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USPatent US9884828

Compile data set for download or QSAR
Found 117 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282619
PNG
(US9884828, 2-114)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2cc(nnc2c1)C(N)=O
Show InChI InChI=1S/C18H16N4O2/c1-22(2)18(24)12-5-3-11(4-6-12)13-7-8-14-10-16(17(19)23)21-20-15(14)9-13/h3-10H,1-2H3,(H2,19,23)
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n/an/a 0.5n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282606
PNG
(US9884828, 2-101)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1cnn(C)c1)C(N)=O)C1CC1
Show InChI InChI=1S/C18H20N6O/c1-10(11-3-4-11)21-16-14-6-5-12(13-8-20-24(2)9-13)7-15(14)22-23-17(16)18(19)25/h5-11H,3-4H2,1-2H3,(H2,19,25)(H,21,22)/t10-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282670
PNG
(US9884828, 9-213)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOC1=O)C(N)=O)C1CC1
Show InChI InChI=1S/C23H23N5O3/c1-13(14-2-3-14)25-20-18-9-6-16(12-19(18)26-27-21(20)22(24)29)15-4-7-17(8-5-15)28-10-11-31-23(28)30/h4-9,12-14H,2-3,10-11H2,1H3,(H2,24,29)(H,25,26)/t13-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282616
PNG
(US9884828, 2-111)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1cccc(c1)S(C)(=O)=O)C(N)=O)C1CC1
Show InChI InChI=1S/C21H22N4O3S/c1-12(13-6-7-13)23-19-17-9-8-15(11-18(17)24-25-20(19)21(22)26)14-4-3-5-16(10-14)29(2,27)28/h3-5,8-13H,6-7H2,1-2H3,(H2,22,26)(H,23,24)/t12-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282625
PNG
(US9884828, 2-120)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc2CC(=O)Nc2c1)C(N)=O)C1CC1
Show InChI InChI=1S/C22H21N5O2/c1-11(12-2-3-12)24-20-16-7-6-14(9-18(16)26-27-21(20)22(23)29)13-4-5-15-10-19(28)25-17(15)8-13/h4-9,11-12H,2-3,10H2,1H3,(H2,23,29)(H,24,26)(H,25,28)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282626
PNG
(US9884828, 2-121)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1cccc2CC(=O)Nc12)C(N)=O)C1CC1
Show InChI InChI=1S/C22H21N5O2/c1-11(12-5-6-12)24-20-16-8-7-13(9-17(16)26-27-21(20)22(23)29)15-4-2-3-14-10-18(28)25-19(14)15/h2-4,7-9,11-12H,5-6,10H2,1H3,(H2,23,29)(H,24,26)(H,25,28)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428701
PNG
(CHEMBL2333115 | US9884828, 2-127)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1cn[nH]c1)C(N)=O
Show InChI InChI=1S/C15H16N6O/c1-8(2)19-13-11-5-9(10-6-17-18-7-10)3-4-12(11)20-21-14(13)15(16)22/h3-8H,1-2H3,(H2,16,22)(H,17,18)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428703
PNG
(CHEMBL2333113 | US9884828, 2-100)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)C1CC1
Show InChI InChI=1S/C19H19N5O/c1-11(12-2-3-12)22-17-15-5-4-14(13-6-8-21-9-7-13)10-16(15)23-24-18(17)19(20)25/h4-12H,2-3H2,1H3,(H2,20,25)(H,22,23)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282607
PNG
(US9884828, 2-102)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1ccc2cc(nnc2c1)C(N)=O
Show InChI InChI=1S/C18H16N4O2/c1-22(2)18(24)14-5-3-4-11(8-14)12-6-7-13-10-16(17(19)23)21-20-15(13)9-12/h3-10H,1-2H3,(H2,19,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428716
PNG
(CHEMBL2333128 | US9884828, 2-41)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CC1
Show InChI InChI=1S/C21H22N4O3S/c1-12(13-3-4-13)23-19-17-10-7-15(11-18(17)24-25-20(19)21(22)26)14-5-8-16(9-6-14)29(2,27)28/h5-13H,3-4H2,1-2H3,(H2,22,26)(H,23,24)/t12-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428717
PNG
(CHEMBL2333127 | US9884828, 2-37)
Show SMILES CC[C@@H](C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C20H22N4O3S/c1-4-12(2)22-18-16-10-7-14(11-17(16)23-24-19(18)20(21)25)13-5-8-15(9-6-13)28(3,26)27/h5-12H,4H2,1-3H3,(H2,21,25)(H,22,23)/t12-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282617
PNG
(US9884828, 2-112)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(=O)n(C)c1)C(N)=O)C1CC1
Show InChI InChI=1S/C20H21N5O2/c1-11(12-3-4-12)22-18-15-7-5-13(14-6-8-17(26)25(2)10-14)9-16(15)23-24-19(18)20(21)27/h5-12H,3-4H2,1-2H3,(H2,21,27)(H,22,23)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282627
PNG
(US9884828, 2-122)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccn(C)c(=O)c1)C(N)=O)C1CC1
Show InChI InChI=1S/C20H21N5O2/c1-11(12-3-4-12)22-18-15-6-5-13(14-7-8-25(2)17(26)10-14)9-16(15)23-24-19(18)20(21)27/h5-12H,3-4H2,1-2H3,(H2,21,27)(H,22,23)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282589
PNG
(US9884828, 2-49)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C22H25N5O2/c1-14(2)24-20-18-8-5-16(13-19(18)25-26-21(20)22(23)28)15-3-6-17(7-4-15)27-9-11-29-12-10-27/h3-8,13-14H,9-12H2,1-2H3,(H2,23,28)(H,24,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282674
PNG
(US9884828, 11-221)
Show SMILES COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1nccn1C
Show InChI InChI=1S/C25H26N6O2/c1-14(15-4-5-15)28-22-19-9-6-16(12-20(19)29-30-23(22)24(26)32)18-8-7-17(13-21(18)33-3)25-27-10-11-31(25)2/h6-15H,4-5H2,1-3H3,(H2,26,32)(H,28,29)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428700
PNG
(CHEMBL2333116 | US9884828, 2-53)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cn[nH]c1)C(N)=O
Show InChI InChI=1S/C15H16N6O/c1-8(2)19-13-11-4-3-9(10-6-17-18-7-10)5-12(11)20-21-14(13)15(16)22/h3-8H,1-2H3,(H2,16,22)(H,17,18)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428698
PNG
(CHEMBL2333118 | US9884828, 2-35)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cnn(C)c1)C(N)=O
Show InChI InChI=1S/C16H18N6O/c1-9(2)19-14-12-5-4-10(11-7-18-22(3)8-11)6-13(12)20-21-15(14)16(17)23/h4-9H,1-3H3,(H2,17,23)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282621
PNG
(US9884828, 2-116)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOCC1=O)C(N)=O)C1CC1
Show InChI InChI=1S/C24H25N5O3/c1-14(15-2-3-15)26-22-19-9-6-17(12-20(19)27-28-23(22)24(25)31)16-4-7-18(8-5-16)29-10-11-32-13-21(29)30/h4-9,12,14-15H,2-3,10-11,13H2,1H3,(H2,25,31)(H,26,27)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428715
PNG
(CHEMBL2333129 | US9884828, 2-19)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CCC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C20H20N4O3S/c1-28(26,27)15-8-5-12(6-9-15)13-7-10-16-17(11-13)23-24-19(20(21)25)18(16)22-14-3-2-4-14/h5-11,14H,2-4H2,1H3,(H2,21,25)(H,22,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282615
PNG
(US9884828, 2-110)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccccc1)C(N)=O)C1CC1
Show InChI InChI=1S/C20H20N4O/c1-12(13-7-8-13)22-18-16-10-9-15(14-5-3-2-4-6-14)11-17(16)23-24-19(18)20(21)25/h2-6,9-13H,7-8H2,1H3,(H2,21,25)(H,22,23)/t12-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282623
PNG
(US9884828, 2-118)
Show SMILES COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)C(=O)N(C)C
Show InChI InChI=1S/C24H27N5O3/c1-13(14-5-6-14)26-21-18-10-7-15(11-19(18)27-28-22(21)23(25)30)17-9-8-16(12-20(17)32-4)24(31)29(2)3/h7-14H,5-6H2,1-4H3,(H2,25,30)(H,26,27)/t13-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282611
PNG
(US9884828, 2-106)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc2NC(=O)Cc2c1)C(N)=O)C1CC1
Show InChI InChI=1S/C22H21N5O2/c1-11(12-2-3-12)24-20-16-6-4-14(9-18(16)26-27-21(20)22(23)29)13-5-7-17-15(8-13)10-19(28)25-17/h4-9,11-12H,2-3,10H2,1H3,(H2,23,29)(H,24,26)(H,25,28)/t11-/m1/s1
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n/an/a 11n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282661
PNG
(US9884828, 5-55)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1c[nH]nn1)C(N)=O
Show InChI InChI=1S/C14H15N7O/c1-7(2)17-12-9-4-3-8(11-6-16-21-19-11)5-10(9)18-20-13(12)14(15)22/h3-7H,1-2H3,(H2,15,22)(H,17,18)(H,16,19,21)
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n/an/a 13n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428704
PNG
(CHEMBL2333112 | US9884828, 2-31)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C17H17N5O/c1-10(2)20-15-13-4-3-12(11-5-7-19-8-6-11)9-14(13)21-22-16(15)17(18)23/h3-10H,1-2H3,(H2,18,23)(H,20,21)
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n/an/a 14n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428718
PNG
(CHEMBL2333126 | US9884828, 2-17)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C19H20N4O3S/c1-11(2)21-17-15-9-6-13(10-16(15)22-23-18(17)19(20)24)12-4-7-14(8-5-12)27(3,25)26/h4-11H,1-3H3,(H2,20,24)(H,21,22)
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n/an/a 15n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282590
PNG
(US9884828, 2-51)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cccc(c1)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C22H25N5O2/c1-14(2)24-20-18-7-6-16(13-19(18)25-26-21(20)22(23)28)15-4-3-5-17(12-15)27-8-10-29-11-9-27/h3-7,12-14H,8-11H2,1-2H3,(H2,23,28)(H,24,25)
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n/an/a 17n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428710
PNG
(CHEMBL2333134 | US9884828, 2-23)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CCOC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C20H20N4O4S/c1-29(26,27)15-5-2-12(3-6-15)13-4-7-16-17(10-13)23-24-19(20(21)25)18(16)22-14-8-9-28-11-14/h2-7,10,14H,8-9,11H2,1H3,(H2,21,25)(H,22,23)
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n/an/a 17n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428714
PNG
(CHEMBL2333130 | US9884828, 2-92)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NCC3CC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C20H20N4O3S/c1-28(26,27)15-7-4-13(5-8-15)14-6-9-16-17(10-14)23-24-19(20(21)25)18(16)22-11-12-2-3-12/h4-10,12H,2-3,11H2,1H3,(H2,21,25)(H,22,23)
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n/an/a 17n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282624
PNG
(US9884828, 2-119)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1cccc2NC(=O)Cc12)C(N)=O)C1CC1
Show InChI InChI=1S/C22H21N5O2/c1-11(12-5-6-12)24-20-15-8-7-13(9-18(15)26-27-21(20)22(23)29)14-3-2-4-17-16(14)10-19(28)25-17/h2-4,7-9,11-12H,5-6,10H2,1H3,(H2,23,29)(H,24,26)(H,25,28)/t11-/m1/s1
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n/an/a 18n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428712
PNG
(CHEMBL2333132 | US9884828, 2-25)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CCOCC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C21H22N4O4S/c1-30(27,28)16-5-2-13(3-6-16)14-4-7-17-18(12-14)24-25-20(21(22)26)19(17)23-15-8-10-29-11-9-15/h2-7,12,15H,8-11H2,1H3,(H2,22,26)(H,23,24)
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n/an/a 23n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282673
PNG
(US9884828, 11-220)
Show SMILES COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1nccnc1OC
Show InChI InChI=1S/C26H26N6O3/c1-14(15-4-5-15)30-23-19-9-6-16(12-20(19)31-32-24(23)25(27)33)18-8-7-17(13-21(18)34-2)22-26(35-3)29-11-10-28-22/h6-15H,4-5H2,1-3H3,(H2,27,33)(H,30,31)/t14-/m1/s1
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n/an/a 25n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282639
PNG
(US9884828, 2-134)
Show SMILES CCC(CC)Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C19H21N5O/c1-3-14(4-2)22-17-15-6-5-13(12-7-9-21-10-8-12)11-16(15)23-24-18(17)19(20)25/h5-11,14H,3-4H2,1-2H3,(H2,20,25)(H,22,23)
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n/an/a 26n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428702
PNG
(CHEMBL2333114 | US9884828, 2-126)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1ccncc1)C(N)=O
Show InChI InChI=1S/C17H17N5O/c1-10(2)20-15-13-9-12(11-5-7-19-8-6-11)3-4-14(13)21-22-16(15)17(18)23/h3-10H,1-2H3,(H2,18,23)(H,20,21)
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n/an/a 30n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282654
PNG
(US9884828, 4-80)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-n1cccn1)C(N)=O
Show InChI InChI=1S/C15H16N6O/c1-9(2)18-13-11-5-4-10(21-7-3-6-17-21)8-12(11)19-20-14(13)15(16)22/h3-9H,1-2H3,(H2,16,22)(H,18,19)
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n/an/a 31n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282658
PNG
(US9884828, 4-190)
Show SMILES COc1ncccc1Nc1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C18H20N6O2/c1-10(2)21-15-12-7-6-11(9-14(12)23-24-16(15)17(19)25)22-13-5-4-8-20-18(13)26-3/h4-10,22H,1-3H3,(H2,19,25)(H,21,23)
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n/an/a 31n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282592
PNG
(US9884828, 2-57)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cccnc1)C(N)=O
Show InChI InChI=1S/C17H17N5O/c1-10(2)20-15-13-6-5-11(12-4-3-7-19-9-12)8-14(13)21-22-16(15)17(18)23/h3-10H,1-2H3,(H2,18,23)(H,20,21)
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n/an/a 33n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282672
PNG
(US9884828, 11-218)
Show SMILES COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ncccc1F
Show InChI InChI=1S/C26H24FN5O2/c1-14(15-5-6-15)30-24-19-10-7-16(12-21(19)31-32-25(24)26(28)33)18-9-8-17(13-22(18)34-2)23-20(27)4-3-11-29-23/h3-4,7-15H,5-6H2,1-2H3,(H2,28,33)(H,30,31)/t14-/m1/s1
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n/an/a 43n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282596
PNG
(US9884828, 2-91)
Show SMILES CC(C)(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C20H22N4O3S/c1-20(2,3)22-17-15-10-7-13(11-16(15)23-24-18(17)19(21)25)12-5-8-14(9-6-12)28(4,26)27/h5-11H,1-4H3,(H2,21,25)(H,22,23)
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n/an/a 45n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428713
PNG
(CHEMBL2333131 | US9884828, 2-93)
Show SMILES CCNc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C18H18N4O3S/c1-3-20-16-14-9-6-12(10-15(14)21-22-17(16)18(19)23)11-4-7-13(8-5-11)26(2,24)25/h4-10H,3H2,1-2H3,(H2,19,23)(H,20,21)
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n/an/a 46n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282602
PNG
(US9884828, 2-97)
Show SMILES COc1cccc(c1)-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H20N4O2/c1-11(2)21-17-15-8-7-13(12-5-4-6-14(9-12)25-3)10-16(15)22-23-18(17)19(20)24/h4-11H,1-3H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428711
PNG
(CHEMBL2333133 | US9884828, 2-29)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3CC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H18N4O3S/c1-27(25,26)14-7-2-11(3-8-14)12-4-9-15-16(10-12)22-23-18(19(20)24)17(15)21-13-5-6-13/h2-4,7-10,13H,5-6H2,1H3,(H2,20,24)(H,21,22)
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n/an/a 47n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282612
PNG
(US9884828, 2-107)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)C(=O)N(C)C
Show InChI InChI=1S/C24H27N5O3/c1-13(14-5-6-14)26-21-17-9-7-15(12-19(17)27-28-22(21)23(25)30)18-11-16(24(31)29(2)3)8-10-20(18)32-4/h7-14H,5-6H2,1-4H3,(H2,25,30)(H,26,27)/t13-/m1/s1
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n/an/a 48n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282620
PNG
(US9884828, 2-115)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)S(C)(=O)=O
Show InChI InChI=1S/C22H24N4O4S/c1-12(13-4-5-13)24-20-16-8-6-14(10-18(16)25-26-21(20)22(23)27)17-11-15(31(3,28)29)7-9-19(17)30-2/h6-13H,4-5H2,1-3H3,(H2,23,27)(H,24,25)/t12-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282618
PNG
(US9884828, 2-113)
Show SMILES NC(=O)c1cc2ccc(cc2nn1)-c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C19H17N3O2/c20-19(23)18-10-15-7-6-14(9-17(15)21-22-18)13-2-1-3-16(8-13)24-11-12-4-5-12/h1-3,6-10,12H,4-5,11H2,(H2,20,23)
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n/an/a 51n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282678
PNG
(US9884828, 13-233)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1ncc[nH]1
Show InChI InChI=1S/C21H21N5O2S/c1-13(2)24-19-17-9-6-15(14-4-7-16(8-5-14)29(3,27)28)12-18(17)25-26-20(19)21-22-10-11-23-21/h4-13H,1-3H3,(H,22,23)(H,24,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428697
PNG
(CHEMBL2333119 | US9884828, 4-188)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)N1CCN(C)CC1)C(N)=O
Show InChI InChI=1S/C17H24N6O/c1-11(2)19-15-13-5-4-12(23-8-6-22(3)7-9-23)10-14(13)20-21-16(15)17(18)24/h4-5,10-11H,6-9H2,1-3H3,(H2,18,24)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282665
PNG
(US9884828, 9-206)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)N1CCOC1=O
Show InChI InChI=1S/C24H25N5O4/c1-13(14-3-4-14)26-21-17-7-5-15(11-19(17)27-28-22(21)23(25)30)18-12-16(6-8-20(18)32-2)29-9-10-33-24(29)31/h5-8,11-14H,3-4,9-10H2,1-2H3,(H2,25,30)(H,26,27)/t13-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282586
PNG
(US9884828, 2-43)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(F)cc1)C(N)=O
Show InChI InChI=1S/C18H17FN4O/c1-10(2)21-16-14-8-5-12(11-3-6-13(19)7-4-11)9-15(14)22-23-17(16)18(20)24/h3-10H,1-2H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282595
PNG
(US9884828, 2-90)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CCOCC1
Show InChI InChI=1S/C23H26N4O4S/c1-14(15-9-11-31-12-10-15)25-21-19-8-5-17(13-20(19)26-27-22(21)23(24)28)16-3-6-18(7-4-16)32(2,29)30/h3-8,13-15H,9-12H2,1-2H3,(H2,24,28)(H,25,26)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282668
PNG
(US9884828, 9-209)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)N1CCOCC1=O
Show InChI InChI=1S/C25H27N5O4/c1-14(15-3-4-15)27-23-18-7-5-16(11-20(18)28-29-24(23)25(26)32)19-12-17(6-8-21(19)33-2)30-9-10-34-13-22(30)31/h5-8,11-12,14-15H,3-4,9-10,13H2,1-2H3,(H2,26,32)(H,27,28)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282657
PNG
(US9884828, 4-189)
Show SMILES COc1ccccc1Nc1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H21N5O2/c1-11(2)21-17-13-9-8-12(10-15(13)23-24-18(17)19(20)25)22-14-6-4-5-7-16(14)26-3/h4-11,22H,1-3H3,(H2,20,25)(H,21,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282653
PNG
(US9884828, 4-78)
Show SMILES CC(C)Nc1c(nnc2cc(Nc3ccccc3)ccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O/c1-11(2)20-16-14-9-8-13(21-12-6-4-3-5-7-12)10-15(14)22-23-17(16)18(19)24/h3-11,21H,1-2H3,(H2,19,24)(H,20,22)
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n/an/a 72n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282604
PNG
(US9884828, 2-99)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)C(C)=C)C(N)=O
Show InChI InChI=1S/C15H18N4O/c1-8(2)10-5-6-11-12(7-10)18-19-14(15(16)20)13(11)17-9(3)4/h5-7,9H,1H2,2-4H3,(H2,16,20)(H,17,18)
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n/an/a 76n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282587
PNG
(US9884828, 2-45)
Show SMILES CCNc1c(nnc2cc(ccc12)-c1cccc(F)c1)C(N)=O
Show InChI InChI=1S/C17H15FN4O/c1-2-20-15-13-7-6-11(10-4-3-5-12(18)8-10)9-14(13)21-22-16(15)17(19)23/h3-9H,2H2,1H3,(H2,19,23)(H,20,21)
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n/an/a 84n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282594
PNG
(US9884828, 2-89)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NCC3CCOCC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C22H24N4O4S/c1-31(28,29)17-5-2-15(3-6-17)16-4-7-18-19(12-16)25-26-21(22(23)27)20(18)24-13-14-8-10-30-11-9-14/h2-7,12,14H,8-11,13H2,1H3,(H2,23,27)(H,24,25)
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n/an/a 110n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282636
PNG
(US9884828, 2-131)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1cncs1)C(N)=O
Show InChI InChI=1S/C15H15N5OS/c1-8(2)18-13-10-5-9(12-6-17-7-22-12)3-4-11(10)19-20-14(13)15(16)21/h3-8H,1-2H3,(H2,16,21)(H,18,19)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282600
PNG
(US9884828, 2-95)
Show SMILES CC(C)Nc1c(nnc2cc(C=C)ccc12)C(N)=O
Show InChI InChI=1S/C14H16N4O/c1-4-9-5-6-10-11(7-9)17-18-13(14(15)19)12(10)16-8(2)3/h4-8H,1H2,2-3H3,(H2,15,19)(H,16,17)
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n/an/a 120n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428706
PNG
(CHEMBL2333138 | US9884828, 2-136)
Show SMILES NC(=O)c1nnc2cc(ccc2c1NCCCO)-c1ccncc1
Show InChI InChI=1S/C17H17N5O2/c18-17(24)16-15(20-6-1-9-23)13-3-2-12(10-14(13)21-22-16)11-4-7-19-8-5-11/h2-5,7-8,10,23H,1,6,9H2,(H2,18,24)(H,20,21)
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n/an/a 120n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428709
PNG
(CHEMBL2333135 | US9884828, 2-94)
Show SMILES CNc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C17H16N4O3S/c1-19-15-13-8-5-11(9-14(13)20-21-16(15)17(18)22)10-3-6-12(7-4-10)25(2,23)24/h3-9H,1-2H3,(H2,18,22)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282633
PNG
(US9884828, 2-128)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1cn[nH]c1)C#N
Show InChI InChI=1S/C15H14N6/c1-9(2)19-15-12-5-10(11-7-17-18-8-11)3-4-13(12)20-21-14(15)6-16/h3-5,7-9H,1-2H3,(H,17,18)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282565
PNG
(US9884828, 1-6)
Show SMILES NC(=O)c1nnc2cc(ccc2c1N)-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C19H19N5O2/c20-17-15-5-4-13(11-16(15)22-23-18(17)19(21)25)12-2-1-3-14(10-12)24-6-8-26-9-7-24/h1-5,10-11H,6-9H2,(H2,20,22)(H2,21,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282566
PNG
(US9884828, 1-7)
Show SMILES CN(C)c1ccc(cc1)-c1ccc2c(N)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C17H17N5O/c1-22(2)12-6-3-10(4-7-12)11-5-8-13-14(9-11)20-21-16(15(13)18)17(19)23/h3-9H,1-2H3,(H2,18,20)(H2,19,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282608
PNG
(US9884828, 2-103)
Show SMILES COc1ccccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C21H22N4O2/c1-12(13-7-8-13)23-19-16-10-9-14(15-5-3-4-6-18(15)27-2)11-17(16)24-25-20(19)21(22)26/h3-6,9-13H,7-8H2,1-2H3,(H2,22,26)(H,23,24)/t12-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428708
PNG
(CHEMBL2333136 | US9884828, 1-5)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(N)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C16H14N4O3S/c1-24(22,23)11-5-2-9(3-6-11)10-4-7-12-13(8-10)19-20-15(14(12)17)16(18)21/h2-8H,1H3,(H2,17,19)(H2,18,21)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428705
PNG
(CHEMBL2333139 | US9884828, 2-137)
Show SMILES NC(=O)c1nnc2cc(ccc2c1NCCO)-c1ccncc1
Show InChI InChI=1S/C16H15N5O2/c17-16(23)15-14(19-7-8-22)12-2-1-11(9-13(12)20-21-15)10-3-5-18-6-4-10/h1-6,9,22H,7-8H2,(H2,17,23)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282655
PNG
(US9884828, 4-85)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)N1CCCC1=O)C(N)=O
Show InChI InChI=1S/C16H19N5O2/c1-9(2)18-14-11-6-5-10(21-7-3-4-13(21)22)8-12(11)19-20-15(14)16(17)23/h5-6,8-9H,3-4,7H2,1-2H3,(H2,17,23)(H,18,19)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428693
PNG
(CHEMBL2333123 | US9884828, 12-231)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H24N4O3S/c1-13(14-4-5-14)24-20-18-11-8-16(12-19(18)25-26-21(20)22(27)23-2)15-6-9-17(10-7-15)30(3,28)29/h6-14H,4-5H2,1-3H3,(H,23,27)(H,24,25)/t13-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282573
PNG
(US9884828, 2-21)
Show SMILES CN1CCC(CC1)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C22H25N5O3S/c1-27-11-9-16(10-12-27)24-20-18-8-5-15(13-19(18)25-26-21(20)22(23)28)14-3-6-17(7-4-14)31(2,29)30/h3-8,13,16H,9-12H2,1-2H3,(H2,23,28)(H,24,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282576
PNG
(US9884828, 2-27)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC3COC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H18N4O4S/c1-28(25,26)14-5-2-11(3-6-14)12-4-7-15-16(8-12)22-23-18(19(20)24)17(15)21-13-9-27-10-13/h2-8,13H,9-10H2,1H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282588
PNG
(US9884828, 2-47)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccccc1F)C(N)=O
Show InChI InChI=1S/C18H17FN4O/c1-10(2)21-16-13-8-7-11(12-5-3-4-6-14(12)19)9-15(13)22-23-17(16)18(20)24/h3-10H,1-2H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282579
PNG
(US9884828, 2-33)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cncnc1)C(N)=O
Show InChI InChI=1S/C16H16N6O/c1-9(2)20-14-12-4-3-10(11-6-18-8-19-7-11)5-13(12)21-22-15(14)16(17)23/h3-9H,1-2H3,(H2,17,23)(H,20,21)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282660
PNG
(US9884828, 4-192)
Show SMILES COc1cccc(Nc2ccc3c(NC(C)C)c(nnc3c2)C(N)=O)c1
Show InChI InChI=1S/C19H21N5O2/c1-11(2)21-17-15-8-7-13(10-16(15)23-24-18(17)19(20)25)22-12-5-4-6-14(9-12)26-3/h4-11,22H,1-3H3,(H2,20,25)(H,21,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282567
PNG
(US9884828, 1-8)
Show SMILES CN(C)c1cccc(c1)-c1ccc2c(N)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C17H17N5O/c1-22(2)12-5-3-4-10(8-12)11-6-7-13-14(9-11)20-21-16(15(13)18)17(19)23/h3-9H,1-2H3,(H2,18,20)(H2,19,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282666
PNG
(US9884828, 9-207)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-n1cccn1
Show InChI InChI=1S/C24H24N6O2/c1-14(15-4-5-15)27-22-18-8-6-16(12-20(18)28-29-23(22)24(25)31)19-13-17(7-9-21(19)32-2)30-11-3-10-26-30/h3,6-15H,4-5H2,1-2H3,(H2,25,31)(H,27,28)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282650
PNG
(US9884828, 3-187)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1nccc(=O)[nH]1
Show InChI InChI=1S/C22H21N5O3S/c1-13(2)24-20-17-9-6-15(14-4-7-16(8-5-14)31(3,29)30)12-18(17)26-27-21(20)22-23-11-10-19(28)25-22/h4-13H,1-3H3,(H,24,26)(H,23,25,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282609
PNG
(US9884828, 2-104)
Show SMILES COCc1ccccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C22H24N4O2/c1-13(14-7-8-14)24-20-18-10-9-15(11-19(18)25-26-21(20)22(23)27)17-6-4-3-5-16(17)12-28-2/h3-6,9-11,13-14H,7-8,12H2,1-2H3,(H2,23,27)(H,24,25)/t13-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282601
PNG
(US9884828, 2-96)
Show SMILES COc1ccccc1-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H20N4O2/c1-11(2)21-17-14-9-8-12(13-6-4-5-7-16(13)25-3)10-15(14)22-23-18(17)19(20)24/h4-11H,1-3H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428699
PNG
(CHEMBL2333117 | US9884828, 2-129)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1cnn(C)c1)C(N)=O
Show InChI InChI=1S/C16H18N6O/c1-9(2)19-14-12-6-10(11-7-18-22(3)8-11)4-5-13(12)20-21-15(14)16(17)23/h4-9H,1-3H3,(H2,17,23)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282610
PNG
(US9884828, 2-105)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1cncc2ccccc12)C(N)=O)C1CC1
Show InChI InChI=1S/C23H21N5O/c1-13(14-6-7-14)26-21-18-9-8-15(10-20(18)27-28-22(21)23(24)29)19-12-25-11-16-4-2-3-5-17(16)19/h2-5,8-14H,6-7H2,1H3,(H2,24,29)(H,26,27)/t13-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428694
PNG
(CHEMBL2333122 | US9884828, 12-227)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1NC(C)C)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H22N4O3S/c1-12(2)22-18-16-10-7-14(11-17(16)23-24-19(18)20(25)21-3)13-5-8-15(9-6-13)28(4,26)27/h5-12H,1-4H3,(H,21,25)(H,22,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282664
PNG
(US9884828, 8-200)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1nc[nH]n1
Show InChI InChI=1S/C20H20N6O2S/c1-12(2)23-18-16-9-6-14(13-4-7-15(8-5-13)29(3,27)28)10-17(16)24-25-19(18)20-21-11-22-26-20/h4-12H,1-3H3,(H,23,24)(H,21,22,26)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282593
PNG
(US9884828, 2-88)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC34CC5CC(CC(C5)C3)C4)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C26H28N4O3S/c1-34(32,33)20-5-2-18(3-6-20)19-4-7-21-22(11-19)29-30-24(25(27)31)23(21)28-26-12-15-8-16(13-26)10-17(9-15)14-26/h2-7,11,15-17H,8-10,12-14H2,1H3,(H2,27,31)(H,28,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282628
PNG
(US9884828, 2-123)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccccc1S(C)(=O)=O)C(N)=O)C1CC1
Show InChI InChI=1S/C21H22N4O3S/c1-12(13-7-8-13)23-19-16-10-9-14(11-17(16)24-25-20(19)21(22)26)15-5-3-4-6-18(15)29(2,27)28/h3-6,9-13H,7-8H2,1-2H3,(H2,22,26)(H,23,24)/t12-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282622
PNG
(US9884828, 2-117)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccccc1Cl)C(N)=O)C1CC1
Show InChI InChI=1S/C20H19ClN4O/c1-11(12-6-7-12)23-18-15-9-8-13(14-4-2-3-5-16(14)21)10-17(15)24-25-19(18)20(22)26/h2-5,8-12H,6-7H2,1H3,(H2,22,26)(H,23,24)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282669
PNG
(US9884828, 9-210)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ccc(cc1OC)N1CCOCC1=O
Show InChI InChI=1S/C32H33N5O5/c1-18(19-4-5-19)34-30-24-9-6-21(15-26(24)35-36-31(30)32(33)39)25-14-20(7-11-27(25)40-2)23-10-8-22(16-28(23)41-3)37-12-13-42-17-29(37)38/h6-11,14-16,18-19H,4-5,12-13,17H2,1-3H3,(H2,33,39)(H,34,35)/t18-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282651
PNG
(US9884828, 4-74)
Show SMILES CC(C)Nc1c(nnc2cc(Oc3ccccc3)ccc12)C(N)=O
Show InChI InChI=1S/C18H18N4O2/c1-11(2)20-16-14-9-8-13(24-12-6-4-3-5-7-12)10-15(14)21-22-17(16)18(19)23/h3-11H,1-2H3,(H2,19,23)(H,20,21)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282582
PNG
(US9884828, 2-38)
Show SMILES CC[C@@H](C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#N
Show InChI InChI=1S/C20H20N4O2S/c1-4-13(2)22-20-17-10-7-15(11-18(17)23-24-19(20)12-21)14-5-8-16(9-6-14)27(3,25)26/h5-11,13H,4H2,1-3H3,(H,22,23)/t13-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282585
PNG
(US9884828, 2-42)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#N)C1CC1
Show InChI InChI=1S/C21H20N4O2S/c1-13(14-3-4-14)23-21-18-10-7-16(11-19(18)24-25-20(21)12-22)15-5-8-17(9-6-15)28(2,26)27/h5-11,13-14H,3-4H2,1-2H3,(H,23,24)/t13-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282652
PNG
(US9884828, 4-76)
Show SMILES CC(C)Nc1c(nnc2cc(Sc3ccccc3)ccc12)C(N)=O
Show InChI InChI=1S/C18H18N4OS/c1-11(2)20-16-14-9-8-13(24-12-6-4-3-5-7-12)10-15(14)21-22-17(16)18(19)23/h3-11H,1-2H3,(H2,19,23)(H,20,21)
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n/an/a 560n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282635
PNG
(US9884828, 2-130)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1nccs1)C(N)=O
Show InChI InChI=1S/C15H15N5OS/c1-8(2)18-12-10-7-9(15-17-5-6-22-15)3-4-11(10)19-20-13(12)14(16)21/h3-8H,1-2H3,(H2,16,21)(H,18,19)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282603
PNG
(US9884828, 2-98)
Show SMILES COc1ccc(F)cc1-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H19FN4O2/c1-10(2)22-17-13-6-4-11(8-15(13)23-24-18(17)19(21)25)14-9-12(20)5-7-16(14)26-3/h4-10H,1-3H3,(H2,21,25)(H,22,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282571
PNG
(US9884828, 2-18)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#N
Show InChI InChI=1S/C19H18N4O2S/c1-12(2)21-19-16-9-6-14(10-17(16)22-23-18(19)11-20)13-4-7-15(8-5-13)26(3,24)25/h4-10,12H,1-3H3,(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282629
PNG
(US9884828, 2-124)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C18H18N4O/c1-11(2)20-16-14-10-13(12-6-4-3-5-7-12)8-9-15(14)21-22-17(16)18(19)23/h3-11H,1-2H3,(H2,19,23)(H,20,21)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282614
PNG
(US9884828, 2-109)
Show SMILES COc1ccc(Br)cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C21H21BrN4O2/c1-11(12-3-4-12)24-19-15-7-5-13(9-17(15)25-26-20(19)21(23)27)16-10-14(22)6-8-18(16)28-2/h5-12H,3-4H2,1-2H3,(H2,23,27)(H,24,25)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282637
PNG
(US9884828, 2-132)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)c1ccccc1
Show InChI InChI=1S/C22H19N5O/c1-14(15-5-3-2-4-6-15)25-20-18-8-7-17(16-9-11-24-12-10-16)13-19(18)26-27-21(20)22(23)28/h2-14H,1H3,(H2,23,28)(H,25,26)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282663
PNG
(US9884828, 7-198)
Show SMILES CC(C)Nc1c(nnc2cc(CCO)ccc12)C(N)=O
Show InChI InChI=1S/C14H18N4O2/c1-8(2)16-12-10-4-3-9(5-6-19)7-11(10)17-18-13(12)14(15)20/h3-4,7-8,19H,5-6H2,1-2H3,(H2,15,20)(H,16,17)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282645
PNG
(US9884828, 3-68)
Show SMILES CC(C)Nc1c(I)nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C18H18IN3O2S/c1-11(2)20-17-15-9-6-13(10-16(15)21-22-18(17)19)12-4-7-14(8-5-12)25(3,23)24/h4-11H,1-3H3,(H,20,21)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282671
PNG
(US9884828, 10-87)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#C
Show InChI InChI=1S/C20H19N3O2S/c1-5-18-20(21-13(2)3)17-11-8-15(12-19(17)23-22-18)14-6-9-16(10-7-14)26(4,24)25/h1,6-13H,2-4H3,(H,21,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428707
PNG
(CHEMBL2333137 | US9884828, 2-39)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)c1ccccc1
Show InChI InChI=1S/C24H22N4O3S/c1-15(16-6-4-3-5-7-16)26-22-20-13-10-18(14-21(20)27-28-23(22)24(25)29)17-8-11-19(12-9-17)32(2,30)31/h3-15H,1-2H3,(H2,25,29)(H,26,27)/t15-/m1/s1
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n/an/a 1.00E+3n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282676
PNG
(US9884828, 12-229)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1NC)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C18H18N4O3S/c1-19-16-14-9-6-12(10-15(14)21-22-17(16)18(23)20-2)11-4-7-13(8-5-11)26(3,24)25/h4-10H,1-3H3,(H,19,21)(H,20,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282638
PNG
(US9884828, 2-133)
Show SMILES C[C@H](Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)c1ccccc1
Show InChI InChI=1S/C22H19N5O/c1-14(15-5-3-2-4-6-15)25-20-18-8-7-17(16-9-11-24-12-10-16)13-19(18)26-27-21(20)22(23)28/h2-14H,1H3,(H2,23,28)(H,25,26)/t14-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282640
PNG
(US9884828, 2-135)
Show SMILES CC(Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)c1cccnc1
Show InChI InChI=1S/C21H18N6O/c1-13(16-3-2-8-24-12-16)25-19-17-5-4-15(14-6-9-23-10-7-14)11-18(17)26-27-20(19)21(22)28/h2-13H,1H3,(H2,22,28)(H,25,26)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282667
PNG
(US9884828, 9-208)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ccc(cc1OC)N1CCOC1=O
Show InChI InChI=1S/C31H31N5O5/c1-17(18-4-5-18)33-28-23-9-6-20(15-25(23)34-35-29(28)30(32)37)24-14-19(7-11-26(24)39-2)22-10-8-21(16-27(22)40-3)36-12-13-41-31(36)38/h6-11,14-18H,4-5,12-13H2,1-3H3,(H2,32,37)(H,33,34)/t17-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282659
PNG
(US9884828, 4-191)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C16H21N5O2/c1-10(2)18-14-12-9-11(21-5-7-23-8-6-21)3-4-13(12)19-20-15(14)16(17)22/h3-4,9-10H,5-8H2,1-2H3,(H2,17,22)(H,18,19)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282679
PNG
(US9884828, 14-235)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)C(C)=C
Show InChI InChI=1S/C18H22N4O/c1-10(2)13-7-8-14-15(9-13)21-22-17(18(23)19-4)16(14)20-11(3)12-5-6-12/h7-9,11-12H,1,5-6H2,2-4H3,(H,19,23)(H,20,21)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282649
PNG
(US9884828, 3-84)
Show SMILES CC(C)Nc1c(Cl)nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C18H18ClN3O2S/c1-11(2)20-17-15-9-6-13(10-16(15)21-22-18(17)19)12-4-7-14(8-5-12)25(3,23)24/h4-11H,1-3H3,(H,20,21)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282680
PNG
(US9884828, 14-236)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)C1CC1
Show InChI InChI=1S/C18H22N4O/c1-10(11-3-4-11)20-16-14-8-7-13(12-5-6-12)9-15(14)21-22-17(16)18(23)19-2/h7-12H,3-6H2,1-2H3,(H,19,23)(H,20,21)/t10-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282630
PNG
(US9884828, 2-125)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C19H20N4O3S/c1-11(2)21-17-15-10-13(6-9-16(15)22-23-18(17)19(20)24)12-4-7-14(8-5-12)27(3,25)26/h4-11H,1-3H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282569
PNG
(US9884828, 1-186)
Show SMILES CC(C)(C)c1ccc2nnc(C(N)=O)c(N)c2c1
Show InChI InChI=1S/C13H16N4O/c1-13(2,3)7-4-5-9-8(6-7)10(14)11(12(15)18)17-16-9/h4-6H,1-3H3,(H2,14,16)(H2,15,18)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282613
PNG
(US9884828, 2-108)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccccc1OC(F)(F)F)C(N)=O)C1CC1
Show InChI InChI=1S/C21H19F3N4O2/c1-11(12-6-7-12)26-18-15-9-8-13(10-16(15)27-28-19(18)20(25)29)14-4-2-3-5-17(14)30-21(22,23)24/h2-5,8-12H,6-7H2,1H3,(H2,25,29)(H,26,27)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282643
PNG
(US9884828, 2-203)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ccc(Br)cc1OC
Show InChI InChI=1S/C28H27BrN4O3/c1-15(16-4-5-16)31-26-21-9-6-18(13-23(21)32-33-27(26)28(30)34)22-12-17(7-11-24(22)35-2)20-10-8-19(29)14-25(20)36-3/h6-16H,4-5H2,1-3H3,(H2,30,34)(H,31,32)/t15-/m1/s1
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n/an/a 8.70E+3n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282644
PNG
(US9884828, 2-243)
Show SMILES CCC(C)Sc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C20H21N3O3S2/c1-4-12(2)27-19-16-10-7-14(11-17(16)22-23-18(19)20(21)24)13-5-8-15(9-6-13)28(3,25)26/h5-12H,4H2,1-3H3,(H2,21,24)
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n/an/a 1.20E+4n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282648
PNG
(US9884828, 3-72)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1cccnc1
Show InChI InChI=1S/C23H22N4O2S/c1-15(2)25-23-20-11-8-17(16-6-9-19(10-7-16)30(3,28)29)13-21(20)26-27-22(23)18-5-4-12-24-14-18/h4-15H,1-3H3,(H,25,26)
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n/an/a 1.30E+4n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282662
PNG
(US9884828, 6-83)
Show SMILES CC(C)Nc1c(C)nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C19H21N3O2S/c1-12(2)20-19-13(3)21-22-18-11-15(7-10-17(18)19)14-5-8-16(9-6-14)25(4,23)24/h5-12H,1-4H3,(H,20,22)
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n/an/a 2.16E+4n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282568
PNG
(US9884828, 1-9)
Show SMILES NC(=O)c1nnc2cc(ccc2c1N)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C19H19N5O2/c20-17-15-6-3-13(11-16(15)22-23-18(17)19(21)25)12-1-4-14(5-2-12)24-7-9-26-10-8-24/h1-6,11H,7-10H2,(H2,20,22)(H2,21,25)
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n/an/a 2.97E+4n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282646
PNG
(US9884828, 3-70)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1cscn1
Show InChI InChI=1S/C21H20N4O2S2/c1-13(2)23-20-17-9-6-15(14-4-7-16(8-5-14)29(3,26)27)10-18(17)24-25-21(20)19-11-28-12-22-19/h4-13H,1-3H3,(H,23,24)
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n/an/a>1.00E+5n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282647
PNG
(US9884828, 3-71)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1ncco1
Show InChI InChI=1S/C21H20N4O3S/c1-13(2)23-19-17-9-6-15(14-4-7-16(8-5-14)29(3,26)27)12-18(17)24-25-20(19)21-22-10-11-28-21/h4-13H,1-3H3,(H,23,24)
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n/an/a>1.00E+5n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%