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USPatent US9249096

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205048
PNG
(US9249096, 65)
Show SMILES CC(C)OCCN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C19H24Cl2N2O4/c1-12(2)27-9-8-23-11-14(17(24)19(23)26)18(25)22-7-3-4-13-5-6-15(20)16(21)10-13/h5-6,10,12,24H,3-4,7-9,11H2,1-2H3,(H,22,25)
KEGG

UniProtKB/SwissProt

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n/an/a 1.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205032
PNG
(US9249096, 45)
Show SMILES CC(C)CCN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C19H24Cl2N2O3/c1-12(2)7-9-23-11-14(17(24)19(23)26)18(25)22-8-3-4-13-5-6-15(20)16(21)10-13/h5-6,10,12,24H,3-4,7-9,11H2,1-2H3,(H,22,25)
KEGG

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n/an/a 2.71n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205029
PNG
(US9249096, 42)
Show SMILES CC(C)CN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C18H22Cl2N2O3/c1-11(2)9-22-10-13(16(23)18(22)25)17(24)21-7-3-4-12-5-6-14(19)15(20)8-12/h5-6,8,11,23H,3-4,7,9-10H2,1-2H3,(H,21,24)
KEGG

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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205031
PNG
(US9249096, 44)
Show SMILES OC1=C(CN(CCc2ccccc2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H22Cl2N2O3/c23-18-9-8-16(13-19(18)24)7-4-11-25-21(28)17-14-26(22(29)20(17)27)12-10-15-5-2-1-3-6-15/h1-3,5-6,8-9,13,27H,4,7,10-12,14H2,(H,25,28)
KEGG

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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205033
PNG
(US9249096, 46)
Show SMILES CCCCN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C18H22Cl2N2O3/c1-2-3-9-22-11-13(16(23)18(22)25)17(24)21-8-4-5-12-6-7-14(19)15(20)10-12/h6-7,10,23H,2-5,8-9,11H2,1H3,(H,21,24)
KEGG

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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205034
PNG
(US9249096, 47)
Show SMILES OC1=C(CN(Cc2cccc(Cl)c2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H19Cl3N2O3/c22-15-5-1-3-14(9-15)11-26-12-16(19(27)21(26)29)20(28)25-8-2-4-13-6-7-17(23)18(24)10-13/h1,3,5-7,9-10,27H,2,4,8,11-12H2,(H,25,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205027
PNG
(US9249096, 40)
Show SMILES OC1=C(CN(Cc2ccccc2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H20Cl2N2O3/c22-17-9-8-14(11-18(17)23)7-4-10-24-20(27)16-13-25(21(28)19(16)26)12-15-5-2-1-3-6-15/h1-3,5-6,8-9,11,26H,4,7,10,12-13H2,(H,24,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205026
PNG
(US9249096, 39)
Show SMILES OC1=C(CN(C2CCC2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H20Cl2N2O3/c19-14-7-6-11(9-15(14)20)3-2-8-21-17(24)13-10-22(12-4-1-5-12)18(25)16(13)23/h6-7,9,12,23H,1-5,8,10H2,(H,21,24)
KEGG

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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205039
PNG
(US9249096, 53)
Show SMILES OC1=C(CN(CCc2ccccc2Cl)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H21Cl3N2O3/c23-17-6-2-1-5-15(17)9-11-27-13-16(20(28)22(27)30)21(29)26-10-3-4-14-7-8-18(24)19(25)12-14/h1-2,5-8,12,28H,3-4,9-11,13H2,(H,26,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205037
PNG
(US9249096, 51)
Show SMILES OC1=C(CN(Cc2ccc(F)cc2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H19Cl2FN2O3/c22-17-8-5-13(10-18(17)23)2-1-9-25-20(28)16-12-26(21(29)19(16)27)11-14-3-6-15(24)7-4-14/h3-8,10,27H,1-2,9,11-12H2,(H,25,28)
KEGG

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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205047
PNG
(US9249096, 64)
Show SMILES OC1=C(CN(CCc2ccc(F)cc2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H21Cl2FN2O3/c23-18-8-5-15(12-19(18)24)2-1-10-26-21(29)17-13-27(22(30)20(17)28)11-9-14-3-6-16(25)7-4-14/h3-8,12,28H,1-2,9-11,13H2,(H,26,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205046
PNG
(US9249096, 60)
Show SMILES OC1=C(CN(Cc2cc(Cl)cc(Cl)c2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H18Cl4N2O3/c22-14-6-13(7-15(23)9-14)10-27-11-16(19(28)21(27)30)20(29)26-5-1-2-12-3-4-17(24)18(25)8-12/h3-4,6-9,28H,1-2,5,10-11H2,(H,26,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205041
PNG
(US9249096, 55)
Show SMILES CC(C)(C)CCN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C20H26Cl2N2O3/c1-20(2,3)8-10-24-12-14(17(25)19(24)27)18(26)23-9-4-5-13-6-7-15(21)16(22)11-13/h6-7,11,25H,4-5,8-10,12H2,1-3H3,(H,23,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205036
PNG
(US9249096, 50)
Show SMILES OC1=C(CN(Cc2cccc(F)c2)C1=O)C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H19Cl2FN2O3/c22-17-7-6-13(10-18(17)23)4-2-8-25-20(28)16-12-26(21(29)19(16)27)11-14-3-1-5-15(24)9-14/h1,3,5-7,9-10,27H,2,4,8,11-12H2,(H,25,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205043
PNG
(US9249096, 57)
Show SMILES CCOCCN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C18H22Cl2N2O4/c1-2-26-9-8-22-11-13(16(23)18(22)25)17(24)21-7-3-4-12-5-6-14(19)15(20)10-12/h5-6,10,23H,2-4,7-9,11H2,1H3,(H,21,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205135
PNG
(US9249096, 208)
Show SMILES CN1CC(C(=O)NCCCc2c(Cl)cccc2Cl)=C(O)C1=O
Show InChI InChI=1S/C15H16Cl2N2O3/c1-19-8-10(13(20)15(19)22)14(21)18-7-3-4-9-11(16)5-2-6-12(9)17/h2,5-6,20H,3-4,7-8H2,1H3,(H,18,21)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205006
PNG
(US9249096, 17)
Show SMILES CN1C(C(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O)C(C)(C)C
Show InChI InChI=1S/C19H24Cl2N2O3/c1-19(2,3)16-14(15(24)18(26)23(16)4)17(25)22-9-5-6-11-7-8-12(20)13(21)10-11/h7-8,10,16,24H,5-6,9H2,1-4H3,(H,22,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205167
PNG
(US9249096, 294)
Show SMILES CN1CC(C(=O)NCCCc2ccccc2C(F)(F)F)=C(O)C1=O
Show InChI InChI=1S/C16H17F3N2O3/c1-21-9-11(13(22)15(21)24)14(23)20-8-4-6-10-5-2-3-7-12(10)16(17,18)19/h2-3,5,7,22H,4,6,8-9H2,1H3,(H,20,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205168
PNG
(US9249096, 193)
Show SMILES CC1N(CCc2ccc(F)cc2)C(=O)C(O)=C1C(=O)NCCCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H23Cl2FN2O3/c1-14-20(22(30)27-11-2-3-16-6-9-18(24)19(25)13-16)21(29)23(31)28(14)12-10-15-4-7-17(26)8-5-15/h4-9,13-14,29H,2-3,10-12H2,1H3,(H,27,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205129
PNG
(US9249096, 192)
Show SMILES OC(=O)c1ccccc1CN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C22H20Cl2N2O5/c23-17-8-7-13(10-18(17)24)4-3-9-25-20(28)16-12-26(21(29)19(16)27)11-14-5-1-2-6-15(14)22(30)31/h1-2,5-8,10,27H,3-4,9,11-12H2,(H,25,28)(H,30,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205169
PNG
(US9249096, 195)
Show SMILES CN1C(CCc2ccccc2)C(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C23H24Cl2N2O3/c1-27-19(12-10-15-6-3-2-4-7-15)20(21(28)23(27)30)22(29)26-13-5-8-16-9-11-17(24)18(25)14-16/h2-4,6-7,9,11,14,19,28H,5,8,10,12-13H2,1H3,(H,26,29)
KEGG

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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM204993
PNG
(US9249096, 1)
Show SMILES CN1CC(C(=O)NCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C14H14Cl2N2O3/c1-18-7-9(12(19)14(18)21)13(20)17-5-4-8-2-3-10(15)11(16)6-8/h2-3,6,19H,4-5,7H2,1H3,(H,17,20)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM204997
PNG
(US9249096, 5)
Show SMILES CN1CC(C(=O)NCCc2ccc(Cl)cc2)=C(O)C1=O
Show InChI InChI=1S/C14H15ClN2O3/c1-17-8-11(12(18)14(17)20)13(19)16-7-6-9-2-4-10(15)5-3-9/h2-5,18H,6-8H2,1H3,(H,16,19)
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UniProtKB/SwissProt

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n/an/a 559n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205018
PNG
(US9249096, 30)
Show SMILES CN1C(Cc2ccc(C)cc2)C(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C23H24Cl2N2O3/c1-14-5-7-16(8-6-14)13-19-20(21(28)23(30)27(19)2)22(29)26-11-3-4-15-9-10-17(24)18(25)12-15/h5-10,12,19,28H,3-4,11,13H2,1-2H3,(H,26,29)
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n/an/a 584n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM204995
PNG
(US9249096, 3)
Show SMILES CN1CC(C(=O)NCCc2ccccc2)=C(O)C1=O
Show InChI InChI=1S/C14H16N2O3/c1-16-9-11(12(17)14(16)19)13(18)15-8-7-10-5-3-2-4-6-10/h2-6,17H,7-9H2,1H3,(H,15,18)
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UniChem
n/an/a 2.95E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205151
PNG
(US9249096, 235)
Show SMILES CN1CC(C(=O)NC(CCc2ccc(Cl)c(Cl)c2)c2ccccc2)=C(O)C1=O
Show InChI InChI=1S/C21H20Cl2N2O3/c1-25-12-15(19(26)21(25)28)20(27)24-18(14-5-3-2-4-6-14)10-8-13-7-9-16(22)17(23)11-13/h2-7,9,11,18,26H,8,10,12H2,1H3,(H,24,27)
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n/an/a 3.06E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205164
PNG
(US9249096, 265)
Show SMILES CCN1CC(C(=O)NCCCc2cccc(OC)n2)=C(O)C1=O
Show InChI InChI=1S/C16H21N3O4/c1-3-19-10-12(14(20)16(19)22)15(21)17-9-5-7-11-6-4-8-13(18-11)23-2/h4,6,8,20H,3,5,7,9-10H2,1-2H3,(H,17,21)
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n/an/a 3.46E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205147
PNG
(US9249096, 229)
Show SMILES CC(CCc1ccc(Cl)c(Cl)c1)NC(=O)C1=C(O)C(=O)N(C)C1
Show InChI InChI=1S/C16H18Cl2N2O3/c1-9(3-4-10-5-6-12(17)13(18)7-10)19-15(22)11-8-20(2)16(23)14(11)21/h5-7,9,21H,3-4,8H2,1-2H3,(H,19,22)
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n/an/a 4.55E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205116
PNG
(US9249096, 166)
Show SMILES CN1CC(C(=O)NCCCc2ccccc2)=C(O)C1=O
Show InChI InChI=1S/C15H18N2O3/c1-17-10-12(13(18)15(17)20)14(19)16-9-5-8-11-6-3-2-4-7-11/h2-4,6-7,18H,5,8-10H2,1H3,(H,16,19)
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n/an/a 6.45E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM205148
PNG
(US9249096, 230)
Show SMILES CC(C)C(CCc1ccc(Cl)c(Cl)c1)NC(=O)C1=C(O)C(=O)N(C)C1
Show InChI InChI=1S/C18H22Cl2N2O3/c1-10(2)15(7-5-11-4-6-13(19)14(20)8-11)21-17(24)12-9-22(3)18(25)16(12)23/h4,6,8,10,15,23H,5,7,9H2,1-3H3,(H,21,24)
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n/an/a 9.64E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 uL of assay buffer (50 mM HEPES pH 8.0, 50 mM N...


US Patent US9249096 (2016)


BindingDB Entry DOI: 10.7270/Q2RX99X0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%