)18-19(17-7-4-10-27-17)26(25-23-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H3,21,22,24)
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0.5n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50388878
PNG
(CHEMBL1999931 | US9163007, 73)
Show SMILES O=C(Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1)c1ccccc1
Show InChI InChI=1S/C23H18N6O/c30-23(17-9-5-2-6-10-17)24-22-19-13-18(11-12-20(19)25-27-22)21-15-29(28-26-21)14-16-7-3-1-4-8-16/h1-13,15H,14H2,(H2,24,25,27,30)
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0.600n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185839
PNG
(US9163007, 87)
Show SMILES C(c1ccccc1)n1nnc(c1-c1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C22H17N5/c1-3-7-16(8-4-1)15-27-22(17-9-5-2-6-10-17)21(25-26-27)18-11-12-20-19(13-18)14-23-24-20/h1-14H,15H2,(H,23,24)
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0.601n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185846
PNG
(US9163007, 151)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C22H17FN6/c23-17-9-6-15(7-10-17)21-20(16-8-11-19-18(12-16)22(24)27-25-19)26-28-29(21)13-14-4-2-1-3-5-14/h1-12H,13H2,(H3,24,25,27)
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0.800n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185858
PNG
(US9163007, 198)
Show SMILES O=C(Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H22N6O/c36-29(22-14-8-3-9-15-22)30-28-24-18-23(16-17-25(24)31-33-28)26-27(21-12-6-2-7-13-21)35(34-32-26)19-20-10-4-1-5-11-20/h1-18H,19H2,(H2,30,31,33,36)
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0.800n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185863
PNG
(US9163007, 205)
Show SMILES Fc1cccc(c1)C(=O)Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C26H21FN6O/c27-20-8-4-7-19(13-20)26(34)28-25-21-14-18(11-12-22(21)29-31-25)23-24(17-9-10-17)33(32-30-23)15-16-5-2-1-3-6-16/h1-8,11-14,17H,9-10,15H2,(H2,28,29,31,34)
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0.900n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185858
PNG
(US9163007, 198)
Show SMILES O=C(Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H22N6O/c36-29(22-14-8-3-9-15-22)30-28-24-18-23(16-17-25(24)31-33-28)26-27(21-12-6-2-7-13-21)35(34-32-26)19-20-10-4-1-5-11-20/h1-18H,19H2,(H2,30,31,33,36)
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0.900n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185888
PNG
(US9163007, 395)
Show SMILES Fc1cccc(c1)C(=O)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C23H17FN6O/c24-18-8-4-7-17(11-18)23(31)25-22-19-12-16(9-10-20(19)26-28-22)21-14-30(29-27-21)13-15-5-2-1-3-6-15/h1-12,14H,13H2,(H2,25,26,28,31)
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1n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185850
PNG
(US9163007, 167)
Show SMILES Fc1ccc(cc1)-c1c(nnn1CC1CCOCC1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H20FN5O/c22-18-4-1-15(2-5-18)21-20(16-3-6-19-17(11-16)12-23-24-19)25-26-27(21)13-14-7-9-28-10-8-14/h1-6,11-12,14H,7-10,13H2,(H,23,24)
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1.05n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185898
PNG
(US9163007, 405)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1Cc1ccccc1
Show InChI InChI=1S/C23H20N6/c24-23-19-14-18(11-12-20(19)25-27-23)22-21(13-16-7-3-1-4-8-16)29(28-26-22)15-17-9-5-2-6-10-17/h1-12,14H,13,15H2,(H3,24,25,27)
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1.10n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185841
PNG
(US9163007, 102)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C22H18N6/c23-22-18-13-17(11-12-19(18)24-26-22)20-21(16-9-5-2-6-10-16)28(27-25-20)14-15-7-3-1-4-8-15/h1-13H,14H2,(H3,23,24,26)
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1.20n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185855
PNG
(US9163007, 189)
Show SMILES Cn1cc(cn1)-c1c(nnn1Cc1ccccc1)-c1ccc2[nH]nc(N)c2c1
Show InChI InChI=1S/C20H18N8/c1-27-12-15(10-22-27)19-18(14-7-8-17-16(9-14)20(21)25-23-17)24-26-28(19)11-13-5-3-2-4-6-13/h2-10,12H,11H2,1H3,(H3,21,23,25)
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1.90n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185841
PNG
(US9163007, 102)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C22H18N6/c23-22-18-13-17(11-12-19(18)24-26-22)20-21(16-9-5-2-6-10-16)28(27-25-20)14-15-7-3-1-4-8-15/h1-13H,14H2,(H3,23,24,26)
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2.10n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185846
PNG
(US9163007, 151)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C22H17FN6/c23-17-9-6-15(7-10-17)21-20(16-8-11-19-18(12-16)22(24)27-25-19)26-28-29(21)13-14-4-2-1-3-5-14/h1-12H,13H2,(H3,24,25,27)
PDB

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2.20n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185848
PNG
(US9163007, 162)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccccc1C
Show InChI InChI=1S/C24H21N5/c1-16-8-6-7-11-20(16)24-23(19-12-13-22-21(14-19)17(2)25-26-22)27-28-29(24)15-18-9-4-3-5-10-18/h3-14H,15H2,1-2H3,(H,25,26)
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2.25n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185863
PNG
(US9163007, 205)
Show SMILES Fc1cccc(c1)C(=O)Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C26H21FN6O/c27-20-8-4-7-19(13-20)26(34)28-25-21-14-18(11-12-22(21)29-31-25)23-24(17-9-10-17)33(32-30-23)15-16-5-2-1-3-6-16/h1-8,11-14,17H,9-10,15H2,(H2,28,29,31,34)
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2.40n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185849
PNG
(US9163007, 163)
Show SMILES Cc1ccccc1-c1c(nnn1Cc1ccccc1)-c1ccc2[nH]nc(N)c2c1
Show InChI InChI=1S/C23H20N6/c1-15-7-5-6-10-18(15)22-21(17-11-12-20-19(13-17)23(24)27-25-20)26-28-29(22)14-16-8-3-2-4-9-16/h2-13H,14H2,1H3,(H3,24,25,27)
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3.40n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185894
PNG
(US9163007, 401)
Show SMILES C(c1ccccc1)n1cc(nn1)-c1ccc2[nH]nc(-c3cccs3)c2c1
Show InChI InChI=1S/C20H15N5S/c1-2-5-14(6-3-1)12-25-13-18(22-24-25)15-8-9-17-16(11-15)20(23-21-17)19-7-4-10-26-19/h1-11,13H,12H2,(H,21,23)
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4.92n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185870
PNG
(US9163007, 224)
Show SMILES Clc1cccc(c1)C(=O)Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C26H21ClN6O/c27-20-8-4-7-19(13-20)26(34)28-25-21-14-18(11-12-22(21)29-31-25)23-24(17-9-10-17)33(32-30-23)15-16-5-2-1-3-6-16/h1-8,11-14,17H,9-10,15H2,(H2,28,29,31,34)
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6.30n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185833
PNG
(US9163007, 61)
Show SMILES C(c1ccccc1)n1cc(nn1)-c1ccc2[nH]nc(-c3ccccc3)c2c1
Show InChI InChI=1S/C22H17N5/c1-3-7-16(8-4-1)14-27-15-21(24-26-27)18-11-12-20-19(13-18)22(25-23-20)17-9-5-2-6-10-17/h1-13,15H,14H2,(H,23,25)
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7.70n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185896
PNG
(US9163007, 403)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1CC1CCCCC1
Show InChI InChI=1S/C23H26N6/c24-23-19-14-18(11-12-20(19)25-27-23)22-21(13-16-7-3-1-4-8-16)29(28-26-22)15-17-9-5-2-6-10-17/h2,5-6,9-12,14,16H,1,3-4,7-8,13,15H2,(H3,24,25,27)
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8.20n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50337315
PNG
(5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C16H14N6/c17-16-13-8-12(6-7-14(13)18-20-16)15-10-22(21-19-15)9-11-4-2-1-3-5-11/h1-8,10H,9H2,(H3,17,18,20)
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12n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185830
PNG
(US9163007, 32)
Show SMILES Clc1ccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c(Cl)c1
Show InChI InChI=1S/C16H11Cl2N5/c17-13-3-1-11(14(18)6-13)8-23-9-16(21-22-23)10-2-4-15-12(5-10)7-19-20-15/h1-7,9H,8H2,(H,19,20)
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12.7n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185860
PNG
(US9163007, 200)
Show SMILES COc1ccc(NC(=O)Nc2n[nH]c3ccc(cc23)-c2nnn(Cc3ccccc3)c2-c2ccccc2)cc1
Show InChI InChI=1S/C30H25N7O2/c1-39-24-15-13-23(14-16-24)31-30(38)32-29-25-18-22(12-17-26(25)33-35-29)27-28(21-10-6-3-7-11-21)37(36-34-27)19-20-8-4-2-5-9-20/h2-18H,19H2,1H3,(H3,31,32,33,35,38)
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13n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185861
PNG
(US9163007, 201)
Show SMILES CCCC(=O)Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C26H24N6O/c1-2-9-23(33)27-26-21-16-20(14-15-22(21)28-30-26)24-25(19-12-7-4-8-13-19)32(31-29-24)17-18-10-5-3-6-11-18/h3-8,10-16H,2,9,17H2,1H3,(H2,27,28,30,33)
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13n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185835
PNG
(US9163007, 64)
Show SMILES COCC(=O)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C19H18N6O2/c1-27-12-18(26)20-19-15-9-14(7-8-16(15)21-23-19)17-11-25(24-22-17)10-13-5-3-2-4-6-13/h2-9,11H,10,12H2,1H3,(H2,20,21,23,26)
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15n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185871
PNG
(US9163007, 227)
Show SMILES Clc1ccc(CNc2n[nH]c3ccc(cc23)-c2nnn(Cc3ccccc3)c2C2CC2)cc1
Show InChI InChI=1S/C26H23ClN6/c27-21-11-6-17(7-12-21)15-28-26-22-14-20(10-13-23(22)29-31-26)24-25(19-8-9-19)33(32-30-24)16-18-4-2-1-3-5-18/h1-7,10-14,19H,8-9,15-16H2,(H2,28,29,31)
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15n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185842
PNG
(US9163007, 123)
Show SMILES Cc1c(nnn1Cc1ccccc1)-c1ccc2[nH]nc(N)c2c1
Show InChI InChI=1S/C17H16N6/c1-11-16(13-7-8-15-14(9-13)17(18)21-19-15)20-22-23(11)10-12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H3,18,19,21)
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17n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185902
PNG
(US9163007, 409)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1CC1CCCC1
Show InChI InChI=1S/C22H24N6/c23-22-18-13-17(10-11-19(18)24-26-22)21-20(12-15-6-4-5-7-15)28(27-25-21)14-16-8-2-1-3-9-16/h1-3,8-11,13,15H,4-7,12,14H2,(H3,23,24,26)
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20n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185878
PNG
(US9163007, 263)
Show SMILES NC(=O)N(c1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1)c1ccccc1Cl
Show InChI InChI=1S/C26H22ClN7O/c27-20-8-4-5-9-22(20)34(26(28)35)25-19-14-18(12-13-21(19)29-31-25)23-24(17-10-11-17)33(32-30-23)15-16-6-2-1-3-7-16/h1-9,12-14,17H,10-11,15H2,(H2,28,35)(H,29,31)
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22n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185842
PNG
(US9163007, 123)
Show SMILES Cc1c(nnn1Cc1ccccc1)-c1ccc2[nH]nc(N)c2c1
Show InChI InChI=1S/C17H16N6/c1-11-16(13-7-8-15-14(9-13)17(18)21-19-15)20-22-23(11)10-12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H3,18,19,21)
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23n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185852
PNG
(US9163007, 171)
Show SMILES Cc1ccccc1-c1c(nnn1CC1CCOCC1)-c1ccc2[nH]nc(N)c2c1
Show InChI InChI=1S/C22H24N6O/c1-14-4-2-3-5-17(14)21-20(16-6-7-19-18(12-16)22(23)26-24-19)25-27-28(21)13-15-8-10-29-11-9-15/h2-7,12,15H,8-11,13H2,1H3,(H3,23,24,26)
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30n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185885
PNG
(US9163007, 322)
Show SMILES CCNC(=O)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C19H19N7O/c1-2-20-19(27)21-18-15-10-14(8-9-16(15)22-24-18)17-12-26(25-23-17)11-13-6-4-3-5-7-13/h3-10,12H,2,11H2,1H3,(H3,20,21,22,24,27)
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34n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185843
PNG
(US9163007, 125)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1I
Show InChI InChI=1S/C16H13IN6/c17-15-14(11-6-7-13-12(8-11)16(18)21-19-13)20-22-23(15)9-10-4-2-1-3-5-10/h1-8H,9H2,(H3,18,19,21)
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35n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185840
PNG
(US9163007, 89)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C19H18N6/c20-19-15-10-14(8-9-16(15)21-23-19)17-18(13-6-7-13)25(24-22-17)11-12-4-2-1-3-5-12/h1-5,8-10,13H,6-7,11H2,(H3,20,21,23)
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35n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185895
PNG
(US9163007, 402)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CCCCC1
Show InChI InChI=1S/C22H24N6/c23-22-18-13-17(11-12-19(18)24-26-22)20-21(16-9-5-2-6-10-16)28(27-25-20)14-15-7-3-1-4-8-15/h1,3-4,7-8,11-13,16H,2,5-6,9-10,14H2,(H3,23,24,26)
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37n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185909
PNG
(US9163007, 416)
Show SMILES Fc1ccc(CNc2n[nH]c3ccc(cc23)-c2cn(Cc3ccccc3)nn2)c(F)c1
Show InChI InChI=1S/C23H18F2N6/c24-18-8-6-17(20(25)11-18)12-26-23-19-10-16(7-9-21(19)27-29-23)22-14-31(30-28-22)13-15-4-2-1-3-5-15/h1-11,14H,12-13H2,(H2,26,27,29)
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37n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185907
PNG
(US9163007, 414)
Show SMILES Fc1cccc(CNc2n[nH]c3ccc(cc23)-c2cn(Cc3ccccc3)nn2)c1
Show InChI InChI=1S/C23H19FN6/c24-19-8-4-7-17(11-19)13-25-23-20-12-18(9-10-21(20)26-28-23)22-15-30(29-27-22)14-16-5-2-1-3-6-16/h1-12,15H,13-14H2,(H2,25,26,28)
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38n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185903
PNG
(US9163007, 410)
Show SMILES CCCCNc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C20H22N6/c1-2-3-11-21-20-17-12-16(9-10-18(17)22-24-20)19-14-26(25-23-19)13-15-7-5-4-6-8-15/h4-10,12,14H,2-3,11,13H2,1H3,(H2,21,22,24)
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40n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185877
PNG
(US9163007, 262)
Show SMILES NC(=O)N(Cc1ccccc1)c1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C27H25N7O/c28-27(35)33(16-18-7-3-1-4-8-18)26-22-15-21(13-14-23(22)29-31-26)24-25(20-11-12-20)34(32-30-24)17-19-9-5-2-6-10-19/h1-10,13-15,20H,11-12,16-17H2,(H2,28,35)(H,29,31)
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41n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185864
PNG
(US9163007, 207)
Show SMILES C(Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1)c1ccccc1
Show InChI InChI=1S/C26H24N6/c1-3-7-18(8-4-1)16-27-26-22-15-21(13-14-23(22)28-30-26)24-25(20-11-12-20)32(31-29-24)17-19-9-5-2-6-10-19/h1-10,13-15,20H,11-12,16-17H2,(H2,27,28,30)
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46n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185906
PNG
(US9163007, 413)
Show SMILES COc1ccc(CNc2n[nH]c3ccc(cc23)-c2cn(Cc3ccccc3)nn2)cc1
Show InChI InChI=1S/C24H22N6O/c1-31-20-10-7-17(8-11-20)14-25-24-21-13-19(9-12-22(21)26-28-24)23-16-30(29-27-23)15-18-5-3-2-4-6-18/h2-13,16H,14-15H2,1H3,(H2,25,26,28)
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52n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185829
PNG
(US9163007, 1)
Show SMILES C(c1ccccc1)n1nncc1-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H13N5/c1-2-4-12(5-3-1)11-21-16(10-18-20-21)13-6-7-15-14(8-13)9-17-19-15/h1-10H,11H2,(H,17,19)
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52.3n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185832
PNG
(US9163007, 60)
Show SMILES C(c1ccccc1)n1cc(nn1)-c1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C25H20N8/c1-3-7-18(8-4-1)14-32-16-23(27-30-32)20-11-12-22-21(13-20)25(29-26-22)24-17-33(31-28-24)15-19-9-5-2-6-10-19/h1-13,16-17H,14-15H2,(H,26,29)
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55.6n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM50337330
PNG
(5-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-in...)
Show SMILES Fc1ccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C16H12FN5/c17-14-4-1-11(2-5-14)9-22-10-16(20-21-22)12-3-6-15-13(7-12)8-18-19-15/h1-8,10H,9H2,(H,18,19)
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56.3n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185837
PNG
(US9163007, 66)
Show SMILES CCCC(=O)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C20H20N6O/c1-2-6-19(27)21-20-16-11-15(9-10-17(16)22-24-20)18-13-26(25-23-18)12-14-7-4-3-5-8-14/h3-5,7-11,13H,2,6,12H2,1H3,(H2,21,22,24,27)
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58n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185908
PNG
(US9163007, 415)
Show SMILES N#Cc1ccc(CNc2n[nH]c3ccc(cc23)-c2cn(Cc3ccccc3)nn2)cc1
Show InChI InChI=1S/C24H19N7/c25-13-17-6-8-18(9-7-17)14-26-24-21-12-20(10-11-22(21)27-29-24)23-16-31(30-28-23)15-19-4-2-1-3-5-19/h1-12,16H,14-15H2,(H2,26,27,29)
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65n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185882
PNG
(US9163007, 319)
Show SMILES CCCN(C(N)=O)c1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C20H21N7O/c1-2-10-27(20(21)28)19-16-11-15(8-9-17(16)22-24-19)18-13-26(25-23-18)12-14-6-4-3-5-7-14/h3-9,11,13H,2,10,12H2,1H3,(H2,21,28)(H,22,24)
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68n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185856
PNG
(US9163007, 194)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C26H25N7O/c27-26-22-16-19(9-10-23(22)28-30-26)24-25(33(31-29-24)17-18-5-2-1-3-6-18)20-7-4-8-21(15-20)32-11-13-34-14-12-32/h1-10,15-16H,11-14,17H2,(H3,27,28,30)
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68n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185890
PNG
(US9163007, 397)
Show SMILES COC(=O)c1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C18H15N5O2/c1-25-18(24)17-14-9-13(7-8-15(14)19-21-17)16-11-23(22-20-16)10-12-5-3-2-4-6-12/h2-9,11H,10H2,1H3,(H,19,21)
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81.1n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185869
PNG
(US9163007, 222)
Show SMILES Clc1ccccc1CNc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C26H23ClN6/c27-22-9-5-4-8-20(22)15-28-26-21-14-19(12-13-23(21)29-31-26)24-25(18-10-11-18)33(32-30-24)16-17-6-2-1-3-7-17/h1-9,12-14,18H,10-11,15-16H2,(H2,28,29,31)
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93n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185862
PNG
(US9163007, 204)
Show SMILES O=C(Nc1nn(C(=O)c2ccccc2)c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1)c1ccccc1
Show InChI InChI=1S/C33H26N6O2/c40-32(24-12-6-2-7-13-24)34-31-27-20-26(18-19-28(27)39(36-31)33(41)25-14-8-3-9-15-25)29-30(23-16-17-23)38(37-35-29)21-22-10-4-1-5-11-22/h1-15,18-20,23H,16-17,21H2,(H,34,36,40)
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110n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185904
PNG
(US9163007, 411)
Show SMILES C(Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1)c1ccccc1
Show InChI InChI=1S/C23H20N6/c1-3-7-17(8-4-1)14-24-23-20-13-19(11-12-21(20)25-27-23)22-16-29(28-26-22)15-18-9-5-2-6-10-18/h1-13,16H,14-15H2,(H2,24,25,27)
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120n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185865
PNG
(US9163007, 216)
Show SMILES CCS(=O)(=O)Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C21H22N6O2S/c1-2-30(28,29)25-21-17-12-16(10-11-18(17)22-24-21)19-20(15-8-9-15)27(26-23-19)13-14-6-4-3-5-7-14/h3-7,10-12,15H,2,8-9,13H2,1H3,(H2,22,24,25)
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120n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185838
PNG
(US9163007, 80)
Show SMILES C(C1CCOCC1)n1cc(nn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C15H17N5O/c1-2-14-13(8-16-17-14)7-12(1)15-10-20(19-18-15)9-11-3-5-21-6-4-11/h1-2,7-8,10-11H,3-6,9H2,(H,16,17)
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127n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185905
PNG
(US9163007, 412)
Show SMILES Clc1ccc(CNc2n[nH]c3ccc(cc23)-c2cn(Cc3ccccc3)nn2)cc1
Show InChI InChI=1S/C23H19ClN6/c24-19-9-6-16(7-10-19)13-25-23-20-12-18(8-11-21(20)26-28-23)22-15-30(29-27-22)14-17-4-2-1-3-5-17/h1-12,15H,13-14H2,(H2,25,26,28)
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140n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185879
PNG
(US9163007, 314)
Show SMILES O=C(CN1CCNC(=O)C1)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C22H22N8O2/c31-20-13-29(9-8-23-20)14-21(32)24-22-17-10-16(6-7-18(17)25-27-22)19-12-30(28-26-19)11-15-4-2-1-3-5-15/h1-7,10,12H,8-9,11,13-14H2,(H,23,31)(H2,24,25,27,32)
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180n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185886
PNG
(US9163007, 323)
Show SMILES O=C1CCCN1c1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C20H18N6O/c27-19-7-4-10-26(19)20-16-11-15(8-9-17(16)21-23-20)18-13-25(24-22-18)12-14-5-2-1-3-6-14/h1-3,5-6,8-9,11,13H,4,7,10,12H2,(H,21,23)
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180n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185911
PNG
(US9163007, 418)
Show SMILES c1n[nH]c2ccc(cc12)-c1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C15H11N5/c1-2-4-13(5-3-1)20-10-15(18-19-20)11-6-7-14-12(8-11)9-16-17-14/h1-10H,(H,16,17)
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192n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185900
PNG
(US9163007, 407)
Show SMILES C(CN1CCOCC1)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C22H25N7O/c1-2-4-17(5-3-1)15-29-16-21(25-27-29)18-6-7-20-19(14-18)22(26-24-20)23-8-9-28-10-12-30-13-11-28/h1-7,14,16H,8-13,15H2,(H2,23,24,26)
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220n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185844
PNG
(US9163007, 146)
Show SMILES Clc1cccc(c1)C(=O)c1c(nnn1CC1CCOCC1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C22H20ClN5O2/c23-18-3-1-2-16(11-18)22(29)21-20(15-4-5-19-17(10-15)12-24-25-19)26-27-28(21)13-14-6-8-30-9-7-14/h1-5,10-12,14H,6-9,13H2,(H,24,25)
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229n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185893
PNG
(US9163007, 400)
Show SMILES CN1CCN(CC1)c1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C21H23N7/c1-26-9-11-27(12-10-26)21-18-13-17(7-8-19(18)22-24-21)20-15-28(25-23-20)14-16-5-3-2-4-6-16/h2-8,13,15H,9-12,14H2,1H3,(H,22,24)
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230n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185836
PNG
(US9163007, 65)
Show SMILES CN(C)CC(=O)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C20H21N7O/c1-26(2)13-19(28)21-20-16-10-15(8-9-17(16)22-24-20)18-12-27(25-23-18)11-14-6-4-3-5-7-14/h3-10,12H,11,13H2,1-2H3,(H2,21,22,24,28)
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242n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185897
PNG
(US9163007, 404)
Show SMILES C(c1ccccc1)n1cc(nn1)-c1ccc2[nH]nc(-c3nccs3)c2c1
Show InChI InChI=1S/C19H14N6S/c1-2-4-13(5-3-1)11-25-12-17(22-24-25)14-6-7-16-15(10-14)18(23-21-16)19-20-8-9-26-19/h1-10,12H,11H2,(H,21,23)
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258n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185859
PNG
(US9163007, 199)
Show SMILES O=S(=O)(Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H22N6O2S/c35-37(36,23-14-8-3-9-15-23)32-28-24-18-22(16-17-25(24)29-31-28)26-27(21-12-6-2-7-13-21)34(33-30-26)19-20-10-4-1-5-11-20/h1-18H,19H2,(H2,29,31,32)
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340n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185910
PNG
(US9163007, 417)
Show SMILES C(Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1)C1CCCCC1
Show InChI InChI=1S/C23H26N6/c1-3-7-17(8-4-1)14-24-23-20-13-19(11-12-21(20)25-27-23)22-16-29(28-26-22)15-18-9-5-2-6-10-18/h2,5-6,9-13,16-17H,1,3-4,7-8,14-15H2,(H2,24,25,27)
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350n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185883
PNG
(US9163007, 320)
Show SMILES CCS(=O)(=O)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C18H18N6O2S/c1-2-27(25,26)22-18-15-10-14(8-9-16(15)19-21-18)17-12-24(23-20-17)11-13-6-4-3-5-7-13/h3-10,12H,2,11H2,1H3,(H2,19,21,22)
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410n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185845
PNG
(US9163007, 150)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccc(cc2)C(F)(F)F)c1-c1ccc(F)cc1
Show InChI InChI=1S/C23H16F4N6/c24-17-8-3-14(4-9-17)21-20(15-5-10-19-18(11-15)22(28)31-29-19)30-32-33(21)12-13-1-6-16(7-2-13)23(25,26)27/h1-11H,12H2,(H3,28,29,31)
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430n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185872
PNG
(US9163007, 241)
Show SMILES CC(C)N(C)C(=O)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H22N6O/c1-14(2)26(3)21(28)20-19(16-9-10-18-17(11-16)12-22-23-18)24-25-27(20)13-15-7-5-4-6-8-15/h4-12,14H,13H2,1-3H3,(H,22,23)
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473n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185891
PNG
(US9163007, 398)
Show SMILES Cn1ccnc1-c1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C20H17N7/c1-26-10-9-21-20(26)19-16-11-15(7-8-17(16)22-24-19)18-13-27(25-23-18)12-14-5-3-2-4-6-14/h2-11,13H,12H2,1H3,(H,22,24)
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489n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185880
PNG
(US9163007, 316)
Show SMILES O=C(CNC1CCCCC1)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C24H27N7O/c32-23(14-25-19-9-5-2-6-10-19)26-24-20-13-18(11-12-21(20)27-29-24)22-16-31(30-28-22)15-17-7-3-1-4-8-17/h1,3-4,7-8,11-13,16,19,25H,2,5-6,9-10,14-15H2,(H2,26,27,29,32)
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500n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185884
PNG
(US9163007, 321)
Show SMILES C(Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1)C1CC1
Show InChI InChI=1S/C20H20N6/c1-2-4-15(5-3-1)12-26-13-19(23-25-26)16-8-9-18-17(10-16)20(24-22-18)21-11-14-6-7-14/h1-5,8-10,13-14H,6-7,11-12H2,(H2,21,22,24)
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570n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185892
PNG
(US9163007, 399)
Show SMILES C(c1ccccc1)n1cc(nn1)-c1ccc2[nH]nc(N3CCOCC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-2-4-15(5-3-1)13-26-14-19(22-24-26)16-6-7-18-17(12-16)20(23-21-18)25-8-10-27-11-9-25/h1-7,12,14H,8-11,13H2,(H,21,23)
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630n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185847
PNG
(US9163007, 157)
Show SMILES CN(C)C(=O)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C19H18N6O/c1-24(2)19(26)18-17(14-8-9-16-15(10-14)11-20-21-16)22-23-25(18)12-13-6-4-3-5-7-13/h3-11H,12H2,1-2H3,(H,20,21)
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640n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185889
PNG
(US9163007, 396)
Show SMILES CN(C)C(=O)c1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C19H18N6O/c1-24(2)19(26)18-15-10-14(8-9-16(15)20-22-18)17-12-25(23-21-17)11-13-6-4-3-5-7-13/h3-10,12H,11H2,1-2H3,(H,20,22)
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681n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185868
PNG
(US9163007, 220)
Show SMILES Clc1ccc(cc1)S(=O)(=O)Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C25H21ClN6O2S/c26-19-9-11-20(12-10-19)35(33,34)30-25-21-14-18(8-13-22(21)27-29-25)23-24(17-6-7-17)32(31-28-23)15-16-4-2-1-3-5-16/h1-5,8-14,17H,6-7,15H2,(H2,27,29,30)
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AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185866
PNG
(US9163007, 217)
Show SMILES O=S(=O)(Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1)c1ccccc1
Show InChI InChI=1S/C25H22N6O2S/c32-34(33,20-9-5-2-6-10-20)29-25-21-15-19(13-14-22(21)26-28-25)23-24(18-11-12-18)31(30-27-23)16-17-7-3-1-4-8-17/h1-10,13-15,18H,11-12,16H2,(H2,26,28,29)
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AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185834
PNG
(US9163007, 63)
Show SMILES CN1CCC(CC1)C(=O)n1nc(N)c2cc(ccc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C23H25N7O/c1-28-11-9-17(10-12-28)23(31)30-21-8-7-18(13-19(21)22(24)26-30)20-15-29(27-25-20)14-16-5-3-2-4-6-16/h2-8,13,15,17H,9-12,14H2,1H3,(H2,24,26)
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>1.23E+3n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185857
PNG
(US9163007, 197)
Show SMILES NC1CCN(CC1)C(=O)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C22H23N7O/c23-18-8-10-28(11-9-18)22(30)21-20(16-6-7-19-17(12-16)13-24-25-19)26-27-29(21)14-15-4-2-1-3-5-15/h1-7,12-13,18H,8-11,14,23H2,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185853
PNG
(US9163007, 172)
Show SMILES O=C(N1CCOCC1)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H20N6O2/c28-21(26-8-10-29-11-9-26)20-19(16-6-7-18-17(12-16)13-22-23-18)24-25-27(20)14-15-4-2-1-3-5-15/h1-7,12-13H,8-11,14H2,(H,22,23)
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AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185881
PNG
(US9163007, 318)
Show SMILES O=C(CNC1CCC1)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C22H23N7O/c30-21(12-23-17-7-4-8-17)24-22-18-11-16(9-10-19(18)25-27-22)20-14-29(28-26-20)13-15-5-2-1-3-6-15/h1-3,5-6,9-11,14,17,23H,4,7-8,12-13H2,(H2,24,25,27,30)
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AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185867
PNG
(US9163007, 218)
Show SMILES Clc1ccccc1S(=O)(=O)Nc1n[nH]c2ccc(cc12)-c1nnn(Cc2ccccc2)c1C1CC1
Show InChI InChI=1S/C25H21ClN6O2S/c26-20-8-4-5-9-22(20)35(33,34)30-25-19-14-18(12-13-21(19)27-29-25)23-24(17-10-11-17)32(31-28-23)15-16-6-2-1-3-7-16/h1-9,12-14,17H,10-11,15H2,(H2,27,29,30)
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AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM60787
PNG
(US9163007, 311)
Show SMILES CN(C)CCC(=O)Nc1ccc2[nH]cc(-c3cn(Cc4ccccc4)nn3)c2c1
Show InChI InChI=1S/C22H24N6O/c1-27(2)11-10-22(29)24-17-8-9-20-18(12-17)19(13-23-20)21-15-28(26-25-21)14-16-6-4-3-5-7-16/h3-9,12-13,15,23H,10-11,14H2,1-2H3,(H,24,29)
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AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185851
PNG
(US9163007, 169)
Show SMILES O=C(N1CCCCC1)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C22H22N6O/c29-22(27-11-5-2-6-12-27)21-20(17-9-10-19-18(13-17)14-23-24-19)25-26-28(21)15-16-7-3-1-4-8-16/h1,3-4,7-10,13-14H,2,5-6,11-12,15H2,(H,23,24)
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AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185876
PNG
(US9163007, 255)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C23H23N7O2/c1-16(31)28-9-11-29(12-10-28)23(32)22-21(18-7-8-20-19(13-18)14-24-25-20)26-27-30(22)15-17-5-3-2-4-6-17/h2-8,13-14H,9-12,15H2,1H3,(H,24,25)
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AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185875
PNG
(US9163007, 254)
Show SMILES O=C(NCCN1CCOCC1)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C23H25N7O2/c31-23(24-8-9-29-10-12-32-13-11-29)22-21(18-6-7-20-19(14-18)15-25-26-20)27-28-30(22)16-17-4-2-1-3-5-17/h1-7,14-15H,8-13,16H2,(H,24,31)(H,25,26)
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AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185874
PNG
(US9163007, 243)
Show SMILES O=C(Nc1ccccc1)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C23H18N6O/c30-23(25-19-9-5-2-6-10-19)22-21(17-11-12-20-18(13-17)14-24-26-20)27-28-29(22)15-16-7-3-1-4-8-16/h1-14H,15H2,(H,24,26)(H,25,30)
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AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185887
PNG
(US9163007, 324)
Show SMILES CN(C)CCCC(=O)Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1
Show InChI InChI=1S/C22H25N7O/c1-28(2)12-6-9-21(30)23-22-18-13-17(10-11-19(18)24-26-22)20-15-29(27-25-20)14-16-7-4-3-5-8-16/h3-5,7-8,10-11,13,15H,6,9,12,14H2,1-2H3,(H2,23,24,26,30)
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AbbVie Inc.

US Patent


Assay Description
11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185873
PNG
(US9163007, 242)
Show SMILES COCCN(C)C(=O)c1c(nnn1Cc1ccccc1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H22N6O2/c1-26(10-11-29-2)21(28)20-19(16-8-9-18-17(12-16)13-22-23-18)24-25-27(20)14-15-6-4-3-5-7-15/h3-9,12-13H,10-11,14H2,1-2H3,(H,22,23)
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AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)


(Homo sapiens (Human))
BDBM185831
PNG
(US9163007, 35)
Show SMILES FC(F)(F)c1ccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C18H11F6N5/c19-17(20,21)13-3-1-11(14(6-13)18(22,23)24)8-29-9-16(27-28-29)10-2-4-15-12(5-10)7-25-26-15/h1-7,9H,8H2,(H,25,26)
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AbbVie Inc.

US Patent


Assay Description
6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...


US Patent US9163007 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DTG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%