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USPatent US9730937

Compile Data Set for Download or QSAR

Found 1155 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333445
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimeth...)
Show SMILES COc1cc2ncnc(Oc3cc(NC(=O)Nc4cc(on4)C(C)(C)C)ccc3F)c2cc1OC
Show InChI InChI=1S/C24H24FN5O5/c1-24(2,3)20-11-21(30-35-20)29-23(31)28-13-6-7-15(25)17(8-13)34-22-14-9-18(32-4)19(33-5)10-16(14)26-12-27-22/h6-12H,1-5H3,(H2,28,29,30,31)
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n/an/an/a 750n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333469
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7-...)
Show SMILES CCOc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OC
Show InChI InChI=1S/C25H27N5O5/c1-6-33-20-11-17-18(12-19(20)32-5)26-14-27-23(17)34-16-9-7-8-15(10-16)28-24(31)29-22-13-21(35-30-22)25(2,3)4/h7-14H,6H2,1-5H3,(H2,28,29,30,31)
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n/an/an/a>1.00E+3n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333469
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7-...)
Show SMILES CCOc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OC
Show InChI InChI=1S/C25H27N5O5/c1-6-33-20-11-17-18(12-19(20)32-5)26-14-27-23(17)34-16-9-7-8-15(10-16)28-24(31)29-22-13-21(35-30-22)25(2,3)4/h7-14H,6H2,1-5H3,(H2,28,29,30,31)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333471
PNG
(1-(5-tert- Butylisoxazol- 3-yl)-3-[3- (6,7- dietho...)
Show SMILES CCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCC
Show InChI InChI=1S/C26H29N5O5/c1-6-33-20-12-18-19(13-21(20)34-7-2)27-15-28-24(18)35-17-10-8-9-16(11-17)29-25(32)30-23-14-22(36-31-23)26(3,4)5/h8-15H,6-7H2,1-5H3,(H2,29,30,31,32)
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n/an/an/a>1.00E+3n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333475
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-(2-(4- (h...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCC(CO)CC1
Show InChI InChI=1S/C31H38N6O6/c1-31(2,3)27-17-28(36-43-27)35-30(39)34-21-6-5-7-22(14-21)42-29-23-15-26(25(40-4)16-24(23)32-19-33-29)41-13-12-37-10-8-20(18-38)9-11-37/h5-7,14-17,19-20,38H,8-13,18H2,1-4H3,(H2,34,35,36,39)
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n/an/an/a 750n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333475
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-(2-(4- (h...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCC(CO)CC1
Show InChI InChI=1S/C31H38N6O6/c1-31(2,3)27-17-28(36-43-27)35-30(39)34-21-6-5-7-22(14-21)42-29-23-15-26(25(40-4)16-24(23)32-19-33-29)41-13-12-37-10-8-20(18-38)9-11-37/h5-7,14-17,19-20,38H,8-13,18H2,1-4H3,(H2,34,35,36,39)
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n/an/an/a 750n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333478
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCOCC1
Show InChI InChI=1S/C29H34N6O6/c1-29(2,3)25-17-26(34-41-25)33-28(36)32-19-6-5-7-20(14-19)40-27-21-15-24(23(37-4)16-22(21)30-18-31-27)39-13-10-35-8-11-38-12-9-35/h5-7,14-18H,8-13H2,1-4H3,(H2,32,33,34,36)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333482
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-(3-(4- (h...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCC(CO)CC1
Show InChI InChI=1S/C32H40N6O6/c1-32(2,3)28-18-29(37-44-28)36-31(40)35-22-7-5-8-23(15-22)43-30-24-16-27(26(41-4)17-25(24)33-20-34-30)42-14-6-11-38-12-9-21(19-39)10-13-38/h5,7-8,15-18,20-21,39H,6,9-14,19H2,1-4H3,(H2,35,36,37,40)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333483
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H39N7O7S/c1-31(2,3)27-19-28(36-45-27)35-30(39)34-21-8-6-9-22(16-21)44-29-23-17-26(25(42-4)18-24(23)32-20-33-29)43-15-7-10-37-11-13-38(14-12-37)46(5,40)41/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333483
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H39N7O7S/c1-31(2,3)27-19-28(36-45-27)35-30(39)34-21-8-6-9-22(16-21)44-29-23-17-26(25(42-4)18-24(23)32-20-33-29)43-15-7-10-37-11-13-38(14-12-37)46(5,40)41/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333484
PNG
(1-(5-tert- butyl- isoxazol-3- yl)-3-(3-{6- [3-(1,1...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCS(=O)(=O)CC1
Show InChI InChI=1S/C30H36N6O7S/c1-30(2,3)26-18-27(35-43-26)34-29(37)33-20-7-5-8-21(15-20)42-28-22-16-25(24(40-4)17-23(22)31-19-32-28)41-12-6-9-36-10-13-44(38,39)14-11-36/h5,7-8,15-19H,6,9-14H2,1-4H3,(H2,33,34,35,37)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333484
PNG
(1-(5-tert- butyl- isoxazol-3- yl)-3-(3-{6- [3-(1,1...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCS(=O)(=O)CC1
Show InChI InChI=1S/C30H36N6O7S/c1-30(2,3)26-18-27(35-43-26)34-29(37)33-20-7-5-8-21(15-20)42-28-22-16-25(24(40-4)17-23(22)31-19-32-28)41-12-6-9-36-10-13-44(38,39)14-11-36/h5,7-8,15-19H,6,9-14H2,1-4H3,(H2,33,34,35,37)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333487
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(3-(4- hy...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCCN1CCC(CO)CC1
Show InChI InChI=1S/C32H40N6O6/c1-32(2,3)28-18-29(37-44-28)36-31(40)35-22-7-5-8-23(15-22)43-30-24-16-26(41-4)27(17-25(24)33-20-34-30)42-14-6-11-38-12-9-21(19-39)10-13-38/h5,7-8,15-18,20-21,39H,6,9-14,19H2,1-4H3,(H2,35,36,37,40)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333492
PNG
((R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(3-(3...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCCN1CC[C@@H](O)C1
Show InChI InChI=1S/C30H36N6O6/c1-30(2,3)26-16-27(35-42-26)34-29(38)33-19-7-5-8-21(13-19)41-28-22-14-24(39-4)25(15-23(22)31-18-32-28)40-12-6-10-36-11-9-20(37)17-36/h5,7-8,13-16,18,20,37H,6,9-12,17H2,1-4H3,(H2,33,34,35,38)/t20-/m1/s1
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333497
PNG
(1-(5-tert- Butyl- isoxazol-3- yl)-3-(3-{7- [2-(1,1...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCN1CCS(=O)(=O)CC1
Show InChI InChI=1S/C29H34N6O7S/c1-29(2,3)25-17-26(34-42-25)33-28(36)32-19-6-5-7-20(14-19)41-27-21-15-23(39-4)24(16-22(21)30-18-31-27)40-11-8-35-9-12-43(37,38)13-10-35/h5-7,14-18H,8-13H2,1-4H3,(H2,32,33,34,36)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333499
PNG
(1-(5-tert- Butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCS(C)(=O)=O
Show InChI InChI=1S/C27H31N5O7S/c1-27(2,3)23-15-24(32-39-23)31-26(33)30-17-8-6-9-18(12-17)38-25-19-13-22(37-10-7-11-40(5,34)35)21(36-4)14-20(19)28-16-29-25/h6,8-9,12-16H,7,10-11H2,1-5H3,(H2,30,31,32,33)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333499
PNG
(1-(5-tert- Butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCS(C)(=O)=O
Show InChI InChI=1S/C27H31N5O7S/c1-27(2,3)23-15-24(32-39-23)31-26(33)30-17-8-6-9-18(12-17)38-25-19-13-22(37-10-7-11-40(5,34)35)21(36-4)14-20(19)28-16-29-25/h6,8-9,12-16H,7,10-11H2,1-5H3,(H2,30,31,32,33)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333505
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- difluo...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Sc3ncnc4cc(F)c(F)cc34)c2)no1
Show InChI InChI=1S/C22H19F2N5O2S/c1-22(2,3)18-10-19(29-31-18)28-21(30)27-12-5-4-6-13(7-12)32-20-14-8-15(23)16(24)9-17(14)25-11-26-20/h4-11H,1-3H3,(H2,27,28,29,30)
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n/an/an/a>1.00E+3n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333506
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7- methoxy-...)
Show SMILES COc1ccc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2c1
Show InChI InChI=1S/C23H23N5O3S/c1-23(2,3)19-12-20(28-31-19)27-22(29)26-14-6-5-7-16(10-14)32-21-17-9-8-15(30-4)11-18(17)24-13-25-21/h5-13H,1-4H3,(H2,26,27,28,29)
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333506
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7- methoxy-...)
Show SMILES COc1ccc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2c1
Show InChI InChI=1S/C23H23N5O3S/c1-23(2,3)19-12-20(28-31-19)27-22(29)26-14-6-5-7-16(10-14)32-21-17-9-8-15(30-4)11-18(17)24-13-25-21/h5-13H,1-4H3,(H2,26,27,28,29)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333510
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-{3- [6-methoxy- ...)
Show SMILES COCCOc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OC
Show InChI InChI=1S/C26H29N5O5S/c1-26(2,3)22-14-23(31-36-22)30-25(32)29-16-7-6-8-17(11-16)37-24-18-12-20(34-5)21(35-10-9-33-4)13-19(18)27-15-28-24/h6-8,11-15H,9-10H2,1-5H3,(H2,29,30,31,32)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333512
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-[3- (7,8-dihydro...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Sc3ncnc4cc5OCCOc5cc34)c2)no1
Show InChI InChI=1S/C24H23N5O4S/c1-24(2,3)20-12-21(29-33-20)28-23(30)27-14-5-4-6-15(9-14)34-22-16-10-18-19(32-8-7-31-18)11-17(16)25-13-26-22/h4-6,9-13H,7-8H2,1-3H3,(H2,27,28,29,30)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333513
PNG
(1-(5-tert- Butylisoxazol- 3-yl)-3-{3- [7-methoxy- ...)
Show SMILES COc1cc(OC2CCOCC2)c2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2c1
Show InChI InChI=1S/C28H31N5O5S/c1-28(2,3)23-15-24(33-38-23)32-27(34)31-17-6-5-7-20(12-17)39-26-25-21(29-16-30-26)13-19(35-4)14-22(25)37-18-8-10-36-11-9-18/h5-7,12-16,18H,8-11H2,1-4H3,(H2,31,32,33,34)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333514
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7-...)
Show SMILES CCOc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OC
Show InChI InChI=1S/C25H27N5O4S/c1-6-33-20-11-17-18(12-19(20)32-5)26-14-27-23(17)35-16-9-7-8-15(10-16)28-24(31)29-22-13-21(34-30-22)25(2,3)4/h7-14H,6H2,1-5H3,(H2,28,29,30,31)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333518
PNG
(1-(5-tert- Butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H39N7O4S/c1-31(2,3)27-19-28(36-42-27)35-30(39)34-21-8-6-9-22(16-21)43-29-23-17-26(25(40-5)18-24(23)32-20-33-29)41-15-7-10-38-13-11-37(4)12-14-38/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333519
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoixy-...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H39N7O6S2/c1-31(2,3)27-19-28(36-44-27)35-30(39)34-21-8-6-9-22(16-21)45-29-23-17-26(25(42-4)18-24(23)32-20-33-29)43-15-7-10-37-11-13-38(14-12-37)46(5,40)41/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333519
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoixy-...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C31H39N7O6S2/c1-31(2,3)27-19-28(36-44-27)35-30(39)34-21-8-6-9-22(16-21)45-29-23-17-26(25(42-4)18-24(23)32-20-33-29)43-15-7-10-37-11-13-38(14-12-37)46(5,40)41/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333525
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-(2-(4- (h...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCC(CO)CC1
Show InChI InChI=1S/C31H38N6O5S/c1-31(2,3)27-17-28(36-42-27)35-30(39)34-21-6-5-7-22(14-21)43-29-23-15-26(25(40-4)16-24(23)32-19-33-29)41-13-12-37-10-8-20(18-38)9-11-37/h5-7,14-17,19-20,38H,8-13,18H2,1-4H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333526
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCN(C)CC1
Show InChI InChI=1S/C30H37N7O4S/c1-30(2,3)26-18-27(35-41-26)34-29(38)33-20-7-6-8-21(15-20)42-28-22-16-25(24(39-5)17-23(22)31-19-32-28)40-14-13-37-11-9-36(4)10-12-37/h6-8,15-19H,9-14H2,1-5H3,(H2,33,34,35,38)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333528
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- ...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C30H37N7O6S2/c1-30(2,3)26-18-27(35-43-26)34-29(38)33-20-7-6-8-21(15-20)44-28-22-16-25(24(41-4)17-23(22)31-19-32-28)42-14-13-36-9-11-37(12-10-36)45(5,39)40/h6-8,15-19H,9-14H2,1-5H3,(H2,33,34,35,38)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333532
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C31H39N7O4S/c1-31(2,3)27-19-28(36-42-27)35-30(39)34-21-8-6-9-22(16-21)43-29-23-17-25(40-5)26(18-24(23)32-20-33-29)41-15-7-10-38-13-11-37(4)12-14-38/h6,8-9,16-20H,7,10-15H2,1-5H3,(H2,34,35,36,39)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333533
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(3-(4- (h...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCCN1CCC(CO)CC1
Show InChI InChI=1S/C32H40N6O5S/c1-32(2,3)28-18-29(37-43-28)36-31(40)35-22-7-5-8-23(15-22)44-30-24-16-26(41-4)27(17-25(24)33-20-34-30)42-14-6-11-38-12-9-21(19-39)10-13-38/h5,7-8,15-18,20-21,39H,6,9-14,19H2,1-4H3,(H2,35,36,37,40)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333537
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCN1CCOCC1
Show InChI InChI=1S/C29H34N6O5S/c1-29(2,3)25-17-26(34-40-25)33-28(36)32-19-6-5-7-20(14-19)41-27-21-15-23(37-4)24(16-22(21)30-18-31-27)39-13-10-35-8-11-38-12-9-35/h5-7,14-18H,8-13H2,1-4H3,(H2,32,33,34,36)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333538
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCN1CCCCC1
Show InChI InChI=1S/C30H36N6O4S/c1-30(2,3)26-18-27(35-40-26)34-29(37)33-20-9-8-10-21(15-20)41-28-22-16-24(38-4)25(17-23(22)31-19-32-28)39-14-13-36-11-6-5-7-12-36/h8-10,15-19H,5-7,11-14H2,1-4H3,(H2,33,34,35,37)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333539
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCCN1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C30H37N7O6S2/c1-30(2,3)26-18-27(35-43-26)34-29(38)33-20-7-6-8-21(15-20)44-28-22-16-24(41-4)25(17-23(22)31-19-32-28)42-14-13-36-9-11-37(12-10-36)45(5,39)40/h6-8,15-19H,9-14H2,1-5H3,(H2,33,34,35,38)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333543
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-(2- metho...)
Show SMILES COCCOc1ccc2ncnc(Sc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2c1
Show InChI InChI=1S/C25H27N5O4S/c1-25(2,3)21-14-22(30-34-21)29-24(31)28-16-6-5-7-18(12-16)35-23-19-13-17(33-11-10-32-4)8-9-20(19)26-15-27-23/h5-9,12-15H,10-11H2,1-4H3,(H2,28,29,30,31)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333547
PNG
(1-(5-tert- Butyl- isoxazol-3- yl)-3-(3-{6- [2-(1,1...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1OCCN1CCS(=O)(=O)CC1
Show InChI InChI=1S/C29H34N6O7S/c1-29(2,3)25-17-26(34-42-25)33-28(36)32-19-6-5-7-20(14-19)41-27-21-15-24(23(39-4)16-22(21)30-18-31-27)40-11-8-35-9-12-43(37,38)13-10-35/h5-7,14-18H,8-13H2,1-4H3,(H2,32,33,34,36)
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AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333548
PNG
(1-(5-tert- butylisoxazol- 3-yl)-3-{3- [6-(5-{[2- (...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3ncnc4ccc(cc34)-c3ccc(CNCCS(C)(=O)=O)o3)c2)no1
Show InChI InChI=1S/C30H32N6O6S/c1-30(2,3)26-16-27(36-42-26)35-29(37)34-20-6-5-7-21(15-20)41-28-23-14-19(8-10-24(23)32-18-33-28)25-11-9-22(40-25)17-31-12-13-43(4,38)39/h5-11,14-16,18,31H,12-13,17H2,1-4H3,(H2,34,35,36,37)
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n/an/an/a 750n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333554
PNG
((R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-metho...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1O[C@@H]1CCN(C)C1
Show InChI InChI=1S/C28H32N6O5/c1-28(2,3)24-14-25(33-39-24)32-27(35)31-17-7-6-8-18(11-17)38-26-20-12-22(36-5)23(13-21(20)29-16-30-26)37-19-9-10-34(4)15-19/h6-8,11-14,16,19H,9-10,15H2,1-5H3,(H2,31,32,33,35)/t19-/m1/s1
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333555
PNG
((R)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-(2- h...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OC[C@H](O)CN1CCN(C)CC1
Show InChI InChI=1S/C31H39N7O6/c1-31(2,3)27-16-28(36-44-27)35-30(40)34-20-7-6-8-22(13-20)43-29-23-14-25(41-5)26(15-24(23)32-19-33-29)42-18-21(39)17-38-11-9-37(4)10-12-38/h6-8,13-16,19,21,39H,9-12,17-18H2,1-5H3,(H2,34,35,36,40)/t21-/m1/s1
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333556
PNG
(1-(3-tert- Butylisoxazol- 5-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C29H34N6O5/c1-29(2,3)25-15-26(35-40-25)34-28(36)33-19-6-5-7-20(12-19)39-27-21-13-23(37-4)24(14-22(21)31-17-32-27)38-16-18-8-10-30-11-9-18/h5-7,12-15,17-18,30H,8-11,16H2,1-4H3,(H2,33,34,35,36)
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333557
PNG
(1-(3-tert- butylisoxazol- 5-yl)-3-(3- (6-methoxy- ...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C30H36N6O5/c1-30(2,3)26-16-27(35-41-26)34-29(37)33-20-7-6-8-21(13-20)40-28-22-14-24(38-5)25(15-23(22)31-18-32-28)39-17-19-9-11-36(4)12-10-19/h6-8,13-16,18-19H,9-12,17H2,1-5H3,(H2,33,34,35,37)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333559
PNG
((S)-1-(5-tert- Butylisoxazol- 3-yl)-3-(3- {6-metho...)
Show SMILES COc1cc2c(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)ncnc2cc1O[C@H]1CCN(CC(F)(F)F)C1
Show InChI InChI=1S/C29H31F3N6O5/c1-28(2,3)24-13-25(37-43-24)36-27(39)35-17-6-5-7-18(10-17)42-26-20-11-22(40-4)23(12-21(20)33-16-34-26)41-19-8-9-38(14-19)15-29(30,31)32/h5-7,10-13,16,19H,8-9,14-15H2,1-4H3,(H2,35,36,37,39)/t19-/m0/s1
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n/an/an/a>1.00E+3n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333564
PNG
((S)-1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-(1-(2...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C)c3)c2cc1O[C@H]1CCN(CC(F)F)C1
Show InChI InChI=1S/C29H32F2N6O5/c1-29(2,3)24-13-26(36-42-24)35-28(38)34-17-6-5-7-18(10-17)41-27-20-11-23(22(39-4)12-21(20)32-16-33-27)40-19-8-9-37(14-19)15-25(30)31/h5-7,10-13,16,19,25H,8-9,14-15H2,1-4H3,(H2,34,35,36,38)/t19-/m0/s1
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM333567
PNG
((1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)-c4ccccc4)c3)c2cc1OC
Show InChI InChI=1S/C26H21N5O5/c1-33-22-12-19-20(13-23(22)34-2)27-15-28-25(19)35-18-10-6-9-17(11-18)29-26(32)30-24-14-21(36-31-24)16-7-4-3-5-8-16/h3-15H,1-2H3,(H2,29,30,31,32)
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n/an/an/a 750n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333573
PNG
(1-(3-tert- butylphenyl)- 3-(3-(6,7- dimethoxy- qui...)
Show SMILES COc1cc2ncnc(Sc3cccc(NC(=O)Nc4cccc(c4)C(C)(C)C)c3)c2cc1OC
Show InChI InChI=1S/C27H28N4O3S/c1-27(2,3)17-8-6-9-18(12-17)30-26(32)31-19-10-7-11-20(13-19)35-25-21-14-23(33-4)24(34-5)15-22(21)28-16-29-25/h6-16H,1-5H3,(H2,30,31,32)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333577
PNG
(1-(3-(2- cyanopropan-2- yl)isoxazol- 5-yl)- 3-(3-(...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C#N)c3)c2cc1OC
Show InChI InChI=1S/C24H22N6O5/c1-24(2,12-25)20-11-21(30-35-20)29-23(31)28-14-6-5-7-15(8-14)34-22-16-9-18(32-3)19(33-4)10-17(16)26-13-27-22/h5-11,13H,1-4H3,(H2,28,29,30,31)
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n/an/an/a 375n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333585
PNG
(1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)C)c3)c2cc1OC
Show InChI InChI=1S/C23H23N5O5/c1-13(2)18-11-21(28-33-18)27-23(29)26-14-6-5-7-15(8-14)32-22-16-9-19(30-3)20(31-4)10-17(16)24-12-25-22/h5-13H,1-4H3,(H2,26,27,28,29)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM333592
PNG
(1-(3-chloro- 5- (trifluoromethyl) phenyl)- 3-(2-(6...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(Cl)cc(c4)C(F)(F)F)c3)c2cc1OC
Show InChI InChI=1S/C24H18ClF3N4O4/c1-34-20-10-18-19(11-21(20)35-2)29-12-30-22(18)36-17-5-3-4-15(9-17)31-23(33)32-16-7-13(24(26,27)28)6-14(25)8-16/h3-12H,1-2H3,(H2,31,32,33)
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n/an/an/a 750n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM333596
PNG
(1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)...)
Show SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cccc(c4)C(C)C)c3)c2cc1OC
Show InChI InChI=1S/C26H26N4O4/c1-16(2)17-7-5-8-18(11-17)29-26(31)30-19-9-6-10-20(12-19)34-25-21-13-23(32-3)24(33-4)14-22(21)27-15-28-25/h5-16H,1-4H3,(H2,29,30,31)
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n/an/an/a<250n/an/an/an/an/a



AMBIT BIOSCIENCES CORPORATION

US Patent


Assay Description
Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....


US Patent US9730937 (2017)

More data for this
Ligand-Target Pair
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