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PubChem AID 463220

Compile data set for download or QSAR
Found 127 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM50738
PNG
(MLS000762832 | N-[(2,3-dimethoxyphenyl)methylidene...)
Show SMILES COc1cccc(CN=Nc2ncnc3c4cc(C)ccc4[nH]c23)c1OC
Show InChI InChI=1S/C20H19N5O2/c1-12-7-8-15-14(9-12)17-18(24-15)20(22-11-21-17)25-23-10-13-5-4-6-16(26-2)19(13)27-3/h4-9,11,24H,10H2,1-3H3
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n/an/a 571n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM34336
PNG
(2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonyl-pheny...)
Show SMILES O=c1n(sc2ccccc12)-c1cc(ccc1N1CCOCC1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C21H23N3O5S2/c25-21-17-3-1-2-4-20(17)30-24(21)19-15-16(31(26,27)23-9-13-29-14-10-23)5-6-18(19)22-7-11-28-12-8-22/h1-6,15H,7-14H2
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n/an/a 1.44E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75786
PNG
(2-(3-furanylmethylidene)-7-methyl-3-oxo-5-phenyl-5...)
Show SMILES COC(=O)C1=C(C)N=c2sc(=Cc3ccoc3)c(=O)n2C1c1ccccc1
Show InChI InChI=1S/C20H16N2O4S/c1-12-16(19(24)25-2)17(14-6-4-3-5-7-14)22-18(23)15(27-20(22)21-12)10-13-8-9-26-11-13/h3-11,17H,1-2H3
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n/an/a>2.07E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM61086
PNG
(3-[(E)-3-[4-(dimethylamino)phenyl]-1-oxoprop-2-eny...)
Show SMILES CN(C)c1ccc(C=CC(=O)c2c(O)c3ccccc3oc2=O)cc1
Show InChI InChI=1S/C20H17NO4/c1-21(2)14-10-7-13(8-11-14)9-12-16(22)18-19(23)15-5-3-4-6-17(15)25-20(18)24/h3-12,23H,1-2H3
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n/an/a>2.07E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM46036
PNG
(2-[[3-(3-keto-1,2-benzothiazol-2-yl)phenyl]sulfony...)
Show SMILES OC(=O)c1ccccc1NS(=O)(=O)c1cccc(c1)-n1sc2ccccc2c1=O
Show InChI InChI=1S/C20H14N2O5S2/c23-19-16-9-2-4-11-18(16)28-22(19)13-6-5-7-14(12-13)29(26,27)21-17-10-3-1-8-15(17)20(24)25/h1-12,21H,(H,24,25)
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n/an/a 2.10E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM46058
PNG
(3-(3-keto-1,2-benzothiazol-2-yl)benzoic acid | 3-(...)
Show SMILES OC(=O)c1cccc(c1)-n1sc2ccccc2c1=O
Show InChI InChI=1S/C14H9NO3S/c16-13-11-6-1-2-7-12(11)19-15(13)10-5-3-4-9(8-10)14(17)18/h1-8H,(H,17,18)
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n/an/a 2.38E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75784
PNG
(2-[[5-(3-chlorophenyl)-4-(furan-2-ylmethyl)-1,2,4-...)
Show SMILES Clc1cccc(c1)-c1nnc(SCc2nc3ccccc3[nH]2)n1Cc1ccco1
Show InChI InChI=1S/C21H16ClN5OS/c22-15-6-3-5-14(11-15)20-25-26-21(27(20)12-16-7-4-10-28-16)29-13-19-23-17-8-1-2-9-18(17)24-19/h1-11H,12-13H2,(H,23,24)
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n/an/a 2.57E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75800
PNG
((E)-3-[5-(4-chlorophenyl)-2-furanyl]-2-cyano-N-(1,...)
Show SMILES Cc1c(NC(=O)C(=C\c2ccc(o2)-c2ccc(Cl)cc2)\C#N)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C25H19ClN4O3/c1-16-23(25(32)30(29(16)2)20-6-4-3-5-7-20)28-24(31)18(15-27)14-21-12-13-22(33-21)17-8-10-19(26)11-9-17/h3-14H,1-2H3,(H,28,31)/b18-14+
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n/an/a 2.70E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75787
PNG
(3-[[4-(2-methyl-2,3-dihydroindole-1-carbonyl)pheny...)
Show SMILES CC1Cc2ccccc2N1C(=O)c1ccc(CNc2c(N3CCC(C)CC3)c(=O)c2=O)cc1
Show InChI InChI=1S/C27H29N3O3/c1-17-11-13-29(14-12-17)24-23(25(31)26(24)32)28-16-19-7-9-20(10-8-19)27(33)30-18(2)15-21-5-3-4-6-22(21)30/h3-10,17-18,28H,11-16H2,1-2H3
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n/an/a 2.98E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM34981
PNG
(2,3-bis(oxidanyl)-1H-quinolin-4-one | 2,3-dihydrox...)
Show SMILES Oc1c(O)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C9H7NO3/c11-7-5-3-1-2-4-6(5)10-9(13)8(7)12/h1-4,12H,(H2,10,11,13)
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n/an/a 3.28E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75792
PNG
(2-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]carbony...)
Show SMILES CC1C=CCc2c(O)n(c(O)c12)-c1cccc(c1)C(=O)N1CCN(CC1)c1cccc(C)c1C
Show InChI InChI=1S/C28H31N3O3/c1-18-7-5-12-24(20(18)3)29-13-15-30(16-14-29)26(32)21-9-6-10-22(17-21)31-27(33)23-11-4-8-19(2)25(23)28(31)34/h4-10,12,17,19,33-34H,11,13-16H2,1-3H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM34340
PNG
(2-(4-methyl-3-piperidin-1-ylsulfonyl-phenyl)-1,2-b...)
Show SMILES Cc1ccc(cc1S(=O)(=O)N1CCCCC1)-n1sc2ccccc2c1=O
Show InChI InChI=1S/C19H20N2O3S2/c1-14-9-10-15(21-19(22)16-7-3-4-8-17(16)25-21)13-18(14)26(23,24)20-11-5-2-6-12-20/h3-4,7-10,13H,2,5-6,11-12H2,1H3
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n/an/a 4.05E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75848
PNG
(MLS001157827 | N-(3-imidazol-1-ylpropyl)-3-(2-keto...)
Show SMILES Cc1c(CCC(=O)NCCCn2ccnc2)c(=O)oc2cc3oc4CCCCc4c3cc12
Show InChI InChI=1S/C25H27N3O4/c1-16-17(7-8-24(29)27-9-4-11-28-12-10-26-15-28)25(30)32-22-14-23-20(13-19(16)22)18-5-2-3-6-21(18)31-23/h10,12-15H,2-9,11H2,1H3,(H,27,29)
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n/an/a 4.31E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM61694
PNG
(MLS000689389 | N-(4-bromanyl-3-methyl-phenyl)-2-(4...)
Show SMILES Cc1cc(C)c2c(n1)sn(CC(=O)Nc1ccc(Br)c(C)c1)c2=O
Show InChI InChI=1S/C17H16BrN3O2S/c1-9-7-12(4-5-13(9)18)20-14(22)8-21-17(23)15-10(2)6-11(3)19-16(15)24-21/h4-7H,8H2,1-3H3,(H,20,22)
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n/an/a 4.54E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75856
PNG
(1-oxido-4-pyridin-1-iumcarboxylic acid [2-oxo-2-[(...)
Show SMILES [O-][n+]1ccc(cc1)C(=O)OCC(=O)N(CC=C)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C20H17N3O4S/c1-2-10-23(20-21-17(14-28-20)15-6-4-3-5-7-15)18(24)13-27-19(25)16-8-11-22(26)12-9-16/h2-9,11-12,14H,1,10,13H2
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n/an/a 4.84E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM50149200
PNG
(2-Pyridin-4-yl-thiazole-4-carboxylic acid (3-trifl...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2csc(n2)-c2ccncc2)c1
Show InChI InChI=1S/C16H10F3N3OS/c17-16(18,19)11-2-1-3-12(8-11)21-14(23)13-9-24-15(22-13)10-4-6-20-7-5-10/h1-9H,(H,21,23)
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n/an/a 5.34E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75814
PNG
(MLS000539595 | N-[(E)-1-[[(4-methylbenzylidene)ami...)
Show SMILES Cc1ccc(C=NNC(=O)C(NC(=O)c2ccccc2)C=Nc2nccc(C)n2)cc1
Show InChI InChI=1S/C23H22N6O2/c1-16-8-10-18(11-9-16)14-26-29-22(31)20(15-25-23-24-13-12-17(2)27-23)28-21(30)19-6-4-3-5-7-19/h3-15,20H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 5.43E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75783
PNG
(2-[[4-(furan-2-ylmethyl)-5-(3-methylphenyl)-1,2,4-...)
Show SMILES Cc1cccc(c1)-c1nnc(SCc2nc3ccccc3[nH]2)n1Cc1ccco1
Show InChI InChI=1S/C22H19N5OS/c1-15-6-4-7-16(12-15)21-25-26-22(27(21)13-17-8-5-11-28-17)29-14-20-23-18-9-2-3-10-19(18)24-20/h2-12H,13-14H2,1H3,(H,23,24)
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n/an/a 5.67E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75857
PNG
(2-furancarboxylic acid [4-[(Z)-(3-acetamido-4-oxo-...)
Show SMILES COc1cc(\C=C2/SC(=S)N(NC(C)=O)C2=O)ccc1OC(=O)c1ccco1
Show InChI InChI=1S/C18H14N2O6S2/c1-10(21)19-20-16(22)15(28-18(20)27)9-11-5-6-12(14(8-11)24-2)26-17(23)13-4-3-7-25-13/h3-9H,1-2H3,(H,19,21)/b15-9-
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n/an/a 5.78E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM59012
PNG
(2-(3-methoxy-4-oxidanyl-phenyl)chromen-4-one | 2-(...)
Show SMILES COc1cc(ccc1O)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C16H12O4/c1-19-16-8-10(6-7-12(16)17)15-9-13(18)11-4-2-3-5-14(11)20-15/h2-9,17H,1H3
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n/an/a>6.21E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM53398
PNG
((5E)-5-[[5-(diethylamino)-2-furanyl]methylidene]-1...)
Show SMILES CCN(CC)c1ccc(C=C2C(=O)NC(=S)N(C2=O)c2ccc(OC)cc2OC)o1
Show InChI InChI=1S/C21H23N3O5S/c1-5-23(6-2)18-10-8-14(29-18)11-15-19(25)22-21(30)24(20(15)26)16-9-7-13(27-3)12-17(16)28-4/h7-12H,5-6H2,1-4H3,(H,22,25,30)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75788
PNG
(6-[(2-amino-2-keto-ethyl)thio]-5-cyano-2-keto-4-o-...)
Show SMILES CCOC(=O)C1C(C(C#N)=C(NC1=O)SCC(N)=O)c1ccccc1OCC
Show InChI InChI=1S/C19H21N3O5S/c1-3-26-13-8-6-5-7-11(13)15-12(9-20)18(28-10-14(21)23)22-17(24)16(15)19(25)27-4-2/h5-8,15-16H,3-4,10H2,1-2H3,(H2,21,23)(H,22,24)
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n/an/a>6.21E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM50993
PNG
((6E)-5-azanylidene-3-methylsulfanyl-6-[(6-oxidanyl...)
Show SMILES CSC1=NSC2=NC(=O)\C(=C\c3coc4ccc(O)cc4c3=O)C(=N)N12
Show InChI InChI=1S/C16H10N4O4S2/c1-25-16-19-26-15-18-14(23)10(13(17)20(15)16)4-7-6-24-11-3-2-8(21)5-9(11)12(7)22/h2-6,17,21H,1H3/b10-4+,17-13?
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM51024
PNG
(3-Benzoyl-5-(2-chloro-phenyl)-1-phenyl-3a,6a-dihyd...)
Show SMILES Oc1n(-c2ccccc2Cl)c(=O)c2c([nH]n(-c3ccccc3)c12)C(=O)c1ccccc1
Show InChI InChI=1S/C24H16ClN3O3/c25-17-13-7-8-14-18(17)27-23(30)19-20(22(29)15-9-3-1-4-10-15)26-28(21(19)24(27)31)16-11-5-2-6-12-16/h1-14,26,31H
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75790
PNG
(3-[(4-hydroxy-3-methoxybenzylidene)amino]-2-thioxo...)
Show SMILES COc1cc(C=Nn2c(O)csc2=S)ccc1O
Show InChI InChI=1S/C11H10N2O3S2/c1-16-9-4-7(2-3-8(9)14)5-12-13-10(15)6-18-11(13)17/h2-6,14-15H,1H3
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n/an/a>6.22E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75804
PNG
((5Z)-2-(p-anisidino)-5-vanillylidene-2-thiazolin-4...)
Show SMILES COc1ccc(NC2=NC(=O)C(S2)=Cc2ccc(O)c(OC)c2)cc1
Show InChI InChI=1S/C18H16N2O4S/c1-23-13-6-4-12(5-7-13)19-18-20-17(22)16(25-18)10-11-3-8-14(21)15(9-11)24-2/h3-10,21H,1-2H3,(H,19,20,22)
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n/an/a>6.22E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75797
PNG
(MLS000576177 | N-[2,4-bis(chloranyl)-5-[[(E)-(2-ox...)
Show SMILES CC(=O)Nc1cc(N=Cc2ccc(O)cc2O)c(Cl)cc1Cl
Show InChI InChI=1S/C15H12Cl2N2O3/c1-8(20)19-14-6-13(11(16)5-12(14)17)18-7-9-2-3-10(21)4-15(9)22/h2-7,21-22H,1H3,(H,19,20)
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n/an/a>6.22E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM73525
PNG
(2-[(2Z)-2-(1-hexyl-2-pyridinylidene)ethylidene]pro...)
Show SMILES CCCCCCN1C=CC=C\C1=C\C=C(C#N)C#N
Show InChI InChI=1S/C16H19N3/c1-2-3-4-6-11-19-12-7-5-8-16(19)10-9-15(13-17)14-18/h5,7-10,12H,2-4,6,11H2,1H3/b16-10-
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75846
PNG
(MLS001031372 | SMR000634550 | cid_4327876)
Show SMILES Cc1cccc(N2CCN(CC2)C(=O)c2cccc(c2)N2C(=O)C3C4CC(C=C4)C3C2=O)c1C
Show InChI InChI=1S/C28H29N3O3/c1-17-5-3-8-23(18(17)2)29-11-13-30(14-12-29)26(32)21-6-4-7-22(16-21)31-27(33)24-19-9-10-20(15-19)25(24)28(31)34/h3-10,16,19-20,24-25H,11-15H2,1-2H3
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n/an/a 6.73E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75823
PNG
(3-methyl-N-(2-pyridin-3-ylpyrimidin-4-yl)benzamide...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccnc(n1)-c1cccnc1
Show InChI InChI=1S/C17H14N4O/c1-12-4-2-5-13(10-12)17(22)21-15-7-9-19-16(20-15)14-6-3-8-18-11-14/h2-11H,1H3,(H,19,20,21,22)
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n/an/a 7.00E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM60966
PNG
(2-[(2-amino-5-methylsulfonylphenyl)disulfanyl]-4-m...)
Show SMILES CS(=O)(=O)c1ccc(N)c(SSc2cc(ccc2N)S(C)(=O)=O)c1
Show InChI InChI=1S/C14H16N2O4S4/c1-23(17,18)9-3-5-11(15)13(7-9)21-22-14-8-10(24(2,19)20)4-6-12(14)16/h3-8H,15-16H2,1-2H3
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n/an/a 7.08E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM34520
PNG
(2-(3-keto-4,6-dimethyl-isothiazolo[5,4-b]pyridin-2...)
Show SMILES Cc1cc(C)c2c(n1)sn(CC(=O)NCCCN1CCOCC1)c2=O
Show InChI InChI=1S/C17H24N4O3S/c1-12-10-13(2)19-16-15(12)17(23)21(25-16)11-14(22)18-4-3-5-20-6-8-24-9-7-20/h10H,3-9,11H2,1-2H3,(H,18,22)
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n/an/a 7.16E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75824
PNG
(3-methyl-N-(2-pyridin-4-yl-4-pyrimidinyl)benzamide...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccnc(n1)-c1ccncc1
Show InChI InChI=1S/C17H14N4O/c1-12-3-2-4-14(11-12)17(22)21-15-7-10-19-16(20-15)13-5-8-18-9-6-13/h2-11H,1H3,(H,19,20,21,22)
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n/an/a 7.39E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM48090
PNG
((5E)-3-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyra...)
Show SMILES COc1cc(\C=C2\SC(=S)N(C2=O)c2c(C)n(C)n(-c3ccccc3)c2=O)ccc1O
Show InChI InChI=1S/C22H19N3O4S2/c1-13-19(21(28)25(23(13)2)15-7-5-4-6-8-15)24-20(27)18(31-22(24)30)12-14-9-10-16(26)17(11-14)29-3/h4-12,26H,1-3H3/b18-12+
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n/an/a 7.99E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75094
PNG
((E)-2-Cyano-N-cyclohexyl-3-(5-morpholin-4-yl-furan...)
Show SMILES O=C(NC1CCCCC1)C(=C\c1ccc(o1)N1CCOCC1)\C#N
Show InChI InChI=1S/C18H23N3O3/c19-13-14(18(22)20-15-4-2-1-3-5-15)12-16-6-7-17(24-16)21-8-10-23-11-9-21/h6-7,12,15H,1-5,8-11H2,(H,20,22)/b14-12+
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n/an/a 8.05E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM60519
PNG
((5Z)-5-[(2Z)-2-(1-methyl-2-pyrrolidinylidene)ethyl...)
Show SMILES CN1CCCC1=CC=C1SC(S)=NC1=O
Show InChI InChI=1S/C10H12N2OS2/c1-12-6-2-3-7(12)4-5-8-9(13)11-10(14)15-8/h4-5H,2-3,6H2,1H3,(H,11,13,14)
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n/an/a 8.17E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75854
PNG
((E)-3-(3,5-dimethyl-1-phenyl-4-pyrazolyl)-2-propen...)
Show SMILES COc1cccc(NC(=O)COC(=O)\C=C\c2c(C)nn(c2C)-c2ccccc2)c1
Show InChI InChI=1S/C23H23N3O4/c1-16-21(17(2)26(25-16)19-9-5-4-6-10-19)12-13-23(28)30-15-22(27)24-18-8-7-11-20(14-18)29-3/h4-14H,15H2,1-3H3,(H,24,27)/b13-12+
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n/an/a 8.29E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM61622
PNG
((E)-2-cyano-3-(5-piperidin-1-ylfuran-2-yl)prop-2-e...)
Show SMILES NC(=O)C(=C\c1ccc(o1)N1CCCCC1)\C#N
Show InChI InChI=1S/C13H15N3O2/c14-9-10(13(15)17)8-11-4-5-12(18-11)16-6-2-1-3-7-16/h4-5,8H,1-3,6-7H2,(H2,15,17)/b10-8+
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n/an/a 8.72E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75820
PNG
(3-[(2E)-2-(3-ethyl-1,3-benzothiazol-2(3H)-ylidene)...)
Show SMILES CCN1C(Sc2ccccc12)=CC=C(C(C)=O)C(C)=O
Show InChI InChI=1S/C16H17NO2S/c1-4-17-14-7-5-6-8-15(14)20-16(17)10-9-13(11(2)18)12(3)19/h5-10H,4H2,1-3H3
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n/an/a 8.83E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75795
PNG
(MLS000543226 | N-[5-acetyl-6-[(E)-2-(dimethylamino...)
Show SMILES CN(C)C=Cc1oc(=O)c(NC(=O)c2ccccc2)cc1C(C)=O
Show InChI InChI=1S/C18H18N2O4/c1-12(21)14-11-15(18(23)24-16(14)9-10-20(2)3)19-17(22)13-7-5-4-6-8-13/h4-11H,1-3H3,(H,19,22)
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n/an/a 8.93E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75781
PNG
(4-(8-methoxy-5H-pyrimid[5,4-b]indol-4-yl)piperazin...)
Show SMILES CCOC(=O)N1CCN(CC1)c1ncnc2c3cc(OC)ccc3[nH]c12
Show InChI InChI=1S/C18H21N5O3/c1-3-26-18(24)23-8-6-22(7-9-23)17-16-15(19-11-20-17)13-10-12(25-2)4-5-14(13)21-16/h4-5,10-11,21H,3,6-9H2,1-2H3
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n/an/a 9.15E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75830
PNG
(2-[3-[5-chloranyl-4-[(2-chlorophenyl)methylamino]-...)
Show SMILES OC(=O)CC12CC3CC(C1)CC(C3)(C2)n1ncc(NCc2ccccc2Cl)c(Cl)c1=O
Show InChI InChI=1S/C23H25Cl2N3O3/c24-17-4-2-1-3-16(17)11-26-18-12-27-28(21(31)20(18)25)23-8-14-5-15(9-23)7-22(6-14,13-23)10-19(29)30/h1-4,12,14-15,26H,5-11,13H2,(H,29,30)
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n/an/a 9.59E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM58616
PNG
((E)-N-[[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phe...)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)C=Cc3ccc(C)cc3)cc2)no1
Show InChI InChI=1S/C21H20N4O4S2/c1-14-3-5-16(6-4-14)7-12-20(26)23-21(30)22-17-8-10-18(11-9-17)31(27,28)25-19-13-15(2)29-24-19/h3-13H,1-2H3,(H,24,25)(H2,22,23,26,30)
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n/an/a 9.71E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM47577
PNG
((5Z)-3-ethyl-2-sulfanylidene-5-[(1,2,5-trimethyl-3...)
Show SMILES CCN1C(=S)S\C(=C/c2cc(C)n(C)c2C)C1=O
Show InChI InChI=1S/C13H16N2OS2/c1-5-15-12(16)11(18-13(15)17)7-10-6-8(2)14(4)9(10)3/h6-7H,5H2,1-4H3/b11-7-
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n/an/a 9.74E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM60208
PNG
(2-[2-(1-Allyl-1H-pyridin-4-ylidene)-ethylidene]-ma...)
Show SMILES C=CCN1C=CC(=CC=C(C#N)C#N)C=C1
Show InChI InChI=1S/C13H11N3/c1-2-7-16-8-5-12(6-9-16)3-4-13(10-14)11-15/h2-6,8-9H,1,7H2
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n/an/a 1.04E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75850
PNG
(4-[(6-amino-1-butyl-2,4-diketo-pyrimidin-5-yl)-amy...)
Show SMILES CCCCCN(C(=O)CCC(=O)OCC(=O)c1ccc(CCC)cc1)c1c(N)n(CCCC)c(=O)[nH]c1=O
Show InChI InChI=1S/C28H40N4O6/c1-4-7-9-18-31(25-26(29)32(17-8-5-2)28(37)30-27(25)36)23(34)15-16-24(35)38-19-22(33)21-13-11-20(10-6-3)12-14-21/h11-14H,4-10,15-19,29H2,1-3H3,(H,30,36,37)
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n/an/a 1.06E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM50322743
PNG
(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Show SMILES Clc1ccc2[nH]c3c(NCCCN4CCOCC4)ncnc3c2c1
Show InChI InChI=1S/C17H20ClN5O/c18-12-2-3-14-13(10-12)15-16(22-14)17(21-11-20-15)19-4-1-5-23-6-8-24-9-7-23/h2-3,10-11,22H,1,4-9H2,(H,19,20,21)
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n/an/a 1.09E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75844
PNG
((Z)-3-[3,4-bis(oxidanyl)phenyl]-N-[(4-chlorophenyl...)
Show SMILES Oc1ccc(\C=C(\C#N)C(=O)NCc2ccc(Cl)cc2)cc1O
Show InChI InChI=1S/C17H13ClN2O3/c18-14-4-1-11(2-5-14)10-20-17(23)13(9-19)7-12-3-6-15(21)16(22)8-12/h1-8,21-22H,10H2,(H,20,23)/b13-7-
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n/an/a 1.16E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM54126
PNG
((4E)-2-(6-methyl-2-pyridinyl)-4-[[2-(5-oxo-3-sulfa...)
Show SMILES Cc1cccc(n1)-n1c(O)c(C=Nc2ccccc2-c2n[nH]c(=S)[nH]c2=O)c2ccccc2c1=O
Show InChI InChI=1S/C25H18N6O3S/c1-14-7-6-12-20(27-14)31-23(33)16-9-3-2-8-15(16)18(24(31)34)13-26-19-11-5-4-10-17(19)21-22(32)28-25(35)30-29-21/h2-13,34H,1H3,(H2,28,30,32,35)
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n/an/a 1.22E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75825
PNG
(3-[4-[(Z)-(3-ethyl-1,3-benzothiazol-2-ylidene)meth...)
Show SMILES CCN1\C(Sc2ccccc12)=C\c1cc[n+](CCCS([O-])(=O)=O)c2ccccc12
Show InChI InChI=1S/C22H22N2O3S2/c1-2-24-20-10-5-6-11-21(20)28-22(24)16-17-12-14-23(13-7-15-29(25,26)27)19-9-4-3-8-18(17)19/h3-6,8-12,14,16H,2,7,13,15H2,1H3
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n/an/a 1.23E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75805
PNG
(MLS000418558 | N-[[(3E)-3-[4-(diethylamino)benzyli...)
Show SMILES CCN(CC)c1ccc(\C=C2/CCC(C=NNC(=O)c3ccc(=O)n(C)c3)=C2N2CCOCC2)cc1
Show InChI InChI=1S/C28H35N5O3/c1-4-32(5-2)25-11-6-21(7-12-25)18-22-8-9-23(27(22)33-14-16-36-17-15-33)19-29-30-28(35)24-10-13-26(34)31(3)20-24/h6-7,10-13,18-20H,4-5,8-9,14-17H2,1-3H3,(H,30,35)/b22-18+,29-19?
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n/an/a 1.25E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75839
PNG
((5Z)-2-anilino-5-(5-bromo-3-ethoxy-2-hydroxy-benzy...)
Show SMILES CCOc1cc(Br)cc(C=C2SC(Nc3ccccc3)=NC2=O)c1O
Show InChI InChI=1S/C18H15BrN2O3S/c1-2-24-14-10-12(19)8-11(16(14)22)9-15-17(23)21-18(25-15)20-13-6-4-3-5-7-13/h3-10,22H,2H2,1H3,(H,20,21,23)
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n/an/a 1.27E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75716
PNG
((E)-2-cyano-3-[4-(dimethylamino)phenyl]-2-propenoi...)
Show SMILES CC(OC(=O)C(=C\c1ccc(cc1)N(C)C)\C#N)C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C23H25N3O3/c1-17(22(27)26(4)16-19-8-6-5-7-9-19)29-23(28)20(15-24)14-18-10-12-21(13-11-18)25(2)3/h5-14,17H,16H2,1-4H3/b20-14+
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n/an/a 1.28E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM60138
PNG
((Z)-2-cyano-3-[5-(diethylamino)-2-furanyl]-N-propa...)
Show SMILES CCN(CC)c1ccc(\C=C(\C#N)C(=O)NC(C)C)o1
Show InChI InChI=1S/C15H21N3O2/c1-5-18(6-2)14-8-7-13(20-14)9-12(10-16)15(19)17-11(3)4/h7-9,11H,5-6H2,1-4H3,(H,17,19)/b12-9-
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n/an/a 1.32E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75807
PNG
(4-[(4E)-4-[4-(dimethylamino)benzylidene]-5-keto-3-...)
Show SMILES CN(C)c1ccc(\C=C2\N(C)C(=S)N(C2=O)c2c(C)n(C)n(-c3ccccc3)c2=O)cc1
Show InChI InChI=1S/C24H25N5O2S/c1-16-21(23(31)29(27(16)5)19-9-7-6-8-10-19)28-22(30)20(26(4)24(28)32)15-17-11-13-18(14-12-17)25(2)3/h6-15H,1-5H3/b20-15+
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n/an/a 1.39E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM53395
PNG
((5E)-5-[[5-(diethylamino)-2-furanyl]methylidene]-1...)
Show SMILES CCN(CC)c1ccc(\C=C2/C(=O)NC(=S)N(C)C2=O)o1
Show InChI InChI=1S/C14H17N3O3S/c1-4-17(5-2)11-7-6-9(20-11)8-10-12(18)15-14(21)16(3)13(10)19/h6-8H,4-5H2,1-3H3,(H,15,18,21)/b10-8+
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n/an/a 1.40E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75841
PNG
(5-[(2R,3R,4S,5R)-5-methoxy-6,6-dimethyl-3,4-bis(ox...)
Show SMILES CO[C@@H]1[C@@H](O)[C@@H](O)[C@H](Oc2ccc(-c3ccc(Oc4ccccc4)cc3)c(c2)C(=O)NCc2ccccc2)OC1(C)C
Show InChI InChI=1S/C34H35NO7/c1-34(2)31(39-3)29(36)30(37)33(42-34)41-26-18-19-27(28(20-26)32(38)35-21-22-10-6-4-7-11-22)23-14-16-25(17-15-23)40-24-12-8-5-9-13-24/h4-20,29-31,33,36-37H,21H2,1-3H3,(H,35,38)/t29-,30+,31+,33+/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75812
PNG
(5-[(diethylamino)carbonyl]-2-[2-(1H-indol-3-yl)vin...)
Show SMILES CCN(CC)C(=O)c1ccc(\C=C\c2c[nH]c3ccccc23)[n+](C)c1
Show InChI InChI=1S/C21H23N3O/c1-4-24(5-2)21(25)17-11-13-18(23(3)15-17)12-10-16-14-22-20-9-7-6-8-19(16)20/h6-15H,4-5H2,1-3H3/p+1
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n/an/a 1.61E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75852
PNG
(5-ethyl-4-methyl-N-[3-(1,2,3,4-tetrazol-1-yl)pheny...)
Show SMILES CCc1sc(cc1C)C(=O)Nc1cccc(c1)-n1cnnn1
Show InChI InChI=1S/C15H15N5OS/c1-3-13-10(2)7-14(22-13)15(21)17-11-5-4-6-12(8-11)20-9-16-18-19-20/h4-9H,3H2,1-2H3,(H,17,21)
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n/an/a 1.73E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75836
PNG
((5Z)-5-(4,5-dimethyl-6-oxidanylidene-cyclohexa-2,4...)
Show SMILES Cc1ccc(-c2cc([nH]n2)C(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ncccn2)c(O)c1C
Show InChI InChI=1S/C22H20N6O4S/c1-13-4-9-17(20(29)14(13)2)18-12-19(27-26-18)21(30)25-15-5-7-16(8-6-15)33(31,32)28-22-23-10-3-11-24-22/h3-12,29H,1-2H3,(H,25,30)(H,26,27)(H,23,24,28)
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n/an/a 1.77E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75840
PNG
((5Z)-5-[4-(dimethylamino)benzylidene]-2-piperidino...)
Show SMILES CN(C)c1ccc(\C=C2/SC(=NC2=O)N2CCCCC2)cc1
Show InChI InChI=1S/C17H21N3OS/c1-19(2)14-8-6-13(7-9-14)12-15-16(21)18-17(22-15)20-10-4-3-5-11-20/h6-9,12H,3-5,10-11H2,1-2H3/b15-12-
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n/an/a 1.79E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM60094
PNG
(2-[3-[5-chloranyl-4-[(2-chloranyl-4-fluoranyl-phen...)
Show SMILES OC(=O)CC12CC3CC(C1)CC(C3)(C2)n1ncc(NCc2ccc(F)cc2Cl)c(Cl)c1=O
Show InChI InChI=1S/C23H24Cl2FN3O3/c24-17-4-16(26)2-1-15(17)10-27-18-11-28-29(21(32)20(18)25)23-7-13-3-14(8-23)6-22(5-13,12-23)9-19(30)31/h1-2,4,11,13-14,27H,3,5-10,12H2,(H,30,31)
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n/an/a 1.81E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM50988
PNG
((5Z)-2-(3,4-dimethylanilino)-5-[(1-methyl-3-indoly...)
Show SMILES Cc1ccc(NC2=NC(=O)C(S2)=Cc2cn(C)c3ccccc23)cc1C
Show InChI InChI=1S/C21H19N3OS/c1-13-8-9-16(10-14(13)2)22-21-23-20(25)19(26-21)11-15-12-24(3)18-7-5-4-6-17(15)18/h4-12H,1-3H3,(H,22,23,25)
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n/an/a 1.84E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75838
PNG
(1-[4-(7-chloranylquinolin-4-yl)piperazin-1-yl]-2,2...)
Show SMILES CC(C)(C)C(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12
Show InChI InChI=1S/C18H22ClN3O/c1-18(2,3)17(23)22-10-8-21(9-11-22)16-6-7-20-15-12-13(19)4-5-14(15)16/h4-7,12H,8-11H2,1-3H3
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n/an/a 1.86E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75816
PNG
(7-chloro-4-[4-(2-furoyl)-1-piperazinyl]quinoline |...)
Show SMILES Clc1ccc2c(ccnc2c1)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C18H16ClN3O2/c19-13-3-4-14-15(12-13)20-6-5-16(14)21-7-9-22(10-8-21)18(23)17-2-1-11-24-17/h1-6,11-12H,7-10H2
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n/an/a>1.86E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM46572
PNG
((6E)-5-azanylidene-6-[(4-oxidanylidenechromen-3-yl...)
Show SMILES N=C1N2N=C(SC2=NC(=O)\C1=C\c1coc2ccccc2c1=O)c1ccncc1
Show InChI InChI=1S/C20H11N5O3S/c21-17-14(9-12-10-28-15-4-2-1-3-13(15)16(12)26)18(27)23-20-25(17)24-19(29-20)11-5-7-22-8-6-11/h1-10,21H/b14-9+,21-17?
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n/an/a>1.86E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM52782
PNG
((2Z)-2-[1-(4-methoxyanilino)ethylidene]-1-benzothi...)
Show SMILES COc1ccc(cc1)N=C(C)c1sc2ccccc2c1O
Show InChI InChI=1S/C17H15NO2S/c1-11(18-12-7-9-13(20-2)10-8-12)17-16(19)14-5-3-4-6-15(14)21-17/h3-10,19H,1-2H3
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n/an/a>1.87E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75791
PNG
(2-[3-[5-chloranyl-4-[(3,4-dimethylphenyl)amino]-6-...)
Show SMILES Cc1ccc(Nc2cnn(c(=O)c2Cl)C23CC4CC(CC(CC(O)=O)(C4)C2)C3)cc1C
Show InChI InChI=1S/C24H28ClN3O3/c1-14-3-4-18(5-15(14)2)27-19-12-26-28(22(31)21(19)25)24-9-16-6-17(10-24)8-23(7-16,13-24)11-20(29)30/h3-5,12,16-17,27H,6-11,13H2,1-2H3,(H,29,30)
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n/an/a 1.88E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75843
PNG
(4-(7-chloro-4-quinolinyl)-1-piperazinecarboxylic a...)
Show SMILES CCOC(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12
Show InChI InChI=1S/C16H18ClN3O2/c1-2-22-16(21)20-9-7-19(8-10-20)15-5-6-18-14-11-12(17)3-4-13(14)15/h3-6,11H,2,7-10H2,1H3
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n/an/a 1.89E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75827
PNG
(2-(3-acetylphenoxy)-1-[4-[5-(trifluoromethyl)-2-py...)
Show SMILES CC(=O)c1cccc(OCC(=O)N2CCN(CC2)c2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C20H20F3N3O3/c1-14(27)15-3-2-4-17(11-15)29-13-19(28)26-9-7-25(8-10-26)18-6-5-16(12-24-18)20(21,22)23/h2-6,11-12H,7-10,13H2,1H3
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n/an/a 1.92E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75813
PNG
((5E)-1-(1,3-benzodioxol-5-yl)-5-[(5-pyrrolidin-1-y...)
Show SMILES O=C1NC(=O)C(=Cc2ccc(o2)N2CCCC2)C(=O)N1c1ccc2OCOc2c1
Show InChI InChI=1S/C20H17N3O6/c24-18-14(10-13-4-6-17(29-13)22-7-1-2-8-22)19(25)23(20(26)21-18)12-3-5-15-16(9-12)28-11-27-15/h3-6,9-10H,1-2,7-8,11H2,(H,21,24,26)
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n/an/a 2.07E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75803
PNG
((5Z)-1-(1,3-benzodioxol-5-yl)-5-[(5-piperidin-1-yl...)
Show SMILES O=C1NC(=O)C(=Cc2ccc(o2)N2CCCCC2)C(=O)N1c1ccc2OCOc2c1
Show InChI InChI=1S/C21H19N3O6/c25-19-15(11-14-5-7-18(30-14)23-8-2-1-3-9-23)20(26)24(21(27)22-19)13-4-6-16-17(10-13)29-12-28-16/h4-7,10-11H,1-3,8-9,12H2,(H,22,25,27)
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n/an/a 2.10E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM55051
PNG
((E)-3-(3,5-dibromo-2-hydroxy-phenyl)-1-(5-methyl-2...)
Show SMILES Cc1ccc(o1)C(=O)\C=C\c1cc(Br)cc(Br)c1O
Show InChI InChI=1S/C14H10Br2O3/c1-8-2-5-13(19-8)12(17)4-3-9-6-10(15)7-11(16)14(9)18/h2-7,18H,1H3/b4-3+
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n/an/a 2.10E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75793
PNG
(2-furfuryl-(8-methoxy-5H-pyrimid[5,4-b]indol-4-yl)...)
Show SMILES COc1ccc2[nH]c3c(NCc4ccco4)ncnc3c2c1
Show InChI InChI=1S/C16H14N4O2/c1-21-10-4-5-13-12(7-10)14-15(20-13)16(19-9-18-14)17-8-11-3-2-6-22-11/h2-7,9,20H,8H2,1H3,(H,17,18,19)
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n/an/a 2.12E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75851
PNG
((E)-2-cyano-3-[4-(dimethylamino)phenyl]-2-propenoi...)
Show SMILES CC(OC(=O)C(=C\c1ccc(cc1)N(C)C)\C#N)C(=O)N(C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-16(21(26)25(4)20-8-6-5-7-9-20)28-22(27)18(15-23)14-17-10-12-19(13-11-17)24(2)3/h5-14,16H,1-4H3/b18-14+
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n/an/a 2.14E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75789
PNG
(2-[3-[5-chloranyl-4-[(3,5-dimethylphenyl)amino]-6-...)
Show SMILES Cc1cc(C)cc(Nc2cnn(c(=O)c2Cl)C23CC4CC(CC(CC(O)=O)(C4)C2)C3)c1
Show InChI InChI=1S/C24H28ClN3O3/c1-14-3-15(2)5-18(4-14)27-19-12-26-28(22(31)21(19)25)24-9-16-6-17(10-24)8-23(7-16,13-24)11-20(29)30/h3-5,12,16-17,27H,6-11,13H2,1-2H3,(H,29,30)
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n/an/a 2.15E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75845
PNG
(3-[(3-bromobenzoyl)amino]-N-(3-pyridylmethyleneami...)
Show SMILES Brc1cccc(c1)C(=O)Nc1cccc(c1)C(=O)NN=Cc1cccnc1
Show InChI InChI=1S/C20H15BrN4O2/c21-17-7-1-5-15(10-17)19(26)24-18-8-2-6-16(11-18)20(27)25-23-13-14-4-3-9-22-12-14/h1-13H,(H,24,26)(H,25,27)
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n/an/a 2.19E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75835
PNG
((2E)-2-[[(4Z)-4-(dimethylaminomethylidene)-5-oxo-2...)
Show SMILES CCOC(=O)C(=CC1=CC(=CN(C)C)C(=O)O1)C(C)=O
Show InChI InChI=1S/C14H17NO5/c1-5-19-14(18)12(9(2)16)7-11-6-10(8-15(3)4)13(17)20-11/h6-8H,5H2,1-4H3
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n/an/a 2.21E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75798
PNG
((5E)-1-(4-fluorophenyl)carbonyl-5-(phenylmethylide...)
Show SMILES Fc1ccc(cc1)C(=O)N1C(=S)NC(=O)\C1=C/c1ccccc1
Show InChI InChI=1S/C17H11FN2O2S/c18-13-8-6-12(7-9-13)16(22)20-14(15(21)19-17(20)23)10-11-4-2-1-3-5-11/h1-10H,(H,19,21,23)/b14-10+
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n/an/a 2.22E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM49455
PNG
((2Z)-2-[1-(3-methylanilino)ethylidene]-1-benzothio...)
Show SMILES CC(=Nc1cccc(C)c1)c1sc2ccccc2c1O
Show InChI InChI=1S/C17H15NOS/c1-11-6-5-7-13(10-11)18-12(2)17-16(19)14-8-3-4-9-15(14)20-17/h3-10,19H,1-2H3
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n/an/a 2.27E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75818
PNG
((E)-2-cyano-3-(5-morpholin-4-ylfuran-2-yl)-N-(oxol...)
Show SMILES O=C(NCC1CCCO1)C(=C\c1ccc(o1)N1CCOCC1)\C#N
Show InChI InChI=1S/C17H21N3O4/c18-11-13(17(21)19-12-15-2-1-7-23-15)10-14-3-4-16(24-14)20-5-8-22-9-6-20/h3-4,10,15H,1-2,5-9,12H2,(H,19,21)/b13-10+
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n/an/a 2.53E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM33115
PNG
(1,5-diphenyl-3-(phenylcarbonyl)-3a,6a-dihydropyrro...)
Show SMILES Oc1n(-c2ccccc2)c(=O)c2c([nH]n(-c3ccccc3)c12)C(=O)c1ccccc1
Show InChI InChI=1S/C24H17N3O3/c28-22(16-10-4-1-5-11-16)20-19-21(27(25-20)18-14-8-3-9-15-18)24(30)26(23(19)29)17-12-6-2-7-13-17/h1-15,25,30H
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n/an/a 2.55E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM52737
PNG
(3-chloranyl-N-[(3-oxidanylidenecyclohexylidene)ami...)
Show SMILES Clc1c(sc2ccccc12)C(=O)NNC1=CC(=O)CCC1
Show InChI InChI=1S/C15H13ClN2O2S/c16-13-11-6-1-2-7-12(11)21-14(13)15(20)18-17-9-4-3-5-10(19)8-9/h1-2,6-8,17H,3-5H2,(H,18,20)
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n/an/a 2.63E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75817
PNG
((5Z)-2-azanylidene-3-(4-fluorophenyl)-5-[(3-methox...)
Show SMILES COc1cc(\C=C2/SC(=N)N(C2=O)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C17H13FN2O3S/c1-23-14-8-10(2-7-13(14)21)9-15-16(22)20(17(19)24-15)12-5-3-11(18)4-6-12/h2-9,19,21H,1H3/b15-9-,19-17?
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n/an/a 2.93E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM50598
PNG
((5Z)-3-(4-ethoxyphenyl)-5-[(3-methoxy-4-oxidanyl-p...)
Show SMILES CCOc1ccc(cc1)N1C(=O)S\C(=C/c2ccc(O)c(OC)c2)C1=O
Show InChI InChI=1S/C19H17NO5S/c1-3-25-14-7-5-13(6-8-14)20-18(22)17(26-19(20)23)11-12-4-9-15(21)16(10-12)24-2/h4-11,21H,3H2,1-2H3/b17-11-
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n/an/a 2.98E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75833
PNG
((5Z)-1-(2-methylphenyl)-5-[(5-morpholin-4-ylfuran-...)
Show SMILES Cc1ccccc1N1C(=O)NC(=O)C(=Cc2ccc(o2)N2CCOCC2)C1=O
Show InChI InChI=1S/C20H19N3O5/c1-13-4-2-3-5-16(13)23-19(25)15(18(24)21-20(23)26)12-14-6-7-17(28-14)22-8-10-27-11-9-22/h2-7,12H,8-11H2,1H3,(H,21,24,26)
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n/an/a 3.05E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75819
PNG
((5Z)-3-ethyl-5-[(2Z)-2-(1-methyl-2-pyrrolidinylide...)
Show SMILES CCN1C(=S)O\C(=C/C=C2/CCCN2C)C1=O
Show InChI InChI=1S/C12H16N2O2S/c1-3-14-11(15)10(16-12(14)17)7-6-9-5-4-8-13(9)2/h6-7H,3-5,8H2,1-2H3/b9-6-,10-7-
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n/an/a 3.07E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75837
PNG
(MLS000860928 | SMR000459712 | [4-(7-chloranylquino...)
Show SMILES Clc1ccc2c(ccnc2c1)N1CCN(CC1)C(=O)C1CCC1
Show InChI InChI=1S/C18H20ClN3O/c19-14-4-5-15-16(12-14)20-7-6-17(15)21-8-10-22(11-9-21)18(23)13-2-1-3-13/h4-7,12-13H,1-3,8-11H2
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n/an/a 3.16E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75815
PNG
((5Z)-5-(4-morpholin-4-ylbenzylidene)-3-propyl-2-th...)
Show SMILES CCCN1C(=S)N\C(=C/c2ccc(cc2)N2CCOCC2)C1=O
Show InChI InChI=1S/C17H21N3O2S/c1-2-7-20-16(21)15(18-17(20)23)12-13-3-5-14(6-4-13)19-8-10-22-11-9-19/h3-6,12H,2,7-11H2,1H3,(H,18,23)/b15-12-
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n/an/a 3.31E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75821
PNG
(2-[3-[1,2-dioxo-2-(4-phenyl-3,6-dihydro-2H-pyridin...)
Show SMILES CCN(CC)C(=O)Cn1cc(C(=O)C(=O)N2CCC(=CC2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C27H29N3O3/c1-3-28(4-2)25(31)19-30-18-23(22-12-8-9-13-24(22)30)26(32)27(33)29-16-14-21(15-17-29)20-10-6-5-7-11-20/h5-14,18H,3-4,15-17,19H2,1-2H3
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n/an/a 3.51E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75808
PNG
((2E)-5-bromo-4-chloro-2-{[(3-methylphenyl)amino]me...)
Show SMILES Cc1cccc(c1)N=Cc1[nH]c2ccc(Br)c(Cl)c2c1O
Show InChI InChI=1S/C16H12BrClN2O/c1-9-3-2-4-10(7-9)19-8-13-16(21)14-12(20-13)6-5-11(17)15(14)18/h2-8,20-21H,1H3/b19-8+
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n/an/a 3.82E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75832
PNG
(2-[[(Z)-2-benzamido-3-(9-methyl-3-carbazolyl)-1-ox...)
Show SMILES Cn1c2ccccc2c2cc(\C=C(/NC(=O)c3ccccc3)C(=O)NCC(O)=O)ccc12
Show InChI InChI=1S/C25H21N3O4/c1-28-21-10-6-5-9-18(21)19-13-16(11-12-22(19)28)14-20(25(32)26-15-23(29)30)27-24(31)17-7-3-2-4-8-17/h2-14H,15H2,1H3,(H,26,32)(H,27,31)(H,29,30)/b20-14-
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n/an/a 4.25E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM46809
PNG
(3-[5-[[(4-nitrophenyl)hydrazinylidene]methyl]-2-fu...)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(CN=Nc2ccc(cc2)[N+]([O-])=O)o1
Show InChI InChI=1S/C18H13N3O5/c22-18(23)13-3-1-2-12(10-13)17-9-8-16(26-17)11-19-20-14-4-6-15(7-5-14)21(24)25/h1-10H,11H2,(H,22,23)
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n/an/a>5.59E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75842
PNG
(1-benzyl-5-[3-(tert-butylamino)-2-hydroxy-propoxy]...)
Show SMILES CCOC(=O)c1c(C)n(Cc2ccccc2)c2ccc(OCC(O)CNC(C)(C)C)cc12
Show InChI InChI=1S/C26H34N2O4/c1-6-31-25(30)24-18(2)28(16-19-10-8-7-9-11-19)23-13-12-21(14-22(23)24)32-17-20(29)15-27-26(3,4)5/h7-14,20,27,29H,6,15-17H2,1-5H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM51304
PNG
((3Z)-3-[(2-phenyl-1H-imidazol-5-yl)methylene]oxind...)
Show SMILES O=C1Nc2ccccc2C1=Cc1cnc([nH]1)-c1ccccc1
Show InChI InChI=1S/C18H13N3O/c22-18-15(14-8-4-5-9-16(14)21-18)10-13-11-19-17(20-13)12-6-2-1-3-7-12/h1-11H,(H,19,20)(H,21,22)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75853
PNG
(2-[(3-chlorobenzyl)thio]-5-pyrrolidinosulfonyl-pyr...)
Show SMILES Clc1cccc(CSc2ccc(cn2)S(=O)(=O)N2CCCC2)c1
Show InChI InChI=1S/C16H17ClN2O2S2/c17-14-5-3-4-13(10-14)12-22-16-7-6-15(11-18-16)23(20,21)19-8-1-2-9-19/h3-7,10-11H,1-2,8-9,12H2
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75831
PNG
(MLS001047459 | N-Acetyl-N-(4-phenyl-1-{[1-phenyl-m...)
Show SMILES CC(=O)N(C(C)=O)c1nc(cn1N=Cc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H18N4O2/c1-15(25)24(16(2)26)20-22-19(18-11-7-4-8-12-18)14-23(20)21-13-17-9-5-3-6-10-17/h3-14H,1-2H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75785
PNG
(2-(4-keto-3H-phthalazin-1-yl)-N-[3-(6,7,8,9-tetrah...)
Show SMILES O=C(Cc1n[nH]c(=O)c2ccccc12)Nc1cccc(c1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C23H22N6O2/c30-21(14-19-17-9-3-4-10-18(17)23(31)28-25-19)24-16-8-6-7-15(13-16)22-27-26-20-11-2-1-5-12-29(20)22/h3-4,6-10,13H,1-2,5,11-12,14H2,(H,24,30)(H,28,31)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75849
PNG
(2-[(6-keto-7,8,9,10-tetrahydrobenzo[c]chromen-3-yl...)
Show SMILES CC(Oc1ccc2c3CCCCc3c(=O)oc2c1)C(=O)NCc1ccncc1
Show InChI InChI=1S/C22H22N2O4/c1-14(21(25)24-13-15-8-10-23-11-9-15)27-16-6-7-18-17-4-2-3-5-19(17)22(26)28-20(18)12-16/h6-12,14H,2-5,13H2,1H3,(H,24,25)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM48777
PNG
(2-(2-hydroxy-3,5-dinitro-benzylidene)thiazolo[3,2-...)
Show SMILES Oc1c(\C=c2/sc3nc4ccccc4n3c2=O)cc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C16H8N4O6S/c21-14-8(5-9(19(23)24)7-12(14)20(25)26)6-13-15(22)18-11-4-2-1-3-10(11)17-16(18)27-13/h1-7,21H/b13-6-
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75855
PNG
(MLS002472284 | N-cyclopropyl-6-(4-methyl-1-piperid...)
Show SMILES CC1CCN(CC1)c1ccc2C(=O)c3c(cccc3S(=O)(=O)c2c1)C(=O)NC1CC1
Show InChI InChI=1S/C23H24N2O4S/c1-14-9-11-25(12-10-14)16-7-8-17-20(13-16)30(28,29)19-4-2-3-18(21(19)22(17)26)23(27)24-15-5-6-15/h2-4,7-8,13-15H,5-6,9-12H2,1H3,(H,24,27)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75802
PNG
((3-Amino-6-phenyl-thieno[2,3-b]pyridin-2-yl)-(4-me...)
Show SMILES COc1ccc(cc1)C(=O)c1sc2nc(ccc2c1N)-c1ccccc1
Show InChI InChI=1S/C21H16N2O2S/c1-25-15-9-7-14(8-10-15)19(24)20-18(22)16-11-12-17(23-21(16)26-20)13-5-3-2-4-6-13/h2-12H,22H2,1H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75799
PNG
(4-[2,2-bis(1-phenyl-1,2,3,4-tetrazol-5-yl)ethenyl]...)
Show SMILES CCN(CC)c1ccc(C=C(c2nnnn2-c2ccccc2)c2nnnn2-c2ccccc2)cc1
Show InChI InChI=1S/C26H25N9/c1-3-33(4-2)21-17-15-20(16-18-21)19-24(25-27-29-31-34(25)22-11-7-5-8-12-22)26-28-30-32-35(26)23-13-9-6-10-14-23/h5-19H,3-4H2,1-2H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75847
PNG
(2-[(4-methyl-6-oxidanylidene-7,8,9,10-tetrahydrobe...)
Show SMILES CC(Oc1ccc2c3CCCCc3c(=O)oc2c1C)C(=O)NCc1ccncc1
Show InChI InChI=1S/C23H24N2O4/c1-14-20(28-15(2)22(26)25-13-16-9-11-24-12-10-16)8-7-18-17-5-3-4-6-19(17)23(27)29-21(14)18/h7-12,15H,3-6,13H2,1-2H3,(H,25,26)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75826
PNG
(3-chloranyl-6-methoxy-N-[(3-oxidanylidenecyclohexy...)
Show SMILES COc1ccc2c(Cl)c(sc2c1)C(=O)NNC1=CC(=O)CCC1
Show InChI InChI=1S/C16H15ClN2O3S/c1-22-11-5-6-12-13(8-11)23-15(14(12)17)16(21)19-18-9-3-2-4-10(20)7-9/h5-8,18H,2-4H2,1H3,(H,19,21)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75829
PNG
(2-(3-chlorophenyl)-3-methyl-4-quinolinecarboxylic ...)
Show SMILES CN(C1CCS(=O)(=O)C1)C(=O)COC(=O)c1c(C)c(nc2ccccc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C24H23ClN2O5S/c1-15-22(24(29)32-13-21(28)27(2)18-10-11-33(30,31)14-18)19-8-3-4-9-20(19)26-23(15)16-6-5-7-17(25)12-16/h3-9,12,18H,10-11,13-14H2,1-2H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM52848
PNG
(MLS000333673 | Methanesulfonic acid 3-oxo-2-[1-(2,...)
Show SMILES COc1cc(OC)c(\C=C2/Oc3cc(OS(C)(=O)=O)ccc3C2=O)cc1OC
Show InChI InChI=1S/C19H18O8S/c1-23-14-10-17(25-3)16(24-2)7-11(14)8-18-19(20)13-6-5-12(9-15(13)26-18)27-28(4,21)22/h5-10H,1-4H3/b18-8-
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75810
PNG
(1-(3,4-dihydro-2H-quinolin-1-yl)-2-[[4-(2-ethoxyph...)
Show SMILES CCOc1ccccc1-n1c(SCC(=O)N2CCCc3ccccc23)nnc1-c1cccnc1
Show InChI InChI=1S/C26H25N5O2S/c1-2-33-23-14-6-5-13-22(23)31-25(20-10-7-15-27-17-20)28-29-26(31)34-18-24(32)30-16-8-11-19-9-3-4-12-21(19)30/h3-7,9-10,12-15,17H,2,8,11,16,18H2,1H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM63381
PNG
((5Z)-3-[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]-5-...)
Show SMILES CN(C)c1ccc(\C=C2/SC(=O)N(CCc3nnc(N)s3)C2=O)cc1
Show InChI InChI=1S/C16H17N5O2S2/c1-20(2)11-5-3-10(4-6-11)9-12-14(22)21(16(23)24-12)8-7-13-18-19-15(17)25-13/h3-6,9H,7-8H2,1-2H3,(H2,17,19)/b12-9-
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM37382
PNG
((1-methylbenzimidazol-2-yl)-(1-propylbenzimidazol-...)
Show SMILES CCCn1c(Nc2nc3ccccc3n2C)nc2ccccc12
Show InChI InChI=1S/C18H19N5/c1-3-12-23-16-11-7-5-9-14(16)20-18(23)21-17-19-13-8-4-6-10-15(13)22(17)2/h4-11H,3,12H2,1-2H3,(H,19,20,21)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM31699
PNG
((4-methoxy-1,3-benzothiazol-2-yl)-[5-(4-methoxyphe...)
Show SMILES COc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
Show InChI InChI=1S/C17H14N4O3S/c1-22-11-8-6-10(7-9-11)15-20-21-16(24-15)19-17-18-14-12(23-2)4-3-5-13(14)25-17/h3-9H,1-2H3,(H,18,19,21)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75796
PNG
((3Z)-3-[(4-fluoroanilino)methylene]isobenzothiophe...)
Show SMILES Fc1ccc(NC=C2SC(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10FNOS/c16-10-5-7-11(8-6-10)17-9-14-12-3-1-2-4-13(12)15(18)19-14/h1-9,17H
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75782
PNG
(11-amino-2-phenyl-7,8,9,10-tetrahydro-6H-cyclohept...)
Show SMILES Nc1c2CCCCCc2nc2ccn(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C19H19N3O/c20-18-14-9-5-2-6-10-15(14)21-16-11-12-22(19(23)17(16)18)13-7-3-1-4-8-13/h1,3-4,7-8,11-12H,2,5-6,9-10H2,(H2,20,21)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM65122
PNG
(1-[1-(2-phenoxyethyl)-2-benzimidazolyl]-3-phenylth...)
Show SMILES S=C(Nc1nc2ccccc2n1CCOc1ccccc1)Nc1ccccc1
Show InChI InChI=1S/C22H20N4OS/c28-22(23-17-9-3-1-4-10-17)25-21-24-19-13-7-8-14-20(19)26(21)15-16-27-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,28)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM52777
PNG
(MLS000559965 | Methanesulfonic acid 3-oxo-2-[(E)-3...)
Show SMILES CS(=O)(=O)Oc1ccc2C(=O)\C(Oc2c1)=C\C=C\c1ccccc1
Show InChI InChI=1S/C18H14O5S/c1-24(20,21)23-14-10-11-15-17(12-14)22-16(18(15)19)9-5-8-13-6-3-2-4-7-13/h2-12H,1H3/b8-5+,16-9-
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75801
PNG
(2-(4-chloro-3-{[4-(2-methoxyphenyl)piperazin-1-yl]...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(ccc1Cl)N1C(=O)C2C3CCC(C3)C2C1=O
Show InChI InChI=1S/C27H28ClN3O4/c1-35-22-5-3-2-4-21(22)29-10-12-30(13-11-29)25(32)19-15-18(8-9-20(19)28)31-26(33)23-16-6-7-17(14-16)24(23)27(31)34/h2-5,8-9,15-17,23-24H,6-7,10-14H2,1H3
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The Scripps Research Institute Molecular Screening Center

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Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75806
PNG
((5Z)-1-phenyl-5-[(E)-3-phenylazanylprop-2-enyliden...)
Show SMILES Oc1c(C=CC=Nc2ccccc2)c(=O)[nH]c(=O)n1-c1ccccc1
Show InChI InChI=1S/C19H15N3O3/c23-17-16(12-7-13-20-14-8-3-1-4-9-14)18(24)22(19(25)21-17)15-10-5-2-6-11-15/h1-13,24H,(H,21,23,25)/b12-7+,20-13+
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75822
PNG
((2Z)-2-(p-anisidinomethylene)benzo[e]benzofuran-1-...)
Show SMILES COc1ccc(cc1)N=Cc1oc2ccc3ccccc3c2c1O
Show InChI InChI=1S/C20H15NO3/c1-23-15-9-7-14(8-10-15)21-12-18-20(22)19-16-5-3-2-4-13(16)6-11-17(19)24-18/h2-12,22H,1H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75828
PNG
(MLS000516892 | N-(tert-butylcarbamoyl)-2-[4-(3-chl...)
Show SMILES CC(C)(C)NC(=O)NC(=O)CN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C17H25ClN4O2/c1-17(2,3)20-16(24)19-15(23)12-21-7-9-22(10-8-21)14-6-4-5-13(18)11-14/h4-6,11H,7-10,12H2,1-3H3,(H2,19,20,23,24)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM47494
PNG
(4-[3-(4-methoxyphenyl)-5-thiophen-2-yl-3,4-dihydro...)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1ccc(C=O)cc1)c1cccs1
Show InChI InChI=1S/C21H18N2O2S/c1-25-18-10-6-16(7-11-18)20-13-19(21-3-2-12-26-21)22-23(20)17-8-4-15(14-24)5-9-17/h2-12,14,20H,13H2,1H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


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Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75811
PNG
(MLS000702066 | N-(3,4-dimethylphenyl)-2-[[4-methyl...)
Show SMILES Cc1ccc(NC(=O)CSc2nnc(CN3CCOCC3)n2C)cc1C
Show InChI InChI=1S/C18H25N5O2S/c1-13-4-5-15(10-14(13)2)19-17(24)12-26-18-21-20-16(22(18)3)11-23-6-8-25-9-7-23/h4-5,10H,6-9,11-12H2,1-3H3,(H,19,24)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM50977
PNG
((5Z)-3-(2-furanylmethyl)-5-[[1-(4-methoxyphenyl)-2...)
Show SMILES COc1ccc(cc1)-n1c(C)cc(\C=C2/SC(=S)N(Cc3ccco3)C2=O)c1C
Show InChI InChI=1S/C22H20N2O3S2/c1-14-11-16(15(2)24(14)17-6-8-18(26-3)9-7-17)12-20-21(25)23(22(28)29-20)13-19-5-4-10-27-19/h4-12H,13H2,1-3H3/b20-12-
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75794
PNG
(5-(5-chloranyl-2-oxidanyl-phenyl)carbonyl-1-(1,5-d...)
Show SMILES Cc1c(-n2cc(cc(C#N)c2=O)C(=O)c2cc(Cl)ccc2O)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C24H17ClN4O4/c1-14-21(24(33)29(27(14)2)18-6-4-3-5-7-18)28-13-16(10-15(12-26)23(28)32)22(31)19-11-17(25)8-9-20(19)30/h3-11,13,30H,1-2H3
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75834
PNG
(5-(4-hydroxy-3,5-dimethyl-benzylidene)-2-thioxo-th...)
Show SMILES Cc1cc(C=C2SC(S)=NC2=O)cc(C)c1O
Show InChI InChI=1S/C12H11NO2S2/c1-6-3-8(4-7(2)10(6)14)5-9-11(15)13-12(16)17-9/h3-5,14H,1-2H3,(H,13,15,16)
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The Scripps Research Institute Molecular Screening Center

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Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM49746
PNG
(1-(2,1,3-benzothiadiazol-5-yl)-3-[2-(1-cyclohexeny...)
Show SMILES O=C(NCCC1=CCCCC1)Nc1ccc2nsnc2c1
Show InChI InChI=1S/C15H18N4OS/c20-15(16-9-8-11-4-2-1-3-5-11)17-12-6-7-13-14(10-12)19-21-18-13/h4,6-7,10H,1-3,5,8-9H2,(H2,16,17,20)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM48094
PNG
((5Z)-3-ethyl-5-[(2E)-2-[3-(2-hydroxyethyl)-1,3-ben...)
Show SMILES CCN1C(=S)S\C(=C/C=C2/Sc3ccccc3N2CCO)C1=O
Show InChI InChI=1S/C16H16N2O2S3/c1-2-17-15(20)13(23-16(17)21)7-8-14-18(9-10-19)11-5-3-4-6-12(11)22-14/h3-8,19H,2,9-10H2,1H3/b13-7-,14-8+
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75809
PNG
(2-amino-4-(cyanomethyl)-6-(3-methylanilino)pyridin...)
Show SMILES Cc1cccc(Nc2nc(N)c(C#N)c(CC#N)c2C#N)c1
Show InChI InChI=1S/C16H12N6/c1-10-3-2-4-11(7-10)21-16-14(9-19)12(5-6-17)13(8-18)15(20)22-16/h2-4,7H,5H2,1H3,(H3,20,21,22)
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The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2416VHJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%