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PubChem AID 2654

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65928
PNG
(1-(3-chlorophenyl)-3-(3-pyridinyl)urea | 1-(3-chlo...)
Show SMILES Clc1cccc(NC(=O)Nc2cccnc2)c1
Show InChI InChI=1S/C12H10ClN3O/c13-9-3-1-4-10(7-9)15-12(17)16-11-5-2-6-14-8-11/h1-8H,(H2,15,16,17)
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n/an/an/an/a 1.83E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65949
PNG
(1-(6-bromanylpyridin-3-yl)-3-(3-fluorophenyl)urea ...)
Show SMILES Fc1cccc(NC(=O)Nc2ccc(Br)nc2)c1
Show InChI InChI=1S/C12H9BrFN3O/c13-11-5-4-10(7-15-11)17-12(18)16-9-3-1-2-8(14)6-9/h1-7H,(H2,16,17,18)
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n/an/an/an/a 4.04E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65941
PNG
(1-(3,5-dimethylphenyl)-3-(3-pyridinyl)urea | 1-(3,...)
Show SMILES Cc1cc(C)cc(NC(=O)Nc2cccnc2)c1
Show InChI InChI=1S/C14H15N3O/c1-10-6-11(2)8-13(7-10)17-14(18)16-12-4-3-5-15-9-12/h3-9H,1-2H3,(H2,16,17,18)
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n/an/an/an/a 1.07E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65942
PNG
(1-(3-methylphenyl)-3-(3-pyridinyl)urea | 1-(3-meth...)
Show SMILES Cc1cccc(NC(=O)Nc2cccnc2)c1
Show InChI InChI=1S/C13H13N3O/c1-10-4-2-5-11(8-10)15-13(17)16-12-6-3-7-14-9-12/h2-9H,1H3,(H2,15,16,17)
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n/an/an/an/a 1.68E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65946
PNG
(1-(3-fluorophenyl)-3-(6-fluoro-3-pyridinyl)urea | ...)
Show SMILES Fc1cccc(NC(=O)Nc2ccc(F)nc2)c1
Show InChI InChI=1S/C12H9F2N3O/c13-8-2-1-3-9(6-8)16-12(18)17-10-4-5-11(14)15-7-10/h1-7H,(H2,16,17,18)
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n/an/an/an/a 5.76E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65947
PNG
(1-(6-chloranylpyridin-3-yl)-3-(3-fluorophenyl)urea...)
Show SMILES Fc1cccc(NC(=O)Nc2ccc(Cl)nc2)c1
Show InChI InChI=1S/C12H9ClFN3O/c13-11-5-4-10(7-15-11)17-12(18)16-9-3-1-2-8(14)6-9/h1-7H,(H2,16,17,18)
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n/an/an/an/a 2.81E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65933
PNG
(1-(4-anilinophenyl)-3-(3-pyridinyl)thiourea | 1-(4...)
Show SMILES S=C(Nc1ccc(Nc2ccccc2)cc1)Nc1cccnc1
Show InChI InChI=1S/C18H16N4S/c23-18(22-17-7-4-12-19-13-17)21-16-10-8-15(9-11-16)20-14-5-2-1-3-6-14/h1-13,20H,(H2,21,22,23)
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n/an/an/an/a 1.10E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65937
PNG
(1-(2,3-dimethylphenyl)-3-(3-pyridinyl)urea | 1-(2,...)
Show SMILES Cc1cccc(NC(=O)Nc2cccnc2)c1C
Show InChI InChI=1S/C14H15N3O/c1-10-5-3-7-13(11(10)2)17-14(18)16-12-6-4-8-15-9-12/h3-9H,1-2H3,(H2,16,17,18)
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n/an/an/an/a 1.60E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65945
PNG
(1-(2,4-dichlorobenzyl)-3-(5-fluoro-3-pyridyl)urea;...)
Show SMILES Fc1cncc(NC(=O)NCc2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C13H10Cl2FN3O/c14-9-2-1-8(12(15)3-9)5-18-13(20)19-11-4-10(16)6-17-7-11/h1-4,6-7H,5H2,(H2,18,19,20)
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n/an/an/an/a 8.64E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65950
PNG
(1-(3-fluorophenyl)-3-(5-methyl-3-pyridinyl)urea;2,...)
Show SMILES Cc1cncc(NC(=O)Nc2cccc(F)c2)c1
Show InChI InChI=1S/C13H12FN3O/c1-9-5-12(8-15-7-9)17-13(18)16-11-4-2-3-10(14)6-11/h2-8H,1H3,(H2,16,17,18)
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n/an/an/an/a 1.24E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65925
PNG
(1-(4-methylphenyl)-3-(3-pyridinyl)urea | 1-(4-meth...)
Show SMILES Cc1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C13H13N3O/c1-10-4-6-11(7-5-10)15-13(17)16-12-3-2-8-14-9-12/h2-9H,1H3,(H2,15,16,17)
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n/an/an/an/a 1.28E+5n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65930
PNG
(1-(1,3-benzodioxol-5-yl)-3-(3-pyridinyl)urea | 1-(...)
Show SMILES O=C(Nc1cccnc1)Nc1ccc2OCOc2c1
Show InChI InChI=1S/C13H11N3O3/c17-13(16-10-2-1-5-14-7-10)15-9-3-4-11-12(6-9)19-8-18-11/h1-7H,8H2,(H2,15,16,17)
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n/an/an/an/a 1.52E+5n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65932
PNG
(1-(4-butylphenyl)-3-(3-pyridinyl)thiourea | 1-(4-b...)
Show SMILES CCCCc1ccc(NC(=S)Nc2cccnc2)cc1
Show InChI InChI=1S/C16H19N3S/c1-2-3-5-13-7-9-14(10-8-13)18-16(20)19-15-6-4-11-17-12-15/h4,6-12H,2-3,5H2,1H3,(H2,18,19,20)
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n/an/an/an/a 2.68E+5n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65922
PNG
(1-(2,4-dichlorobenzyl)-3-phenyl-urea | 1-[(2,4-dic...)
Show SMILES Clc1ccc(CNC(=O)Nc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C14H12Cl2N2O/c15-11-7-6-10(13(16)8-11)9-17-14(19)18-12-4-2-1-3-5-12/h1-8H,9H2,(H2,17,18,19)
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n/an/an/an/a 2.22E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65931
PNG
(1-(3-chloranyl-4-fluoranyl-phenyl)-3-pyridin-3-yl-...)
Show SMILES Fc1ccc(NC(=O)Nc2cccnc2)cc1Cl
Show InChI InChI=1S/C12H9ClFN3O/c13-10-6-8(3-4-11(10)14)16-12(18)17-9-2-1-5-15-7-9/h1-7H,(H2,16,17,18)
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n/an/an/an/a 4.21E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65939
PNG
(1-(4-ethoxyphenyl)-3-(3-pyridinyl)urea | 1-(4-etho...)
Show SMILES CCOc1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C14H15N3O2/c1-2-19-13-7-5-11(6-8-13)16-14(18)17-12-4-3-9-15-10-12/h3-10H,2H2,1H3,(H2,16,17,18)
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n/an/an/an/a 1.43E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65948
PNG
(1-(6-bromanyl-5-methyl-pyridin-3-yl)-3-(3-fluoroph...)
Show SMILES Cc1cc(NC(=O)Nc2cccc(F)c2)cnc1Br
Show InChI InChI=1S/C13H11BrFN3O/c1-8-5-11(7-16-12(8)14)18-13(19)17-10-4-2-3-9(15)6-10/h2-7H,1H3,(H2,17,18,19)
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n/an/an/an/a 6.61E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65924
PNG
(1-(4-methoxyphenyl)-3-(3-pyridinyl)urea | 1-(4-met...)
Show SMILES COc1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C13H13N3O2/c1-18-12-6-4-10(5-7-12)15-13(17)16-11-3-2-8-14-9-11/h2-9H,1H3,(H2,15,16,17)
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n/an/an/an/a 2.03E+5n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65929
PNG
(1-(3-fluorophenyl)-3-(3-pyridinyl)thiourea | 1-(3-...)
Show SMILES Fc1cccc(NC(=S)Nc2cccnc2)c1
Show InChI InChI=1S/C12H10FN3S/c13-9-3-1-4-10(7-9)15-12(17)16-11-5-2-6-14-8-11/h1-8H,(H2,15,16,17)
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n/an/an/an/a 4.19E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65886
PNG
(1-(4-phenoxyphenyl)-3-(3-pyridinyl)thiourea | 1-(4...)
Show SMILES S=C(Nc1ccc(Oc2ccccc2)cc1)Nc1cccnc1
Show InChI InChI=1S/C18H15N3OS/c23-18(21-15-5-4-12-19-13-15)20-14-8-10-17(11-9-14)22-16-6-2-1-3-7-16/h1-13H,(H2,20,21,23)
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n/an/an/an/a 4.45E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65936
PNG
(1-(3-pyridyl)-3-(4-sec-butylphenyl)thiourea | 1-(4...)
Show SMILES CCC(C)c1ccc(NC(=S)Nc2cccnc2)cc1
Show InChI InChI=1S/C16H19N3S/c1-3-12(2)13-6-8-14(9-7-13)18-16(20)19-15-5-4-10-17-11-15/h4-12H,3H2,1-2H3,(H2,18,19,20)
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n/an/an/an/a 1.26E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65923
PNG
(1-(3-Fluoro-phenyl)-3-pyridin-3-yl-urea | 1-(3-flu...)
Show SMILES Fc1cccc(NC(=O)Nc2cccnc2)c1
Show InChI InChI=1S/C12H10FN3O/c13-9-3-1-4-10(7-9)15-12(17)16-11-5-2-6-14-8-11/h1-8H,(H2,15,16,17)
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n/an/an/an/a 6.28E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65926
PNG
(1-(4-chlorophenyl)-3-(3-pyridinyl)urea | 1-(4-chlo...)
Show SMILES Clc1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C12H10ClN3O/c13-9-3-5-10(6-4-9)15-12(17)16-11-2-1-7-14-8-11/h1-8H,(H2,15,16,17)
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n/an/an/an/a 6.85E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65927
PNG
(1-phenyl-3-(3-pyridinyl)urea | 1-phenyl-3-(3-pyrid...)
Show SMILES O=C(Nc1ccccc1)Nc1cccnc1
Show InChI InChI=1S/C12H11N3O/c16-12(14-10-5-2-1-3-6-10)15-11-7-4-8-13-9-11/h1-9H,(H2,14,15,16)
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n/an/an/an/a 2.18E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65951
PNG
(1-(3-fluorophenyl)-3-(5-fluoro-3-pyridinyl)urea;2,...)
Show SMILES Fc1cccc(NC(=O)Nc2cncc(F)c2)c1
Show InChI InChI=1S/C12H9F2N3O/c13-8-2-1-3-10(4-8)16-12(18)17-11-5-9(14)6-15-7-11/h1-7H,(H2,16,17,18)
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n/an/an/an/a 6.32E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65934
PNG
(1-(3-fluoranyl-4-methyl-phenyl)-3-pyridin-3-yl-ure...)
Show SMILES Cc1ccc(NC(=O)Nc2cccnc2)cc1F
Show InChI InChI=1S/C13H12FN3O/c1-9-4-5-10(7-12(9)14)16-13(18)17-11-3-2-6-15-8-11/h2-8H,1H3,(H2,16,17,18)
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n/an/an/an/a 9.14E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65938
PNG
(1-(4-butylphenyl)-3-(3-pyridinyl)urea | 1-(4-butyl...)
Show SMILES CCCCc1ccc(NC(=O)Nc2cccnc2)cc1
Show InChI InChI=1S/C16H19N3O/c1-2-3-5-13-7-9-14(10-8-13)18-16(20)19-15-6-4-11-17-12-15/h4,6-12H,2-3,5H2,1H3,(H2,18,19,20)
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n/an/an/an/a 1.37E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65940
PNG
(1-(3,4-dimethylphenyl)-3-(3-pyridinyl)urea | 1-(3,...)
Show SMILES Cc1ccc(NC(=O)Nc2cccnc2)cc1C
Show InChI InChI=1S/C14H15N3O/c1-10-5-6-12(8-11(10)2)16-14(18)17-13-4-3-7-15-9-13/h3-9H,1-2H3,(H2,16,17,18)
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n/an/an/an/a 1.35E+4n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65943
PNG
(1-(2,4-dichlorobenzyl)-3-(6-fluoro-3-pyridyl)urea ...)
Show SMILES Fc1ccc(NC(=O)NCc2ccc(Cl)cc2Cl)cn1
Show InChI InChI=1S/C13H10Cl2FN3O/c14-9-2-1-8(11(15)5-9)6-18-13(20)19-10-3-4-12(16)17-7-10/h1-5,7H,6H2,(H2,18,19,20)
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n/an/an/an/a 6.31E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65944
PNG
(1-(6-chloranylpyridin-3-yl)-3-[(2,4-dichlorophenyl...)
Show SMILES Clc1ccc(CNC(=O)Nc2ccc(Cl)nc2)c(Cl)c1
Show InChI InChI=1S/C13H10Cl3N3O/c14-9-2-1-8(11(15)5-9)6-18-13(20)19-10-3-4-12(16)17-7-10/h1-5,7H,6H2,(H2,18,19,20)
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n/an/an/an/a 3.74E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2


(Rattus norvegicus)
BDBM65935
PNG
(1-(3-chlorophenyl)-3-(3-pyridinyl)thiourea | 1-(3-...)
Show SMILES Clc1cccc(NC(=S)Nc2cccnc2)c1
Show InChI InChI=1S/C12H10ClN3S/c13-9-3-1-4-10(7-9)15-12(17)16-11-5-2-6-14-8-11/h1-8H,(H2,15,16,17)
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n/an/an/an/a 9.33E+3n/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
Name: Dose response of Retigabine-insensitive compounds that potentiate KCNQ2 potassium channel BioAssay Type: Confirmatory, Concentration-Response R...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2KP80KF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%