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USPatent US9266870

Compile data set for download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208487
PNG
(US9266870, 3)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-8-9-27-31)18(13-16)23(32)30-10-2-12-33-22(30)15-29-11-7-20(28-29)19-5-4-17(24)14-25-19/h3-9,11,13-14,22H,2,10,12,15H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208524
PNG
(US9266870, 40 | US9266870, 49)
Show SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-7-8-28-32)20(9-16)24(33)31-12-17(2)15-34-23(31)14-30-13-18(10-29-30)21-5-4-19(25)11-26-21/h3-11,13,17,23H,12,14-15H2,1-2H3
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n/an/a 0.800n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208519
PNG
(US9266870, 35)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C24H23FN6O2/c1-17-3-8-22(31-26-9-10-27-31)21(13-17)24(32)30-11-2-12-33-23(30)16-29-15-19(14-28-29)18-4-6-20(25)7-5-18/h3-10,13-15,23H,2,11-12,16H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208511
PNG
(US9266870, 27)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-7-19(30-24-9-10-25-30)21(26-15)22(31)29-12-13-32-20(29)14-28-11-8-18(27-28)16-3-5-17(23)6-4-16/h2-11,20H,12-14H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208519
PNG
(US9266870, 35)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C24H23FN6O2/c1-17-3-8-22(31-26-9-10-27-31)21(13-17)24(32)30-11-2-12-33-23(30)16-29-15-19(14-28-29)18-4-6-20(25)7-5-18/h3-10,13-15,23H,2,11-12,16H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208525
PNG
(US9266870, 41)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1)-c1ncccn1
Show InChI InChI=1S/C26H24FN5O2/c1-18-4-9-21(25-28-11-2-12-29-25)22(16-18)26(33)32-13-3-15-34-24(32)17-31-14-10-23(30-31)19-5-7-20(27)8-6-19/h2,4-12,14,16,24H,3,13,15,17H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208525
PNG
(US9266870, 41)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1)-c1ncccn1
Show InChI InChI=1S/C26H24FN5O2/c1-18-4-9-21(25-28-11-2-12-29-25)22(16-18)26(33)32-13-3-15-34-24(32)17-31-14-10-23(30-31)19-5-7-20(27)8-6-19/h2,4-12,14,16,24H,3,13,15,17H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208521
PNG
(US9266870, 37)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H21FN6O3/c1-15-3-8-19(30-25-9-10-26-30)18(13-15)23(31)29-11-2-12-32-21(29)14-20-27-22(33-28-20)16-4-6-17(24)7-5-16/h3-10,13,21H,2,11-12,14H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208487
PNG
(US9266870, 3)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-8-9-27-31)18(13-16)23(32)30-10-2-12-33-22(30)15-29-11-7-20(28-29)19-5-4-17(24)14-25-19/h3-9,11,13-14,22H,2,10,12,15H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208513
PNG
(US9266870, 29)
Show SMILES Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H23FN6O2/c1-17-4-9-20(24-27-11-2-12-28-24)23(29-17)25(33)32-13-3-15-34-22(32)16-31-14-10-21(30-31)18-5-7-19(26)8-6-18/h2,4-12,14,22H,3,13,15-16H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208524
PNG
(US9266870, 40 | US9266870, 49)
Show SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-7-8-28-32)20(9-16)24(33)31-12-17(2)15-34-23(31)14-30-13-18(10-29-30)21-5-4-19(25)11-26-21/h3-11,13,17,23H,12,14-15H2,1-2H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208521
PNG
(US9266870, 37)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H21FN6O3/c1-15-3-8-19(30-25-9-10-26-30)18(13-15)23(31)29-11-2-12-32-21(29)14-20-27-22(33-28-20)16-4-6-17(24)7-5-16/h3-10,13,21H,2,11-12,14H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208522
PNG
(US9266870, 38)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O3/c1-14-3-8-17(30-24-9-10-25-30)20(26-14)22(31)29-11-2-12-32-19(29)13-18-27-21(33-28-18)15-4-6-16(23)7-5-15/h3-10,19H,2,11-13H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208518
PNG
(US9266870, 34)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCCN2C(=O)c2cc(F)ccc2-c2ncccn2)n1
Show InChI InChI=1S/C24H20F2N6O2/c25-16-3-5-18(23-27-8-1-9-28-23)19(13-16)24(33)32-10-2-12-34-22(32)15-31-11-7-21(30-31)20-6-4-17(26)14-29-20/h1,3-9,11,13-14,22H,2,10,12,15H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208501
PNG
(US9266870, 17 | US9266870, 22)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208501
PNG
(US9266870, 17 | US9266870, 22)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208512
PNG
(US9266870, 28)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-8-20(31-25-10-11-26-31)22(27-16)23(32)30-12-2-14-33-21(30)15-29-13-9-19(28-29)17-4-6-18(24)7-5-17/h3-11,13,21H,2,12,14-15H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208527
PNG
(US9266870, 43)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-c1ncccn1
Show InChI InChI=1S/C26H24FN5O2/c1-18-4-9-22(25-28-10-2-11-29-25)23(14-18)26(33)32-12-3-13-34-24(32)17-31-16-20(15-30-31)19-5-7-21(27)8-6-19/h2,4-11,14-16,24H,3,12-13,17H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208514
PNG
(US9266870, 30)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1
Show InChI InChI=1S/C22H19F2N7O2/c23-15-3-5-20(31-26-7-8-27-31)17(12-15)22(32)30-9-1-11-33-21(30)14-29-10-6-19(28-29)18-4-2-16(24)13-25-18/h2-8,10,12-13,21H,1,9,11,14H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208529
PNG
(US9266870, 45)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cc1ccn(n1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-4-19(30-25-7-8-26-30)18(12-15)22(31)28-10-11-32-21(28)13-17-6-9-29(27-17)20-5-3-16(23)14-24-20/h2-9,12,14,21H,10-11,13H2,1H3
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UniChem
n/an/a 2.70n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208514
PNG
(US9266870, 30)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1
Show InChI InChI=1S/C22H19F2N7O2/c23-15-3-5-20(31-26-7-8-27-31)17(12-15)22(32)30-9-1-11-33-21(30)14-29-10-6-19(28-29)18-4-2-16(24)13-25-18/h2-8,10,12-13,21H,1,9,11,14H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208511
PNG
(US9266870, 27)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-7-19(30-24-9-10-25-30)21(26-15)22(31)29-12-13-32-20(29)14-28-11-8-18(27-28)16-3-5-17(23)6-4-16/h2-11,20H,12-14H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208488
PNG
(US9266870, 4)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-7-8-27-31)19(11-16)23(32)30-9-2-10-33-22(30)15-29-14-17(12-28-29)20-5-4-18(24)13-25-20/h3-8,11-14,22H,2,9-10,15H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208513
PNG
(US9266870, 29)
Show SMILES Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H23FN6O2/c1-17-4-9-20(24-27-11-2-12-28-24)23(29-17)25(33)32-13-3-15-34-22(32)16-31-14-10-21(30-31)18-5-7-19(26)8-6-18/h2,4-12,14,22H,3,13,15-16H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208527
PNG
(US9266870, 43)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-c1ncccn1
Show InChI InChI=1S/C26H24FN5O2/c1-18-4-9-22(25-28-10-2-11-29-25)23(14-18)26(33)32-12-3-13-34-24(32)17-31-16-20(15-30-31)19-5-7-21(27)8-6-19/h2,4-11,14-16,24H,3,12-13,17H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208531
PNG
(US9266870, 47)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1cnn(c1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-5-20(31-26-7-8-27-31)19(11-16)23(32)29-9-2-10-33-22(29)12-17-13-28-30(15-17)21-6-4-18(24)14-25-21/h3-8,11,13-15,22H,2,9-10,12H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208531
PNG
(US9266870, 47)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1cnn(c1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-5-20(31-26-7-8-27-31)19(11-16)23(32)29-9-2-10-33-22(29)12-17-13-28-30(15-17)21-6-4-18(24)14-25-21/h3-8,11,13-15,22H,2,9-10,12H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208520
PNG
(US9266870, 36)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O3/c1-14-3-6-18(30-25-7-8-26-30)16(11-14)22(31)29-9-2-10-32-20(29)12-19-27-21(33-28-19)17-5-4-15(23)13-24-17/h3-8,11,13,20H,2,9-10,12H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208512
PNG
(US9266870, 28)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-8-20(31-25-10-11-26-31)22(27-16)23(32)30-12-2-14-33-21(30)15-29-13-9-19(28-29)17-4-6-18(24)7-5-17/h3-11,13,21H,2,12,14-15H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208485
PNG
(US9266870, 1)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-5-20(30-25-7-8-26-30)17(12-15)22(31)29-10-11-32-21(29)14-28-9-6-19(27-28)18-4-3-16(23)13-24-18/h2-9,12-13,21H,10-11,14H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208501
PNG
(US9266870, 17 | US9266870, 22)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208518
PNG
(US9266870, 34)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCCN2C(=O)c2cc(F)ccc2-c2ncccn2)n1
Show InChI InChI=1S/C24H20F2N6O2/c25-16-3-5-18(23-27-8-1-9-28-23)19(13-16)24(33)32-10-2-12-34-22(32)15-31-11-7-21(30-31)20-6-4-17(26)14-29-20/h1,3-9,11,13-14,22H,2,10,12,15H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208520
PNG
(US9266870, 36)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O3/c1-14-3-6-18(30-25-7-8-26-30)16(11-14)22(31)29-9-2-10-32-20(29)12-19-27-21(33-28-19)17-5-4-15(23)13-24-17/h3-8,11,13,20H,2,9-10,12H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208491
PNG
(US9266870, 7)
Show SMILES C[C@@H]1CO[C@@H](Cn2ccc(n2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-8-9-27-31)18(11-15)23(32)30-16(2)14-33-22(30)13-29-10-7-20(28-29)19-5-4-17(24)12-25-19/h3-12,16,22H,13-14H2,1-2H3/t16-,22+/m1/s1
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208522
PNG
(US9266870, 38)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O3/c1-14-3-8-17(30-24-9-10-25-30)20(26-14)22(31)29-11-2-12-32-19(29)13-18-27-21(33-28-18)15-4-6-16(23)7-5-15/h3-10,19H,2,11-13H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208515
PNG
(US9266870, 31)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cn1)-c1ncccn1
Show InChI InChI=1S/C25H23FN6O2/c1-17-4-6-19(24-27-9-2-10-28-24)20(14-17)25(33)32-11-3-13-34-23(32)16-31-12-8-22(30-31)21-7-5-18(26)15-29-21/h2,4-10,12,14-15,23H,3,11,13,16H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208524
PNG
(US9266870, 40 | US9266870, 49)
Show SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-7-8-28-32)20(9-16)24(33)31-12-17(2)15-34-23(31)14-30-13-18(10-29-30)21-5-4-19(25)11-26-21/h3-11,13,17,23H,12,14-15H2,1-2H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208524
PNG
(US9266870, 40 | US9266870, 49)
Show SMILES CC1COC(Cn2cc(cn2)-c2ccc(F)cn2)N(C1)C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-7-8-28-32)20(9-16)24(33)31-12-17(2)15-34-23(31)14-30-13-18(10-29-30)21-5-4-19(25)11-26-21/h3-11,13,17,23H,12,14-15H2,1-2H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208498
PNG
(US9266870, 14)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cn1)-c1ncccn1
Show InChI InChI=1S/C24H21FN6O2/c1-16-3-5-18(23-26-8-2-9-27-23)19(13-16)24(32)31-11-12-33-22(31)15-30-10-7-21(29-30)20-6-4-17(25)14-28-20/h2-10,13-14,22H,11-12,15H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208488
PNG
(US9266870, 4)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-6-21(31-26-7-8-27-31)19(11-16)23(32)30-9-2-10-33-22(30)15-29-14-17(12-28-29)20-5-4-18(24)13-25-20/h3-8,11-14,22H,2,9-10,15H2,1H3
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n/an/a 9.60n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208498
PNG
(US9266870, 14)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cn1)-c1ncccn1
Show InChI InChI=1S/C24H21FN6O2/c1-16-3-5-18(23-26-8-2-9-27-23)19(13-16)24(32)31-11-12-33-22(31)15-30-10-7-21(29-30)20-6-4-17(25)14-28-20/h2-10,13-14,22H,11-12,15H2,1H3
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n/an/a 9.70n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208490
PNG
(US9266870, 6)
Show SMILES C[C@@H]1CN([C@H](Cn2cc(cn2)-c2ccc(F)cn2)O1)C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-12-16(2)33-22(30)14-29-13-17(10-28-29)20-5-4-18(24)11-25-20/h3-11,13,16,22H,12,14H2,1-2H3/t16-,22+/m1/s1
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n/an/a 9.80n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208515
PNG
(US9266870, 31)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cn1ccc(n1)-c1ccc(F)cn1)-c1ncccn1
Show InChI InChI=1S/C25H23FN6O2/c1-17-4-6-19(24-27-9-2-10-28-24)20(14-17)25(33)32-11-3-13-34-23(32)16-31-12-8-22(30-31)21-7-5-18(26)15-29-21/h2,4-10,12,14-15,23H,3,11,13,16H2,1H3
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n/an/a 10.9n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208489
PNG
(US9266870, 5)
Show SMILES C[C@H]1CN([C@H](Cn2cc(cn2)-c2ccc(F)cn2)O1)C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-12-16(2)33-22(30)14-29-13-17(10-28-29)20-5-4-18(24)11-25-20/h3-11,13,16,22H,12,14H2,1-2H3/t16-,22-/m0/s1
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n/an/a 11.5n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208529
PNG
(US9266870, 45)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cc1ccn(n1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-4-19(30-25-7-8-26-30)18(12-15)22(31)28-10-11-32-21(28)13-17-6-9-29(27-17)20-5-3-16(23)14-24-20/h2-9,12,14,21H,10-11,13H2,1H3
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n/an/a 12.1n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208504
PNG
(US9266870, 20)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-c1ncccn1
Show InChI InChI=1S/C25H22FN5O2/c1-17-3-8-20(24-27-10-2-11-28-24)21(15-17)25(32)31-13-14-33-23(31)16-30-12-9-22(29-30)18-4-6-19(26)7-5-18/h2-12,15,23H,13-14,16H2,1H3
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n/an/a 12.3n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208486
PNG
(US9266870, 2)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1cc(cn1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-5-20(30-25-6-7-26-30)18(10-15)22(31)29-8-9-32-21(29)14-28-13-16(11-27-28)19-4-3-17(23)12-24-19/h2-7,10-13,21H,8-9,14H2,1H3
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n/an/a 14.3n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208499
PNG
(US9266870, 15)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-c2ncccn2)n1
Show InChI InChI=1S/C23H19FN6O2/c24-16-6-7-19(27-14-16)20-8-11-29(28-20)15-21-30(12-13-32-21)23(31)18-5-2-1-4-17(18)22-25-9-3-10-26-22/h1-11,14,21H,12-13,15H2
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n/an/a 16.9n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208526
PNG
(US9266870, 42)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1cnn(c1)-c1ccc(F)cn1)-c1ncccn1
Show InChI InChI=1S/C25H23FN6O2/c1-17-4-6-20(24-27-8-2-9-28-24)21(12-17)25(33)31-10-3-11-34-23(31)13-18-14-30-32(16-18)22-7-5-19(26)15-29-22/h2,4-9,12,14-16,23H,3,10-11,13H2,1H3
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n/an/a 17.2n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208495
PNG
(US9266870, 11)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-n2nccn2)n1
Show InChI InChI=1S/C21H18FN7O2/c22-15-5-6-17(23-13-15)18-7-10-27(26-18)14-20-28(11-12-31-20)21(30)16-3-1-2-4-19(16)29-24-8-9-25-29/h1-10,13,20H,11-12,14H2
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n/an/a 17.5n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208485
PNG
(US9266870, 1)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-5-20(30-25-7-8-26-30)17(12-15)22(31)29-10-11-32-21(29)14-28-9-6-19(27-28)18-4-3-16(23)13-24-18/h2-9,12-13,21H,10-11,14H2,1H3
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n/an/a 18.5n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208486
PNG
(US9266870, 2)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1cc(cn1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-5-20(30-25-6-7-26-30)18(10-15)22(31)29-8-9-32-21(29)14-28-13-16(11-27-28)19-4-3-17(23)12-24-19/h2-7,10-13,21H,8-9,14H2,1H3
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n/an/a 18.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208496
PNG
(US9266870, 12 | US9266870, 13)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1
Show InChI InChI=1S/C21H17F2N7O2/c22-14-2-4-19(30-25-6-7-26-30)16(11-14)21(31)29-9-10-32-20(29)13-28-8-5-18(27-28)17-3-1-15(23)12-24-17/h1-8,11-12,20H,9-10,13H2
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n/an/a 19.5n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208526
PNG
(US9266870, 42)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCOC1Cc1cnn(c1)-c1ccc(F)cn1)-c1ncccn1
Show InChI InChI=1S/C25H23FN6O2/c1-17-4-6-20(24-27-8-2-9-28-24)21(12-17)25(33)31-10-3-11-34-23(31)13-18-14-30-32(16-18)22-7-5-19(26)15-29-22/h2,4-9,12,14-16,23H,3,10-11,13H2,1H3
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n/an/a 20.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208510
PNG
(US9266870, 26)
Show SMILES Cc1ccc(-c2ncccn2)c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cn1
Show InChI InChI=1S/C24H21FN6O3/c1-15-4-6-17(22-26-8-2-9-27-22)18(12-15)24(32)31-10-3-11-33-21(31)13-20-29-23(34-30-20)19-7-5-16(25)14-28-19/h2,4-9,12,14,21H,3,10-11,13H2,1H3
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n/an/a 21.7n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208516
PNG
(US9266870, 32)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-8-20(31-25-9-10-26-31)22(28-16)23(32)30-11-2-12-33-21(30)15-29-14-18(13-27-29)17-4-6-19(24)7-5-17/h3-10,13-14,21H,2,11-12,15H2,1H3
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n/an/a 22.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208493
PNG
(US9266870, 9)
Show SMILES C[C@H]1CO[C@@H](Cn2ccc(n2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-8-9-27-31)18(11-15)23(32)30-16(2)14-33-22(30)13-29-10-7-20(28-29)19-5-4-17(24)12-25-19/h3-12,16,22H,13-14H2,1-2H3/t16-,22-/m0/s1
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n/an/a 23.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208502
PNG
(US9266870, 18)
Show SMILES Fc1ccc(cc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-n2nccn2)n1
Show InChI InChI=1S/C22H19FN6O2/c23-17-7-5-16(6-8-17)19-9-12-27(26-19)15-21-28(13-14-31-21)22(30)18-3-1-2-4-20(18)29-24-10-11-25-29/h1-12,21H,13-15H2
PDB

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n/an/a 26.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208508
PNG
(US9266870, 24)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1cc(cn1)-c1ccc(F)cc1)-c1ncccn1
Show InChI InChI=1S/C25H22FN5O2/c1-17-3-8-21(24-27-9-2-10-28-24)22(13-17)25(32)31-11-12-33-23(31)16-30-15-19(14-29-30)18-4-6-20(26)7-5-18/h2-10,13-15,23H,11-12,16H2,1H3
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n/an/a 26.7n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208490
PNG
(US9266870, 6)
Show SMILES C[C@@H]1CN([C@H](Cn2cc(cn2)-c2ccc(F)cn2)O1)C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-12-16(2)33-22(30)14-29-13-17(10-28-29)20-5-4-18(24)11-25-20/h3-11,13,16,22H,12,14H2,1-2H3/t16-,22+/m1/s1
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n/an/a 27.5n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208500
PNG
(US9266870, 16)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-c2ncccn2)n1
Show InChI InChI=1S/C23H18F2N6O2/c24-15-2-4-17(22-26-7-1-8-27-22)18(12-15)23(32)31-10-11-33-21(31)14-30-9-6-20(29-30)19-5-3-16(25)13-28-19/h1-9,12-13,21H,10-11,14H2
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n/an/a 28.9n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208505
PNG
(US9266870, 21)
Show SMILES Fc1ccc(cc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-c2ncccn2)n1
Show InChI InChI=1S/C24H19F2N5O2/c25-17-4-2-16(3-5-17)21-8-11-30(29-21)15-22-31(12-13-33-22)24(32)20-14-18(26)6-7-19(20)23-27-9-1-10-28-23/h1-11,14,22H,12-13,15H2
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n/an/a 30.2n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208530
PNG
(US9266870, 46)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cc1cnn(c1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-4-19(30-25-6-7-26-30)18(10-15)22(31)28-8-9-32-21(28)11-16-12-27-29(14-16)20-5-3-17(23)13-24-20/h2-7,10,12-14,21H,8-9,11H2,1H3
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n/an/a 31.9n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208516
PNG
(US9266870, 32)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-16-3-8-20(31-25-9-10-26-31)22(28-16)23(32)30-11-2-12-33-21(30)15-29-14-18(13-27-29)17-4-6-19(24)7-5-17/h3-10,13-14,21H,2,11-12,15H2,1H3
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n/an/a 34.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208508
PNG
(US9266870, 24)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1cc(cn1)-c1ccc(F)cc1)-c1ncccn1
Show InChI InChI=1S/C25H22FN5O2/c1-17-3-8-21(24-27-9-2-10-28-24)22(13-17)25(32)31-11-12-33-23(31)16-30-15-19(14-29-30)18-4-6-20(26)7-5-18/h2-10,13-15,23H,11-12,16H2,1H3
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n/an/a 34.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208530
PNG
(US9266870, 46)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cc1cnn(c1)-c1ccc(F)cn1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-4-19(30-25-6-7-26-30)18(10-15)22(31)28-8-9-32-21(28)11-16-12-27-29(14-16)20-5-3-17(23)13-24-20/h2-7,10,12-14,21H,8-9,11H2,1H3
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n/an/a 38.7n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208493
PNG
(US9266870, 9)
Show SMILES C[C@H]1CO[C@@H](Cn2ccc(n2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-8-9-27-31)18(11-15)23(32)30-16(2)14-33-22(30)13-29-10-7-20(28-29)19-5-4-17(24)12-25-19/h3-12,16,22H,13-14H2,1-2H3/t16-,22-/m0/s1
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n/an/a 41.5n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208523
PNG
(US9266870, 39)
Show SMILES C[C@H]1CCO[C@@H](Cn2cc(cn2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-8-9-28-32)20(11-16)24(33)31-17(2)7-10-34-23(31)15-30-14-18(12-29-30)21-5-4-19(25)13-26-21/h3-6,8-9,11-14,17,23H,7,10,15H2,1-2H3/t17-,23-/m0/s1
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n/an/a 46.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208501
PNG
(US9266870, 17 | US9266870, 22)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3
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n/an/a 46.7n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208528
PNG
(US9266870, 44)
Show SMILES Fc1ccc(nc1)-n1cc(CC2OCCCN2C(=O)c2cc(F)ccc2-c2ncccn2)cn1
Show InChI InChI=1S/C24H20F2N6O2/c25-17-3-5-19(23-27-7-1-8-28-23)20(12-17)24(33)31-9-2-10-34-22(31)11-16-13-30-32(15-16)21-6-4-18(26)14-29-21/h1,3-8,12-15,22H,2,9-11H2
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n/an/a 51.8n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208491
PNG
(US9266870, 7)
Show SMILES C[C@@H]1CO[C@@H](Cn2ccc(n2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-8-9-27-31)18(11-15)23(32)30-16(2)14-33-22(30)13-29-10-7-20(28-29)19-5-4-17(24)12-25-19/h3-12,16,22H,13-14H2,1-2H3/t16-,22+/m1/s1
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n/an/a 54.9n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208510
PNG
(US9266870, 26)
Show SMILES Cc1ccc(-c2ncccn2)c(c1)C(=O)N1CCCOC1Cc1noc(n1)-c1ccc(F)cn1
Show InChI InChI=1S/C24H21FN6O3/c1-15-4-6-17(22-26-8-2-9-27-22)18(12-15)24(32)31-10-3-11-33-21(31)13-20-29-23(34-30-20)19-7-5-16(25)14-28-19/h2,4-9,12,14,21H,3,10-11,13H2,1H3
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n/an/a 59.1n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208528
PNG
(US9266870, 44)
Show SMILES Fc1ccc(nc1)-n1cc(CC2OCCCN2C(=O)c2cc(F)ccc2-c2ncccn2)cn1
Show InChI InChI=1S/C24H20F2N6O2/c25-17-3-5-19(23-27-7-1-8-28-23)20(12-17)24(33)31-9-2-10-34-22(31)11-16-13-30-32(15-16)21-6-4-18(26)14-29-21/h1,3-8,12-15,22H,2,9-11H2
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n/an/a 60.4n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208492
PNG
(US9266870, 8)
Show SMILES C[C@@H]1CO[C@@H](Cn2cc(cn2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-16(2)14-33-22(30)13-29-12-17(10-28-29)20-5-4-18(24)11-25-20/h3-12,16,22H,13-14H2,1-2H3/t16-,22+/m1/s1
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n/an/a 60.9n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208500
PNG
(US9266870, 16)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-c2ncccn2)n1
Show InChI InChI=1S/C23H18F2N6O2/c24-15-2-4-17(22-26-7-1-8-27-22)18(12-15)23(32)31-10-11-33-21(31)14-30-9-6-20(29-30)19-5-3-16(25)13-28-19/h1-9,12-13,21H,10-11,14H2
PDB

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n/an/a 71.7n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208503
PNG
(US9266870, 19)
Show SMILES Fc1ccc(cc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1
Show InChI InChI=1S/C22H18F2N6O2/c23-16-3-1-15(2-4-16)19-7-10-28(27-19)14-21-29(11-12-32-21)22(31)18-13-17(24)5-6-20(18)30-25-8-9-26-30/h1-10,13,21H,11-12,14H2
PDB

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n/an/a 76.8n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208523
PNG
(US9266870, 39)
Show SMILES C[C@H]1CCO[C@@H](Cn2cc(cn2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-3-6-22(32-27-8-9-28-32)20(11-16)24(33)31-17(2)7-10-34-23(31)15-30-14-18(12-29-30)21-5-4-19(25)13-26-21/h3-6,8-9,11-14,17,23H,7,10,15H2,1-2H3/t17-,23-/m0/s1
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n/an/a 81.2n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208489
PNG
(US9266870, 5)
Show SMILES C[C@H]1CN([C@H](Cn2cc(cn2)-c2ccc(F)cn2)O1)C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-12-16(2)33-22(30)14-29-13-17(10-28-29)20-5-4-18(24)11-25-20/h3-11,13,16,22H,12,14H2,1-2H3/t16-,22-/m0/s1
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n/an/a 86n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208507
PNG
(US9266870, 23)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-7-19(30-24-8-9-25-30)21(27-15)22(31)29-10-11-32-20(29)14-28-13-17(12-26-28)16-3-5-18(23)6-4-16/h2-9,12-13,20H,10-11,14H2,1H3
PDB

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n/an/a 96.3n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208509
PNG
(US9266870, 25)
Show SMILES Fc1ccc(cc1)-c1cnn(CC2OCCN2C(=O)c2cc(F)ccc2-c2ncccn2)c1
Show InChI InChI=1S/C24H19F2N5O2/c25-18-4-2-16(3-5-18)17-13-29-30(14-17)15-22-31(10-11-33-22)24(32)21-12-19(26)6-7-20(21)23-27-8-1-9-28-23/h1-9,12-14,22H,10-11,15H2
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n/an/a 98.6n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208504
PNG
(US9266870, 20)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-c1ncccn1
Show InChI InChI=1S/C25H22FN5O2/c1-17-3-8-20(24-27-10-2-11-28-24)21(15-17)25(32)31-13-14-33-23(31)16-30-12-9-22(29-30)18-4-6-19(26)7-5-18/h2-12,15,23H,13-14,16H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208509
PNG
(US9266870, 25)
Show SMILES Fc1ccc(cc1)-c1cnn(CC2OCCN2C(=O)c2cc(F)ccc2-c2ncccn2)c1
Show InChI InChI=1S/C24H19F2N5O2/c25-18-4-2-16(3-5-18)17-13-29-30(14-17)15-22-31(10-11-33-22)24(32)21-12-19(26)6-7-20(21)23-27-8-1-9-28-23/h1-9,12-14,22H,10-11,15H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208507
PNG
(US9266870, 23)
Show SMILES Cc1ccc(c(n1)C(=O)N1CCOC1Cn1cc(cn1)-c1ccc(F)cc1)-n1nccn1
Show InChI InChI=1S/C22H20FN7O2/c1-15-2-7-19(30-24-8-9-25-30)21(27-15)22(31)29-10-11-32-20(29)14-28-13-17(12-26-28)16-3-5-18(23)6-4-16/h2-9,12-13,20H,10-11,14H2,1H3
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208496
PNG
(US9266870, 12 | US9266870, 13)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1
Show InChI InChI=1S/C21H17F2N7O2/c22-14-2-4-19(30-25-6-7-26-30)16(11-14)21(31)29-9-10-32-20(29)13-28-8-5-18(27-28)17-3-1-15(23)12-24-17/h1-8,11-12,20H,9-10,13H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208496
PNG
(US9266870, 12 | US9266870, 13)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1
Show InChI InChI=1S/C21H17F2N7O2/c22-14-2-4-19(30-25-6-7-26-30)16(11-14)21(31)29-9-10-32-20(29)13-28-8-5-18(27-28)17-3-1-15(23)12-24-17/h1-8,11-12,20H,9-10,13H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208502
PNG
(US9266870, 18)
Show SMILES Fc1ccc(cc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-n2nccn2)n1
Show InChI InChI=1S/C22H19FN6O2/c23-17-7-5-16(6-8-17)19-9-12-27(26-19)15-21-28(13-14-31-21)22(30)18-3-1-2-4-20(18)29-24-10-11-25-29/h1-12,21H,13-15H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208494
PNG
(US9266870, 10)
Show SMILES C[C@H]1CO[C@@H](Cn2cc(cn2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-16(2)14-33-22(30)13-29-12-17(10-28-29)20-5-4-18(24)11-25-20/h3-12,16,22H,13-14H2,1-2H3/t16-,22-/m0/s1
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208499
PNG
(US9266870, 15)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-c2ncccn2)n1
Show InChI InChI=1S/C23H19FN6O2/c24-16-6-7-19(27-14-16)20-8-11-29(28-20)15-21-30(12-13-32-21)23(31)18-5-2-1-4-17(18)22-25-9-3-10-26-22/h1-11,14,21H,12-13,15H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208503
PNG
(US9266870, 19)
Show SMILES Fc1ccc(cc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1
Show InChI InChI=1S/C22H18F2N6O2/c23-16-3-1-15(2-4-16)19-7-10-28(27-19)14-21-29(11-12-32-21)22(31)18-13-17(24)5-6-20(18)30-25-8-9-26-30/h1-10,13,21H,11-12,14H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208505
PNG
(US9266870, 21)
Show SMILES Fc1ccc(cc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-c2ncccn2)n1
Show InChI InChI=1S/C24H19F2N5O2/c25-17-4-2-16(3-5-17)21-8-11-30(29-21)15-22-31(12-13-33-22)24(32)20-14-18(26)6-7-19(20)23-27-9-1-10-28-23/h1-11,14,22H,12-13,15H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208496
PNG
(US9266870, 12 | US9266870, 13)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2cc(F)ccc2-n2nccn2)n1
Show InChI InChI=1S/C21H17F2N7O2/c22-14-2-4-19(30-25-6-7-26-30)16(11-14)21(31)29-9-10-32-20(29)13-28-8-5-18(27-28)17-3-1-15(23)12-24-17/h1-8,11-12,20H,9-10,13H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208495
PNG
(US9266870, 11)
Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-n2nccn2)n1
Show InChI InChI=1S/C21H18FN7O2/c22-15-5-6-17(23-13-15)18-7-10-27(26-18)14-20-28(11-12-31-20)21(30)16-3-1-2-4-19(16)29-24-8-9-25-29/h1-10,13,20H,11-12,14H2
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208494
PNG
(US9266870, 10)
Show SMILES C[C@H]1CO[C@@H](Cn2cc(cn2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-16(2)14-33-22(30)13-29-12-17(10-28-29)20-5-4-18(24)11-25-20/h3-12,16,22H,13-14H2,1-2H3/t16-,22-/m0/s1
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208492
PNG
(US9266870, 8)
Show SMILES C[C@@H]1CO[C@@H](Cn2cc(cn2)-c2ccc(F)cn2)N1C(=O)c1cc(C)ccc1-n1nccn1
Show InChI InChI=1S/C23H22FN7O2/c1-15-3-6-21(31-26-7-8-27-31)19(9-15)23(32)30-16(2)14-33-22(30)13-29-12-17(10-28-29)20-5-4-18(24)11-25-20/h3-12,16,22H,13-14H2,1-2H3/t16-,22+/m1/s1
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM208517
PNG
(US9266870, 33)
Show SMILES Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H23FN6O2/c1-17-4-9-21(24-27-10-2-11-28-24)23(30-17)25(33)32-12-3-13-34-22(32)16-31-15-19(14-29-31)18-5-7-20(26)8-6-18/h2,4-11,14-15,22H,3,12-13,16H2,1H3
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n/an/a 3.59E+3n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM208517
PNG
(US9266870, 33)
Show SMILES Cc1ccc(-c2ncccn2)c(n1)C(=O)N1CCCOC1Cn1cc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H23FN6O2/c1-17-4-9-21(24-27-10-2-11-28-24)23(30-17)25(33)32-12-3-13-34-22(32)16-31-15-19(14-29-31)18-5-7-20(26)8-6-18/h2,4-11,14-15,22H,3,12-13,16H2,1H3
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n/an/a 4.54E+3n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...


US Patent US9266870 (2016)


BindingDB Entry DOI: 10.7270/Q2J38RCP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%