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PubChem AID 504589

Compile data set for download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
alternatively spliced Trp4


(Mus musculus)
BDBM79626
PNG
(2-(1-azepanyl)-4,6-dimethylquinoline;2,2,2-trifluo...)
Show SMILES Cc1ccc2nc(cc(C)c2c1)N1CCCCCC1
Show InChI InChI=1S/C17H22N2/c1-13-7-8-16-15(11-13)14(2)12-17(18-16)19-9-5-3-4-6-10-19/h7-8,11-12H,3-6,9-10H2,1-2H3
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n/an/a 900n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79629
PNG
(2-(1-azepanyl)-6-fluoro-4-methylquinoline;2,2,2-tr...)
Show SMILES Cc1cc(nc2ccc(F)cc12)N1CCCCCC1
Show InChI InChI=1S/C16H19FN2/c1-12-10-16(19-8-4-2-3-5-9-19)18-15-7-6-13(17)11-14(12)15/h6-7,10-11H,2-5,8-9H2,1H3
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n/an/a 1.63E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79628
PNG
(2-(1-azepanyl)-4-methylquinoline;2,2,2-trifluoroac...)
Show SMILES Cc1cc(nc2ccccc12)N1CCCCCC1
Show InChI InChI=1S/C16H20N2/c1-13-12-16(18-10-6-2-3-7-11-18)17-15-9-5-4-8-14(13)15/h4-5,8-9,12H,2-3,6-7,10-11H2,1H3
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n/an/a 1.96E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79627
PNG
(2-(1-azepanyl)-6-ethyl-4-methylquinoline;2,2,2-tri...)
Show SMILES CCc1ccc2nc(cc(C)c2c1)N1CCCCCC1
Show InChI InChI=1S/C18H24N2/c1-3-15-8-9-17-16(13-15)14(2)12-18(19-17)20-10-6-4-5-7-11-20/h8-9,12-13H,3-7,10-11H2,1-2H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79623
PNG
(6-ethyl-4-methyl-2-(1-piperidinyl)quinoline;2,2,2-...)
Show SMILES CCc1ccc2nc(cc(C)c2c1)N1CCCCC1
Show InChI InChI=1S/C17H22N2/c1-3-14-7-8-16-15(12-14)13(2)11-17(18-16)19-9-5-4-6-10-19/h7-8,11-12H,3-6,9-10H2,1-2H3
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n/an/a 3.73E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79624
PNG
(6-fluoranyl-4-methyl-2-pyrrolidin-1-yl-quinoline;2...)
Show SMILES Cc1cc(nc2ccc(F)cc12)N1CCCC1
Show InChI InChI=1S/C14H15FN2/c1-10-8-14(17-6-2-3-7-17)16-13-5-4-11(15)9-12(10)13/h4-5,8-9H,2-3,6-7H2,1H3
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n/an/a 3.94E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79618
PNG
(N,N-diethyl-4-methyl-2-quinolinamine;2,2,2-trifluo...)
Show SMILES CCN(CC)c1cc(C)c2ccccc2n1
Show InChI InChI=1S/C14H18N2/c1-4-16(5-2)14-10-11(3)12-8-6-7-9-13(12)15-14/h6-10H,4-5H2,1-3H3
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n/an/a 7.54E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79620
PNG
(2-[4-(4-methyl-2-quinolinyl)-1-piperazinyl]benzoni...)
Show SMILES Cc1cc(nc2ccccc12)N1CCN(CC1)c1ccccc1C#N
Show InChI InChI=1S/C21H20N4/c1-16-14-21(23-19-8-4-3-7-18(16)19)25-12-10-24(11-13-25)20-9-5-2-6-17(20)15-22/h2-9,14H,10-13H2,1H3
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n/an/a 8.90E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79622
PNG
(1-(4-methyl-2-quinolinyl)-3-piperidinol;2,2,2-trif...)
Show SMILES Cc1cc(nc2ccccc12)N1CCCC(O)C1
Show InChI InChI=1S/C15H18N2O/c1-11-9-15(17-8-4-5-12(18)10-17)16-14-7-3-2-6-13(11)14/h2-3,6-7,9,12,18H,4-5,8,10H2,1H3
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n/an/a 9.40E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79619
PNG
(2-[4-(2-methoxyphenyl)-1-piperazinyl]-4-methylquin...)
Show SMILES COc1ccccc1N1CCN(CC1)c1cc(C)c2ccccc2n1
Show InChI InChI=1S/C21H23N3O/c1-16-15-21(22-18-8-4-3-7-17(16)18)24-13-11-23(12-14-24)19-9-5-6-10-20(19)25-2/h3-10,15H,11-14H2,1-2H3
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n/an/a 9.89E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79625
PNG
(4,8-dimethyl-2-(1-pyrrolidinyl)quinoline;2,2,2-tri...)
Show SMILES Cc1cccc2c(C)cc(nc12)N1CCCC1
Show InChI InChI=1S/C15H18N2/c1-11-6-5-7-13-12(2)10-14(16-15(11)13)17-8-3-4-9-17/h5-7,10H,3-4,8-9H2,1-2H3
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n/an/a 9.96E+3n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79617
PNG
(2-(3,5-dimethyl-1-piperidinyl)-4-methylquinoline;2...)
Show SMILES CC1CC(C)CN(C1)c1cc(C)c2ccccc2n1
Show InChI InChI=1S/C17H22N2/c1-12-8-13(2)11-19(10-12)17-9-14(3)15-6-4-5-7-16(15)18-17/h4-7,9,12-13H,8,10-11H2,1-3H3
PDB

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n/an/a 1.19E+4n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
alternatively spliced Trp4


(Mus musculus)
BDBM79621
PNG
(4-(4-methyl-2-quinolinyl)-2,3-dihydro-1,4-benzoxaz...)
Show SMILES Cc1cc(nc2ccccc12)N1CCOc2ccccc12
Show InChI InChI=1S/C18H16N2O/c1-13-12-18(19-15-7-3-2-6-14(13)15)20-10-11-21-17-9-5-4-8-16(17)20/h2-9,12H,10-11H2,1H3
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n/an/a 2.45E+4n/an/an/an/an/an/a



Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay


Assay Description
The inhibitory effects of test compounds on TRPC4 channels were evaluated in electrophysiological assays using a QPatch16 automated electrophysiology...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2T43RK9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%