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USPatent US9238625

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202585
PNG
(US10035761, Compound 8j | US9238625, 8j)
Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1
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0.800n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202585
PNG
(US10035761, Compound 8j | US9238625, 8j)
Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1
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1.16n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202584
PNG
(US10035761, Compound 8h | US9238625, 8h)
Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1
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1.19n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202582
PNG
(US10035761, Compound 8a | US9238625, 8a)
Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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1.40n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202582
PNG
(US10035761, Compound 8a | US9238625, 8a)
Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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2.38n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202584
PNG
(US10035761, Compound 8h | US9238625, 8h)
Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1
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2.39n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202581
PNG
(US10035761, Compound 7g | US9238625, 7g)
Show SMILES CCOCCCCNC(CC(C)C)C1(CCC1)c1ccc(SC)cc1
Show InChI InChI=1S/C22H37NOS/c1-5-24-16-7-6-15-23-21(17-18(2)3)22(13-8-14-22)19-9-11-20(25-4)12-10-19/h9-12,18,21,23H,5-8,13-17H2,1-4H3
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2.99n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202587
PNG
(US10035761, Compound 12c | US9238625, 12c)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCSCC
Show InChI InChI=1S/C21H35NOS/c1-5-23-19-10-8-18(9-11-19)21(12-7-13-21)20(16-17(3)4)22-14-15-24-6-2/h8-11,17,20,22H,5-7,12-16H2,1-4H3
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3.31n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202583
PNG
(US10035761, Compound 8d | US9238625, 8d)
Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1
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3.80n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202583
PNG
(US10035761, Compound 8d | US9238625, 8d)
Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1
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5.45n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202585
PNG
(US10035761, Compound 8j | US9238625, 8j)
Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1
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11.0n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202584
PNG
(US10035761, Compound 8h | US9238625, 8h)
Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1
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12.7n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202588
PNG
(US10035761, Compound 13c | US9238625, 13c)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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14.8n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202588
PNG
(US10035761, Compound 13c | US9238625, 13c)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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17.1n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202586
PNG
(US10035761, Compound 12b | US9238625, 12b)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H34ClNS/c1-4-24-15-6-5-14-23-20(16-17(2)3)21(12-7-13-21)18-8-10-19(22)11-9-18/h8-11,17,20,23H,4-7,12-16H2,1-3H3
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18.8n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202588
PNG
(US10035761, Compound 13c | US9238625, 13c)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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23.9n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202591
PNG
(US10035761, Compound 17a | US9238625, 17a)
Show SMILES CCS(=O)(=O)CCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO2S/c1-4-27(25,26)13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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29.4n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202581
PNG
(US10035761, Compound 7g | US9238625, 7g)
Show SMILES CCOCCCCNC(CC(C)C)C1(CCC1)c1ccc(SC)cc1
Show InChI InChI=1S/C22H37NOS/c1-5-24-16-7-6-15-23-21(17-18(2)3)22(13-8-14-22)19-9-11-20(25-4)12-10-19/h9-12,18,21,23H,5-8,13-17H2,1-4H3
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37.2n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202591
PNG
(US10035761, Compound 17a | US9238625, 17a)
Show SMILES CCS(=O)(=O)CCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO2S/c1-4-27(25,26)13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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38.4n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202591
PNG
(US10035761, Compound 17a | US9238625, 17a)
Show SMILES CCS(=O)(=O)CCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO2S/c1-4-27(25,26)13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3
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44.7n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202582
PNG
(US10035761, Compound 8a | US9238625, 8a)
Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3
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46.7n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202590
PNG
(US9238625, 13f)
Show SMILES CCSCCNC(CC)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2NS/c1-3-16(20-10-11-21-4-2)17(8-5-9-17)13-6-7-14(18)15(19)12-13/h6-7,12,16,20H,3-5,8-11H2,1-2H3
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49.2n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202589
PNG
(US10035761, Compound 13d | US9238625, 13d)
Show SMILES CCCCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H37Cl2NS/c1-4-5-14-27-15-7-6-13-26-22(16-18(2)3)23(11-8-12-23)19-9-10-20(24)21(25)17-19/h9-10,17-18,22,26H,4-8,11-16H2,1-3H3
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51.0n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202586
PNG
(US10035761, Compound 12b | US9238625, 12b)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H34ClNS/c1-4-24-15-6-5-14-23-20(16-17(2)3)21(12-7-13-21)18-8-10-19(22)11-9-18/h8-11,17,20,23H,4-7,12-16H2,1-3H3
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51.9n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202589
PNG
(US10035761, Compound 13d | US9238625, 13d)
Show SMILES CCCCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H37Cl2NS/c1-4-5-14-27-15-7-6-13-26-22(16-18(2)3)23(11-8-12-23)19-9-10-20(24)21(25)17-19/h9-10,17-18,22,26H,4-8,11-16H2,1-3H3
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65.3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202586
PNG
(US10035761, Compound 12b | US9238625, 12b)
Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H34ClNS/c1-4-24-15-6-5-14-23-20(16-17(2)3)21(12-7-13-21)18-8-10-19(22)11-9-18/h8-11,17,20,23H,4-7,12-16H2,1-3H3
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67.6n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202583
PNG
(US10035761, Compound 8d | US9238625, 8d)
Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1
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72.0n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202581
PNG
(US10035761, Compound 7g | US9238625, 7g)
Show SMILES CCOCCCCNC(CC(C)C)C1(CCC1)c1ccc(SC)cc1
Show InChI InChI=1S/C22H37NOS/c1-5-24-16-7-6-15-23-21(17-18(2)3)22(13-8-14-22)19-9-11-20(25-4)12-10-19/h9-12,18,21,23H,5-8,13-17H2,1-4H3
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92.0n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202589
PNG
(US10035761, Compound 13d | US9238625, 13d)
Show SMILES CCCCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H37Cl2NS/c1-4-5-14-27-15-7-6-13-26-22(16-18(2)3)23(11-8-12-23)19-9-10-20(24)21(25)17-19/h9-10,17-18,22,26H,4-8,11-16H2,1-3H3
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104n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM202587
PNG
(US10035761, Compound 12c | US9238625, 12c)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCSCC
Show InChI InChI=1S/C21H35NOS/c1-5-23-19-10-8-18(9-11-19)21(12-7-13-21)20(16-17(3)4)22-14-15-24-6-2/h8-11,17,20,22H,5-7,12-16H2,1-4H3
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116n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202590
PNG
(US9238625, 13f)
Show SMILES CCSCCNC(CC)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2NS/c1-3-16(20-10-11-21-4-2)17(8-5-9-17)13-6-7-14(18)15(19)12-13/h6-7,12,16,20H,3-5,8-11H2,1-2H3
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119n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (human))
BDBM202590
PNG
(US9238625, 13f)
Show SMILES CCSCCNC(CC)C1(CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H25Cl2NS/c1-3-16(20-10-11-21-4-2)17(8-5-9-17)13-6-7-14(18)15(19)12-13/h6-7,12,16,20H,3-5,8-11H2,1-2H3
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224n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (human))
BDBM202587
PNG
(US10035761, Compound 12c | US9238625, 12c)
Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCSCC
Show InChI InChI=1S/C21H35NOS/c1-5-23-19-10-8-18(9-11-19)21(12-7-13-21)20(16-17(3)4)22-14-15-24-6-2/h8-11,17,20,22H,5-7,12-16H2,1-4H3
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1.42E+3n/an/an/an/an/an/an/an/a



REVIVA PHARMACEUTICALS, INC.

US Patent


Assay Description
The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...


US Patent US9238625 (2016)


BindingDB Entry DOI: 10.7270/Q2CV4GKK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%