Compile Data Set for Download or QSAR
maximum 50k data
Found 274 Enz. Inhib. hit(s) with all data for entry = 8472
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251572(US9452998, Table 4 Compound 2)
Affinity DataIC50:  0.100nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251508(US9452998, 57)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251517(US9452998, 66 | US9452998, 77)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251507(US9452998, 56 | US9452998, 76)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251525(US9452998, 74)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251524(US9452998, 73)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251544(US9452998, 93)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251572(US9452998, Table 4 Compound 2)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251544(US9452998, 93)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251523(US9452998, 72 | US9452998, 78)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251507(US9452998, 56 | US9452998, 76)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251506(US9452998, 55)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251509(US9452998, 58)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251574(US9452998, Table 4 Compound 4)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251523(US9452998, 72 | US9452998, 78)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251522(US9452998, 71)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251517(US9452998, 66 | US9452998, 77)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251516(US9452998, 65)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251455(US9452998, 4)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251515(US9452998, 64)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251458(US9452998, 7)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251513(US9452998, 62)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251491(US9452998, 40 | US9452998, 51)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251496(US9452998, 45)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251497(US9452998, 46)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251512(US9452998, 61)
Affinity DataIC50:  0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251511(US9452998, 60)
Affinity DataIC50:  0.140nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251573(US9452998, Table 4 Compound 3)
Affinity DataIC50:  0.150nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251524(US9452998, 73)
Affinity DataIC50:  0.160nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251540(US9452998, 89)
Affinity DataIC50:  0.160nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251493(US9452998, 42)
Affinity DataIC50:  0.170nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251575(US9452998, Table 4 Compound 5)
Affinity DataIC50:  0.190nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251501(US9452998, 50)
Affinity DataIC50:  0.190nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251491(US9452998, 40 | US9452998, 51)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251574(US9452998, Table 4 Compound 4)
Affinity DataIC50:  0.200nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251523(US9452998, 72 | US9452998, 78)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251523(US9452998, 72 | US9452998, 78)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251504(US9452998, 53)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251576(US9452998, Table 4 Compound 6)
Affinity DataIC50:  0.200nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251575(US9452998, Table 4 Compound 5)
Affinity DataIC50:  0.200nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251457(US9452998, 6)
Affinity DataIC50:  0.220nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251522(US9452998, 71)
Affinity DataIC50:  0.230nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251521(US9452998, 70)
Affinity DataIC50:  0.240nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251480(US9452998, 29)
Affinity DataIC50:  0.240nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251543(US9452998, 92)
Affinity DataIC50:  0.25nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251573(US9452998, Table 4 Compound 3)
Affinity DataIC50:  0.25nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251453(US9452998, 2)
Affinity DataIC50:  0.25nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251505(US9452998, 54)
Affinity DataIC50:  0.25nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251566(US9452998, 115)
Affinity DataIC50:  0.260nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251458(US9452998, 7)
Affinity DataIC50:  0.270nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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