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Found 8 Enz. Inhib. hit(s) with all data for entry = 7735
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107106(US8592371, 7 | US9278976, (3S,5R)-5-[2-(cyclopropa...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107103(US8592371, 5 | US9278976, (3S,5R)-5-[2-(cyclopenta...)
Affinity DataIC50:  1.30nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107104(US8592371, 6 | US9278976, (3S,5R)-5-[1-(cyclopropa...)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107102(US8592371, 4 | US9278976, (3S,5R)-5-[2-(cyclopenta...)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107105(US8592371, 8 | US9278976, (3S,5R)-5-[2-(cyclopropa...)
Affinity DataIC50:  1.90nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107100(US8592371, 2 | US9278976, (3S,5R)-5-{2-methanesulf...)
Affinity DataIC50:  2.20nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM107099(US8592371, 1 | US9278976, (3S,5R)-2-(2,5-difluorop...)
Affinity DataIC50:  2.5nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM213365(US9278976, (3S,5R)-5-[1-(cyclopentanesulfonyl)-1H,...)
Affinity DataIC50:  2.60nMpH: 7.5 T: 2°CAssay Description:A continuous fluorometric assay is employed with the substrate Gly-Pro-AMC, which is cleaved by DPP-4 to release the fluorescent AMC leaving group. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent