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PubChem AID 434954

Compile Data Set for Download or QSAR

Found 2198 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68342
PNG
(5,5-Dimethyl-3-(pyridin-2-ylamino)-cyclohex-2-enon...)
Show SMILES CC1(C)CC(=O)C=C(C1)Nc1ccccn1
Show InChI InChI=1S/C13H16N2O/c1-13(2)8-10(7-11(16)9-13)15-12-5-3-4-6-14-12/h3-7H,8-9H2,1-2H3,(H,14,15)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68343
PNG
(1-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-2-(5-pyrid...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)Cn1nnc(n1)-c1ccncc1
Show InChI InChI=1S/C19H21N7O2/c1-28-17-5-3-2-4-16(17)24-10-12-25(13-11-24)18(27)14-26-22-19(21-23-26)15-6-8-20-9-7-15/h2-9H,10-14H2,1H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68352
PNG
((4-Dimethylaminomethyl-5-hydroxy-benzofuran-3-yl)-...)
Show SMILES COc1ccc2occ(C(=O)c3coc4ccc(O)c(CN(C)C)c34)c2c1
Show InChI InChI=1S/C21H19NO5/c1-22(2)9-14-17(23)5-7-19-20(14)16(11-27-19)21(24)15-10-26-18-6-4-12(25-3)8-13(15)18/h4-8,10-11,23H,9H2,1-3H3
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n/an/an/an/a 1.99E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68354
PNG
(3-methoxy-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)b...)
Show SMILES COc1cccc(c1)C(=O)Nc1nnc(s1)C(C)C
Show InChI InChI=1S/C13H15N3O2S/c1-8(2)12-15-16-13(19-12)14-11(17)9-5-4-6-10(7-9)18-3/h4-8H,1-3H3,(H,14,16,17)
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM38798
PNG
(3-piperidin-1-ylpropyl 4-hydroxybenzoate | 3-piper...)
Show SMILES Oc1ccc(cc1)C(=O)OCCCN1CCCCC1
Show InChI InChI=1S/C15H21NO3/c17-14-7-5-13(6-8-14)15(18)19-12-4-11-16-9-2-1-3-10-16/h5-8,17H,1-4,9-12H2
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68367
PNG
(5-(2-thienyl)-3,4,6,7,8,9-hexahydrobenzothiopheno[...)
Show SMILES O=C1CN=C(c2cccs2)c2c3CCCCc3sc2N1
Show InChI InChI=1S/C15H14N2OS2/c18-12-8-16-14(11-6-3-7-19-11)13-9-4-1-2-5-10(9)20-15(13)17-12/h3,6-7H,1-2,4-5,8H2,(H,17,18)
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n/an/an/an/a 3.09E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68370
PNG
(2-(4-Fluoro-phenyl)-5-(3-methoxy-benzylsulfanyl)-[...)
Show SMILES COc1cccc(CSc2nnc(o2)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C16H13FN2O2S/c1-20-14-4-2-3-11(9-14)10-22-16-19-18-15(21-16)12-5-7-13(17)8-6-12/h2-9H,10H2,1H3
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n/an/an/an/a 2.25E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68377
PNG
(5-Bromo-3-dimethylaminomethyl-1,2-dimethyl-1H-inde...)
Show SMILES CN(C)Cc1c(C)n(C)c2C(=O)c3ccc(Br)cc3-c12
Show InChI InChI=1S/C16H17BrN2O/c1-9-13(8-18(2)3)14-12-7-10(17)5-6-11(12)16(20)15(14)19(9)4/h5-7H,8H2,1-4H3
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n/an/an/an/a 1.78E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68386
PNG
(2,2-Dimethyl-6-(morpholine-4-carbonyl)-4-(2-morpho...)
Show SMILES CC1(C)Oc2ccc(cc2N(CC(=O)N2CCOCC2)C1=O)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H27N3O6/c1-21(2)20(27)24(14-18(25)22-5-9-28-10-6-22)16-13-15(3-4-17(16)30-21)19(26)23-7-11-29-12-8-23/h3-4,13H,5-12,14H2,1-2H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68400
PNG
(3-cyclohexyl-5H-pyrimid[5,4-b]indol-4-one | 3-cycl...)
Show SMILES O=c1n(cnc2c3ccccc3[nH]c12)C1CCCCC1
Show InChI InChI=1S/C16H17N3O/c20-16-15-14(12-8-4-5-9-13(12)18-15)17-10-19(16)11-6-2-1-3-7-11/h4-5,8-11,18H,1-3,6-7H2
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68405
PNG
(MLS000030539 | SMR000036328 | cid_659223)
Show SMILES CC1CCc2c(C1)sc1c2c(=O)n(-c2ccccc2)c2nnc(C)n12
Show InChI InChI=1S/C19H18N4OS/c1-11-8-9-14-15(10-11)25-18-16(14)17(24)23(13-6-4-3-5-7-13)19-21-20-12(2)22(18)19/h3-7,11H,8-10H2,1-2H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68408
PNG
(2-[(N'-allyl-N-cyano-amidino)thio]-N-tert-butyl-ac...)
Show SMILES CC(C)(C)NC(=O)CSC(NC#N)=NCC=C
Show InChI InChI=1S/C11H18N4OS/c1-5-6-13-10(14-8-12)17-7-9(16)15-11(2,3)4/h5H,1,6-7H2,2-4H3,(H,13,14)(H,15,16)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68409
PNG
(2-(3-cyano-6-pyridin-3-yl-pyridin-2-yl)sulfanyl-N-...)
Show SMILES Cc1cc(NC(=O)CSc2nc(ccc2C#N)-c2cccnc2)no1
Show InChI InChI=1S/C17H13N5O2S/c1-11-7-15(22-24-11)21-16(23)10-25-17-12(8-18)4-5-14(20-17)13-3-2-6-19-9-13/h2-7,9H,10H2,1H3,(H,21,22,23)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM62600
PNG
(MLS000081583 | SMR000042939 | cid_662290)
Show SMILES CN1CCc2c(C1)sc1c2c(=O)n(-c2ccc(Cl)cc2)c2nncn12
Show InChI InChI=1S/C17H14ClN5OS/c1-21-7-6-12-13(8-21)25-16-14(12)15(24)23(17-20-19-9-22(16)17)11-4-2-10(18)3-5-11/h2-5,9H,6-8H2,1H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68415
PNG
(2-amino-6-(3-pyridinyl)-4-thiophen-2-yl-3-pyridine...)
Show SMILES Nc1nc(cc(-c2cccs2)c1C#N)-c1cccnc1
Show InChI InChI=1S/C15H10N4S/c16-8-12-11(14-4-2-6-20-14)7-13(19-15(12)17)10-3-1-5-18-9-10/h1-7,9H,(H2,17,19)
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n/an/an/an/a 1.04E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68423
PNG
(5-(4-bromophenyl)-4-(3-ethoxy-4-hydroxy-phenyl)-3-...)
Show SMILES CCOc1cc(ccc1O)C1N(C(=O)c2n[nH]c(C)c12)c1ccc(Br)cc1
Show InChI InChI=1S/C20H18BrN3O3/c1-3-27-16-10-12(4-9-15(16)25)19-17-11(2)22-23-18(17)20(26)24(19)14-7-5-13(21)6-8-14/h4-10,19,25H,3H2,1-2H3,(H,22,23)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68425
PNG
(2-(ethylthio)-7-methyl-6,8-dihydro-5H-pyrido[4,5]t...)
Show SMILES CCSc1nc(N)c2c3CCN(C)Cc3sc2n1
Show InChI InChI=1S/C12H16N4S2/c1-3-17-12-14-10(13)9-7-4-5-16(2)6-8(7)18-11(9)15-12/h3-6H2,1-2H3,(H2,13,14,15)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68427
PNG
(1-[(7-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrid...)
Show SMILES CCC(O)CNc1nc(SC)nc2sc3CN(C)CCc3c12
Show InChI InChI=1S/C15H22N4OS2/c1-4-9(20)7-16-13-12-10-5-6-19(2)8-11(10)22-14(12)18-15(17-13)21-3/h9,20H,4-8H2,1-3H3,(H,16,17,18)
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n/an/an/an/a 1.75E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68428
PNG
(2-(4-methoxyphenyl)-3-(3-methoxypropyl)imidazo[4,5...)
Show SMILES COCCCn1c(nc2nc3ccccc3nc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C20H20N4O2/c1-25-13-5-12-24-19(14-8-10-15(26-2)11-9-14)23-18-20(24)22-17-7-4-3-6-16(17)21-18/h3-4,6-11H,5,12-13H2,1-2H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68457
PNG
(MLS000058733 | N-(3,5-dichloro-6-methyl-2-pyridiny...)
Show SMILES COCCn1c(SCC(=O)Nc2nc(C)c(Cl)cc2Cl)nc2ccccc12
Show InChI InChI=1S/C18H18Cl2N4O2S/c1-11-12(19)9-13(20)17(21-11)23-16(25)10-27-18-22-14-5-3-4-6-15(14)24(18)7-8-26-2/h3-6,9H,7-8,10H2,1-2H3,(H,21,23,25)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68458
PNG
(MLS000054999 | SMR000065806 | [3,4-dihydroxy-5-(5-...)
Show SMILES Cc1cn(C2OC(COC(=O)c3ccccc3)C(O)C2O)c(=O)[nH]c1=O
Show InChI InChI=1S/C17H18N2O7/c1-9-7-19(17(24)18-14(9)22)15-13(21)12(20)11(26-15)8-25-16(23)10-5-3-2-4-6-10/h2-7,11-13,15,20-21H,8H2,1H3,(H,18,22,24)
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n/an/an/an/a 1.92E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68460
PNG
((3,3-dimethyl-2-oxidanylidene-butyl) 4-oxidanylben...)
Show SMILES CC(C)(C)C(=O)COC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C13H16O4/c1-13(2,3)11(15)8-17-12(16)9-4-6-10(14)7-5-9/h4-7,14H,8H2,1-3H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68464
PNG
(3-imidazol-1-ylpropyl-(2-methylquinazolin-4-yl)ami...)
Show SMILES Cc1nc(NCCCn2ccnc2)c2ccccc2n1
Show InChI InChI=1S/C15H17N5/c1-12-18-14-6-3-2-5-13(14)15(19-12)17-7-4-9-20-10-8-16-11-20/h2-3,5-6,8,10-11H,4,7,9H2,1H3,(H,17,18,19)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


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Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68465
PNG
(1-[3-(3,4-dimethoxyphenyl)-1-phenyl-4-pyrazolyl]-N...)
Show SMILES COc1ccc(cc1OC)-c1nn(cc1C=Nn1cnnc1)-c1ccccc1
Show InChI InChI=1S/C20H18N6O2/c1-27-18-9-8-15(10-19(18)28-2)20-16(11-23-25-13-21-22-14-25)12-26(24-20)17-6-4-3-5-7-17/h3-14H,1-2H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


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Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68467
PNG
(MLS000054097 | SMR000061511 | cid_5742531 | ethano...)
Show SMILES Cc1nn(c2N=C3CCCC(=O)C3C(c3ccsc3)c12)-c1ccccn1
Show InChI InChI=1S/C20H18N4OS/c1-12-17-18(13-8-10-26-11-13)19-14(5-4-6-15(19)25)22-20(17)24(23-12)16-7-2-3-9-21-16/h2-3,7-11,18-19H,4-6H2,1H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


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Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM48132
PNG
(MLS000055504 | N-(3-imidazol-1-ylpropyl)-2-[(2,3,5...)
Show SMILES Cc1cc(C)c(C)c(c1C)S(=O)(=O)Nc1ccccc1C(=O)NCCCn1ccnc1
Show InChI InChI=1S/C23H28N4O3S/c1-16-14-17(2)19(4)22(18(16)3)31(29,30)26-21-9-6-5-8-20(21)23(28)25-10-7-12-27-13-11-24-15-27/h5-6,8-9,11,13-15,26H,7,10,12H2,1-4H3,(H,25,28)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM38084
PNG
(MLS000089904 | N,N-dimethyl-4-(1-methyl-2-benzimid...)
Show SMILES CN(C)c1ccc(cc1)-c1nc2ccccc2n1C
Show InChI InChI=1S/C16H17N3/c1-18(2)13-10-8-12(9-11-13)16-17-14-6-4-5-7-15(14)19(16)3/h4-11H,1-3H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


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Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM37897
PNG
(1-(4-amino-1,2,5-oxadiazol-3-yl)-5-thiophen-2-yl-4...)
Show SMILES COC(=O)c1nnn(-c2nonc2N)c1-c1cccs1
Show InChI InChI=1S/C10H8N6O3S/c1-18-10(17)6-7(5-3-2-4-20-5)16(15-12-6)9-8(11)13-19-14-9/h2-4H,1H3,(H2,11,13)
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n/an/an/an/a 2.62E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM32334
PNG
(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Show SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1
Show InChI InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15)
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n/an/an/an/a 2.07E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM48565
PNG
(6-(ethylthio)-3-(3-fluorophenyl)-[1,2,4]triazolo[4...)
Show SMILES CCSc1ccc2nnc(-c3cccc(F)c3)n2n1
Show InChI InChI=1S/C13H11FN4S/c1-2-19-12-7-6-11-15-16-13(18(11)17-12)9-4-3-5-10(14)8-9/h3-8H,2H2,1H3
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n/an/an/an/a 1.87E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68485
PNG
(5-(2-methyl-1-piperidinyl)-1,3,4-thiadiazol-2-amin...)
Show SMILES CC1CCCCN1c1nnc(N)s1
Show InChI InChI=1S/C8H14N4S/c1-6-4-2-3-5-12(6)8-11-10-7(9)13-8/h6H,2-5H2,1H3,(H2,9,10)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68487
PNG
(1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(4-ethoxyphenyl...)
Show SMILES CCOC(=O)c1nnn(-c2nonc2N)c1-c1ccc(OCC)cc1
Show InChI InChI=1S/C15H16N6O4/c1-3-23-10-7-5-9(6-8-10)12-11(15(22)24-4-2)17-20-21(12)14-13(16)18-25-19-14/h5-8H,3-4H2,1-2H3,(H2,16,18)
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n/an/an/an/a 2.00E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68488
PNG
(7-(5-bromo-2-fluoro-phenyl)-5-methyl-1,7-dihydro-[...)
Show SMILES CCOC(=O)C1C(c2cc(Br)ccc2F)n2ncnc2N=C1C
Show InChI InChI=1S/C15H14BrFN4O2/c1-3-23-14(22)12-8(2)20-15-18-7-19-21(15)13(12)10-6-9(16)4-5-11(10)17/h4-7,12-13H,3H2,1-2H3
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n/an/an/an/a 2.40E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68489
PNG
(4-[5-bromo-1-(cyclopropanecarbonyl)indolin-7-yl]su...)
Show SMILES CCOC(=O)N1CCN(CC1)S(=O)(=O)c1cc(Br)cc2CCN(C(=O)C3CC3)c12
Show InChI InChI=1S/C19H24BrN3O5S/c1-2-28-19(25)21-7-9-22(10-8-21)29(26,27)16-12-15(20)11-14-5-6-23(17(14)16)18(24)13-3-4-13/h11-13H,2-10H2,1H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68497
PNG
(1-benzyl-5-(4-hydroxy-3-methoxy-phenyl)-8,8-dimeth...)
Show SMILES COc1cc(ccc1O)C1C2C(=O)CC(C)(C)CC2=Nc2c1c(=O)[nH]c(=O)n2Cc1ccccc1
Show InChI InChI=1S/C27H27N3O5/c1-27(2)12-17-22(19(32)13-27)21(16-9-10-18(31)20(11-16)35-3)23-24(28-17)30(26(34)29-25(23)33)14-15-7-5-4-6-8-15/h4-11,21-22,31H,12-14H2,1-3H3,(H,29,33,34)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68500
PNG
(6-ethoxy-4-(4-methyl-1-piperazinyl)-3-quinolinecar...)
Show SMILES CCOC(=O)c1cnc2ccc(OCC)cc2c1N1CCN(C)CC1
Show InChI InChI=1S/C19H25N3O3/c1-4-24-14-6-7-17-15(12-14)18(22-10-8-21(3)9-11-22)16(13-20-17)19(23)25-5-2/h6-7,12-13H,4-5,8-11H2,1-3H3
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n/an/an/an/a 4.95E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68509
PNG
(MLS000087405 | N-[1-(3,4-dichlorobenzyl)-3,5-dimet...)
Show SMILES Cc1nn(Cc2ccc(Cl)c(Cl)c2)c(C)c1NC(=O)c1noc2CCCCCc12
Show InChI InChI=1S/C21H22Cl2N4O2/c1-12-19(13(2)27(25-12)11-14-8-9-16(22)17(23)10-14)24-21(28)20-15-6-4-3-5-7-18(15)29-26-20/h8-10H,3-7,11H2,1-2H3,(H,24,28)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

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Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68514
PNG
((4-ethyl-1-piperazinyl)-(6-methoxy-2-thieno[2,3-b]...)
Show SMILES CCN1CCN(CC1)C(=O)c1cc2cc3cc(OC)ccc3nc2s1
Show InChI InChI=1S/C19H21N3O2S/c1-3-21-6-8-22(9-7-21)19(23)17-12-14-10-13-11-15(24-2)4-5-16(13)20-18(14)25-17/h4-5,10-12H,3,6-9H2,1-2H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68519
PNG
(1-[2-(3-methoxyanilino)-2-oxoethyl]triazole-4,5-di...)
Show SMILES CCOC(=O)c1nnn(CC(=O)Nc2cccc(OC)c2)c1C(=O)OCC
Show InChI InChI=1S/C17H20N4O6/c1-4-26-16(23)14-15(17(24)27-5-2)21(20-19-14)10-13(22)18-11-7-6-8-12(9-11)25-3/h6-9H,4-5,10H2,1-3H3,(H,18,22)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM48576
PNG
(2-[[3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyrid...)
Show SMILES CCOC(=O)C(C)Sc1ccc2nnc(-c3ccc(F)cc3)n2n1
Show InChI InChI=1S/C16H15FN4O2S/c1-3-23-16(22)10(2)24-14-9-8-13-18-19-15(21(13)20-14)11-4-6-12(17)7-5-11/h4-10H,3H2,1-2H3
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n/an/an/an/a 1.93E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68522
PNG
(8-methoxy-4-[4-(4-methoxyphenyl)-1-piperazinyl]-3-...)
Show SMILES CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(CC1)c1ccc(OC)cc1
Show InChI InChI=1S/C24H27N3O4/c1-4-31-24(28)20-16-25-22-19(6-5-7-21(22)30-3)23(20)27-14-12-26(13-15-27)17-8-10-18(29-2)11-9-17/h5-11,16H,4,12-15H2,1-3H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68526
PNG
(2,2'-bipyridine-3,3'-dicarboxylic acid | 2...)
Show SMILES OC(=O)c1cccnc1-c1ncccc1C(O)=O
Show InChI InChI=1S/C12H8N2O4/c15-11(16)7-3-1-5-13-9(7)10-8(12(17)18)4-2-6-14-10/h1-6H,(H,15,16)(H,17,18)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM39252
PNG
((phenylmethyl) 1-(4-azanyl-1,2,5-oxadiazol-3-yl)-5...)
Show SMILES Cc1c(nnn1-c1nonc1N)C(=O)OCc1ccccc1
Show InChI InChI=1S/C13H12N6O3/c1-8-10(13(20)21-7-9-5-3-2-4-6-9)15-18-19(8)12-11(14)16-22-17-12/h2-6H,7H2,1H3,(H2,14,16)
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n/an/an/an/a 7.34E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM42772
PNG
(MLS000064410 | N-(1,3-diketoisoindolin-4-yl)tetrah...)
Show SMILES O=C(Nc1cccc2C(=O)NC(=O)c12)C1CCCO1
Show InChI InChI=1S/C13H12N2O4/c16-11-7-3-1-4-8(10(7)13(18)15-11)14-12(17)9-5-2-6-19-9/h1,3-4,9H,2,5-6H2,(H,14,17)(H,15,16,18)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68541
PNG
(2-[(2-fluorobenzyl)thio]-5-phenyl-1,3,4-oxadiazole...)
Show SMILES Fc1ccccc1CSc1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C15H11FN2OS/c16-13-9-5-4-8-12(13)10-20-15-18-17-14(19-15)11-6-2-1-3-7-11/h1-9H,10H2
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM42784
PNG
(5-bromanyl-N-[2-(4-methylpiperazin-1-yl)phenyl]fur...)
Show SMILES CN1CCN(CC1)c1ccccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C16H18BrN3O2/c1-19-8-10-20(11-9-19)13-5-3-2-4-12(13)18-16(21)14-6-7-15(17)22-14/h2-7H,8-11H2,1H3,(H,18,21)
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n/an/an/an/a 1.93E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68554
PNG
(2-(ethylthio)-4-hydroxy-6-phenyl-5-pyrimidinecarbo...)
Show SMILES CCSc1nc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C13H11N3OS/c1-2-18-13-15-11(9-6-4-3-5-7-9)10(8-14)12(17)16-13/h3-7H,2H2,1H3,(H,15,16,17)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68556
PNG
(3-acetyl-8-methoxy-1-benzopyran-2-one | 3-acetyl-8...)
Show SMILES COc1cccc2cc(C(C)=O)c(=O)oc12
Show InChI InChI=1S/C12H10O4/c1-7(13)9-6-8-4-3-5-10(15-2)11(8)16-12(9)14/h3-6H,1-2H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68570
PNG
(MLS000052177 | N-(1,3-benzodioxol-5-yl)-2-(2-chlor...)
Show SMILES Clc1cc(ccc1OCC(=O)Nc1ccc2OCOc2c1)S(=O)(=O)N1CCCC1
Show InChI InChI=1S/C19H19ClN2O6S/c20-15-10-14(29(24,25)22-7-1-2-8-22)4-6-16(15)26-11-19(23)21-13-3-5-17-18(9-13)28-12-27-17/h3-6,9-10H,1-2,7-8,11-12H2,(H,21,23)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM68573
PNG
(2-[(4-phenyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)th...)
Show SMILES CCOC(=O)CSc1nnc(-c2cccs2)n1-c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-2-21-14(20)11-23-16-18-17-15(13-9-6-10-22-13)19(16)12-7-4-3-5-8-12/h3-10H,2,11H2,1H3
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%